Kodi telomerase activator-cycloastraganol yomwe yapezeka pano ndi chiyani?

Mu 1985, Greider ndi anzake adapeza koyamba telomerase, ndipo enzyme yatsopanoyi yomwe yangopezeka kumene imatha kuwonjezera ma DNA repeats kumapeto kwa ma chromosome kuti isunge kutalika kwa telomere. Telomerase ndi ribonucleoprotein complex yomwe maziko ake amaphatikizapo TERT ndi TERC, zomwe TERT ndiye chinsinsi chowongolera ntchito ya telomerase. Kutalika kwa telomere kumapitirira kufupika pamene maselo akugawikana. Ikafika pamtengo wofunikira, imayambitsa zizindikiro za kuwonongeka kwa DNA, zomwe zimapangitsa kuti maselo azifupikitsidwa komanso matenda osiyanasiyana omwe amadziwika ndi ma telomere afupikitsidwa.

Mu 2010, kampani yaku America ya Geron idagwirizana ndi Hong Kong University of Science and Technology pa ntchito yofufuza kuti ifufuze ma telomerase activators. Zinapezeka kuticycloastraganolimatha kuyambitsa ntchito ya telomerase ndikuyambitsa kufalikira kwa telomere. Kupeza kumeneku kunalimbikitsa kwambiri chitukuko cha ma activator a telomerase. Kupita patsogolo kwa kafukufuku ndi chitukuko cha mankhwala okhudzana ndi astragalus alcohol. Cycloastragenol (CAG) pakadali pano ndiye choyambitsa telomerase chokha chomwe chanenedwa pakati pa zinthu zachilengedwe. Imatha kulimbana bwino ndi kufupikitsa kwa telomere ndipo ili ndi anti-ukalamba, anti-apoptosis, anti-fibrosis, malamulo a chitetezo chamthupi, kulimbikitsa kuchulukana kwa maselo ndi kuchiritsa mabala, ndi zina zotero. Zotsatira za mankhwala, motero zimakhala ndi zotsatirapo zochiritsira matenda okhudzana ndi kusagwira bwino ntchito kwa telomere.

Cycloastragenol ndi ukalamba

ma telomere
Ma Telomere ndi mapangidwe apadera kumapeto kwa ma chromosome omwe amateteza ma chromosome ndi kufupika ndi kubwerezabwereza kwa ma chromosome ndikugawa maselo. Maselo amakalambanso pamene ma telomere amafupika.

telomerase
Telomerase imatha kupanga ma telomere kuti ikhazikitse kutalika ndi kapangidwe ka ma telomere, motero imateteza ma chromosome ndikuchedwetsa kukalamba kwa maselo.

Choletsa ukalamba: Choyambitsa telomerase, chomwe chimagwira ntchito yoletsa ukalamba powonjezera telomerase motero chimachedwetsa kufupikitsa kwa ma telomere.

Ma Telomere ndi zipewa zomwe zili kumapeto kwa ma chromosome a maselo zomwe zimawateteza ku kuwonongeka panthawi yogawa maselo. Pamene maselo akupitiriza kugawikana, ma telomere amapitirira kufupika, kufika pamlingo wofunikira kwambiri pomwe maselo amakalamba kapena kufa. Telomerase imatha kukulitsa kutalika kwa ma telomere, ndipo nthawi ya moyo wa maselo imawonjezeka mwachibadwa.

Ukalamba ndi gawo losapeŵeka la moyo; komabe, ofufuza akuphunzira njira zosiyanasiyana zochiritsira pofuna kupewa zotsatira zina za ukalamba, kuphatikizapo kuphunzira za senolytics. Senolytics ndi mankhwala omwe amachotsa maselo okalamba ndipo awonetsedwa kuti amachepetsa zotsatira za ukalamba. Kafukufuku watsopano akusonyeza kuti cycloastraganol ili ndi mphamvu zotsutsana ndi ukalamba.

Kafukufukuyu, wochokera ku China ndipo adasindikizidwa mu International Journal of Molecular Sciences, adayang'ana kwambiri maselo a anthu okalamba komanso mbewa zomwe zimakhala ndi ukalamba woyambitsidwa ndi kuwala kwa dzuwa. Cycloastragenol imachepetsa maselo okalamba popanda kukhudza maselo omwe si okalamba. Chithandizo cha cycloastragenol chimachepetsanso mapuloteni m'maselo okalamba omwe amafunikira kuti maselo akule ndikukhalabe ndi moyo. Kuphatikiza apo, chimaletsa mayendedwe a maselo okhudzana ndi maselo otupa okhudzana ndi ukalamba. Mbewa zokalamba zomwe zimalandira cycloastraganol zidapezeka kuti zili ndi maselo okalamba ochepa komanso zimawonjezera kufooka kwa thupi chifukwa cha ukalamba.

