Kodi spermidine ndi chiyani? Njira yosavuta yopangira spermidine

Spermidinendi mtundu wa polyamine. Ma polyamines ndi ang'onoang'ono, mafuta, polycationic (-NH3+) biomolecules. Pali ma polyamines anayi mu nyama zoyamwitsa: spermine, spermidine, putrescine ndi cadaverine. Spermine ndi ya tetramines, spermidine ndi ya triamines, putrescine ndi cadaverine ndi ya diamines. Magulu osiyanasiyana a amino amawapatsa mawonekedwe osiyanasiyana okhudza thupi.

Spermidine mwa anthu

Spermidine sikuti imangopezeka mu umuna, komanso imafalitsidwa kwambiri muzinthu zina ndi maselo a thupi la munthu. The intracellular spermidine ndende makamaka zimadalira zinthu zinayi:

①Intracellular synthesis:

Arginine → putrescine → spermidine ← umuna. Arginine ndiye chopangira chachikulu cha kaphatikizidwe ka spermidine m'maselo. Amapangidwa ndi arginase kuti apange ornithine ndi urea. Ornithine imagwiritsidwa ntchito popanga putrescine pansi pa ornithine decarboxylase (ODC1). Ichi ndi sitepe yochepetsera mlingo), putrescine imapanga spermidine pansi pa zochita za spermidine synthase (SPDS). Spermidine imatha kupangidwanso ndi kuwonongeka kwa umuna.

②Kutenga ma extracellular:

Agawika mu chakudya kudya ndi matumbo tizilombo tating'onoting'ono synthesis. Zakudya zolemera mu spermidine zimaphatikizapo nyongolosi ya tirigu, natto, soya, bowa, ndi zina zotero. Spermine ndi spermidine zomwe zimalowetsedwa kuchokera ku chakudya zimatengedwa mofulumira kuchokera m'matumbo ndikugawidwa popanda kuwonongeka, kotero ndende ya spermidine m'magazi ndi Concentrations ndizosiyana kwambiri. Mabakiteriya a probiotic omwe ali m'matumbo a microbiota monga Bifidobacterium amathanso kupanga spermidine.

③Catabolism:

Spermine m'thupi imawola pang'onopang'ono kukhala spermidine ndi putrescine ndi N1-acetyltransferase (SSAT), polyamine oxidase (PAO) ndi ma amine oxidase ena, pomwe putrescine imasinthidwa kukhala aminobutyric acid ndi oxidase. Potsirizira pake, ma ayoni a amine ndi carbon dioxide amapangidwa ndi kuchotsedwa m’thupi.

④Msinkhu:

Kuchuluka kwa spermidine kumasintha ndi zaka. Ochita kafukufuku anayeza kuchuluka kwa ma polyamines m'matenda osiyanasiyana ndi ziwalo za mbewa za masabata atatu, masabata a 10 ndi 26 ndipo adapeza kuti zimasungidwa mu kapamba, ubongo ndi chiberekero. Kusintha kwa matumbo kumachepetsa pang'ono ndi zaka, ndikuchepa kwambiri mu thymus, ndulu, ovary, chiwindi, m'mimba, m'mapapo, impso, mtima ndi minofu. Sikovuta kuti tiganizire kuti zifukwa za kusinthaku zikuphatikizapo kusintha kwa zakudya, kusintha kwa zomera za m'mimba, kuchepetsa ntchito ya polyamine synthase, ndi zina zotero.

Zolinga zachilengedwe za spermidine

Kodi n’chifukwa chiyani kamolekyu waung’ono chonchi ndi wofunika kwambiri m’thupi la munthu? Chinsinsi chagona mu kapangidwe kake: Spermidine ndi polycationic (-NH3 +) mafuta amine molekyulu yaying'ono yomwe imakhalapo mumitundu yambiri ya ma protonated pansi pamikhalidwe ya pH ya thupi, yokhala ndi ma ion abwino omwe amagawidwa mumtundu wa kaboni. Mphamvu yamagetsi, imakhala ndi zochitika zolimbitsa thupi.

Chifukwa chake, kaya ndi ma nucleic acid, phospholipids, mapuloteni acidic okhala ndi zotsalira za acidic, pectic polysaccharides okhala ndi magulu a carboxyl ndi sulfates, kapena ma neurotransmitters ndi mahomoni (dopamine, epinephrine, serotonin, mahomoni a chithokomiro, etc.) okhala ndi mawonekedwe ofanana, Mwachiwonekere chandamale cha spermidine kumanga. Zovuta kwambiri ndi izi:

① Nucleic acid:

Kafukufuku wapeza kuti ma polyamines ambiri amapezeka mu mawonekedwe a polyamine-RNA complexes mkati mwa maselo, ndi 1-4 ofanana ndi polyamine omangidwa pa 100 ofanana ndi mankhwala a phosphate. Choncho, ntchito yaikulu ya spermidine ikugwirizana ndi kusintha kwapangidwe ndi kumasulira kwa RNA, monga momwe zimakhudzira magawo osiyanasiyana a mapuloteni okhudzana ndi kukhudzidwa kwachiwiri kwa mRNA, tRNA ndi rRNA. Spermidine amathanso kupanga "milatho" yokhazikika pakati pa zingwe za DNA ziwiri-helical, kuchepetsa kupezeka kwa ma radicals aulere kapena owononga DNA, komanso kuteteza DNA ku kutentha kwa kutentha ndi X-ray.

②Mapuloteni:

Spermidine imatha kumangirira ku mapuloteni omwe ali ndi milandu yayikulu yoyipa ndikusintha mawonekedwe a protein, potero amakhudza momwe thupi limagwirira ntchito. Zitsanzo zimaphatikizapo mapuloteni kinases/phosphatases (ulalo wofunikira m'njira zingapo zotumizira ma sign), michere yomwe imakhudzidwa ndi histone methylation ndi acetylation (yokhudza mafotokozedwe a jini mwa kusintha epigenetics), acetylcholinesterase (gawo lofunikira la matenda a neurodegenerative). amodzi mwa mankhwala achire), ma ion channel receptors (monga AMPA, AMDA receptors), etc.

Suzhou Myland ndi wopanga olembetsedwa ndi FDA yemwe amapereka ufa wapamwamba kwambiri komanso ukhondo wapamwamba wa Spermidine.

Ku Suzhou Myland, tadzipereka kupereka zinthu zabwino kwambiri pamitengo yabwino kwambiri. Ufa wathu wa Spermidine umayesedwa mwamphamvu kuti ukhale woyera ndi potency, kuonetsetsa kuti mumapeza chowonjezera chapamwamba chomwe mungakhulupirire. Kaya mukufuna kuthandizira thanzi la ma cell, kulimbikitsa chitetezo chamthupi kapena kuwonjezera thanzi labwino, ufa wathu wa Spermidine ndiye chisankho chabwino kwambiri.

Pokhala ndi zaka 30 zachidziwitso ndikuyendetsedwa ndi luso lapamwamba laukadaulo komanso njira yabwino kwambiri ya R&D, Spermidine yapanga zinthu zingapo zopikisana kuti zikhale zatsopano zowonjezera sayansi ya moyo, kaphatikizidwe kachitidwe ndi kampani yopanga ntchito zopanga.

Kuphatikiza apo, Suzhou Myland ndi wopanga olembetsedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira zinthu, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani mu sikelo, ndikutsatira miyezo ya ISO 9001 ndi mafotokozedwe a GMP.