Kodi telomerase activator-cycloastraganol yomwe yapezeka pano ndi chiyani?

Mu 1985, Greider et al. telomerase anatulukira koyamba, ndipo enzyme yomwe yangopezeka kumeneyi imatha kuwonjezera DNA kubwereza kumapeto kwa ma chromosome kuti asunge utali wa telomere. Telomerase ndi ribonucleoprotein complex yomwe chigawo chake chothandizira chimaphatikizapo TERT ndi TERC, yomwe TERT ndiye chinsinsi chowongolera zochita za telomerase. Kutalika kwa telomere kumapitirira kufupikitsa pamene maselo amagawanika. Ikafika pamtengo wovuta kwambiri, imayambitsa zizindikiro zowonongeka kwa DNA, zomwe zimatsogolera kufupikitsa maselo amtundu wa maselo ndi mndandanda wa matenda olephereka a minofu omwe amadziwika ndi ma telomere amfupi.

Mu 2010, kampani ya ku America ya Geron inagwirizana ndi Hong Kong University of Science and Technology pa ntchito yofufuza zowonetsera ma telomerase activator. Zinapezeka kuticycloastraganolimatha kuyambitsa ntchito ya telomerase ndikulimbikitsa kukulitsa kwa telomere. Kupezeka kumeneku kunalimbikitsa kwambiri chitukuko cha ma telomerase activator. Kupita patsogolo kwa kafukufuku ndi kukulitsa kwazinthu zokhudzana ndi mowa wa astragalus. Cycloastragenol (CAG) ndiye yekhayo woyambitsa telomerase pakati pa zinthu zachilengedwe. Ikhoza kulimbana bwino ndi kufupikitsa kwa telomere ndipo imakhala ndi anti-kukalamba, anti-apoptosis, anti-fibrosis, chitetezo cha mthupi, kulimbikitsa kukula kwa maselo ndi machiritso a bala, ndi zina zotero.

Cycloastragenol ndi kukalamba

telomeres
Ma telomere ndi mapangidwe apadera kumapeto kwa ma chromosome omwe amateteza ma chromosome ndikufupikitsa ndi kubwerezabwereza kwa chromosome ndi kugawikana kwa maselo. Maselo amakalambanso pamene ma telomere amafupikitsa.

telomerase
Telomerase imatha kupanga ma telomere kuti akhazikitse utali ndi kapangidwe ka ma telomere, potero kuteteza ma chromosome ndikuchedwetsa kukalamba kwa ma cell.

Anti-kukalamba: Choyambitsa cha telomerase, chomwe chimagwira ntchito yoletsa kukalamba mwa kuonjezera telomerase ndipo potero kuchedwetsa kufupikitsa ma telomere.

Ma telomeres ndi zipewa zomwe zili kumapeto kwa ma chromosomes omwe amawateteza kuti asawonongeke panthawi yagawanika kwa maselo. Pamene maselo akupitiriza kugawanika, ma telomere amapitiriza kufupikitsa, kufika pamalo ovuta kwambiri pamene maselo amakalamba kapena kufa. Telomerase imatha kukulitsa utali wa ma telomere, ndipo moyo wa maselo udzawonjezeka moyenerera.

Kukalamba ndi gawo losapeŵeka la moyo; komabe, ochita kafukufuku akufufuza njira zosiyanasiyana zochiritsira pofuna kupewa zina mwa zotsatira za ukalamba, kuphatikizapo kuphunzira senolytics. Senolytics ndi mankhwala omwe amachotsa maselo a senescent (okalamba) ndipo awonetsedwa kuti amachepetsa zotsatira za ukalamba. Kafukufuku watsopano akuwonetsa kuti cycloastraganol ili ndi zotsutsana ndi ukalamba.

Kafukufukuyu, wochokera ku China ndipo adasindikizidwa mu International Journal of Molecular Sciences, adayang'ana kwambiri ma cell amunthu komanso mbewa zokhala ndi ma radiation. Cycloastragenol imachepetsa ma cell a senescent popanda kukhudza ma cell omwe alibe. Chithandizo cha Cycloastragenol chimachepetsanso mapuloteni m'maselo a senescent omwe amafunikira kuti ma cell akule komanso kuti apulumuke. Kuphatikiza apo, imalepheretsa kusuntha kwa maselo komwe kumayenderana ndi ma cell otupa okhudzana ndi ukalamba ndi njira. Makoswe okalamba omwe amathandizidwa ndi cycloastraganol adapezeka kuti ali ndi ma cell ocheperako komanso kusagwira bwino ntchito kwakuthupi kokhudzana ndi ukalamba.

