Calcium Alpha ketoglutarate (AKG) ndi metabolite yapakati ya tricarboxylic acid cycle ndipo imatenga nawo mbali popanga ma amino acid, mavitamini ndi ma organic acid komanso kagayidwe ka mphamvu. Itha kugwiritsidwa ntchito ngati chowonjezera pazakudya ndipo ili ndi mwayi wogwiritsidwa ntchito kwambiri. Kuphatikiza pa ntchito zake zamoyo m'thupi la munthu, calcium alpha-ketoglutarate imagwiritsidwanso ntchito kwambiri m'munda wamankhwala ndipo yakhala gawo lofunikira kwambiri pazinthu zambiri zaumoyo ndi mayankho azachipatala.
Kodi alpha-ketoglutarate ndi chiyani?
AKG ndi metabolite yochokera kuzinthu zachilengedwe yomwe ndi gawo la kayendedwe ka Krebs, zomwe zikutanthauza kuti matupi athu ndi omwe amapanga. Makampani owonjezera amapanganso mtundu wopangidwa womwe umafanana ndi wa AKG wopangidwa mwachilengedwe.
Kodi AKG imagwira ntchito bwanji?
AKG ndi molekyulu yomwe imakhudzidwa ndi njira zambiri za kagayidwe kachakudya ndi maselo. Imagwira ntchito ngati wopereka mphamvu, woyambitsa kupanga amino acid ndi mamolekyulu ozindikiritsa maselo, komanso imasintha njira za epigenetic. Ndi molekyulu yofunika kwambiri mu kayendedwe ka Krebs, yomwe imayang'anira liwiro lonse la kayendedwe ka citric acid m'thupi. Imagwira ntchito m'njira zosiyanasiyana m'thupi kuti ithandize kumanga minofu ndikuthandizira kuchira kwa mabala, chomwe ndi chimodzi mwa zifukwa zomwe imatchuka kwambiri m'dziko lolimbitsa thupi.
AKG imagwiranso ntchito ngati chotsitsa nayitrogeni, kuteteza kuchuluka kwa nayitrogeni komanso kupewa kuchuluka kwa ammonia. Ndi gwero labwino kwambiri la glutamate ndi glutamine, zomwe zimapangitsa kuti mapuloteni apangidwe m'minofu ndikuletsa kuwonongeka kwa mapuloteni.
Kuphatikiza apo, imayang'anira enzyme ya 10-11 translocation (TET) yomwe imakhudzidwa ndi demethylation ya DNA ndi lysine demethylase yomwe ili ndi Jumonji C domain-containing, yomwe ndi histone demethylase yayikulu. Mwanjira imeneyi, ndi wosewera wofunikira pakulamulira ndi kufotokozera majini.
Kodi AKG ingachedwetse kukalamba?
Pali umboni wakuti AKG ingakhudze ukalamba, ndipo maphunziro ambiri akusonyeza kuti izi ndi zoona. Kafukufuku wa mu 2014 anasonyeza kuti AKG inawonjezera moyo wa C. elegans wamkulu ndi pafupifupi 50% poletsa ATP synthase ndi cholinga cha rapamycin (TOR).
Mu kafukufukuyu, tapeza kuti AKG sikuti imangowonjezera nthawi ya moyo komanso imachedwetsa zinthu zina zokhudzana ndi ukalamba, monga kutayika kwa mayendedwe ogwirizana mwachangu omwe amapezeka mwa okalamba a C. elegans. Kuti timvetse momwe AKG imakhudzira ukalamba, tifotokoza njira zomwe AKG imalepheretsa ATP synthase ndi TOR kuti iwonjezere nthawi ya moyo mwa C. elegans komanso mwina mitundu ina.
Momwe calcium alpha-ketoglutarate imagwirira ntchito
Choyamba, calcium alpha-ketoglutarate imagwira ntchito yofunika kwambiri pa kagayidwe ka mphamvu. Monga chinthu chapakati pa kayendedwe ka tricarboxylic acid (TCA cycle), calcium α-ketoglutarate imatenga nawo mbali popanga mphamvu mkati mwa maselo. Kudzera mu kayendedwe ka TCA, michere monga chakudya, mafuta, ndi mapuloteni amasungunuka ndikuwola kuti apange ATP (adenosine triphosphate) kuti ipereke mphamvu ku maselo. Monga chinthu chofunikira kwambiri pa kayendedwe ka TCA, calcium α-ketoglutarate imatha kulimbikitsa kagayidwe ka mphamvu m'maselo, kuwonjezera mphamvu m'thupi, kuthandiza kulimbitsa mphamvu ndi kupirira, komanso kulimbitsa kutopa kwakuthupi.
