Chifukwa Chiyani Muyenera Kugula Spermidine Powder? Ubwino Waukulu Wafotokozedwa

Spermidine,amadziwikanso kuti spermidine, ndi triamine polyamine mankhwala omwe amapezeka kwambiri muzomera monga tirigu, soya, ndi mbatata, tizilombo toyambitsa matenda monga lactobacilli ndi bifidobacteria, ndi mitundu yosiyanasiyana ya nyama. Spermidine ndi hydrocarbon yokhala ndi mafupa owoneka ngati zigzag opangidwa ndi ma atomu a kaboni 7 ndi magulu a amino kumapeto ndi pakati.

Kafukufuku wamakono watsimikizira kuti spermidine imakhudzidwa ndi zochitika zofunika kwambiri za moyo monga kubwereza kwa DNA ya ma cell, kulembedwa kwa mRNA, ndi kumasulira kwa mapuloteni, komanso njira zambiri zapathophysiological monga chitetezo cha thupi ndi metabolism. Lili ndi chitetezo cha mtima ndi neuroprotection, anti-chotupa, ndi lamulo la kutupa, etc. Zofunika kwambiri zamoyo.

Spermidine amaonedwa ngati activator yamphamvu ya autophagy, intracellular recycling process kudzera m'maselo akale amadzikonzanso ndikuyambiranso ntchito. Spermidine imagwira ntchito yofunika kwambiri pakugwira ntchito kwa maselo komanso kukhala ndi moyo. M'thupi, spermidine imapangidwa kuchokera ku precursor putrescine, yomwe imakhala kalambulabwalo wa polyamine ina yotchedwa spermine, yomwe imakhalanso yofunika kwambiri pakugwira ntchito kwa selo.

Spermidine ndi putrescine zimalimbikitsa autophagy, kachitidwe kamene kamaphwanya zinyalala zamkati ndikubwezeretsanso zigawo za ma cell ndipo ndi njira yoyendetsera mitochondria, nyumba zopangira mphamvu zama cell. Autophagy imasweka ndikutaya mitochondria yowonongeka kapena yosalongosoka, ndipo kutaya kwa mitochondrial ndi njira yoyendetsedwa mwamphamvu. Ma polyamines amatha kumangirira ku mitundu yosiyanasiyana ya mamolekyu, kuwapangitsa kukhala osinthasintha. Amathandizira njira monga kukula kwa maselo, kukhazikika kwa DNA, kuchuluka kwa ma cell, ndi apoptosis. Ma polyamines amawoneka kuti akugwira ntchito mofanana ndi zinthu zomwe zimakula panthawi yamagulu a maselo, chifukwa chake putrescine ndi spermidine ndizofunikira kwambiri pakukula ndi kugwira ntchito kwa minofu yathanzi.

Ochita kafukufuku adaphunzira momwe spermidine imatetezera maselo ku nkhawa ya okosijeni, yomwe imatha kuwononga maselo ndikuyambitsa matenda osiyanasiyana. Iwo adapeza kuti spermidine imayendetsa autophagy. Kafukufukuyu adawonetsa majini angapo ofunikira omwe amakhudzidwa ndi spermidine omwe amachepetsa kupsinjika kwa okosijeni ndikulimbikitsa autophagy m'maselo awa. Kuphatikiza apo, adapeza kuti kutsekereza njira ya mTOR, yomwe nthawi zambiri imalepheretsa autophagy, kumawonjezera chitetezo cha spermidine.

Ndi zakudya ziti zomwe zili ndi spermidine yambiri?

Spermidine ndi polyamine yofunika. Kuphatikiza pa kupangidwa ndi thupi la munthu palokha, magwero ake azakudya zambiri komanso tizilombo tating'onoting'ono tamatumbo ndi njira zazikulu zoperekera. Kuchuluka kwa spermidine m'zakudya zosiyanasiyana kumasiyana kwambiri, ndi majeremusi a tirigu omwe amadziwika bwino. Zakudya zina ndi monga mphesa, mankhwala a soya, nyemba, chimanga, mbewu zonse, nandolo, nandolo, tsabola wobiriwira, broccoli, malalanje, tiyi wobiriwira, chinangwa cha mpunga ndi tsabola watsopano wobiriwira. Kuphatikiza apo, zakudya monga bowa wa shiitake, njere za amaranth, kolifulawa, tchizi wokhwima ndi durian zilinso ndi spermidine.

Ndizofunikira kudziwa kuti zakudya za ku Mediterranean zimakhala ndi zakudya zambiri zokhala ndi spermidine, zomwe zingathandize kufotokozera zochitika za "blue zone" kumene anthu amakhala nthawi yaitali m'madera ena. Komabe, kwa anthu omwe sangathe kudya umuna wokwanira kudzera muzakudya, zowonjezera za spermidine ndizothandiza. Ma spermidine omwe ali muzowonjezera izi ndi molekyu yomwe imachitika mwachilengedwe, ndikupangitsa kuti ikhale njira yabwino.

