Chifukwa Chake Alpha Ketoglutarate Magnesium Ndi Yofunikira Pa Thanzi Lanu

Calcium Alpha ketoglutarate (AKG) ndi metabolite wapakatikati wa tricarboxylic acid cycle ndipo amatenga nawo gawo pakupanga ma amino acid, mavitamini ndi ma organic acid ndi metabolism yamphamvu. Itha kugwiritsidwa ntchito ngati chowonjezera chazakudya ndipo imakhala ndi chiyembekezo chogwiritsa ntchito. Kuphatikiza pa ntchito zake zachilengedwe m'thupi la munthu, calcium alpha-ketoglutarate imagwiritsidwanso ntchito kwambiri m'munda wamankhwala ndipo yakhala gawo lofunikira pazamankhwala ambiri komanso mayankho azachipatala.

Kodi alpha-ketoglutarate ndi chiyani?

AKG ndi metabolite yokhazikika yokhazikika yomwe ili gawo la Krebs cycle, kutanthauza kuti matupi athu omwe amapanga. Makampani othandizira amatulutsanso mtundu wopangidwa womwe ndi wofanana ndi AKG wopangidwa mwachilengedwe.

Kodi AKG imachita chiyani?

AKG ndi molekyu yomwe imakhudzidwa ndi njira zambiri zama metabolic ndi ma cellular. Imagwira ntchito ngati wopereka mphamvu, kalambulabwalo wa kupanga amino acid ndi ma cell signing molecule, ndipo ndi modulator ya epigenetic process. Ndi molekyulu yofunika kwambiri pamayendedwe a Krebs, omwe amawongolera liwiro lonse la chamoyo cha citric acid. Zimagwira ntchito m'njira zosiyanasiyana m'thupi kuti zithandizire kumanga minofu ndikuthandizira kuchiritsa mabala, chomwe ndi chimodzi mwazifukwa zomwe zimatchuka m'dziko lomanga thupi.

AKG imagwiranso ntchito ngati mkangaziwisi wa nayitrogeni, kuletsa kuchuluka kwa nayitrogeni ndikuletsa kuchuluka kwa ammonia ochulukirapo. Ndiwonso gwero lalikulu la glutamate ndi glutamine, zomwe zimalimbikitsa kaphatikizidwe ka mapuloteni mu minofu ndikuletsa kuwonongeka kwa mapuloteni.

Kuphatikiza apo, imayang'anira enzyme ya 10-11 translocation (TET) yomwe imakhudzidwa ndi DNA demethylation ndi Jumonji C domain-containing lysine demethylase, yomwe ndi histone demethylase yayikulu. Mwanjira iyi, ndi gawo lofunikira pakuwongolera ma jini ndi mafotokozedwe.

Kodi AKG ingachedwetse kukalamba?

Pali umboni wosonyeza kuti AKG ikhoza kusokoneza ukalamba, ndipo kafukufuku wambiri amasonyeza kuti ndi choncho. Kafukufuku wa 2014 adawonetsa kuti AKG idakulitsa moyo wa ma C. elegans akuluakulu pafupifupi 50% mwa kuletsa ATP synthase ndi chandamale cha rapamycin (TOR).

Mu phunziro ili, tapeza kuti AKG sikuti imangowonjezera nthawi ya moyo komanso imachedwetsa ma phenotypes ena okhudzana ndi zaka, monga kutayika kwa kayendetsedwe ka thupi kogwirizana komwe kaŵirikaŵiri kwa okalamba C. elegans. Kuti timvetse momwe AKG imakhudzira ukalamba, tidzalongosola njira zomwe AKG imalepheretsa ATP synthase ndi TOR kuti iwonjezere moyo wa C. elegans ndipo mwina mitundu ina.

