SLU-PP-332 Nambala ya CAS: 303760-60-3
Magawo a Zamalonda
| Dzina la chinthu | SLU-PP-332 |
| Dzina lina | SLU-PP-332； (E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide；4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide； |
| Nambala ya CAS | 303760-60-3 |
| Fomula ya maselo | C18H14N2O2 |
| Kulemera kwa maselo | 290.32 |
| Chiyero | 98% |
| Maonekedwe | Ufa woyera kapena wopanda mtundu woyera |
| Kulongedza | 1kg/thumba, 25kg/mbiya |
| Kugwiritsa ntchito | Zakudya Zowonjezera Zakudya |
Chiyambi cha malonda
SLU-PP-332 ndi mankhwala atsopano ang'onoang'ono a molekyulu omwe amagwira ntchito ngati perifollicle estrogen receptor (ERR) agonist, makamaka yolunjika ku ERRα, ERRβ, ndi ERRγ, yokhala ndi mphamvu yayikulu yoyambitsa ERRα (EC₅₀=98 nM). Mankhwalawa amayambitsa njira yolumikizirana ya ERR potengera njira zoyendetsera kagayidwe kachakudya m'thupi, potero amasintha kagayidwe kachakudya m'thupi, ntchito ya mitochondrial, ndi kupirira kwa minofu.
Mbali
(1) Njira yogwirira ntchito: kuyambitsa ERRα/β/γ, kuonjezera mafuta acid oxidation (FAO) ndi majini okhudzana ndi kupuma kwa mitochondrial, kulimbikitsa kusweka kwa mafuta kuti apereke mphamvu, kuchepetsa kusonkhanitsa mafuta, kukulitsa ntchito ya minofu ya mafupa, kukonza mphamvu ya okosijeni ndi kupirira, mofanana ndi momwe maphunziro a aerobic amakhudzira.
(2) Kugwira ntchito kwa thupi: a) Zotsatira za chitsanzo cha nyama: Mbewa zonenepa: atatha masiku 28 akumwa mankhwala, kulemera kwa thupi kunachepa ndi 12%, ndipo mafuta a chiwindi, cholesterol, ndi triglycerides zinachepa kwambiri; mbewa zabwinobwino: nthawi yogwira ntchito inawonjezeka ndi 70%, mtunda unawonjezeka ndi 45%, popanda kusokoneza chilakolako cha chakudya kapena kuyenda mwaufulu. b) Chitetezo: palibe zotsatirapo zoyipa zomwe zinawonedwa mu maphunziro asanalandire chithandizo.
(3) Kapangidwe ka thupi ndi mankhwala: koyera mpaka koyera kolimba, kosungunuka mu DMSO (75 mg/mL) ndi ethanol, kosasungunuka m'madzi; kuyenera kusungidwa mumdima.
Mapulogalamu
SLU-PP-332 imakwaniritsa kutayika kwa mafuta ndi kulamulira shuga m'magazi mwa kulimbikitsa kusungunuka kwa mafuta ndikuwonjezera mphamvu ya insulin; imawongolera matenda a chiwindi amafuta osamwa mowa (NAFLD), imachepetsa kuchuluka kwa mafuta m'chiwindi; imapereka chithandizo cha kagayidwe kachakudya kwa anthu omwe sangathe kuchita masewera olimbitsa thupi, kusunga minofu ndi kugwira ntchito bwino; imachepetsa kutayika kwa minofu panthawi yotaya mafuta; ndipo ili ndi mwayi waukulu m'madera otaya mafuta, kupirira bwino, komanso kusintha kagayidwe kachakudya.