Kodi putrescine ndi chiyani?

Kupanga putrescine kumaphatikizapo njira ziwiri, zonse zomwe zimayamba ndi amino acid arginine. Panjira yoyamba, arginine imasinthidwa kukhala agmatine yopangidwa ndi arginine decarboxylase. Pambuyo pake, agmatine imasinthidwa kukhala N-carbamoylputrescine kudzera mu zochita za agmatine iminohydroxylase. Pamapeto pake, N-carbamoylputrescine imasinthidwa kukhala putrescine, kumaliza njira yosinthira. Njira yachiwiri ndiyosavuta, imasintha mwachindunji arginine kukhala ornithine, kenako imatembenuza ornithine kukhala putrescine kudzera muzochita za ornithine decarboxylase. Ngakhale njira ziwirizi zili ndi masitepe osiyanasiyana, onsewa amatha kusintha kuchokera ku arginine kupita ku putrescine.

Putrescine ndi diamine yomwe imapezeka mu ziwalo zosiyanasiyana monga kapamba, thymus, khungu, ubongo, chiberekero ndi mazira. Putrescine amapezekanso muzakudya monga nyongolosi yatirigu, tsabola wobiriwira, soya, pistachios, ndi malalanje. Kafukufuku waposachedwa wasonyeza kuti putrescine ndi chinthu chofunikira chowongolera kagayidwe kachakudya chomwe chimatha kuyanjana ndi ma macromolecules achilengedwe monga DNA, RNA, ma ligand osiyanasiyana (monga β1 ndi β2 adrenergic receptors), ndi mapuloteni a membrane. , zomwe zimatsogolera ku kusintha kwa thupi kapena kusintha kwa thupi m'thupi.

Mphamvu ya spermidine

Ntchito ya Antioxidant: Spermidine ili ndi mphamvu ya antioxidant ndipo imatha kuchitapo kanthu ndi ma free radicals kuti achepetse kuwonongeka kwa okosijeni ku maselo obwera chifukwa cha ma free radicals. M'thupi, spermidine imathanso kulimbikitsa mawonetsedwe a antioxidant michere ndikuwonjezera mphamvu ya antioxidant.

Kuwongolera mphamvu za kagayidwe kagayidwe: Spermidine imakhudzidwa ndi kayendetsedwe ka kagayidwe kazamoyo, imatha kulimbikitsa kuyamwa ndi kugwiritsa ntchito shuga mutatha kudya, ndipo imakhudza chiŵerengero cha kagayidwe ka aerobic ndi kagayidwe ka anaerobic mwa kuwongolera mphamvu ya mitochondrial kupanga mphamvu.

odana ndi kutupa kwenikweni

Spermidine imakhala ndi zotsutsana ndi zotupa ndipo imatha kuwongolera mawonekedwe azinthu zotupa ndikuchepetsa kupezeka kwa kutupa kosatha. Makamaka zokhudzana ndi njira ya nyukiliya-κB (NF-κB).

Kukula, chitukuko ndi chitetezo cha mthupi: Spermidine imathandizanso kwambiri pakukula, chitukuko ndi chitetezo cha mthupi. Ikhoza kulimbikitsa katulutsidwe ka hormone yakukula m'thupi la munthu ndikuthandizira kupititsa patsogolo kukula kwa minofu ndi ziwalo zosiyanasiyana za thupi. Panthawi imodzimodziyo, mu kayendetsedwe ka chitetezo cha mthupi, spermidine imapangitsa kuti thupi likhale lolimba ku mavairasi ndi matenda poyendetsa kupanga maselo oyera a magazi ndi kulimbikitsa kuchotsedwa kwa mitundu yogwira ntchito ya okosijeni.

Kuchedwetsa ukalamba: Spermidine imatha kulimbikitsa autophagy, njira yoyeretsera mkati mwa maselo omwe amathandiza kuchotsa organelles ndi mapuloteni owonongeka, potero akuchedwetsa kukalamba.

Kuwongolera ma cell a Glial: Spermidine imagwira ntchito yofunika kwambiri pakuwongolera ma cell a glial. Imatha kutenga nawo mbali pamakina owonetsera ma cell ndi kulumikizana kogwira ntchito pakati pa ma cell a mitsempha, ndipo imakhala ndi gawo lofunikira pakuwongolera ma neuron, kufalikira kwa ma synaptic, komanso kukana matenda amisala.

Chitetezo chamtima: Mumtima, spermidine imatha kuchepetsa kuchuluka kwa lipid m'mitsempha ya atherosclerotic, kuchepetsa mtima wa hypertrophy, komanso kupititsa patsogolo ntchito ya diastolic, potero amateteza mtima. Kuphatikiza apo, kudya kwa spermidine kumathandizira kuthamanga kwa magazi ndikuchepetsa kudwala kwamtima komanso kufa.