Cycloastragenol imachepetsa ma cell a senescent

Senescence ndi chizindikiro chodziwika bwino cha ukalamba, koma ofufuza apeza kuti kuchotsa ma cell a senescent ndi mamolekyu awo oyambitsa zotupa kungathandize kupewa matenda okhudzana ndi ukalamba komanso kuwasintha nthawi zina. Apa, ofufuza adachiza ma cell amunthu ndi cycloastraganol ndipo adapeza kuti idachotsa bwino ma cell a senescent popanda kukhudza ma cell omwe alibe. Kuphatikiza apo, zolembera zama cell a senescent zidachepetsedwa kwambiri pambuyo pa chithandizo cha cycloastraganol.

Kafukufuku wam'mbuyo wasonyeza kuti njira ya PI3K/AKT/mTOR-njira yowonetsera yomwe imakhudzidwa ndi kukula kwa maselo ndi kupulumuka-imakhudzidwa ndi njira zotupa zomwe zimayambitsidwa ndi maselo a senescent, zomwe zimathandiza kulimbikitsa senescence m'maselo ozungulira. Ofufuzawa adapeza kuti cycloastragenol idathandizira kuchepetsa mapuloteni munjira iyi, kutanthauza kuti chigawochi chikhoza kugwira ntchito poletsa njira ya PI3K/AKT/mTOR kuti iteteze kukalamba. Kuphatikiza apo, cycloastragenol yasonyezedwa kuti imachepetsa mphamvu ya maselo a senescent kulimbikitsa senescence kupyolera mu kutulutsidwa kwa mamolekyu otupa, kukula, ndi ma immunomodulators, mogwirizana ndi malingaliro omwe kuchepetsa PI3K, AKT, ndi chizindikiro cha mTOR kungachepetse zotsatira zolimbikitsa senescence pakati pa maselo ozungulira. .

Cycloastragenol ndi ya triterpene saponins ndipo imapezeka makamaka kuchokera ku hydrolysis ya astragaloside IV. Ili ndi kulemera kochepa kwa maselo ndi lipophilicity yamphamvu, yomwe imakhala yopindulitsa kulowetsa kwa biofilm ndi kuyamwa m'mimba kuti ikwaniritse bwino bioavailability. Mphamvu ya cycloastragalinol
1. Chithandizo cha kuwonongeka kwa ubongo
2. Kusintha chiwindi fibrosis
3. Chithandizo cha osteoporosis
4. Anti-kukalamba zotsatira
5. Kuchedwetsa kukalamba kwa maselo

Chifukwa chiyani ndikofunikira kupanga cycloastraganol?

① Cycloastraganol ili ndi zotsatira zosiyanasiyana zamankhwala monga kuletsa ubongo apoptosis ndi neuroinflammation panthawi ya cerebral ischemia ndikusunga chotchinga chamagazi muubongo.
② Cycloastragenol ndiye gawo laling'ono lokhalo la terpenoid lomwe lili ndi zochitika za telomerase zomwe zapezeka mpaka pano ndipo zimatha kuchiza matenda a neurodegenerative.
③ Ili ndi zotsatira zoletsa myocardial fibrosis ndikuwonjezera chitetezo cham'mimba. Ndi molekyulu yotchuka pakufufuza ndi kupanga mankhwala oletsa kukalamba.

Mavuto omwe alipo

Zomwe zili mu cycloastraganol ku Astragalus membranaceus ndizochepa kwambiri ndipo ndizovuta kuzipeza mwachindunji. Njira yopangira cycloastraganol yomwe ilipo imadalira kutulutsa kwamankhwala achi China, komwe kumapezeka makamaka posintha astragaloside IV ku Astragalus membranaceus. Ndiye kuti, astragaloside IV imapezeka kudzera mu kubzala kwa astragalus ndi ukadaulo wa chikhalidwe cha minofu, kenako astragaloside IV imasinthidwa kukhala cycloastragaloside pogwiritsa ntchito acidolysis, Smith degradation, enzyme ndi microbial hydrolysis. Komabe, njira zokonzekerazi ndizokwera mtengo, zosavuta kuwononga chilengedwe, zovuta kuzilekanitsa ndi kuyeretsa, ndipo sizikugwirizana ndi kugwiritsa ntchito ndi kukwezedwa. Chifukwa chake, anthu atembenukira ku kaphatikizidwe ka cycloastraganol.

Momwe mungagwiritsire ntchito biology kupanga kupanga? ---Synthetic Biology

Synthetic Biology imatanthawuza kapangidwe kake, kusintha, ngakhalenso kupangidwa kwa "moyo wochita kupanga" wokhala ndi ntchito zosagwirizana ndi chilengedwe motsogozedwa ndi malingaliro a uinjiniya, ndiko kuti, uinjiniya wa biology. Nthawi zambiri, amapangidwa pogwiritsa ntchito njira zamoyo.