7,8-Dihydroxyflavone (7,8-DHF)ndi flavonoid yopezeka mwachilengedwe, mankhwala a polyphenolic omwe amapezeka m'zomera zosiyanasiyana. Ma Flavonoid amadziwika ndi mphamvu zawo zotsutsana ndi ma antioxidants ndipo amagwira ntchito yofunika kwambiri pa njira zodzitetezera ku zomera. 7,8-Dihydroxyflavone imapezeka makamaka m'zomera monga Godmania aesculifolia ndi Tridax procumbens.
7,8-Dihydroxyflavone imasiyana ndi ma flavonoid ena chifukwa cha kuthekera kwake kutsanzira ntchito ya neurotrophic factor (BDNF) yochokera mu ubongo. BDNF ndi puloteni yomwe imathandizira kupulumuka, chitukuko, ndi ntchito ya ma neuron mu ubongo. Imachita gawo lofunika kwambiri mu neuroplasticity, kuthekera kwa ubongo kudzikonzanso mwa kupanga maulumikizidwe atsopano a mitsempha. Katundu uyu wa 7,8-DHF umatsegula njira zambiri zofufuzira, makamaka m'munda wa neuroscience.
Njira yogwirira ntchito
Njira yaikulu yomwe 7,8-Dihydroxyflavone imagwirira ntchito ndi kuyambitsa kwa cholandirira cha TrkB (tropomyosin receptor kinase B). TrkB ndi cholandirira champhamvu kwambiri cha BDNF. Pamene 7,8-Dihydroxyflavone imagwirizana ndi TrkB, imayambitsa njira zingapo zolumikizirana mkati mwa maselo zomwe zimalimbikitsa kupulumuka, kukula, ndi kusiyana kwa mitsempha.
Kafukufuku woyambirira wasonyeza kuti 7,8-dihydroxyflavone imatha kutsanzira BDNF (neurotrophic factor) ndikuwonjezera mawonekedwe ake ndi kuchuluka kwake mu hippocampus. Mu zitsanzo za nyama, ili ndi kuthekera kochiritsa matenda angapo amitsempha kapena matenda, monga sitiroko, kukhumudwa, ndi matenda a Parkinson. Mu maphunziro awiri osiyanasiyana, 7,8-dihydroxyflavone yawonetsa kupezeka kwakukulu kwa bioavailability pakamwa ndipo yapezeka kuti imadutsa chotchinga cha magazi muubongo (BBB). Chifukwa imagwira ntchito panjira yolumikizirana ndi nitric oxide ndikuyambitsa TrkB receptor (tropomyosin receptor kinase B)
Chinthu cha neurotrophic BDNF chimatumiza zizindikiro makamaka pomangirira ku ma receptor enaake, motero chimakhudza njira za thupi za ma neuron. Ngakhale 7,8-DHF imatha kutsanzira zotsatira za neurotrophic factor BDNF, chinsinsi chake chili mu njira yake yolumikizirana ndi BDNF receptor. Kafukufuku wasonyeza kuti 7,8-DHF imatha kumangirira ku BDNF receptor TrkB ndikuyambitsa njira zotsatsira zizindikiro zotsika.
Makamaka, pamene 7,8-DHF ilumikizana ndi TrkB, imayambitsa zochitika zingapo zotumizira chizindikiro mkati mwa maselo. Izi zikuphatikizapo kuyambitsa ma protein kinases monga njira za PI3K/Akt ndi MAPK/ERK. Kuyambitsa njira izi ndikofunikira kwambiri pakulimbikitsa kupulumuka kwa mitsempha, kukula, ndi pulasitiki ya synaptic. Mwa kutsanzira kuyambitsa njira izi ndi BDNF, 7,8-DHF imathandiza kukulitsa kusinthasintha kwa mitsempha ndi kukana kupsinjika kwakunja.
7,8-DHF imawongoleranso momwe majini amagwirira ntchito mkati mwa ma neuron. Imatha kukhudza kulembedwa kwa majini okhudzana ndi chitukuko cha mitsempha, chitetezo cha mitsempha ndi kapangidwe ka synapse, motero kutsanzira zotsatira za BDNF pamlingo wa mamolekyu. Kusintha kumeneku kwa momwe majini amagwirira ntchito kumathandiziranso ntchito ya 7,8-DHF pakulimbikitsa thanzi la mitsempha.
7,8-Dihydroxyflavone (7,8-DHF) ndi monophenolic flavonoid yokhala ndi zotsatira zambiri. Imagwira ntchito ngati agonist ya neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) ndipo imateteza ma neuron omwe amawonetsa TrkB ku apoptosis. Brain-derived neurotrophic factor (BDNF) ndi puloteni yokhala ndi zotsatira za neurotrophic zomwe ndizofunikira kwambiri pakupanga ubongo, kuphunzira ndi kukumbukira.
• Chitetezo cha mitsempha: 7,8-DHF imateteza mitsempha m'mafano a nyama omwe ali ndi matenda a Parkinson, imathandizira kuphunzira m'maganizo mwa mbewa ndipo imachepetsa kulephera kukumbukira m'mafano a mbewa omwe ali ndi matenda a Alzheimer, ndipo ingathandizenso kugwira ntchito kwa minofu ndikuwonjezera nthawi yopulumuka ya nyama zomwe zili ndi matenda. BDNF imatha kukonza kulimba kwa mitsempha ndi kupulumuka kwa mitsempha, kuthandiza ubongo kupanga maulumikizidwe atsopano a mitsempha, kukonza maselo a ubongo omwe akulephera, ndikuteteza maselo a ubongo athanzi. Ndikofunikira pakupanga ubongo, kuphunzira ndi kukumbukira, ndipo imatha kuteteza ubongo ku zovuta zokhudzana ndi ukalamba. Imachepa luso la kuzindikira ndikuteteza ku matenda a mitsempha monga matenda a Alzheimer ndi matenda a Parkinson.