Cycloastragenol imachepetsa maselo okhwima

Kukalamba ndi chizindikiro chodziwika bwino cha ukalamba, koma ofufuza apeza kuti kuchotsa maselo okalamba ndi mamolekyu awo oyambitsa kutupa kungathandize kupewa matenda okhudzana ndi ukalamba komanso kuwasintha nthawi zina. Apa, ofufuza adachiza maselo a anthu ndi cycloastraganol ndipo adapeza kuti imachotsa maselo okalamba popanda kukhudza maselo osakhala okalamba. Kuphatikiza apo, zizindikiro za maselo okalamba zidachepa kwambiri atalandira chithandizo cha cycloastraganol.

Kafukufuku wakale wasonyeza kuti njira ya PI3K/AKT/mTOR—njira yolumikizirana yomwe imakhudza kukula ndi kupulumuka kwa maselo—imakhudzidwa ndi njira zotupa zomwe zimayambitsidwa ndi maselo okalamba, zomwe zimathandiza kulimbikitsa ukalamba m'maselo ozungulira. Ofufuzawo adapeza kuti cycloastragenol inathandiza kuchepetsa mapuloteni munjira iyi, zomwe zikusonyeza kuti mankhwalawa angagwire ntchito potseka njira ya PI3K/AKT/mTOR kuti athandize kupewa ukalamba. Kuphatikiza apo, cycloastragenol yawonetsedwa kuti imachepetsa kuthekera kwa maselo okalamba kulimbikitsa ukalamba kudzera mu kutulutsidwa kwa mamolekyulu otupa, zinthu zokulira, ndi ma immunomodulators, mogwirizana ndi malingaliro akuti kuchepetsa chizindikiro cha PI3K, AKT, ndi mTOR kungachepetse zotsatira zolimbikitsa ukalamba pakati pa maselo ozungulira.

Cycloastragenol ndi ya triterpene saponins ndipo imapezeka makamaka kuchokera ku hydrolysis ya astragaloside IV. Ili ndi kulemera kochepa kwa mamolekyulu komanso lipophilicity yamphamvu, zomwe zimathandiza kulowa kwa biofilm ndi kuyamwa m'mimba kuti pakhale bioavailability yabwino.
1. Kuchiza kuwonongeka kwa ubongo
2. Kuthandiza chiwindi kukhala ndi fibrosis
3. Chithandizo cha matenda a mafupa
4. Mphamvu yoletsa ukalamba
5. Kuchedwetsa kukalamba kwa maselo

Chifukwa chiyani ndikofunikira kupanga cycloastraganol?

① Cycloastraganol ili ndi zotsatira zosiyanasiyana zamankhwala monga kuletsa apoptosis ya maselo a muubongo ndi kutupa kwa mitsempha panthawi ya ischemia ya ubongo komanso kusunga chotchinga cha magazi ndi ubongo.
② Cycloastragenol ndiye molekyulu yaying'ono yokha ya terpenoid yomwe ili ndi ntchito ya telomerase yomwe yapezeka mpaka pano ndipo imatha kuchiza matenda a neurodegenerative.
③ Ili ndi zotsatira zoletsa matenda a mtima komanso kulimbitsa chitetezo chamthupi cholimbana ndi chotupa. Ndi molekyu yotchuka kwambiri pakufufuza ndi kupanga mankhwala oletsa ukalamba.

Mavuto omwe alipo

Kuchuluka kwa cycloastraganol mu Astragalus membranaceus n'kochepa kwambiri ndipo n'kovuta kupeza mwachindunji. Njira yopangira cycloastraganol yomwe ilipo imadalira kuchotsa mankhwala achi China, omwe amapezeka makamaka posintha astragaloside IV mu Astragalus membranaceus. Ndiko kuti, astragaloside IV imapezeka kudzera mu ukadaulo wobzala ndi kukulitsa minofu ya astragalus, kenako astragaloside IV imasinthidwa kukhala cycloastragaloside pogwiritsa ntchito acidolysis, Smith degradation, enzyme ndi microbial hydrolysis. Komabe, njira zokonzekera izi ndizokwera mtengo, zosavuta kuyambitsa kuipitsa chilengedwe, zovuta kulekanitsa ndikuyeretsa, ndipo sizothandiza kugwiritsa ntchito ndikulimbikitsa. Chifukwa chake, anthu atembenukira ku kapangidwe kochita kupanga ka cycloastraganol.

Kodi mungagwiritse ntchito bwanji biology yopangira kupanga? --- Biology Yopangira

Biology Yopangidwa imatanthauza kapangidwe, kusintha, komanso kulengedwa kwa "zamoyo zopanga" zomwe zili ndi ntchito zosazolowereka motsogozedwa ndi malingaliro aukadaulo, ndiko kuti, uinjiniya wa sayansi ya zamoyo. Kawirikawiri, zimapangidwa pogwiritsa ntchito njira zamoyo.