Wopanga ufa wa Oleoylethanolamide (OEA) Nambala ya CAS: 111-58-0 98%,85% kuyera kwa mphindi zochepa kwa zowonjezera zowonjezera
Magawo a Zamalonda
| Dzina la chinthu | Oleoyl ethanolamide |
| Dzina lina | N-oleoyl ethanolamine; N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide |
| Nambala ya CAS | 111-58-0 |
| Fomula ya maselo | C20H39NO2 |
| Kulemera kwa maselo | 325.53 |
| Chiyero | 98.0% ，85.0% |
| Maonekedwe | Ufa woyera wa kristalo woyera |
| Kulongedza | 1kg/thumba, 25kg/ng'oma |
| Kugwiritsa ntchito | Mpumulo wa ululu, wotsutsa kutupa |
Chiyambi cha malonda
Oleoylethanolamide ndi mankhwala ena a amide omwe amapangidwa ndi lipophilic oleic acid ndi hydrophilic ethanolamine. Oleoylethanolamide ndi molekyulu yamafuta yomwe imapezeka mwachilengedwe m'thupi la nyama ndi zomera zina. Imapezeka kwambiri m'thupi la nyama ndi zomera monga ufa wa koko, soya, ndi mtedza, koma kuchuluka kwake kumakhala kochepa kwambiri. Pokhapokha ngati chilengedwe chakunja chasintha kapena chakudya chalimbikitsidwa, minofu ya maselo a thupi ndi pamene chinthu chochulukachi chidzapangidwa.
Pa kutentha kwa chipinda, Oleoylethanolamide ndi chinthu choyera cholimba chomwe chimasungunuka pafupifupi 50°C. Chimasungunuka mosavuta mu zosungunulira zakumwa monga methanol ndi ethanol, chimasungunuka mosavuta mu zosungunulira zopanda polar monga n-hexane ndi ether, komanso sichisungunuka m'madzi. OEA ndi molekyulu ya amphiphilic yomwe nthawi zambiri imagwiritsidwa ntchito ngati surfactant komanso sopo wothira mankhwala mumakampani opanga mankhwala. Komabe, kafukufuku wowonjezereka adapeza kuti OEA imatha kugwira ntchito ngati molekyulu yolumikizira mafuta mu mtsempha wa m'mimba ndi ubongo ndikuwonetsa zochitika zosiyanasiyana zamoyo m'thupi, kuphatikizapo: kuwongolera chilakolako, kukonza kagayidwe ka mafuta, kukulitsa kukumbukira ndi kuzindikira ndi ntchito zina. Pakati pa izi, ntchito za Oleoylethanolamide zowongolera chilakolako ndikuwongolera kagayidwe ka mafuta zalandiridwa kwambiri.
Oleoylethanolamide imatha kulamulira kudya ndi mphamvu zomwe zimalowa m'thupi mwa kuyambitsa receptor-α yoyambitsidwa ndi peroxisome proliferator. Kuphatikiza apo, Oleoylethanolamide imasonyeza ntchito zina zokhudzana ndi thanzi, kuphatikizapo kusintha ntchito ya converter mu njira yolumikizirana ya lysosomal-to-nuclear yogwirizana ndi malamulo a moyo wautali komanso kuteteza mitsempha yomwe imalamulira machitidwe ovutika maganizo. Kafukufuku akuwonetsanso kuti Oleoylethanolamide ikhoza kukhala ndi zotsatira zoteteza mitsempha. Mu zitsanzo za nyama, yapezeka kuti imachepetsa kuwonongeka chifukwa cha sitiroko ndi kuvulala kwa ubongo koopsa. Mphamvu yolamulira ya Oleoylethanolamide imanenedwa kuti imalumikizana ndi PPARα, yomwe imachepetsa ndi retinoid X receptor (RXR) ndikuyiyambitsa ngati chinthu champhamvu cholembera chomwe chimagwira ntchito mu homeostasis yamphamvu yophatikizana, kagayidwe ka lipid, autophagy, ndi kutupa.
Mbali
(1) Kuyera kwambiri: OEA imatha kupeza zinthu zoyera kwambiri kudzera mu njira zopangira zinthu zoyeretsera. Kuyera kwambiri kumatanthauza kupezeka bwino kwa bioavailability komanso kuchepetsa zotsatirapo zoyipa.
(2) Chitetezo: OEA yatsimikiziridwa kuti ndi yotetezeka ku thupi la munthu.
(3) Kukhazikika: OEA ili ndi kukhazikika kwabwino ndipo imatha kusunga ntchito yake ndi zotsatira zake pansi pa malo osiyanasiyana komanso malo osungiramo zinthu zosiyanasiyana.
(4) Yosavuta kuyamwa: OEA imatha kuyamwa mwachangu ndi thupi la munthu ndikugawidwa ku minofu ndi ziwalo zosiyanasiyana.
Mapulogalamu
Oleoylethanolamide ndi mafuta achilengedwe a ethanolamide omwe amagwiritsidwa ntchito ngati njira yokonzekera zakudya komanso yowongolera kulemera kwa thupi m'mitundu yosiyanasiyana ya zamoyo zam'mimba. Ndi metabolite ya oleic acid yopangidwa m'matumbo ang'onoang'ono a munthu. Oleylethanolamide (OEA) ndi molekyulu yomwe imayang'anira kagayidwe ka mafuta m'thupi ndi homeostasis ya mphamvu. Imamatira ku ma receptor a PPAR Alpha ndipo imathandizira kuwongolera zinthu zinayi: njala, mafuta m'thupi, cholesterol ndi kulemera. PPAR Alpha imayimira alpha ya receptor yoyambitsidwa ndi peroxide proliferator, ndipo lipid amide oleoylethanolamide (OEA) ili ndi zinthu zosiyanasiyana za homeostatic, kuphatikizapo anti-inflammatory activity, immune response modulation, ndi antioxidant effects.
