Wopanga ufa wa Lemairamin (WGX-50) Nambala ya CAS: 29946-61-0 98.0% kuyera kwa zosakaniza zowonjezera
Kanema wa Zamalonda
Magawo a Zamalonda
| Dzina la chinthu | Lemairamin |
| Dzina lina | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; Lemairamin (WGX-50) |
| Nambala ya CAS | 29946-61-0 |
| Fomula ya maselo | C19H21NO3 |
| Kulemera kwa maselo | 311.37 |
| Chiyero | 98.0% |
| Maonekedwe | Ufa woyera mpaka woyera pang'ono |
| Kugwiritsa ntchito | Zakudya Zowonjezera Zakudya |
Chiyambi cha malonda
Lemairamin kapena Wgx50 ndi mankhwala achilengedwe ochokera ku tsabola wa chili omwe awonetsa zotsatira zabwino popewa matenda a Alzheimer's. Kafukufuku wapeza kuti amatha kuletsa apoptosis ya neuronal yomwe imayambitsa Aβ, kuchepetsa poizoni wa calcium wa neuronal, ndikuchepetsa kuchuluka kwa Aβ oligomers mu cerebral cortex. Kuphatikiza apo, wgx50 yawonetsedwa kuti ikuwongolera magwiridwe antchito a ubongo mwa mbewa. Kafukufuku akuwonetsa kuti wgx50 ili ndi kuthekera koletsa kusonkhana kwa mapuloteni pakati pa mamolekyu a amyloid. Ponseponse, wgx50 ili ndi kuthekera koletsa matenda a Alzheimer's ndipo ingapereke njira zatsopano zopangira mankhwala olimbana ndi Aβ oligomers. Kuphatikiza apo, WGX-50 ikuwonetsa ntchito yayikulu yotsutsana ndi kutupa, zomwe zimapangitsa kuti ikhale yoyenera kuchiza matenda otupa. WGX-50 yapezeka kuti ili ndi zotsatira zabwino pakhungu, monga kuchepetsa makwinya ndikuwongolera kusinthasintha kwa khungu. Kuphatikiza pa mankhwala achilengedwe ochokera ku chomera cha Zanthoxylum bungeanum, pakadali pano pali mankhwala ambiri opangidwa omwe amagwiritsidwa ntchito m'njira zosiyanasiyana ndipo ndi oyenera pamsika.
Mbali
(1) Kuyera kwambiri: Lemairamin imatha kupeza zinthu zoyera kwambiri kudzera mu njira zachilengedwe zopangira ndi kuyeretsa. Kuyera kwambiri kumatanthauza kupezeka bwino kwa bioavailability komanso kuchepetsa zotsatira zoyipa.
(2) Chitetezo: Chitetezo chachikulu, zotsatirapo zochepa zoyipa, palibe zotsatirapo zoyipa zoonekeratu ngakhale mutagwiritsa ntchito kwa nthawi yayitali.
(3) Kukhazikika: Lemairamin ili ndi kukhazikika kwabwino ndipo imatha kusunga ntchito yake ndi mphamvu zake pansi pa malo osiyanasiyana komanso malo osungiramo zinthu zosiyanasiyana.
(4) Yosavuta kuyamwa: Lemairamin imatha kuyamwa mwachangu ndi thupi la munthu ndikugawidwa ku minofu ndi ziwalo zosiyanasiyana.
Mapulogalamu
Lemairamin ndi mankhwala a amide otengedwa kuchokera ku khungwa la chomera cha Zanthoxylum bungeanum. Pakadali pano amagwiritsidwa ntchito ngati chowonjezera pazakudya, amagwiranso ntchito ngati agonist wa alpha7 nicotinic acetylcholine receptor (α7nAChR), yomwe imachepetsa kutupa kwa mitsempha mu matenda a Alzheimer's, ndipo imapangidwa kwathunthu. Wgx50 yawonetsa zotsatira zolimbikitsa mu maphunziro asanachitike, kuphatikizapo kuletsa apoptosis ya neuronal yomwe imayambitsa Aβ, kuchepetsa poizoni wa calcium ya mitsempha, kuchepetsa kuchuluka kwa Aβ oligomers mu cerebral cortex, komanso kukonza magwiridwe antchito a ubongo m'makoswe.
