Kodi spermidine ndi chiyani? Buku losavuta lothandizira spermidine

Spermidinendi mtundu wa polyamine. Polyamines ndi ma biomolecule ang'onoang'ono, onenepa, okhala ndi polycationic (-NH3+). Pali ma polyamines anayi akuluakulu m'zinyama zoyamwitsa: spermine, spermidine, putrescine ndi cadaverine. Spermine ndi ya tetramines, spermidine ndi ya triamines, putrescine ndi cadaverine ndi ya diamines. Magulu osiyanasiyana a amino amawapatsa mphamvu zosiyanasiyana za thupi.

Spermidine mwa anthu

Spermidine sipezeka mu umuna wokha, komanso imapezeka kwambiri m'maselo ndi minofu ina ya thupi la munthu. Kuchuluka kwa spermidine mkati mwa maselo kumadalira makamaka zinthu zinayi:

①Kapangidwe ka mkati mwa maselo:

Arginine → putrescine → spermidine ← spermine. Arginine ndiye chinthu chachikulu chomwe chimapanga spermidine m'maselo. Chimathandizidwa ndi arginase kuti chipange ornithine ndi urea. Kenako Ornithine imagwiritsidwa ntchito kupanga putrescine pogwiritsa ntchito ornithine decarboxylase (ODC1). Iyi ndi sitepe yochepetsera liwiro, putrescine imapanga spermidine pogwiritsa ntchito spermidine synthase (SPDS). Spermidine imathanso kupangidwa ndi kuwonongeka kwa spermine.

②Kutengedwa kwa maselo ena:

Amagawidwa m'magulu odyetsera chakudya ndi kupanga tizilombo toyambitsa matenda m'matumbo. Zakudya zokhala ndi umuna wambiri zimaphatikizapo tirigu, natto, soya, bowa, ndi zina zotero. Umuna ndi umuna zomwe zimadyedwa kuchokera ku chakudya zimatengedwa mwachangu kuchokera m'matumbo ndikugawidwa popanda kuwonongeka, kotero kuchuluka kwa umuna m'magazi ndi kosiyana kwambiri. Mabakiteriya a probiotic m'matumbo a microbiota monga Bifidobacterium amathanso kupanga umuna.

③Katabolism:

Umuna m'thupi umasungunuka pang'onopang'ono kukhala spermidine ndi putrescine ndi N1-acetyltransferase (SSAT), polyamine oxidase (PAO) ndi ma amine oxidases ena, pomwe putrescine imasinthidwanso kukhala aminobutyric acid ndi ma oxidases. Pomaliza, ma ayoni a amine ndi carbon dioxide amapangidwa ndikutulutsidwa m'thupi.

Zaka:

Kuchuluka kwa spermidine kumasintha ndi ukalamba. Ofufuza anayeza kuchuluka kwa polyamines m'maselo osiyanasiyana ndi ziwalo za mbewa za masabata atatu, masabata 10 ndi masabata 26 ndipo adapeza kuti zimasungidwa mu kapamba, ubongo ndi chiberekero. Kusintha kwa m'matumbo kumachepa pang'ono ndi ukalamba, ndipo kumachepa kwambiri mu thymus, spleen, ovary, chiwindi, m'mimba, m'mapapo, impso, mtima ndi minofu. Sizovuta kwa ife kuganiza kuti zifukwa za kusinthaku zikuphatikizapo kusintha kwa zakudya, kusintha kwa kapangidwe ka zomera m'matumbo, kuchepa kwa ntchito ya polyamine synthase, ndi zina zotero.

Cholinga chachilengedwe cha spermidine

N’chifukwa chiyani molekyulu yaying’ono yosavuta chonchi ndi chinthu chofunikira kwambiri pa thupi la munthu? Chinsinsi chake chili m’kapangidwe kake: Spermidine ndi molekyulu yaying’ono ya polycationic (-NH3+) yamafuta yomwe imapezeka mu mawonekedwe a multi-protonated pansi pa mkhalidwe wa pH wa thupi, yokhala ndi ma ayoni abwino omwe amagawidwa mu unyolo wonse wa kaboni. Mphamvu yamagetsi, imakhala ndi ntchito yamphamvu ya thupi.

