5-Amino-1-methylquinolinium iodide（NNMTi） Nambala ya CAS:42464-96-0 98.0% kuyera pang'ono | wopanga zowonjezera zowonjezera
Magawo a Zamalonda
| Dzina la chinthu | 5-Amino-1-methylquinolinium iodide (NNMTi) |
| Dzina lina | NNTi5-AMINO-1-METHYLQUINOLIN-1-IUM IODID 5-amino-1-methylquinolinium iodide 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine; iodide 5-Amino-1-methyl-1-quinolinium Iodide 5-Amino-1-mq iodide |
| Nambala ya CAS | 42464-96-0 |
| Fomula ya maselo | C10H11IN2 |
| Kulemera kwa maselo | 286.11 |
| Chiyero | 98.0% |
| Maonekedwe | Cholimba cha bulauni mpaka chofiira |
| Kulongedza | 1kg/thumba, 25kg/mbiya |
| Kugwiritsa ntchito | Zakudya Zowonjezera Zakudya |
Chiyambi cha malonda
Enzyme ya cytosolic nicotinamide N-methyltransferase (NNMT) yapezeka posachedwa kuti ilamulire kuchuluka kwa nicotinamide precursors yofunikira pakupanga kwa NAD+ ndipo motero imagwira ntchito yofunika kwambiri pakulamulira njira yopulumutsira NAD+ ndi kagayidwe ka maselo. NNMT imawonetsedwa mu minofu ya mafupa, ndipo mawonekedwe ake amawonjezeka pang'onopang'ono ndi ukalamba wa minofu. Chofunika kwambiri, NNMT ndi gawo lalikulu la chizindikiro cha sarcopenic gene expression, ndipo kuwonetsa kwake mopitirira muyeso kungayambitse kuchepa kwakukulu kwa milingo ya NAD+ komanso kuchepa kwa minofu, mphamvu, ndi ntchito zomwe zimayenderana ndi ukalamba. Kuchiza mbewa zokalamba ndi molekyulu yaying'ono ya NNMT inhibitor (NNMTTi) kunawonjezera kuchulukana, kusakanikirana, ndi mphamvu yokonzanso ya muSCs, motero kunawongolera magwiridwe antchito a minofu ya mafupa. Zotsatira zofananazo zidapezeka mu vitro pogwiritsa ntchito maselo a C2C12, omwe ali ofanana kwambiri ndi muSCs, komwe chithandizo cha NNMTTi chinalimbikitsa kusiyana kwa myoblast ndikuthandizira kusintha kwa kagayidwe kachakudya m'maselo omwe amagwirizanitsidwa ndi njira yopulumutsira NAD +.
NNMT ndi enzyme yomwe imapangidwa mopitirira muyeso panthawi ya ukalamba wa minofu ya mafupa ndipo imagwirizanitsidwa ndi kuwonongeka kwa njira ya NAD+, ntchito ya sirtuin1 yosakhazikika bwino, komanso kuchuluka kwa ukalamba wa maselo a minofu. NNMT ndi enzyme ya kagayidwe kachakudya yomwe imayambitsa methylation ya nicotinamide (NAM) pogwiritsa ntchito methyl donor S-adenosylmethionine (SAM), kulumikiza mkhalidwe wa kagayidwe kachakudya wa selo ndi methylation balance ndi milingo ya NAD+ ya mkati mwa maselo. NNMT imawonetsedwa kwambiri mu minofu ya chiwindi ndi mafuta, komanso m'mikhalidwe yomwe imadziwika ndi kufunikira kwa kagayidwe kachakudya kowonjezereka, monga matenda ena a chiwindi chamafuta ndi matenda a shuga. NNMT imagwira ntchito m'njira zosiyanasiyana zosiyanitsira, kuphatikizapo kusintha kwa maselo a stem a munthu osabadwa, myogenesis, ndi kusintha kwa epithelial ndi neuromesenchymal m'makhansa osiyanasiyana. Kuwonetsedwa kwa NNMT kumayendetsedwa mwanjira yosiyana ndi minofu ndi malo m'malo motsatira njira yodziwika bwino.
Mbali
(1) Kuyera kwambiri: NNMTi imatha kupeza zinthu zoyera kwambiri kudzera mu njira zopangira zoyeretsedwa. Kuyera kwambiri kumatanthauza kupezeka bwino kwa bioavailability.
(2) Kuyang'anira: NNMTTi imayang'ana makamaka enzyme ya NNMT ndipo imatha kuletsa bwino ntchito yake, motero imakhudza njira ya kagayidwe ka nicotinamide.
(3) Kukhazikika: NNMTi ili ndi kukhazikika kwabwino ndipo imatha kusunga ntchito yake ndi mphamvu zake pansi pa malo osiyanasiyana komanso malo osungiramo zinthu zosiyanasiyana.
(4) Ziyembekezo za chitukuko: Chifukwa cha makhalidwe osiyanasiyana a NNMTi, chitukuko chake chalandiridwa kwambiri ndipo chili ndi kafukufuku wochuluka komanso mwayi wogwiritsa ntchito.
Mapulogalamu
NNMT (CAS 42464-96-0) ndi choletsa cha nicotinamide N-methyltransferase (NNMT), choletsa champhamvu (IC50=1.2 μM) cha nicotinamide N-methyltransferase (NNMT) chomwe chimalimbikitsa kusiyana kwa myoblast. NNMTTi imamangirira mosankha ku zotsalira za NNMT substrate binding site. NNMTTi imalimbikitsa kusiyana kwa myoblast mu vitro ndikuwonjezera kusakanikirana kwa maselo a minofu ndi kukonzanso mwa mbewa zokalamba. NNMT ndi enzyme yofunikira ya cytosolic biotransformation yomwe imayambitsa N-methylation ya xenobiotics ya endogenous ndi exogenous. Poyerekeza ndi kusintha zakudya zopanda mafuta zokha, chithandizo cha NNMTTi pamodzi ndi kusintha zakudya zopanda mafuta chinathandizira kusintha kwa mafuta m'thupi, kuwonjezera kulemera kwa thupi lonse ndi kulemera kwa thupi, kuchepetsa kulemera kwa minofu yoyera ya chiwindi, kuchepetsa mafuta m'chiwindi, komanso kusintha kwa chiwindi. Kuphatikiza apo, NNMTi imatha kuwonjezera mphamvu ndikulimbikitsa mphamvu yobwezeretsa minofu yokalamba, zomwe zingakhale zothandiza pochiza sarcopenia.
