BAM15A CAS No.:210302-02-6 Pangani minofu ndikuchepetsa mafuta.
Magawo a Zamalonda
| Dzina la chinthu | BAM15A |
| Dzina lina | N5,N6-Bis(2-Chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine |
| Nambala ya CAS | 210302-02-6 |
| Fomula ya maselo | C16H10Cl2N6O |
| Kulemera kwa maselo | 373.2 |
| Chiyero | 98% |
| Maonekedwe | Ufa wofiirira mpaka wachikasu wopepuka |
| Kulongedza | 1kg/thumba, 25kg/mbiya |
| Kugwiritsa ntchito | Zakudya Zowonjezera Zakudya |
Chiyambi cha malonda
BAM15A ndi makina atsopano osinthira ma mitochondrial. Monga cholumikizira chabwino kwambiri cha ma proton a mitochondrial, chimawongolera pang'onopang'ono kuchuluka kwa ma proton kudutsa nembanemba yamkati ya mitochondrial, chimawonjezera mphamvu zamagetsi m'thupi ndikufulumizitsa kuwonongeka kwa mafuta mwachilengedwe, popanda kusokoneza minofu kapena chilakolako chabwino cha chakudya.
Kafukufuku woyambirira watsimikizira kuti mankhwalawa amathandiza kuchepetsa kutupa m'thupi, kuwonjezera mphamvu ya insulin, kuchepetsa kuchulukana kwa mafuta m'chiwindi komanso kuchepetsa kutupa m'thupi. Ali ndi bioavailability yokwana 67% pakamwa ndipo ali ndi mphamvu zochepa komanso chitetezo chokwanira. Mosiyana ndi zosakaniza zachikhalidwe zofanana, sayambitsa kutentha thupi kapena kuwonongeka kwa maselo, zomwe zimapangitsa kuti akhale chakudya chabwino kwambiri chothandizira kuchepetsa thupi komanso kusintha kagayidwe kachakudya m'thupi.
Mbali
(1) Kuyera kwambiri: BAM15Aakhoza kupanga zinthu zoyera kwambiri kudzera mu njira yopangira yokonzedwa bwino. Kuyera kwambiri kumatanthauza kupezeka bwino kwa zinthu zachilengedwe.
(2) Njira yolumikizira bwino: Monga chonyamulira cha proton cha mitochondrial, chimasokoneza kusinthasintha kwa proton kwa nembanemba yamkati ya mitochondrial, zomwe zimapangitsa kuti mphamvu ya okosijeni isanduke kuchokera ku michere kukhala mphamvu yotentha m'malo mwa ATP, zomwe zimapangitsa kuti mphamvu igwiritsidwe ntchito kwambiri.
(3) Kutaya mafuta m'thupi motetezeka komanso kusintha kagayidwe kachakudya m'thupi: Mu zoyeserera za nyama, kupezeka kwa mafuta m'thupi m'thupi kunafika pa 67%, kuchepetsa mafuta m'thupi ndi oposa 20% popanda kuchepetsa minofu, zomwe zimakhudza chilakolako cha chakudya kapena kutentha kwa thupi, pomwe zimawonjezera mphamvu ya insulin, kuchepetsa mafuta m'chiwindi ndi kutupa.
(4) Ubwino wochepa wa poizoni: Poyerekeza ndi mankhwala achikhalidwe omangirira, palibe chiopsezo cha kutentha thupi kwambiri kapena poizoni wa cytotoxicity. Popanda kuwonongeka kwa ziwalo kapena zotsatira zoyipa za mitsempha.
Mapulogalamu
1. Kuchepetsa mafuta ndi kusintha kagayidwe kachakudya: Kudzera mu kumasula kwa mitochondrial, kumachepetsa kwambiri mafuta m'thupi (mu zitsanzo za nyama, mafuta m'thupi amachepa ndi oposa 20%), nthawi imodzi kumachepetsa shuga m'magazi, kukana insulin, ndi kuchulukana kwa mafuta m'chiwindi, popanda kusokoneza chilakolako cha chakudya kapena minofu;
2. Kuletsa kukalamba: Kuonjezera minofu (ndi 8%) ndi mphamvu (ndi 40%) mwa nyama zokalamba, kuchepetsa mafuta ndikuletsa kutupa kosatha, ndikuthana ndi kunenepa kwambiri kwa myogenic.
3. Kuletsa kutupa: Kumachepetsa chiopsezo cha kuvulala kwa impso komwe kumachitika chifukwa cha sepsis (AKI), ndipo kumachepetsa kutupa kwa thupi mwa kuletsa kupanga kwa mitochondrial ROS ndi kutulutsidwa kwa mtDNA.
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