• Imalamulira kupulumuka kwa mitsempha: 7,8-DHF imatha kumangirira ku TrkB ndikuyambitsa njira zolumikizirana zotsika, monga njira za PI3K/Akt ndi MAPK/ERK. Kuyambitsa njira izi ndikofunikira kwambiri pakulimbikitsa kupulumuka kwa mitsempha, kukula ndi kusinthasintha kwa synaptic. BDNF ndi chinthu cha neurotrophic chomwe chingayambitse njira zolumikizirana zamkati mwa maselo pomangirira ku ma receptor a TrkB ndikulimbikitsa kupulumuka ndi kukula kwa ma neuron.
• Kulimbikitsa kupangika kwa synaptic: 7,8-DHF imatha kulimbikitsa kupangika ndi kulimbitsa ma synapses mwa kuyambitsa ma TrkB receptors, motero kumawonjezera mphamvu ya kufalikira kwa synaptic. BDNF imaganiziridwanso kuti imalimbikitsa kupangika ndi kulimbitsa ma synapses, motero imawonjezera mphamvu ya kufalikira kwa synaptic ndikuwonjezera luso lophunzira ndi kukumbukira.
• Zotsatira pa kuphunzira ndi kukumbukira: 7,8-DHF imatha kupititsa patsogolo luso lophunzira ndi kukumbukira m'makoswe, zomwe zitha kukhala zokhudzana ndi zotsatira zake pa kupulumuka kwa mitsempha ndi kupangika kwa synaptic. BDNF imagwiranso ntchito yofunika kwambiri pakuphunzira ndi kukumbukira mwa kulimbikitsa kupulumuka kwa ma neuron ndi kupanga ma synapses, motero kumawonjezera luso lophunzira ndi kukumbukira.
• Imasinthasintha momwe munthu akumvera: 7,8-DHF imakhala ndi zotsatira zosinthira momwe munthu akumvera, zomwe zingagwirizane ndi zotsatira zake pa kupulumuka kwa mitsempha ndi kusinthika kwa synaptic. BDNF imaganiziridwanso kuti imagwira ntchito polamulira momwe munthu akumvera mwa kuwongolera kupulumuka kwa mitsempha ndi kupangika kwa ma synapses, motero imakhudza momwe munthu akumvera.
Mwachidule, 7,8-DHF ndi BDNF zili ndi njira zofanana zogwirira ntchito poteteza mitsempha, kuwongolera kupulumuka kwa mitsempha, kulimbikitsa kupangika kwa synaptic, kukhudza kuphunzira ndi kukumbukira, komanso kuwongolera malingaliro.
Suzhou Myland Pharm & Nutrition Inc. ndi kampani yolembetsedwa ndi FDA yomwe imapereka 7,8-Dihydroxyflavone yapamwamba komanso yoyera kwambiri.
Ku Suzhou Myland Pharm, tadzipereka kupereka zinthu zabwino kwambiri pamitengo yabwino kwambiri. 7,8-Dihydroxyflavone yathu yayesedwa bwino kuti ione ngati ndi yoyera komanso yamphamvu, zomwe zimatsimikizira kuti mumapeza chowonjezera chapamwamba chomwe mungachikhulupirire. Kaya mukufuna kuthandiza thanzi la maselo, kulimbitsa chitetezo cha mthupi lanu kapena kulimbitsa thanzi lonse, 7,8-Dihydroxyflavone yathu ndiye chisankho chabwino kwambiri.
Ndi zaka 30 zakuchitikira komanso kutsogoleredwa ndi ukadaulo wapamwamba komanso njira zabwino kwambiri zofufuzira ndi chitukuko, Suzhou Myland Pharm yapanga zinthu zosiyanasiyana zopikisana ndipo yakhala kampani yatsopano yowonjezera sayansi ya moyo, kupanga zinthu mwamakonda komanso kupanga zinthu.
Kuphatikiza apo, Suzhou Myland Pharm ndi kampani yodziwika bwino yopanga mankhwala yomwe ili ndi dzina la FDA. Zipangizo za kafukufuku ndi chitukuko cha kampaniyi, malo opangira mankhwala, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuyambira mamiligalamu mpaka matani ambiri, komanso zimagwirizana ndi miyezo ya ISO 9001 ndi zomwe zimapangidwa ndi GMP.
Chodzikanira: Nkhaniyi ndi yongofuna kudziwa zambiri ndipo siyenera kuonedwa ngati upangiri uliwonse wa zachipatala. Zina mwa zomwe zili mu blog iyi zimachokera pa intaneti ndipo si zaukadaulo. Webusaitiyi ili ndi udindo wosankha, kupanga ndi kusintha nkhani zokha. Cholinga chopereka zambiri sichikutanthauza kuti mukugwirizana ndi malingaliro ake kapena kutsimikizira kuti zomwe zili mkati mwake ndi zoona. Nthawi zonse funsani katswiri wa zaumoyo musanagwiritse ntchito zowonjezera zilizonse kapena kusintha njira yanu yazaumoyo.
Nthawi yotumizira: Sep-24-2024