Chifukwa chake, kaya ndi nucleic acids, phospholipids, mapuloteni a acidic okhala ndi zotsalira za acidic, pectic polysaccharides okhala ndi magulu a carboxyl ndi sulfates, kapena ma neurotransmitters ndi mahomoni (dopamine, epinephrine, serotonin, thyroid hormone, ndi zina zotero) okhala ndi kapangidwe kofanana, Izi zitha kukhala cholinga chomangirira spermidine. Zofunika kwambiri ndi izi:

① Asidi wa nyukiliya:

Kafukufuku wapeza kuti ma polyamine ambiri amapezeka mu mawonekedwe a polyamine-RNA complexes mkati mwa maselo, okhala ndi ma polyamine ofanana 1-4 omangika pa ma phosphate compounds 100 ofanana. Chifukwa chake, ntchito yayikulu ya spermidine ikugwirizana ndi kusintha kwa kapangidwe kake ndi kumasulira kwa RNA, monga kukhudza magawo osiyanasiyana a kapangidwe ka mapuloteni pokhudza kapangidwe kachiwiri ka mRNA, tRNA ndi rRNA. Spermidine ingathenso kupanga "milatho" yokhazikika pakati pa ma DNA strings awiri, kuchepetsa kupezeka kwa ma free radicals kapena zinthu zina zowononga DNA, ndikuteteza DNA ku kutentha kwa dzuwa ndi ma X-ray.

②Mapuloteni:

Spermidine imatha kumangirira ku mapuloteni okhala ndi mphamvu zazikulu zoyipa ndikusintha mawonekedwe a puloteni, motero imakhudza ntchito yake ya thupi. Zitsanzo zikuphatikizapo protein kinases/phosphatases (ulumikizano wofunikira mu njira zambiri zotumizira zizindikiro), ma enzyme omwe amagwira ntchito mu histone methylation ndi acetylation (zomwe zimakhudza mawonekedwe a majini mwa kusintha epigenetics), acetylcholinesterase (gawo lofunika kwambiri la matenda a neurodegenerative). imodzi mwa mankhwala ochiritsira), ma ion channel receptors (monga AMPA, AMDA receptors), ndi zina zotero.

Suzhou Myland ndi kampani yolembetsedwa ndi FDA yomwe imapereka ufa wa Spermidine wabwino kwambiri komanso woyera kwambiri.

Ku Suzhou Myland, tadzipereka kupereka zinthu zabwino kwambiri pamitengo yabwino kwambiri. Ufa wathu wa Spermidine umayesedwa bwino kuti ukhale woyera komanso wamphamvu, zomwe zimakutsimikizirani kuti mumapeza chowonjezera chapamwamba chomwe mungachikhulupirire. Kaya mukufuna kuthandiza thanzi la maselo, kulimbitsa chitetezo cha mthupi lanu kapena kulimbitsa thanzi lonse, ufa wathu wa Spermidine ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zakuchitikira komanso kutsogoleredwa ndi ukadaulo wapamwamba komanso njira yabwino kwambiri yofufuzira ndi chitukuko, Spermidine yapanga zinthu zosiyanasiyana zopikisana kuti ikhale kampani yatsopano yowonjezera sayansi ya moyo, kupanga zinthu mwamakonda komanso yopereka chithandizo chopangira zinthu.

Kuphatikiza apo, Suzhou Myland ndi kampani yodziwika bwino yopanga zinthu zopangidwa ndi FDA. Zipangizo za kafukufuku ndi chitukuko cha kampaniyi, malo opangira zinthu, ndi zida zowunikira, ndi zamakono komanso zogwira ntchito zosiyanasiyana, ndipo zimatha kupanga mankhwala kuyambira mamiligalamu mpaka matani ambiri, ndipo zimagwirizana ndi miyezo ya ISO 9001 ndi zomwe zimapangidwa ndi GMP.