7,8-Dihydroxyflavone (7,8-DHF) ndi flavonoid yochitika mwachilengedwe yomwe imawonetsa lonjezano m'malo osiyanasiyana azaumoyo. Ngati muli ndi chidwi ndi zowonjezera zachilengedwe kapena zakudya zomwe zingathandize kuti ubongo ukhale wathanzi, maganizo, ndi thanzi labwino, 7,8-DHF ingakhale yofunikira kufufuza. 7,8-Dihydroxyflavone Powder yoperekedwa ndi Suzhou Myland ili ndi nambala ya CAS ya 38183-03-8 ndi kuyera mpaka 98%. Zogulitsazo zakhala zikuyang'aniridwa bwino kwambiri ndipo zimagwirizana ndi miyezo yapadziko lonse, kuwonetsetsa kuti mankhwalawa ndi otetezeka komanso otetezeka. , oyenera kafukufuku wa sayansi, chitukuko cha mankhwala, kupanga mankhwala opangira chithandizo chamankhwala ndi zina, kukupatsani chisankho chodalirika.
7,8-Dihydroxyflavone (7,8-DHF)ndi flavonoid yosowa kwambiri yomwe imapezeka mwachilengedwe. Zapezeka ku Astragalus pumila, Primula grandifolia ndi Hubei crabapple. watuluka ngati wolonjeza pawiri nootropic. Zawonetsa zotsatira zingapo za neuropharmacological mu maphunziro a preclinical,
Flavonoids ndi gulu la mankhwala a polyphenolic omwe amapezeka mumitundu yosiyanasiyana ya zipatso, masamba, ndi zomera zina. M'zaka zaposachedwa, adalandira chidwi kwambiri chifukwa cha antioxidant, anti-inflammatory, and neuroprotective properties.
Mankhwalawa awonetsedwa kuti ali ndi phindu paubongo, kuphatikizapo kupititsa patsogolo chidziwitso komanso kupewa matenda a neurodegenerative. 7,8-DHF ndi imodzi mwazinthu zodziwika bwino za polyphenolic zomwe zimalandira chidwi chowonjezereka ngati nootropic. Zaphunziridwa chifukwa cha zotsatira zake pamalingaliro, kukumbukira, kuphunzira, nkhawa, ndi ntchito zina zanzeru.
Zotsatira za minyewa za 7,8-DHF zimaganiziridwa kuti zimalumikizidwa ndi kuyanjana kwake ndi zolandilira zenizeni. Zapezeka kuti ndi TrkA, cholandirira chomwe chimakhudzidwa ndi chizindikiro cha kukula kwa mitsempha komanso chofunikira pakupulumuka kwa neuronal ndi pulasitiki.
7,8-DHF imachita mwa kuwongolera mafotokozedwe a zolandilira zosiyanasiyana, kuphatikiza ma glutamate receptor subunits ndi BDNF. Zimakhudzanso mapangidwe a synapse, mphamvu ya metabolism, ndi kutulutsidwa kwa acetylcholine m'madera ena a ubongo.
Kuonjezera apo, matenda osteoporosis amadziwika kuti "wakupha mwakachetechete" wa thupi la munthu, kuopseza kwambiri thanzi la anthu azaka zapakati ndi okalamba, makamaka amayi omwe ali ndi postmenopausal. Pansi pazochitika zakuthupi, kukonzanso mafupa kumakhala koyenera; koma pakakhala kusamvana pakati pa mapangidwe a mafupa a osteoblast-mediated bone ndi osteoclast-mediated bone resorption, ndipo kuchuluka kwa fupa kumapangidwa sikukwanira kuonjezera fupa lomwe lakhudzidwa, fupa lidzachepa. , microstructure ya fupa minofu imawonongeka, kumayambitsa matenda osteoporosis.
7,8-Dihydroxyflavone (7,8-DHF) ndi flavonoid yochokera ku zomera yomwe ingatsanzire ntchito ya ubongo yochokera ku neurotrophic factor (BDNF), imayambitsa dimerization ya TrkB receptors ndi kuyambitsa mamolekyu ake otsika pansi. Kafukufuku wasonyeza kuti BDNF ikhoza kulimbikitsa kusiyana kwa osteoblast ndi kusamuka ndikufulumizitsa machiritso a fracture.
