Kodi 7,8-Dihydroxyflavone ndi Chiyani Muyenera Kusamala?

7,8-Dihydroxyflavone (7,8-DHF)ndi flavonoid yochitika mwachilengedwe, gulu la polyphenolic lomwe limapezeka muzomera zosiyanasiyana. Flavonoids amadziwika chifukwa cha antioxidant ndipo amagwira ntchito yofunika kwambiri pakuteteza mbewu. 7,8-Dihydroxyflavone imapezeka makamaka muzomera monga Godmania aesculifolia ndi Tridax procumbens.

7,8-Dihydroxyflavone imasiyana ndi ma flavonoids ena pakutha kutsanzira zomwe zimachitika muubongo-derived neurotrophic factor (BDNF). BDNF ndi puloteni yomwe imathandizira kupulumuka, chitukuko, ndi ntchito za neuroni mu ubongo. Imagwira ntchito yofunika kwambiri mu neuroplasticity, kuthekera kwaubongo kudzipanganso popanga kulumikizana kwatsopano kwa neural. Katunduyu wa 7,8-DHF amatsegula njira zingapo zofufuzira, makamaka pankhani ya sayansi ya ubongo.

Njira yochitira

Njira yoyamba yomwe 7,8-Dihydroxyflavone imagwiritsa ntchito zotsatira zake ndikutsegula kwa TrkB (tropomyosin receptor kinase B) receptor. TrkB ndi cholandilira chogwirizana kwambiri cha BDNF. Pamene 7,8-Dihydroxyflavone imamangiriza ku TrkB, imayambitsa njira zowonetsera zamkati zomwe zimalimbikitsa kupulumuka kwa neuronal, kukula, ndi kusiyana.

Kafukufuku wachipatala awonetsa kuti 7,8-dihydroxyflavone imatha kutsanzira BDNF (brain-derived neurotrophic factor) ndikuwonjezera mawonekedwe ake ndi milingo mu hippocampus. Pazitsanzo za nyama, ili ndi mphamvu zochizira matenda angapo amisempha, monga sitiroko, kupsinjika maganizo, ndi matenda a Parkinson. M'maphunziro awiri osiyana, 7,8-dihydroxyflavone yawonetsa bioavailability wapakamwa ndipo idapezeka kuti idutsa chotchinga chaubongo-magazi (BBB). Chifukwa imagwira pa njira yolumikizira nitric oxide ndikuyambitsa TrkB receptor (tropomyosin receptor kinase B)

The neurotrophic factor BDNF makamaka imatumiza ma siginecha pomangirira ku zolandilira zinazake, potero zimakhudza momwe thupi limayendera ma neuron. Ngakhale kuti 7,8-DHF ingatsanzire zotsatira za neurotrophic factor BDNF, chinsinsi chimakhala mu njira yake yolumikizirana ndi BDNF receptor. Kafukufuku wasonyeza kuti 7,8-DHF ikhoza kumangirira ku BDNF receptor TrkB ndikuyambitsa njira zowonetsera pansi.

Makamaka, 7,8-DHF ikamangika ku TrkB, imayambitsa zochitika zingapo zotumizira ma siginecha. Izi zikuphatikiza kuyambitsa kwa protein kinases monga PI3K/Akt ndi MAPK/ERK njira. Kutsegula kwa njirazi ndikofunikira pakulimbikitsa kupulumuka kwa neuronal, kukula, ndi pulasitiki ya synaptic. Poyerekeza kutsegulira kwa njirazi ndi BDNF, 7,8-DHF imathandizira kusinthasintha kwa neuronal komanso kukana kupsinjika kwakunja.

7,8-DHF imayang'aniranso mawonekedwe a jini mkati mwa neurons. Zingakhudze kulembedwa kwa majini okhudzana ndi neurodevelopment, neuroprotection ndi synapse mapangidwe, motero amatsanzira zotsatira za BDNF pa mlingo wa maselo. Kusinthasintha kwa mawu a jini kumeneku kumathandiziranso ntchito ya 7,8-DHF polimbikitsa thanzi la minyewa.

7,8-Dihydroxyflavone (7,8-DHF) ndi monophenolic flavonoid yokhala ndi zotsatira zingapo. Imakhala ngati agonist ya neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) ndipo imateteza TrkB-expressing neurons ku apoptosis. Brain-derived neurotrophic factor (BDNF) ndi puloteni yokhala ndi zotsatira za neurotrophic zomwe ndizofunikira kuti ubongo upangidwe, kuphunzira ndi kukumbukira.

