Wopanga ufa wa CMS121 Nambala ya CAS: 1353224-53-9 98.0% kuyera kwa zosakaniza zowonjezera

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol ndi mankhwala omwe amatchedwanso CMS121. Kuvuta kwa kapangidwe ka mankhwala kumasonyeza kuti akhoza kukhala ndi makhalidwe apadera komanso ntchito zomwe angathe kugwiritsa ntchito. Kuti timvetse kufunika kwake, zimathandiza kuzindikira magulu ogwira ntchito omwe alipo ndikuwunika momwe angakhudzire. Kukhalapo kwa mphete ya quinoline kumasonyeza kuti mankhwalawa akhoza kukhala ogwira ntchito m'thupi. Mamolekyu ochokera ku quinoline amadziwika ndi makhalidwe awo osiyanasiyana achilengedwe, kuphatikizapo ntchito zotsutsana ndi mabakiteriya komanso zotsutsana ndi kutupa. Kuphatikizika kwa gulu la cyclopentyloxy kungathandize kusungunuka kwa mankhwalawa kapena kuwonjezera ntchito yake yachilengedwe kudzera mu zotsatira za steric. Mu kafukufuku pa maselo a HT22, CMS-121 yawonetsa zotsatira zazikulu zoteteza mitsempha, kuteteza maselowa ku ischemia ndi kuwonongeka kwa okosijeni. Kuphatikiza apo, CMS-121 ili ndi mphamvu zotsutsana ndi kutupa, zomwe zikusonyeza kuti imatha kusintha mayankho otupa. Pochita izi, CMS-121 ili ndi kuthekera kochepetsa kutupa m'maselo ndi ziwalo zosiyanasiyana. CMS-121 ili ndi mphamvu yamphamvu ya mankhwala monga choletsa cha acetyl-CoA carboxylase 1 (ACC1). Mphamvu yake yoletsa kwambiri pa ACC1 imapangitsa kuti ikhale mankhwala abwino kwambiri.