7,8-DHF ikhoza kulimbikitsa kufalikira ndi kusiyanitsa kwa osteoblasts mwa kuyanjana ndi TrkB ndi kuyambitsa njira yowonetsera Wnt / β-catenin, ndipo ikhoza kulepheretsa kubadwa kwa osteoclasts mwa kuchepetsa cholembera c-fos; Komanso, 7,8-DHF akhoza kusintha osteoporosis phenotype mu ovariectomized makoswe.
Kapangidwe ka mankhwala ndi katundu wa 7,8-dihydroxyflavone
Ili ndi magulu awiri a hydroxyl pa mphete ya benzene ndi gulu limodzi la hydroxyl pa mphete ya pyrrolone. Tiyeni tiwone mwatsatanetsatane kapangidwe kake ka 7,8-dihydroxyflavone:
Mamolekyu a 7,8-DHF ndi C15H10O5, kusonyeza kuti ali ndi maatomu 15 a carbon, 10 maatomu a haidrojeni, ndi maatomu asanu a okosijeni.
7,8-Dihydroxyflavone ndi crystalline yachikasu yolimba yokhala ndi molekyulu yolemera 286.24 g/mol. Amasungunuka pang'ono m'madzi chifukwa chamagulu angapo a hydroxyl omwe amatha kulumikiza haidrojeni ku mamolekyu amadzi.
7,8-DHF Njira yochitira: BDNF regulation ndi Trkb receptor activation
Pogwiritsa ntchito njira zogwirira ntchito, 7,8-DHF imadziwika kuti imalimbikitsa kupanga BDNF (brain-derived neurotrophic factor) pomangirira ndi kuyambitsa receptor yake TrkB. Popanda ukadaulo kwambiri, izi zimabweretsa kuchulukira kwa zochitika zama cell zomwe zimakhala zopindulitsa pakusunga magwiridwe antchito a neuronal ndikulimbikitsa neurogenesis.
Tiyeni tiwone mwatsatanetsatane njira yayikulu ya 7,8-DHF pansipa.
Brain-derived neurotrophic factor (BDNF) ndi gawo lake mu neuroplasticity
Ndikupeza kuti mawu opangidwa ndi ubongo wa neurotrophic factor (BDNF) amachepetsedwa mu matenda a neurodegenerative, makamaka matenda a Alzheimer's (AD), kufunika kwake pakusunga ndi kupititsa patsogolo thanzi laubongo kukuwonekera kwambiri. .
BDNF ndi yofunika kwambiri pa ntchito zosiyanasiyana za neuronal monga momwe imathandizira kufalitsa kwa synaptic, synaptogenesis, ndi synaptic plasticity kupyolera mu chizindikiro ndi TrkB receptors. Izi zimapangitsa njira yowonetsera BDNF-TrkB kukhala chandamale chothandizira pakupanga njira zochiritsira zomwe cholinga chake ndi kuthana ndi matenda a neurodegenerative.
Kafukufuku waposachedwa wafufuza za phindu lomwe lingakhalepo la molekyulu yaying'ono ya TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) pochepetsa zotsatira zoyambirira za matenda okhudzana ndi AD. Pakufufuza kwa mbewa ya 5xFAD ya AD, mbewa zinathandizidwa ndi 7,8-DHF kwa miyezi iwiri kuyambira pausinkhu wa mwezi umodzi.
Zotsatira za kafukufukuyu zikuwonetsa kuthekera kwachire kwa 7,8-DHF pothana ndi kusintha kwa ma neurochemical okhudzana ndi AD ndi zizindikiro za pathological. Makamaka, chithandizo cha 7,8-DHF chinapangitsa kuchepetsedwa kwa zolembera za cortical Aβ, chizindikiro chachikulu cha AD.
Kuphatikiza apo, imateteza ma cortical neurons kuti asachepetse zovuta za dendritic arbor, zomwe zimathandiza kusunga dongosolo lonse la neuronal. Komabe, sizinakhudze kwambiri dendritic spine density.
Malinga ndi Aytan, Nurgul ndi ena, mankhwalawa adawonetsanso zotsatira za neuroprotective mu hippocampus, kuletsa kuchuluka kwa mankhwala okhala ndi choline ndikuchepetsa kutayika kwa glutamate.
