Wopanga ufa wa Agomelatine CAS No.: 138112-76-2 99% chiyero min.kwa zowonjezera zowonjezera

Agomelatine ndi mtundu watsopano wa antidepressant.Kachitidwe kake kachitidwe kake kamadutsa munjira yachikhalidwe ya monoamine transmitter.Imayatsa zolandilira melatonin, MT1 ndi MT2, ndikutsutsa zolandilira 5-HT2C.Ikhoza kusintha khalidwe la kugona ndikubwezeretsanso chikhalidwe chachilengedwe chokhala ndi antidepressant kwenikweni;pakati pawo, potsutsana ndi 5-HT2C receptor ya postsynaptic membrane, ikhoza kuonjezera kumasulidwa kwa DA ndi NE mu prefrontal cortex ndikugwira ntchito yotsutsa maganizo.Pamene MT agonism ndi 5-HT2C receptor antagonism ilipo nthawi imodzi, mphamvu yapadera ya synergistic ikhoza kupangidwa kuti ipititse patsogolo kutulutsidwa kwa DA ndi NE yambiri mu dera la ubongo la PFC, kulimbitsanso mphamvu ya antidepressant.Kuphatikiza apo, agomelatine ikhoza kulimbikitsanso kutulutsidwa kwa neurotrophic factor yochokera muubongo mu PFC ndikuletsa kutulutsa kwamphamvu kwa glutamate m'chigawo chaubongo cha amygdala.