• Neuroprotection: 7,8-DHF ndi neuroprotective mu zitsanzo za nyama za Parkinson's disease, imathandizira kuphunzira maganizo mu mbewa ndi kubweza kulephera kukumbukira mu zitsanzo za mbewa za matenda a Alzheimer's, ndipo ingathenso kupititsa patsogolo kayendedwe ka galimoto ndikutalikitsa kupulumuka kwa nthawi ya huntingtin ya zinyama zodwala. BDNF imatha kupititsa patsogolo kupulumuka kwa neuroplasticity ndi neuron, kuthandiza ubongo kupanga kulumikizana kwatsopano kwa minyewa, kukonza ma cell aubongo olephera, ndikuteteza maselo athanzi aubongo. Ndikofunikira kuti ubongo upangidwe, kuphunzira ndi kukumbukira, ndipo zimatha kuteteza ubongo ku kuwonongeka kwa chidziwitso chokhudzana ndi ukalamba. Kuchepetsa luso lazidziwitso ndikuteteza ku matenda a neurodegenerative monga matenda a Alzheimer's ndi Parkinson's.

• Imawongolera kupulumuka kwa neuronal: 7,8-DHF imatha kumangirira ku TrkB ndikuyambitsa njira zolozera kunsi kwa mtsinje, monga PI3K/Akt ndi MAPK/ERK njira. Kutsegula kwa njirazi ndikofunikira pakulimbikitsa kupulumuka kwa ma neuronal, kukula ndi pulasitiki ya synaptic. zofunika. BDNF imakhalanso ndi neurotrophic factor yomwe imatha kuyambitsa njira zowonetsera ma intracellular pomangiriza ku TrkB receptors ndikulimbikitsa kupulumuka ndi kukula kwa ma neuron.

• Limbikitsani pulasitiki ya synaptic: 7,8-DHF ikhoza kulimbikitsa mapangidwe ndi kulimbikitsa ma synapses mwa kuyambitsa ma TrkB receptors, potero kumapangitsa kuti ma synaptic transmission atheke. BDNF imaganiziridwanso kuti imalimbikitsa mapangidwe ndi kulimbikitsa ma synapses, potero kumawonjezera mphamvu ya kufalitsa kwa synaptic ndipo potero kumawonjezera luso la kuphunzira ndi kukumbukira.

• Zotsatira za kuphunzira ndi kukumbukira: 7,8-DHF ikhoza kupititsa patsogolo luso la kuphunzira ndi kukumbukira mu mbewa, zomwe zingakhale zogwirizana ndi zotsatira zake pa moyo wa neuronal ndi synaptic plasticity. BDNF imagwiranso ntchito yofunikira pakuphunzira ndi kukumbukira kukumbukira polimbikitsa kupulumuka kwa ma neuroni ndi kupanga ma synapses, potero kumapangitsa kuti luso la kuphunzira ndi kukumbukira.

• Imasintha maganizo: 7,8-DHF ili ndi zotsatira zosintha maganizo, zomwe zingakhale zogwirizana ndi zotsatira zake pa moyo wa neuronal ndi synaptic plasticity. BDNF imaganiziridwanso kuti imagwira ntchito pa kayendetsedwe ka maganizo mwa kulamulira kupulumuka kwa ma neuroni ndi kupanga ma synapses, motero kumakhudza kufotokozera maganizo.

Mwachidule, 7,8-DHF ndi BDNF ali ndi njira zofanana zogwirira ntchito mu neuroprotection, kuyang'anira moyo wa neuronal, kulimbikitsa mapulasitiki a synaptic, okhudza kuphunzira ndi kukumbukira, ndi kulamulira maganizo.

Suzhou Myland Pharm & Nutrition Inc. ndi wopanga zolembetsedwa ndi FDA yemwe amapereka 7,8-Dihydroxyflavone yapamwamba komanso yoyera kwambiri.

Ku Suzhou Myland Pharm tadzipereka kupereka zinthu zapamwamba kwambiri pamitengo yabwino kwambiri. 7,8-Dihydroxyflavone yathu imayesedwa mwamphamvu kuti ikhale yoyera komanso yamphamvu, ndikuwonetsetsa kuti mumapeza chowonjezera chapamwamba chomwe mungakhulupirire. Kaya mukufuna kuthandizira thanzi la ma cell, kulimbikitsa chitetezo chamthupi kapena kuwonjezera thanzi lanu, 7,8-Dihydroxyflavone yathu ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira zokongoletsedwa bwino za R&D, Suzhou Myland Pharm yapanga zinthu zambiri zampikisano ndikukhala kampani yotsogola ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.

Kuphatikiza apo, Suzhou Myland Pharm ndiwopanganso zolembedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira zinthu, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani mumlingo, ndikutsata miyezo ya ISO 9001 ndi zopangira GMP.