Tropomyosin receptor kinase B (Trkb) receptor siginecha njira
Mu 2010, gulu la Pulofesa Ye Keqiang wa University of Emory linanena kwa nthawi yoyamba mu Proceedings of the National Academy of Sciences (PNAS) kuti 7,8-DHF ingagwiritsidwe ntchito ngati agonist yaing'ono ya molekyulu ya tropomyosin receptor kinase B. TrkB), yomwe imatha kutsanzira Ntchito ya neurotrophic factor (BDNF) yochokera muubongo (BDNF) imayambitsanso njira zolumikizira kumunsi kwa TrkB, monga MAPK/ERK, PI3K/Akt ndi PKC. Komanso, kafukufuku wotsatira adapeza kuti 7,8-DHF imatha kuchepetsa kunenepa kwambiri kwamafuta obwera chifukwa chakudya kwa mbewa zazikazi poyambitsa minofu ya TrkB, kuwonetsa kusiyana kwakukulu pakati pa amuna ndi akazi.
Brain-derived neurotrophic factor (BDNF) imatha kulimbikitsa kusiyanitsa kwa osteoblast, kusamuka komanso kuchiritsa kwa fracture. BDNF ndi membala wa banja la neurotrophic factor ndipo amayendetsa njira zosiyanasiyana zamoyo makamaka pomanga transmembrane receptor tyrosine kinase B (TrkB). Komabe, chizindikiro cha TrkB chopangidwa ndi BDNF chinali chosakhalitsa pa 10 min ndikufika pa 60 min. Komabe, BDNF ili ndi theka la moyo wautali ndipo silingadutse mosavuta chotchinga chamagazi-muubongo.
7,8-dihydroxyflavone (7,8-DHF) ndi flavonoid yochokera ku zomera yomwe imatha kuthana ndi malire omwe ali pamwambawa a BDNF ndipo adadziwika kuti ndi BDNF mimetic yogwira ntchito ndipo tsopano imagwiritsidwa ntchito m'machitidwe osiyanasiyana a biochemical ndi ma cellular. imatha kuyambitsa dimerization ya TrkB ndikuyambitsa mamolekyu ake otsikira pansi.
The tropomyosin receptor kinase B (TrkB) receptor imagwira ntchito yofunika kwambiri pakuyanjanitsa zotsatira za BDNF pa neurons. Monga transmembrane tyrosine kinase receptor, TrkB ndiye cholandilira chachikulu cha BDNF ndipo imayambitsa kuchulukira kwa zochitika zamasiginidwe amkati mwa cell zikamangika ku neurotrophic factor.
BDNF imayatsa TrkB kuyambitsa njira zingapo zofunika zamkati mwa cell, kuphatikiza phosphatidylinositol 3-kinase (PI3K)-Akt, mitogen-activated protein kinase (MAPK) -extracellular signal-regulated kinase (ERK), ndi phospholipase Cγ (PLCγ) -protein kinase ( PKC) njira. Iliyonse mwa njirazi imathandizira mbali yosiyana ya ntchito ya neuronal ndi moyo wabwino.
Njira ya PI3K-Akt ndiyofunikira pakulimbikitsa kupulumuka kwa neuronal ndikuletsa apoptosis. Kuzindikiritsa kwa BDNF-TrkB kumayambitsa njira iyi kuti iwonjezere kupulumuka kwa maselo mwa kuletsa zinthu zovomerezeka ndi apoptotic ndikulimbikitsa zinthu zotsutsana ndi apoptotic, motero kuonetsetsa kuti ma neuroni athanzi asungidwa.
Kumbali inayi, njira ya MAPK-ERK imakhala ndi gawo lofunikira pakusiyanitsa ndi kufalikira kwa ma neuronal. Kuzindikiritsa kwa BDNF-TrkB kumalimbikitsa kuyambitsa kwa njira ya MAPK-ERK, yomwe imathandizira kusasitsa kwa neuronal ndi kusiyanitsa komanso kuphatikiza kwawo mu maukonde omwe alipo kale.
Njira ya PLCγ-PKC ndiyofunikira pakuwongolera pulasitiki ya synaptic, njira yofunikira yophunzirira ndi kukumbukira. Kuzindikiritsa kwa BDNF-TrkB kumasintha machitidwe anjirayi, zomwe zimapangitsa kusintha kwa mphamvu ya synaptic ndi kulumikizana.
Kusinthasintha uku kumalimbikitsa kusintha ndi kukonzanso kwa ma neural circuits potsatira zochitika zatsopano komanso zolimbikitsa zachilengedwe.
