Lemairamin (WGX-50) wopanga ufa CAS No.: 29946-61-0 98.0% chiyero min. kwa zowonjezera zowonjezera
Kanema wa Zamalonda
Product Parameters
| Dzina la malonda | Lemairamin |
| Dzina lina | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; Lemairamin (WGX-50) |
| CAS No. | 29946-61-0 |
| Molecular formula | C19H21NO3 |
| Kulemera kwa maselo | 311.37 |
| Chiyero | 98.0% |
| Maonekedwe | Ufa woyera mpaka woyera |
| Kugwiritsa ntchito | Zakudya Zowonjezera Zamasamba |
Chiyambi cha malonda
Lemairamin kapena Wgx50 ndi mankhwala achilengedwe otengedwa ku tsabola omwe awonetsa zotsatira zabwino popewa matenda a Alzheimer's. Kafukufuku wapeza kuti imatha kuletsa Aβ-induced neuronal apoptosis, kuchepetsa kawopsedwe ka neuronal calcium, komanso kuchepetsa kuchuluka kwa ma oligomer a Aβ mu cerebral cortex. Kuphatikiza apo, wgx50 yawonetsedwa kuti imathandizira kuzindikira kwa mbewa. Kafukufuku akuwonetsa kuti wgx50 ili ndi kuthekera koletsa kuphatikiza kwa mapuloteni-mapuloteni pakati pa mamolekyu a amyloid. Ponseponse, wgx50 ili ndi kuthekera kopewa matenda a Alzheimer's ndipo ikhoza kupereka njira zatsopano zopangira mankhwala olimbana ndi ma Aβ oligomers. Kuphatikiza apo, WGX-50 imawonetsa ntchito yayikulu yolimbana ndi kutupa, zomwe zimapangitsa kuti ikhale yodalirika pochiza matenda otupa. WGX-50 yapezeka kuti ili ndi zotsatirapo zazikulu pakhungu, monga kuchepetsa makwinya komanso kuwongolera khungu. Kuphatikiza pa mankhwala achilengedwe omwe amachokera ku chomera cha Zanthoxylum bungeanum, pakali pano pali zowonjezera zowonjezera zomwe zimagwiritsidwa ntchito pazinthu zosiyanasiyana ndipo ndizofunikira kwambiri pamsika.
Mbali
(1) Chiyero chachikulu: Lemairamin amatha kupeza zinthu zoyeretsedwa kwambiri kudzera m'zigawo zachilengedwe komanso kukonza njira zopangira. Kuyeretsedwa kwakukulu kumatanthauza kukhalapo kwa bioavailability ndi zotsatira zochepa.
(2) Chitetezo: Kutetezedwa kwakukulu, kusagwirizana pang'ono, palibe zowonekeratu zoyipa ngakhale mutazigwiritsa ntchito nthawi yayitali.
(3) Kukhazikika: Lemairamin ili ndi bata labwino ndipo imatha kusunga ntchito yake ndi zotsatira zake pansi pa malo osiyanasiyana ndi malo osungira.
(4) Yosavuta kuyamwa: Lemairamin imatha kutengeka mwachangu ndi thupi la munthu ndikugawidwa kumagulu ndi ziwalo zosiyanasiyana.
Mapulogalamu
Lemairamin ndi mankhwala opangidwa kuchokera ku khungwa la Zanthoxylum bungeanum. Pakali pano amagwiritsidwa ntchito ngati zakudya zowonjezera zakudya, zimakhalanso ngati agonist wa alpha7 nicotinic acetylcholine receptor (α7nAChR), yomwe imachepetsa neuroinflammation mu matenda a Alzheimer's, ndipo imakhala yopangidwa kwathunthu.Wgx50 yawonetsa zotsatira zolimbikitsa mu maphunziro a preclinical, kuphatikizapo kulepheretsa Aβ-induced neuronal apoptosis, kuchepetsa kawopsedwe ka neuronal calcium, kuchepetsa kuchuluka kwa ma oligomer a Aβ mu cerebral cortex, ndikuwongolera magwiridwe antchito anzeru mu mbewa.