Mu 2016, kafukufuku wofalitsidwa mu Atherosclerosis adatsimikizira kuti spermidine imatha kuchepetsa kuchuluka kwa lipid m'mitsempha ya atherosclerotic. M'chaka chomwecho, kafukufuku wofalitsidwa mu Nature Medicine adatsimikizira kuti spermidine ikhoza kuchepetsa hypertrophy ya mtima ndi kupititsa patsogolo ntchito ya diastolic, potero kuteteza mtima ndi kukulitsa moyo wa mbewa.

Kupititsa patsogolo matenda a Alzheimer's

Kudya kwa spermidine kumapindulitsa pa ntchito ya kukumbukira anthu. Gulu la Pulofesa Reinhart wa ku Australia linapeza kuti chithandizo cha spermidine chikhoza kupititsa patsogolo chidziwitso cha okalamba. Kafukufukuyu adatengera mawonekedwe apakati akhungu awiri ndipo adalembetsa anthu okalamba 85 m'malo osungira okalamba 6, omwe adagawidwa mwachisawawa m'magulu awiri ndikugwiritsa ntchito mitundu yosiyanasiyana ya spermidine. Ntchito yawo yachidziwitso idawunikidwa kudzera m'mayesero a kukumbukira ndikugawidwa m'magulu anayi: palibe dementia, dementia wofatsa, dementia wapakatikati ndi dementia kwambiri. Magazi adasonkhanitsidwa kuti ayese kuchuluka kwa spermidine m'magazi awo. Zotsatira zinawonetsa kuti ndende ya spermidine inali yogwirizana kwambiri ndi ntchito yachidziwitso mu gulu lopanda matenda a maganizo, ndipo chidziwitso cha anthu okalamba omwe ali ndi vuto la maganizo ofatsa mpaka ochepetsetsa adakula kwambiri atatha kumwa mlingo waukulu wa spermidine.

Autophagy

Spermidine ikhoza kulimbikitsa autophagy, monga mTOR (chandamale cha rapamycin) njira yolepheretsa. Mwa kulimbikitsa autophagy, imathandizira kuchotsa ma organelles owonongeka ndi mapuloteni m'maselo ndikusunga thanzi la cell.

Spermidine hydrochloride amagwiritsidwa ntchito m'madera osiyanasiyana

M'munda wamankhwala, spermidine hydrochloride imagwiritsidwa ntchito ngati mankhwala a hepatoprotective omwe amatha kusintha ntchito ya chiwindi ndikuchepetsa kuwonongeka kwa chiwindi. Kuphatikiza apo, spermidine hydrochloride ingagwiritsidwe ntchito pochiza matenda monga cholesterol yayikulu, hypertriglyceridemia, ndi matenda amtima.

Spermidine hydrochloride imagwira ntchito pochepetsa milingo ya plasma homocysteine ​​​​(Hcy), potero amachepetsa chiopsezo cha matenda amtima. Kafukufuku wasonyeza kuti spermidine hydrochloride akhoza kulimbikitsa kagayidwe Hcy ndi kuchepetsa chiopsezo cha matenda a mtima ndi kuchepetsa plasma Hcy milingo.

Kafukufuku wokhudza zotsatira za spermidine hydrochloride pa chiopsezo cha matenda a mtima ndi mitsempha ya mtima anasonyeza kuti spermidine hydrochloride ikhoza kuchepetsa plasma Hcy milingo, potero kuchepetsa chiopsezo cha matenda a mtima. Mu kafukufukuyu, ofufuza adagawa anthu m'magulu awiri, wina akulandira spermidine hydrochloride supplementation ndipo winayo akulandira placebo.

Zotsatira za phunziroli zidawonetsa kuti omwe adalandira spermidine hydrochloride supplementation anali otsika kwambiri mulingo wa Hcy wa plasma komanso kuchepetsedwa kofananira kwa chiwopsezo cha matenda amtima. Kuphatikiza apo, pali maphunziro ena omwe amathandizira gawo la spermidine hydrochloride pochepetsa chiopsezo cha matenda amtima.

M'munda wazakudya, spermidine hydrochloride imagwiritsidwa ntchito ngati chokometsera komanso chokometsera kukulitsa kukoma kwa chakudya ndikusunga chinyezi cha chakudya. Kuphatikiza apo, spermidine hydrochloride itha kugwiritsidwanso ntchito ngati chowonjezera cha chakudya kuti chiwongolere kukula ndi mtundu wa minofu ya nyama.

Mu zodzoladzola, spermidine hydrochloride amagwiritsidwa ntchito ngati humectant ndi antioxidant kuti asunge chinyezi pakhungu ndikuchepetsa kuwonongeka kwakukulu kwaufulu. Kuonjezera apo, spermidine hydrochloride ingagwiritsidwenso ntchito pa sunscreens kuchepetsa kuwonongeka kwa kuwala kwa ultraviolet pakhungu.

M'munda waulimi, spermidine hydrochloride imagwiritsidwa ntchito ngati chowongolera kukula kwa mbewu kulimbikitsa kukula kwa mbewu ndikuwonjezera zokolola.