Neuroprotective katundu
Kafukufuku akuwonetsa kuti flavonoid iyi imateteza ma neurons ku nkhawa ya okosijeni ndi apoptosis (ma cell kufa kwadongosolo). Kupanikizika kwa okosijeni ndi chinthu chofunikira kwambiri pa matenda a neurodegenerative monga Alzheimer's ndi Parkinson's disease. Pochotsa ma radicals aulere ndikuchepetsa kuwonongeka kwa okosijeni, 7,8-DHF ingathandize kuteteza umphumphu wa neuronal ndi ntchito.
M'maphunziro a nyama, 7,8-DHF yawonetsedwa kuti imathandizira kuzindikira komanso kukumbukira. Mwachitsanzo, m'mitundu ya matenda a Alzheimer's, 7,8-DHF yawonetsedwa kuti imathandizira pulasitiki ya synaptic, yomwe ndi yofunika kwambiri pakuphunzira ndi kukumbukira. Njira yochitira
Anti-kutupa kwenikweni
Kuphatikiza pa ma neuroprotective properties, 7,8-dihydroxyflavone imakhalanso ndi zotsatira zotsutsana ndi kutupa. Kutupa kosatha ndi chinthu chofala pa matenda ambiri, kuphatikiza matenda a neurodegenerative. Mwa kusintha njira zotupa, 7,8-DHF ingathandize kuchepetsa neuroinflammation, yomwe nthawi zambiri imagwirizanitsidwa ndi kuchepa kwa chidziwitso.
Antioxidant katundu: ROS scavenging ndi lipid peroxidation
7,8-DHF ili ndi antioxidant katundu monga umboni ndi mphamvu yake scavenge reactive oxygen mitundu (ROS) ndi kuchepetsa lipid peroxidation. Zotsatirazi zimathandizira ku zotsatira zake za neuroprotective pochepetsa kuwonongeka kwa neuronal komwe kumayambitsidwa ndi okosijeni komanso kusagwira ntchito bwino.
Kafukufuku wasonyeza kuti 7,8-DHF imalepheretsa kupanga ma cytokines okhudzana ndi kutupa ndipo imachepetsa kutsegula kwa microglia, maselo oteteza chitetezo m'kati mwa dongosolo la mitsempha. Izi zotsutsana ndi zotupa sizimangoteteza ma neurons komanso zimapanga malo abwino kwambiri ogwirira ntchito yachidziwitso.
Chifukwa cha zopindulitsa zake pa thanzi laubongo, 7,8-dihydroxyflavone ili ndi ntchito zomwe zingagwiritsidwe ntchito m'malo osiyanasiyana azaumoyo ndi zamankhwala. Ena mwa mapulogalamu otchuka kwambiri ndi awa:
Kuphatikiza kukumbukira ndi kubwezeretsa
7,8-DHF yapezeka kuti imathandizira kuphatikiza kukumbukira ndikubwezeretsanso muzophunzira zosiyanasiyana zodalira hippocampal ndi kukumbukira ntchito zamakoswe. Zotsatirazi zikusonyeza kuti 7,8-DHF ikhoza kukhala nootropic yodalirika yopititsa patsogolo ntchito ya kukumbukira mwa anthu omwe ali ndi thanzi labwino komanso omwe ali ndi vuto la kukumbukira.
Synaptic plasticity: kuthekera kwanthawi yayitali komanso kukhumudwa
Monga tanena kale, 7,8-DHF yawonetsedwa kuti imasintha pulasitiki ya synaptic polimbikitsa LTP ndikuchepetsa LTD mu hippocampus. Zotsatirazi zimaganiziridwa kuti zimayanjanitsidwa ndi kuthekera kwake kuyambitsa ma receptor a TrkB kenako ndikukulitsa njira yolumikizira ya BDNF.
Kusinthika kwa synaptic plasticity kumathandizira kuwongolera kwachidziwitso komwe kumawonedwa potsatira kayendetsedwe ka 7,8-DHF.
Kupititsa patsogolo chidziwitso
Monga tanena kale, 7,8-DHF ikuwonetsa kuthekera kopititsa patsogolo chidziwitso ndi kukumbukira. Izi zimamupangitsa kukhala wokonzekera zowonjezera zomwe zimafuna kuwongolera magwiridwe antchito amisala, makamaka okalamba kapena anthu omwe ali ndi chidziwitso chochepa.
Mayamwidwe, Kugawa, Metabolism, ndi Kutulutsa (ADME): 7,8-DHF imawonetsa zinthu zabwino za pharmacokinetic, kuphatikiza kuyamwa mwachangu, kugawa kwakukulu, komanso kulowa bwino kwaubongo. Imapangidwa makamaka ndi chiwindi, ndipo zambiri zapawiri zimatulutsidwa mu ndowe ndipo pang'ono zimatulutsidwa mumkodzo.