Momwe calcium alpha-ketoglutarate imagwirira ntchito

Choyamba, calcium alpha-ketoglutarate imagwira ntchito yofunika kwambiri mu metabolism yamphamvu. Monga chinthu chapakatikati cha tricarboxylic acid cycle (TCA), calcium α-ketoglutarate imatenga nawo gawo pakupanga mphamvu zamagetsi. Kupyolera mu kayendetsedwe ka TCA, zakudya monga chakudya, mafuta, ndi mapuloteni amapangidwa ndi okosijeni ndikuwonongeka kuti apange ATP (adenosine triphosphate) kuti apereke mphamvu kwa maselo. Monga gawo lapakati lofunikira pakuyenda kwa TCA, calcium α-ketoglutarate imatha kulimbikitsa kagayidwe kazinthu zama cell, kuwonjezera mphamvu ya thupi, kuthandizira kulimbitsa thupi ndi kupirira, komanso kutopa kwathupi.

Kachiwiri, calcium α-ketoglutarate imagwira ntchito yofunika kwambiri mu metabolism ya amino acid. Ma amino acid ndi magawo oyambira a mapuloteni, ndipo calcium α-ketoglutarate imakhudzidwa ndikusintha ndi kagayidwe ka amino acid. Posintha ma amino acid kukhala ma metabolites ena, calcium α-ketoglutarate imadutsa ndi ma amino acid kuti ipange ma amino acid atsopano kapena ma α-keto acid, motero imayendetsa bwino komanso kugwiritsa ntchito ma amino acid. Kuphatikiza apo, calcium α-ketoglutarate imathanso kukhala gawo la oxidation la amino acid, kutenga nawo gawo mu metabolism ya oxidative ya amino acid, ndikupanga mphamvu ndi carbon dioxide. Chifukwa chake, calcium α-ketoglutarate ndiyofunikira kwambiri pakusunga homeostasis ya amino acid ndi protein metabolism m'thupi.

Kuphatikiza apo, calcium alpha-ketoglutarate imagwira ntchito ngati antioxidant yomwe imachotsa ma free radicals ndikuteteza maselo kuti asawonongeke ndi okosijeni. Panthawi imodzimodziyo, calcium α-ketoglutarate ingathenso kulamulira ntchito ya chitetezo cha mthupi, kulimbikitsa kuyambitsa ndi kufalikira kwa maselo a chitetezo cha mthupi, komanso kupititsa patsogolo kukana kwa thupi ku matenda ndi matenda. Chifukwa chake, calcium α-ketoglutarate ndiyofunikira kwambiri pakusunga chitetezo chathupi komanso kukana matenda.

Kafukufuku pa zotsatira za calcium α-ketoglutarate pa ukalamba

Kukalamba kumakhudza tonsefe ndipo ndizomwe zimayambitsa matenda ambiri, ndipo malinga ndi kuchuluka kwa anthu amakampani a Medicare, mwayi wodwala ukuwonjezeka ndi zaka.

Calcium alpha-ketoglutarate ndi metabolite yofunikira m'thupi lathu, yomwe imadziwika ndi gawo la cell mu Krebs cycle, cycle yofunika kuti makutidwe ndi okosijeni amafuta acids ndi amino acid, kulola mitochondria kupanga ATP (ATP ndi gwero lamphamvu la maselo).

Zomwe zimaphatikizapo kutsitsa kwa calcium alpha-ketoglutarate, kotero kuti calcium alpha-ketoglutarate imathanso kusinthidwa kukhala glutamate kenako kukhala glutamine, yomwe ingathandize kulimbikitsa kaphatikizidwe ka mapuloteni ndi kolajeni (collagen ndi mapuloteni A fibrous omwe amapanga 1/3). mapuloteni onse m'thupi ndikuthandizira kulimbikitsa thanzi la mafupa, khungu ndi minofu).

Calcium α-ketoglutarate, monga chowonjezera chamagulu ambiri, chili ndi chiyembekezo chogwiritsa ntchito pazinthu zachipatala. Ntchito zake zosiyanasiyana zachilengedwe monga antioxidant, anti-aging, regulation chitetezo ndi amino acid metabolism zimapangitsa kuti ikhale chida champhamvu chothandizira thanzi la munthu. Ndi chidziwitso chowonjezereka cha chisamaliro chaumoyo komanso kuzama kwa kafukufuku wa sayansi, akukhulupirira kuti kugwiritsa ntchito α-ketoglutarate calcium m'munda wa mankhwala osamalira thanzi kudzalandira chidwi ndi chitukuko.