Wopanga ufa wa Agomelatine Nambala ya CAS: 138112-76-2 99% kuyera pang'ono kwa zosakaniza zowonjezera
Kanema wa Zamalonda
Magawo a Zamalonda
| Dzina la chinthu | Agomelatini |
| Dzina lina | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Nambala ya CAS | 138112-76-2 |
| Fomula ya maselo | C15H17NO2 |
| Kulemera kwa maselo | 243.3082 |
| Chiyero | 99.0% |
| Maonekedwe | Ufa woyera |
| Kulongedza | 1kg/thumba 25kg/ng'oma |
| Kugwiritsa ntchito | Zinthu zopangira thanzi |
Chiyambi cha malonda
Agomelatine idayambitsidwa koyamba ku Europe mu 2009 ndipo tsopano yavomerezedwa kuti igwiritsidwe ntchito m'maiko opitilira 70. Mosiyana ndi mankhwala oletsa kupsinjika maganizo achikhalidwe, agomelatine imagwira ntchito poyang'ana ma melatonin ndi ma serotonin receptors muubongo. Pogwira ntchito ngati agonist pa ma melatonin receptors, agomelatine imathandizira kusintha machitidwe ogona omwe nthawi zambiri amagwirizanitsidwa ndi kupsinjika maganizo. Njirayi sikuti imangothandiza kukonza kugona bwino komanso imathandizanso kubwezeretsa kamvekedwe kachilengedwe ka circadian. Kuphatikiza apo, agomelatine imagwira ntchito ngati mdani pa ma serotonin receptors ena (ma 5-HT2C receptors). Kachitidwe kapadera kameneka kamapangitsa kuti serotonin ipezeke muubongo, neurotransmitter yomwe imayang'anira kusinthasintha kwa malingaliro. Powongolera kuchuluka kwa serotonin, agomelatine imatha kugwira ntchito ngati mankhwala othandiza kupsinjika maganizo, kuchepetsa zizindikiro monga chisoni, kutaya chidwi, kudzimva wolakwa kapena kudziona wopanda pake. Kuphatikiza apo, agomelatine ingapereke zabwino zina. Kafukufuku akusonyeza kuti ingathandize kukonza magwiridwe antchito a ubongo. Kafukufuku akuwonetsa kuthekera kwake kokulitsa kukumbukira, chidwi, ndi ntchito yogwira ntchito, zomwe zimapangitsa kuti ikhale malo osangalatsa ofufuzira mtsogolo.
Mbali
(1) Kuyera Kwambiri: Agomelatine imatha kupeza zinthu zoyera kwambiri kudzera mu njira zopangira zinthu zoyeretsera. Kuyera Kwambiri kumatanthauza kupezeka bwino kwa bioavailability komanso kuchepetsa zotsatirapo zoyipa.
(2) Chitetezo: Chitetezo chachikulu, zotsatirapo zochepa zoyipa.
(3) Kukhazikika: Agomelatine ili ndi kukhazikika kwabwino ndipo imatha kusunga ntchito yake ndi mphamvu zake pansi pa malo osiyanasiyana komanso malo osungiramo zinthu zosiyanasiyana.
Mapulogalamu
Agomelatine ndi mankhwala oletsa kupsinjika maganizo komanso otsutsana ndi melatonin. Amachepetsa zizindikiro za kupsinjika maganizo mwa kulamulira ma receptor a melatonin MT1 (amachepetsa zizindikiro za alamu ya cortical) ndi ma receptor a MT2 (circadian sleep rhythm) ndi kuchuluka kwa serotonin. Ikatengedwa usiku, imatsanzira kamvekedwe kachilengedwe ka kutulutsidwa kwa melatonin ndipo imatha kusintha kwambiri khalidwe la kugona. Kagwiridwe kake ka ntchito kamaphwanya njira yotumizira monoamine. Imayatsa ma receptor a melatonin MT1 ndi MT2 ndikutsutsa ma receptor a 5-HT2C. Imawongolera khalidwe la kugona, kubwezeretsa kamvekedwe ka thupi, komanso imakhala ndi mphamvu yoletsa kupsinjika maganizo; pakati pawo, mwa kutsutsa ma receptor a 5-HT2C pa nembanemba ya postsynaptic, imatha kuwonjezera kutulutsidwa kwa DA ndi NE mu prefrontal cortex, zomwe zimapangitsa kuti munthu asamavutike maganizo. Pamene MT agonism ndi 5-HT2C receptor akutsutsana, mphamvu yapadera yogwirizana imatha kupangidwa, zomwe zimapangitsa kuti DA ndi NE zambiri zitulutsidwe mu ubongo wa PFC, ndikulimbitsa mphamvu yoletsa kupsinjika maganizo. Kuphatikiza apo, agomelatine imatha kulimbikitsa kutulutsidwa kwa neurotrophic factor yochokera mu ubongo mu PFC ndikuletsa kutulutsidwa kwa glutamate komwe kumabwera chifukwa cha kupsinjika m'dera la ubongo la amygdala.