Magazi-ubongo chotchinga permeability ndi ubongo minofu permeability. Chimodzi mwamakhalidwe ofunikira a 7,8-DHFndikutha kuwoloka chotchinga chamagazi-muubongo (BBB) ndikulowa mu minofu yaubongo, yomwe ndiyofunikira kuti ikhale yogwira ntchito ngati nootropic.
Mbiri Yachitetezo cha Preclinical - Kafukufuku Wowopsa komanso Wosatha: Maphunziro achitetezo a preclinical adawonetsa kuti 7,8-DHF ili ndi mbiri yabwino yachitetezo, popanda zotsatirapo zoyipa zomwe zimawonedwa m'maphunziro owopsa komanso osatha mu makoswe. Komabe, kuwunika kwina kwachitetezo, kuphatikiza maphunziro a nyama zapamwamba komanso maphunziro a anthu, ndikofunikira kuti muwone chitetezo chake pakugwiritsa ntchito kuchipatala.
Ngakhale kuti kafukufuku wamankhwala awonetsa kuti 7,8-DHF ili ndi mbiri yabwino yachitetezo, zotsatira zoyipa zomwe zingachitike pamitu ya anthu sizidziwikabe. Monga momwe zilili ndi buku lililonse, kusamala kuyenera kuchitidwa ndikuyang'aniridwa ndi zovuta zomwe zingachitike powunika momwe zimagwiritsidwira ntchito mwa anthu.
Kutengera momwe 7,8-DHF imagwirira ntchito komanso zotsatira zake pa zolandilira za TrkB, zovuta zina zomwe zitha kulumikizidwa ndi 7,8-DHF zingaphatikizepo:
Mutu: BDNF ndi TrkB receptor activation imayang'anira ntchito ya neuronal ndi chisangalalo; Kuwongolera kwa 7,8-DHF kungayambitse mutu kwa anthu ena.
Kusagona tulo: Kuwonjezeka kwa zochitika za neuronal ndi synaptic plasticity zingakhudze njira zogona, zomwe zingayambitse kusowa tulo kapena kusokonezeka kwa kugona.
Mavuto a m’mimba: Mofanana ndi mankhwala ambiri a bioactive, 7,8-DHF ingayambitse mavuto a m’mimba, monga nseru, kusanza, kapena kutsekula m’mimba mwa anthu ena.
Ndikofunika kuzindikira kuti zotsatirazi zomwe zingakhalepo ziyenera kuphunziridwanso m'mayesero achipatala. Chifukwa cha mphamvu yake yosinthira chizindikiro cha BDNF ndi TrkB receptor activation, kusamala kuyeneranso kugwiritsidwa ntchito pophatikiza 7,8-DHF ndi mankhwala ena omwe amayang'ana njirazi kapena kukhala ndi njira zofanana.
Monga gawo lofunikira, 7,8-Dihydroxyflavone yakopa chidwi kwambiri chifukwa cha zochitika zapadera zamoyo. Kwa ofufuza asayansi ndi mabizinesi, ndikofunikira kupeza 7,8-Dihydroxyflavone Powder wapamwamba kwambiri. 7,8-Dihydroxyflavone Powder yoperekedwa ndi Suzhou Myland ili ndi nambala ya CAS ya 38183-03-8 ndi kuyera mpaka 98%. Zogulitsazo zakhala zikuyang'aniridwa bwino kwambiri ndipo zimagwirizana ndi miyezo yapadziko lonse, kuwonetsetsa kuti mankhwalawa ndi otetezeka komanso otetezeka. , oyenera kafukufuku wa sayansi, chitukuko cha mankhwala, kupanga mankhwala opangira chithandizo chamankhwala ndi zina, kukupatsani chisankho chodalirika.
Chitsimikizo chadongosolo
Tikudziwa kuti mtundu wa zinthu zathu umakhudza mwachindunji kafukufuku wamakasitomala ndi zotsatira za ntchito. Chifukwa chake, Suzhou Myland imatsata mosamalitsa GMP (Zochita Zabwino Zopanga) ndi miyezo ya certification ya ISO panthawi yopanga kuti zitsimikizire kukhazikika komanso kusasinthika kwa gulu lililonse lazinthu. Kuphatikiza apo, gulu lathu la R&D likupitilizabe kupanga luso laukadaulo ndipo limayesetsa mosalekeza kuwongolera magwiridwe antchito azinthu.
