Kodi muyenera kudziwa chiyani za palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) ndi mafuta acid acid omwe amapezeka mwachilengedwe omwe amakopa chidwi chifukwa cha mapindu ake azaumoyo. Pagululi limapezeka m'matenda osiyanasiyana m'thupi lonse, ndipo kafukufuku akuwonetsa kuti palmitamideethanol (PEA) imatha kuchepetsa kutupa, kuchepetsa ululu, komanso kulimbikitsa thanzi la m'matumbo ndikuchedwetsa kukalamba. Ikhoza kukhala ndi ubwino wambiri wathanzi. Zomwe zili m'munsizi zidzafufuza ubwino wa palmitoylethanolamide (PEA), momwe zimagwirira ntchito pa thupi la munthu, komanso momwe mungapezere palmitoylethanolamide (PEA) yapamwamba kwambiri.

Kodi palmitoylethanolamide (PEA) ndi chiyani?

Palmitoylethanolamide (PEA) Ndi mankhwala omwe amapezeka mwachilengedwe ngati endocannabinoid omwe amadziwika chifukwa chamankhwala ake osatha komanso odana ndi kutupa. Kuphatikiza pa kupangidwa ndi thupi, PEA imapezeka muzakudya zosiyanasiyana kuphatikiza: tchizi, yolk mazira, nyama, mkaka, mtedza, soya lecithin.

Kodi mumadziwa? Thupi likakumana ndi zovuta, monga kuvulala kapena kutupa, milingo ya PEA imasintha kuti ikhalebe ndi ma cell homeostasis.

Kodi palmitoylethanolamide imakhudza bwanji thupi la munthu?

Asayansi samamvetsetsa bwino momwe ntchito ya palmitoylethanolamide imagwirira ntchito. Ngakhale zili choncho, tafika kutali, chifukwa cha Pulofesa Rita Levi-Montalcini, yemwe mu 1992-1996 adalongosola njira yowonongeka ya palmitoylethanolamide . Kuyambira pamenepo, adapitilizabe kuphunzira zotsatira za palmitoylethanolamide pa ululu wa neuropathic ndi ziwengo.

Palmitoylethanolamide ikhoza kubweretsa zabwino zinayi zazikulu zaumoyo kwa anthu:

●Kuchepetsa kutupa.

●Chepetsani kuyambika kwa mast cell.

● Limbikitsani ntchito ya endogenous hemp system.

●Yambitsani zolandilira m'thupi.

Kodi PEA imagwiritsa ntchito bwanji anti-yotupa ndi analgesic?

Phindu la thanzi la PEA limaphatikizapo zotsatira za maselo a chitetezo cha mthupi omwe amayendetsa kutupa, makamaka mu ubongo. PEA ikhoza kuthandizira kuchepetsa kupanga zinthu zotupa. Komabe, PEA imagwira ntchito kwambiri pama cell receptors, omwe amawongolera magwiridwe antchito a cell. Ma receptor awa amatchedwa PPAR. PEA ndi mankhwala ena omwe amathandiza kuyambitsa PPAR amatha kuchepetsa ululu ndipo amathanso kuonjezera kagayidwe kake mwa kuwotcha mafuta, kuchepetsa serum triglycerides, kuonjezera serum HDL cholesterol, kuwongolera shuga wamagazi, ndikuthandizira kuchepetsa thupi.

Palmitoylethanolamide Ubwino

Chifukwa cha zotsatira zake zowonongeka komanso zotsutsana ndi zotupa, kafukufuku amasonyeza kuti PEA ikhoza kuthandizira ndi matenda osiyanasiyana okhudzana ndi ululu, monga fibromyalgia, sciatica, ndi osteoarthritis.

1. Kuchepetsa ululu ndi kuyankha kotupa

Kupweteka kosalekeza ndi vuto lalikulu lomwe limavutitsa odwala padziko lonse lapansi, ndipo pamene chiwerengero cha anthu chikukula, vutoli lidzakhala lofunika kwambiri. Imodzi mwa ntchito za palmitoylethanolamide ndikuti itha kuthandiza kuchepetsa ululu ndi kutupa. palmitoylethanolamide imalumikizana ndi CB1 ndi CB2 zolandilira, zomwe ndi zigawo zofunika za dongosolo lamkati la hemp. Dongosolo ili ndi udindo wosunga homeostasis kapena kukhazikika m'thupi.

Kuvulala kapena kuyankha kotupa kumachitika, thupi limatulutsa mankhwala a hemp omwe amathandizira kuwongolera chitetezo chamthupi. palmitoylethanolamide imatha kuthandizira kukulitsa kuchuluka kwa hemp m'thupi, potero kuchepetsa ululu ndi kutupa.

Kuonjezera apo, palmitoylethanolamide ikhoza kuchepetsa kutulutsidwa kwa mankhwala opweteka komanso kuchepetsa mayankho okhudzana ndi kutupa kwa mitsempha. Zotsatirazi zimapangitsa palmitoylethanolamide kukhala chida chothandizira kuthetsa ululu ndi mayankho otupa. Kafukufuku akuwonetsa kuti palmitoylethanolamide ingakhalenso yothandiza pa ululu wa sciatica ndi matenda a carpal tunnel.

2. Fibromyalgia

Kafukufuku wambiri akusonyeza kuti PEA ingathandize kuchepetsa zizindikiro za fibromyalgia, matenda a ubongo omwe amachititsa ululu wambiri. Akagwiritsidwa ntchito ngati chothandizira pamankhwala achikhalidwe, kumeza kwa PEA kumachepetsa kupweteka komanso kumapangitsa moyo kukhala wabwino pakapita nthawi. Malinga ndi kafukufuku wina, kutenga PEA kwa miyezi itatu kumachepetsa kwambiri kupweteka kwa anthu omwe ali ndi fibromyalgia.

