Wopanga ufa wa Agomelatine CAS No.: 138112-76-2 99% chiyero min. kwa zowonjezera zowonjezera
Kanema wa Zamalonda
Product Parameters
| Dzina la malonda | Agomelatine |
| Dzina lina | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| CAS No. | 138112-76-2 |
| Molecular formula | C15H17NO2 |
| Kulemera kwa maselo | 243.3082 |
| Chiyero | 99.0% |
| Maonekedwe | White ufa |
| Kulongedza | 1kg/thumba 25kg/ng'oma |
| Kugwiritsa ntchito | Health mankhwala zopangira |
Chiyambi cha malonda
Agomelatine idakhazikitsidwa koyamba ku Europe mu 2009 ndipo tsopano yavomerezedwa kuti igwiritsidwe ntchito m'maiko opitilira 70. Mosiyana ndi mankhwala oletsa kuvutika maganizo, agomelatine amagwira ntchito poyang'ana melatonin ndi serotonin receptors mu ubongo. Pochita ngati agonist pa melatonin zolandilira, agomelatine imathandizira kusokoneza kugona komwe kumalumikizidwa ndi kukhumudwa. Njirayi sikuti imangothandiza kukonza kugona komanso imathandizira kubwezeretsanso ma circadian rhythm. Kuphatikiza apo, agomelatine imakhala ngati wotsutsana ndi ma serotonin receptors (5-HT2C receptors). Kuchita kwapadera kwapawiri kumeneku mosadukiza kumapangitsa kupezeka kwa serotonin muubongo, neurotransmitter yomwe imayang'anira kusinthasintha. Powongolera milingo ya serotonin, agomelatine imatha kukhala ngati antidepressant yogwira mtima, yochotsa zizindikiro monga chisoni, kutaya chidwi, kudzimva wolakwa kapena wopanda pake. Kuphatikiza apo, agomelatine ikhoza kupereka maubwino ena. Kafukufuku akuwonetsa kuti zitha kuthandiza kukonza magwiridwe antchito anzeru Kafukufuku akuwonetsa kuthekera kwake kopititsa patsogolo kukumbukira, chidwi, ndi magwiridwe antchito, ndikupangitsa kukhala malo osangalatsa ochita kafukufuku wamtsogolo.
Mbali
(1) Chiyero chachikulu: Agomelatine amatha kupeza zinthu zoyeretsedwa kwambiri poyeretsa njira zopangira. Kuyeretsedwa kwakukulu kumatanthauza kukhalapo kwa bioavailability ndi zotsatira zochepa.
(2) Chitetezo: Kutetezedwa kwambiri, kusakhala ndi zovuta zochepa.
(3) Kukhazikika: Agomelatine ili ndi kukhazikika bwino ndipo imatha kusunga ntchito ndi zotsatira zake pansi pazigawo zosiyanasiyana komanso zosungirako.
Mapulogalamu
Agomelatine ndi antidepressant ndi melatonin antagonist. Amachepetsa zizindikiro za kuvutika maganizo poyendetsa melatonin MT1 receptors (amachepetsa zizindikiro za cortical alarm) ndi MT2 receptors (circadian sleep rhythm) ndi ma serotonin. Kutengedwa usiku, kumatengera kamvekedwe kachilengedwe kakutulutsa melatonin ndipo kumatha kusintha kwambiri kugona. Kachitidwe kake kachitidwe kake kamadutsa munjira yachikhalidwe ya monoamine transmitter. Imayambitsa melatonin zolandilira MT1 ndi MT2 ndikutsutsa zolandilira 5-HT2C. Imawongolera kugona bwino, imabwezeretsanso kamvekedwe kachilengedwe, komanso imakhala ndi antidepressant; pakati pawo, potsutsana ndi 5-HT2C zolandilira pa nembanemba ya postsynaptic, imatha kukulitsa kutulutsidwa kwa DA ndi NE mu prefrontal cortex, kumachita kupsinjika. Pamene MT agonism ndi 5-HT2C receptor antagonism imakhalapo, mphamvu yapadera ya synergistic imatha kupangidwa, kulimbikitsa kutulutsidwa kwa DA ndi NE yambiri mu dera la ubongo la PFC, kulimbitsanso mphamvu yotsutsa maganizo. Kuonjezera apo, agomelatine ikhoza kulimbikitsa kutulutsidwa kwa ubongo-derived neurotrophic factor mu PFC ndikuletsa kumasulidwa kwa glutamate m'dera la ubongo la amygdala.