Thandizo lamakasitomala
Suzhou Myland sikuti amangopereka zinthu zapamwamba, komanso amalabadira zosowa zamakasitomala. Tili ndi gulu lothandizira zaukadaulo lomwe limatha kupatsa makasitomala malingaliro ogwiritsira ntchito zinthu ndi malangizo aukadaulo kuti athandize makasitomala kupeza zotsatira zabwinoko pakufufuza ndi kugwiritsa ntchito. Kaya ndikuyesa kwakung'ono kapena kupanga kwakukulu, titha kupereka mayankho osinthika kuti tikwaniritse zosowa za makasitomala osiyanasiyana.
Momwe Mungapezere Ufa wa 7,8-Dihydroxyflavone
Ngati mukuyang'ana Ufa wapamwamba kwambiri wa 7,8-Dihydroxyflavone, Suzhou Myland ndiye chisankho chanu chabwino. Mutha kulumikizana nafe kudzera:
Tsamba lovomerezeka: Pitani patsamba lovomerezeka la Suzhou Myland kuti mudziwe zambiri zazamalonda ndi chithandizo chaukadaulo.
Kufunsira pa intaneti: Lumikizanani mwachindunji ndi gulu lathu lothandizira makasitomala kudzera munjira yolumikizirana pa intaneti yoperekedwa ndi webusayiti kuti mupeze zambiri zamalonda ndi mawu omwe mukufuna.
Kuyimba foni: Imbani nambala yathu kuti mulankhule ndi akatswiri ogulitsa ndikupeza zambiri zamalonda ndi malingaliro ogula.
Kufunsa pa imelo: Mutha kutifunsanso zambiri zamalonda kudzera pa imelo, ndipo tidzakuyankhani posachedwa.
Pomaliza
Monga gawo lofunikira lomwe lili ndi zinthu zambiri zamoyo, 7,8-Dihydroxyflavone pang'onopang'ono ikukhala gawo lofunikira pakufufuza kwasayansi ndi ntchito zamakampani. Ufa wapamwamba kwambiri wa 7,8-Dihydroxyflavone woperekedwa ndi Suzhou Myland udzakupatsani chithandizo champhamvu pa kafukufuku wanu ndi chitukuko cha mankhwala ndi khalidwe lake labwino kwambiri komanso ntchito yodalirika. Tikuyembekezera kugwira ntchito nanu kuti tiwone momwe mungagwiritsire ntchito 7,8-Dihydroxyflavone.
Q: 7,8-dihydroxyflavone ndi chiyani?
A:7,8-Dihydroxyflavone ndi flavonoid yochitika mwachilengedwe yomwe imadziwika ndi mphamvu zake zoteteza mitsempha ndipo ikuphunziridwa chifukwa cha zotsatira zake pakugwira ntchito kwachidziwitso komanso kukulitsa malingaliro.
Q:Kodi mapindu a 7,8-dihydroxyflavone ndi ati?
A: Kafukufuku akuwonetsa kuti 7,8-dihydroxyflavone ikhoza kuthandizira kukumbukira, kuchepetsa nkhawa, komanso kupewa matenda a neurodegenerative. Ma antioxidant ake amathanso kulimbikitsa thanzi lonse polimbana ndi kupsinjika kwa okosijeni.
Q: Kodi bioavailability wa 7,8-DHF ndi chiyani?
A: The bioavailability ya 7,8-dihydroxyflavone (7,8-DHF) mu maphunziro a zinyama ndi pafupifupi 5% (mu mbewa) chifukwa cha kusasungunuka kwake komanso kagayidwe kake kachangu. Ngakhale kuti bioavailability yake ndi yotsika, 7,8-DHF imatha kudutsa chotchinga chamagazi ndi ubongo ndikusokoneza ubongo. Kafukufuku wowonjezereka akufunika kuti adziwe momwe bioavailability yake ilipo mwa anthu ndikufufuza njira zopititsira patsogolo.
Q:Kodi 7,8-DHF imakupangitsani kumva bwanji?
A: Monga nootropic, 7,8-dihydroxyflavone (7,8-DHF) ili ndi zotsatira zabwino pa chidziwitso ndi maganizo. Anthu amakumbukira bwino, amaika chidwi kwambiri, komanso amatha kuphunzira bwino.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Oct-14-2024