Kachiwiri, calcium α-ketoglutarate imagwira ntchito yofunika kwambiri pa kagayidwe ka amino acid. Ma amino acid ndi mayunitsi oyambira a mapuloteni, ndipo calcium α-ketoglutarate imagwira ntchito pakusintha ndi kagayidwe ka amino acid. Posintha ma amino acid kukhala ma metabolites ena, calcium α-ketoglutarate imasinthasintha ndi ma amino acid kuti ipange ma amino acid atsopano kapena ma α-keto acid, motero imayang'anira bwino ndikugwiritsa ntchito ma amino acid. Kuphatikiza apo, calcium α-ketoglutarate ingathenso kugwira ntchito ngati gawo la okosijeni la ma amino acid, kutenga nawo mbali mu kagayidwe ka okosijeni ka ma amino acid, ndikupanga mphamvu ndi carbon dioxide. Chifukwa chake, calcium α-ketoglutarate ndi yofunika kwambiri pakusunga homeostasis ya ma amino acid ndi kagayidwe ka mapuloteni m'thupi.
Kuphatikiza apo, calcium alpha-ketoglutarate imagwira ntchito ngati antioxidant yomwe imachotsa ma free radicals ndikuteteza maselo ku kuwonongeka kwa okosijeni. Nthawi yomweyo, calcium α-ketoglutarate imathanso kuwongolera magwiridwe antchito a chitetezo chamthupi, kulimbikitsa kuyambika ndi kuchulukana kwa maselo a chitetezo chamthupi, ndikuwonjezera kukana kwa thupi ku matenda ndi matenda. Chifukwa chake, calcium α-ketoglutarate ndi yofunika kwambiri pakusunga chitetezo chamthupi komanso kukana matenda.
Kafukufuku wokhudza zotsatira za calcium α-ketoglutarate pa ukalamba
Ukalamba umatikhudza tonsefe ndipo ndi chinthu chomwe chimayambitsa matenda ambiri, ndipo malinga ndi ziwerengero za anthu ogwira ntchito ku Medicare, mwayi wodwala umawonjezeka ndi ukalamba.
Calcium alpha-ketoglutarate ndi metabolite yofunika kwambiri m'thupi lathu, yomwe imadziwika ndi gawo la selo mu kayendedwe ka Krebs, kayendedwe kofunikira pakuwotchedwa kwa mafuta acids ndi amino acids, zomwe zimathandiza mitochondria kupanga ATP (ATP ndiye gwero la mphamvu la maselo).
Izi zimaphatikizapo kudzaza kwa njira ya calcium alpha-ketoglutarate, kotero calcium alpha-ketoglutarate imatha kusinthidwa kukhala glutamate kenako kukhala glutamine, yomwe ingathandize kulimbikitsa kapangidwe ka mapuloteni ndi collagen (collagen ndi puloteni ya A yomwe imapanga 1/3 ya mapuloteni onse m'thupi ndipo imathandizira thanzi la mafupa, khungu ndi minofu).
Calcium α-ketoglutarate, monga chowonjezera cha zakudya chogwira ntchito zambiri, ili ndi mwayi waukulu wogwiritsidwa ntchito muzinthu zothandizira zaumoyo. Ntchito zake zosiyanasiyana zamoyo monga antioxidant, anti-ukalamba, malamulo a chitetezo chamthupi komanso kagayidwe ka amino acid zimapangitsa kuti ikhale chida champhamvu chowongolera thanzi la anthu. Chifukwa cha kuchuluka kwa chidziwitso cha chisamaliro chaumoyo komanso kuzama kwa kafukufuku wasayansi, akukhulupirira kuti kugwiritsa ntchito calcium ya α-ketoglutarate m'munda wazinthu zothandizira zaumoyo kudzalandira chidwi ndi chitukuko chochulukirapo.
Chodzikanira: Nkhaniyi ndi yongofuna kudziwa zambiri ndipo siyenera kuonedwa ngati upangiri uliwonse wa zachipatala. Zina mwa zomwe zili mu blog iyi zimachokera pa intaneti ndipo si zaukadaulo. Webusaitiyi ili ndi udindo wosankha, kupanga ndi kusintha nkhani zokha. Cholinga chopereka zambiri sichikutanthauza kuti mukugwirizana ndi malingaliro ake kapena kutsimikizira kuti zomwe zili mkati mwake ndi zoona. Nthawi zonse funsani katswiri wa zaumoyo musanagwiritse ntchito zowonjezera zilizonse kapena kusintha njira yanu yazaumoyo.
Nthawi yotumizira: Okutobala-15-2024
