O-304 CAS No.:1261289-04-6 Pangani minofu ndikuchepetsa mafuta.
Magawo a Zamalonda
| Dzina la chinthu | O-304 |
| Dzina lina | 4-Chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]benzamide |
| Nambala ya CAS | 1261289-04-6 |
| Fomula ya maselo | C16H11Cl2N3O2S |
| Kulemera kwa maselo | 380.25 |
| Chiyero | 98% |
| Maonekedwe | Ufa woyera mpaka woyera pang'ono |
| Kulongedza | 1kg/thumba, 25kg/mbiya |
| Kugwiritsa ntchito | Zakudya Zowonjezera Zakudya |
Chiyambi cha malonda
O-304 ndi choyambitsa AMPK cha mamolekyulu ang'onoang'ono chomwe chimawonjezera ntchito ya AMPK mwa kuletsa dephosphorylation ya AMPK (pAMPK) yokhala ndi phosphorylated, motero kumawonjezera kuchuluka kwa pAMPK popanda kuchepetsa kuchuluka kwa adenosine triphosphate (ATP) mkati mwa maselo. Ili ndi njira zambiri zogwirira ntchito, kuphatikizapo kukonza kagayidwe ka shuga m'magazi, kuchepetsa kukana kwa insulin, komanso kuteteza dongosolo la mtima.
Mbali
(1) Kuyera kwambiri: O-304 imapangidwa kudzera mu njira yokonzedwa bwino yopangira zinthu, zomwe zimapangitsa kuti zinthu zikhale zoyera kwambiri. Kuyera kwambiri kumatanthauza kuti zinthu zimapezeka mosavuta.
(2) Ntchito Zachilengedwe:O-304 ndi choyambitsa matenda a AMPK (AMP-activated protein kinase) chomwe chimagwira ntchito pakamwa. Chimawonjezera ntchito ya AMPK poletsa kusungunuka kwa pAMPK m'thupi.
Mapulogalamu
1. Kuyambitsa kwa AMPK: O-304 imawonjezera ntchito ya AMPK mwa kuletsa njira yochotsera phosphorylation ya AMPK (pAMPK) yokhala ndi phosphorylated, motero imayang'anira bwino kagayidwe ka mphamvu.
2. Kuwongolera kagayidwe ka shuga m'magazi: Mu kafukufuku wa nyama, mlingo wa 100 mg/kg wa O-304 unathandiza kwambiri kusunga shuga m'magazi osadya bwino komanso kuchuluka kwa insulin m'magazi, kuchepetsa kwambiri kagayidwe ka shuga komwe kumachitika chifukwa cha zakudya zokhala ndi mafuta ambiri, komanso kupewa kusinthasintha kwa shuga m'magazi ndi kukwera kwa insulin kosazolowereka komwe kumachitika chifukwa cha kusalinganika kwa zakudya.
3. Pkuteteza kusinthasintha kwa mitsempha yamagazi:O-304 imathandiza kusunga kuthamanga kwa magazi pamlingo wabwino, imachepetsa kupsinjika kwa mitsempha yamagazi, komanso imapereka chitetezo chofatsa komanso cha nthawi yayitali ku machitidwe amtima ndi mitsempha yamagazi, kuthandizira kukhazikika kwa malingaliro ndi mphamvu zokhazikika.
4.Kulimbikitsa unyamata wosatha:O-304 imayang'ana bwino njira yolumikizirana ya AMPK-mTOR, mwanzeru imayang'anira njira ya autophagy ya maselo, kulimbikitsa katabolism ya mapuloteni okalamba ndi mafuta osazolowereka, ndikusunga malo oyera komanso amphamvu a maselo, motero imachedwetsa kukalamba kwa maselo.
