5-amino-1-methylquinolinium iodide CAS No.:42464-96-0 98.0% chiyero min. | | opanga zowonjezera zowonjezera
Product Parameters
| Dzina la malonda | 5-amino-1-methylquinolinium iodide |
| Dzina lina | NNMTi5-Amino-1-mq ayodini 5-amino-1-methylquinolinium iodide 5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine;iodide 5-Amino-1-methyl-1-quinolinium Iodide |
| CAS No. | 42464-96-0 |
| Mapangidwe a maselo | Chithunzi cha C10H11IN2 |
| Kulemera kwa maselo | 286.11 |
| Chiyero | 98% |
| Maonekedwe | Brown mpaka kufiira bulauni wolimba |
| Kulongedza | 1kg / thumba, 25kg / mbiya |
| Kugwiritsa ntchito | Zakudya Zowonjezera Zamasamba |
Chiyambi cha malonda
NNMTi ndi puloteni yomwe imawonetsedwa kwambiri pakukalamba kwachigoba ndipo imalumikizidwa ndi kukonzanso kuwonongeka kwa njira ya NAD +, ntchito ya dysregulated sirtuin1, komanso kuchuluka kwa cell stem cell senescence. NNMTi imalimbikitsa kusiyana kwa myoblast mu vitro ndikuwonjezera kusakanikirana ndi kusinthika kwa maselo amtundu wa minofu mu mbewa zakale. NNMTi ndiyonso inhibitor yamphamvu ya nicotinamide N-methyltransferase (NNMT) (IC50 = 1.2 μM), mwa kusankha kumangiriza zotsalira za NNMT zomanga malo. NNMTi imalimbikitsa kusiyana kwa myoblast mu vitro ndikuwonjezera kusakanikirana ndi kusinthika kwa maselo amtundu wa minofu mu mbewa zakale. Mwa iwo, cytosolic enzyme nicotinamide N-methyltransferase (NNMT) yapezeka kumene kuti iwongolere milingo ya nicotinamide precursors yofunikira pa NAD + biosynthesis, motero imagwira ntchito yofunika kwambiri pakuwongolera njira yopulumutsira ya NAD + ndi metabolism yama cell.
Mbali
(1) Chiyero chachikulu: NNMTi imatha kupeza zinthu zoyera kwambiri kudzera munjira zoyenga. Kuyera kwakukulu kumatanthauza bioavailability yabwino.
(2) Kuwongolera: NNMTi imayang'ana makamaka enzyme ya NNMT ndipo imatha kuletsa bwino ntchito yake, motero imakhudza njira ya metabolic ya nicotinamide.
(3) Kukhazikika: NNMti ili ndi kukhazikika bwino ndipo imatha kusunga ntchito yake ndi zotsatira zake pansi pazigawo zosiyanasiyana ndi malo osungirako.
(4) Zoyembekeza zachitukuko: Chifukwa cha makhalidwe osiyanasiyana a NNMT, chitukuko chake chalandira chidwi chofala ndipo chili ndi kafukufuku wochuluka komanso mwayi wogwiritsa ntchito.
Mapulogalamu
NNMTi ndi nicotinamide N-methyltransferase (NNMT) inhibitor yomwe imalimbikitsa kusiyana kwa myoblast. NNMTi ingagwiritsidwenso ntchito ngati chowonjezera chothandizira kuchepetsa kulemera ndi mafuta komanso kukonza mafuta a chiwindi.