3. Kupweteka kwa msana

Kafukufuku woyambirira akuwonetsa kuthekera kwa PEA kwa ululu wammbuyo. Kafukufuku wowunika wa 2017 adawonetsa kuti PEA idachepetsanso kupweteka kwambiri kwa odwala omwe ali ndi vuto la opareshoni yam'mbuyo.

Anthu omwe akudwala sciatica, kupweteka komwe kumayambira pansi kumbuyo kwa mwendo umodzi kapena miyendo yonse, angapezenso mpumulo atatenga PEA. Mayesero osasinthika, akhungu awiri, oyendetsedwa ndi placebo adaphunzira zotsatira za mlingo wapamwamba ndi wochepa wa PEA motsutsana ndi placebo. Ululu unachepetsedwa ndi oposa 50% mu gulu lapamwamba la mlingo. Ngakhale kuti mlingo wochepa wa PEA sunapeze mlingo wofanana wa ululu wofanana ndi mlingo waukulu, Mlingo wonsewo unali wothandiza kwambiri kuposa placebo.

4. Osteoarthritis

PEA ikhoza kukhala yopindulitsa kwa anthu omwe ali ndi osteoarthritis, matenda omwe amadziwika ndi kuwonongeka kwa chiwombankhanga ndi mafupa. Ochita nawo kafukufuku wina yemwe adalandira PEA adawona kusintha kwakukulu ku Western Ontario ndi McMaster Universities Osteoarthritis Index (WOMAC) poyerekeza ndi gulu la placebo. WOMAC ndi mafunso opangidwa kuti awone momwe zilili ndi zizindikiro (mwachitsanzo, kupweteka, kuuma, kugwira ntchito kwa thupi) kwa odwala omwe ali ndi mawondo ndi chiuno cha osteoarthritis.

Kafukufuku wina wokhudza odwala omwe ali ndi ululu wa temporomandibular arthritic (TMJ) wokhudzana ndi osteoarthritis anasonyeza kuti PEA supplementation imapangitsa kuti ululu ukhale wopweteka kwambiri pambuyo pa masiku 14 poyerekeza ndi ibuprofen. Gulu lopatsidwa PEA kwa masiku a 14 linawonetsa kusintha kwakukulu kwambiri pakutsegula pakamwa (kuchepetsa kupweteka) kuposa gulu la ibuprofen.

5. Ululu wa Neuropathic

Kafukufuku woyambirira komanso kuyezetsa nyama kumasonyeza kuti PEA ingathandize ndi ululu wa neuropathic (womwe umachitika chifukwa cha kuwonongeka kwa mitsempha yomwe imanyamula mauthenga pakati pa ubongo ndi msana), makamaka kwa anthu omwe ali ndi matenda a carpal tunnel syndrome, matenda a shuga, chemotherapy ululu wa m'chiuno, ndi ululu wokhudzana ndi sitiroko ndi multiple sclerosis. Mayesero ena azachipatala amafunikira kuti adziwe mphamvu ya PEA pothetsa ululu wa neuropathic.

6. Ukalamba Wathanzi

Kuchedwetsa ukalamba ndi cholinga chaphindu chotsatiridwa ndi asayansi ambiri padziko lonse lapansi. Palmitoylethanolamide imatengedwa kuti ndi yoletsa kukalamba yomwe ingathandize kuteteza maselo kuti asawonongeke ndi okosijeni, zomwe ndizomwe zimayambitsa ukalamba.

Maselo akakumana ndi zochitika zambiri zaulere, zochita za okosijeni zimatha kuchitika, zomwe zimatsogolera ku kufa msanga kwa maselo. Kudya zakudya zopanda thanzi, kusuta fodya, ndi zochitika zina zachilengedwe monga kuipitsidwa kwa mpweya kumawonjezeranso kuwonongeka kwa okosijeni.Palmitoylethanolamide ingalepheretse kuwonongeka kumeneku pochotsa zowonongeka zaufulu ndi kuchepetsa kuyankha kwathunthu kwa kutupa m'thupi.

Kuphatikiza apo, palmitoylethanolamide ethanol yawonetsedwa kuti ikhoza kulimbikitsa kupanga kolajeni ndi mapuloteni ena ofunikira pakhungu. Choncho, zikhoza kuchepetsa maonekedwe a makwinya ndi mizere yabwino, kukhala ngati chitetezo kuchokera mkati mwa maselo.

Suzhou Myland Pharm & Nutrition Inc. ndi wopanga olembetsedwa ndi FDA yemwe amapereka ufa wapamwamba komanso woyeretsedwa kwambiri wa Palmitoylethanolamide (PEA).

Ku Suzhou Myland Pharm tadzipereka kupereka zinthu zapamwamba kwambiri pamitengo yabwino kwambiri. Palmitoylethanolamide (PEA) ufa wathu umayesedwa mwamphamvu kuti ukhale woyera ndi potency, kuonetsetsa kuti mumapeza chowonjezera chapamwamba chomwe mungakhulupirire. Kaya mukufuna kuthandizira thanzi la ma cell, kulimbikitsa chitetezo chamthupi, kapena kuwonjezera thanzi lanu, Palmitoylethanolamide (PEA) ufa wathu ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira zokongoletsedwa bwino za R&D, Suzhou Myland Pharm yapanga zinthu zambiri zampikisano ndikukhala kampani yotsogola ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.

Kuphatikiza apo, Suzhou Myland Pharm ndiwopanganso zolembedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira, ndi zida zowunikira ndi zamakono komanso zimagwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani mu sikelo, ndikutsatira miyezo ya ISO 9001 ndi mafotokozedwe a GMP.