CMS121 wopanga ufa CAS No.: 1353224-53-9 98.0% chiyero min. kwa zowonjezera zowonjezera
Product Parameters
| Dzina la malonda | Chithunzi cha CMS121 |
| Dzina lina | CMS-121; 1,2-Benzenediol,4--[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC,AcetylCoenzymeACarboxylase, matenda, neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121 |
| CAS No. | 1353224-53-9 |
| Molecular formula | C20H19NO3 |
| Kulemera kwa maselo | 321.37 |
| Chiyero | 98.0% |
| Maonekedwe | Ufa wachikasu wopepuka |
| Kugwiritsa ntchito | Zakudya Zowonjezera Zamasamba |
Chiyambi cha malonda
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol ndi gulu lomwe limatchedwanso CMS121. Kapangidwe kakapangidwe kawo kakuwonetsa kuti akhoza kukhala ndi mawonekedwe apadera komanso momwe angagwiritsire ntchito. Kuti timvetsetse kufunikira kwake, zimathandiza kuzindikira magulu ogwira ntchito omwe alipo ndikuwunika momwe angakhudzire. Kukhalapo kwa mphete ya quinoline kukuwonetsa kuti pawiriyo ikhoza kukhala yogwira ntchito mwachilengedwe. Mamolekyu opangidwa ndi quinoline amadziwika ndi mitundu yosiyanasiyana yachilengedwe, kuphatikiza antibacterial ndi anti-yotupa. Kuphatikizika kwa gulu la cyclopentyloxy kumatha kuthandizira kusungunuka kwa pawiri kapena kupititsa patsogolo ntchito yake yachilengedwe kudzera muzowopsa. M'maphunziro a maselo a HT22, CMS-121 yawonetsa zotsatira zazikulu za neuroprotective, kuteteza bwino maselowa ku ischemia ndi kuwonongeka kwa okosijeni. Kuphatikiza apo, CMS-121 ili ndi zotsutsana ndi zotupa, zomwe zikuwonetsa kuthekera kwake kosinthira mayankho otupa. Pochita zimenezi, CMS-121 imatha kuchepetsa kutupa m'magulu osiyanasiyana ndi ziwalo. CMS-121 ili ndi ntchito yamphamvu yamankhwala monga choletsa cha acetyl-CoA carboxylase 1 (ACC1). Mphamvu yake yoletsa pa ACC1 imapangitsa kuti ikhale yodalirika.
Mbali
(1) Chiyero chachikulu: CMS-121 imatha kupeza zinthu zoyera kwambiri kudzera munjira zoyenga. Kuyeretsedwa kwakukulu kumatanthauza kukhalapo kwa bioavailability ndi zotsatira zochepa.
(2) Chitetezo: Kutetezedwa kwambiri, kusakhala ndi zovuta zochepa.
(3) Kukhazikika: CMS-121 ili ndi kukhazikika bwino ndipo imatha kusunga ntchito ndi zotsatira zake pansi pazigawo zosiyanasiyana ndi malo osungira.
Mapulogalamu
CMS-121 ndi choletsa cha quinolone komanso chogwira ntchito pakamwa cha acetyl-CoA carboxylase 1 (ACC1) chokhala ndi zopatsa chiyembekezo zamankhwala. Kafukufuku wochuluka wachitika kuti afufuze za ubwino wa CMS-121 m'madera osiyanasiyana, kuphatikizapo neuroprotection, anti-inflammatory effects, antioxidant ntchito, ndi zotsatira zake pa zizindikiro zokhudzana ndi ukalamba wathanzi.
