Kodi NAD+ ndi chiyani ndipo chifukwa chiyani mukuifunikira pa thanzi lanu?

Mu dziko lomwe likukula la thanzi ndi thanzi, NAD+ yakhala mawu otchuka, kukopa chidwi cha asayansi ndi okonda zaumoyo. Koma kodi NAD+ kwenikweni ndi chiyani? Nchifukwa chiyani ndi yofunika kwambiri pa thanzi lanu? Tiyeni tiphunzire zambiri za mfundo zofunika pansipa!

Kodi NAD+ ndi chiyani?

Dzina la sayansi la NAD ndi nicotinamide adenine dinucleotide. NAD+ imapezeka mu selo iliyonse ya thupi lathu. Ndi metabolite yofunika kwambiri komanso coenzyme m'njira zosiyanasiyana za kagayidwe kachakudya. Imagwira ntchito m'njira zosiyanasiyana zamoyo. Ma enzyme opitilira 300 amadalira NAD+ kuti igwire ntchito.

NAD+Ndi chidule cha Chingerezi cha Nicotinamide adenine dinucleotide. Dzina lake lonse mu Chitchaina ndi nicotinamide adenine dinucleotide, kapena Coenzyme I mwachidule. Monga coenzyme yomwe imatumiza ma hydrogen ions, NAD+ imagwira ntchito m'mbali zambiri za kagayidwe ka thupi la munthu, kuphatikizapo glycolysis, Gluconeogenesis, tricarboxylic acid cycle, ndi zina zotero. Kafukufuku wina wasonyeza kuti kuchepa kwa NAD+ kumakhudzana ndi ukalamba, ndipo njira za thupi zomwe NAD+ imagwirira ntchito zimagwirizana ndi ukalamba, matenda a kagayidwe kachakudya, matenda a mitsempha ndi khansa, kuphatikizapo kuwongolera homeostasis ya maselo, ma sirtuin omwe amadziwika kuti "majini a moyo wautali", kukonza DNA, mapuloteni a banja la PARP okhudzana ndi necroptosis ndi CD38 yomwe imathandiza pakuwonetsa calcium.

NAD+ imagwira ntchito ngati basi yonyamula ma elekitironi kuchokera ku molekyulu imodzi kupita ku ina. Pamodzi ndi molekyulu ina ya NADH, imagwira ntchito zosiyanasiyana zokhudzana ndi kagayidwe kachakudya kudzera mu kusinthana kwa ma elekitironi komwe kumapanga adenosine triphosphate (ATP), molekyulu ya "mphamvu" ya thupi.

Mwachidule, NAD+ ndi yofunika kwambiri kuti thupi likhale ndi thanzi labwino komanso loyenera. Kagayidwe kachakudya m'thupi, redox, kukonza ndi kukonza DNA, kukhazikika kwa majini, malamulo a epigenetic, ndi zina zotero zimafuna kuti NAD+ itenge nawo mbali.

Chifukwa chake, thupi lathu limafuna kwambiri NAD+. NAD+ imapangidwa nthawi zonse, kusweka ndi kubwezeretsedwanso m'maselo kuti ikhalebe ndi milingo yokhazikika ya NAD+.

NAD+ ndi gawo lofunika kwambiri pa ntchito ya maselo ndipo limakhudzidwa ndi kupereka mphamvu ndi kukonza DNA, zomwe zonsezi zimagwirizana kwambiri ndi ukalamba wathanzi.

1) Imapezeka kwambiri m'maselo onse a thupi la munthu ndipo imatenga nawo mbali m'machitidwe ambirimbiri a biocatalytic. Imatha kulimbikitsa kagayidwe ka shuga, mafuta ndi ma amino acid, komanso kutenga nawo mbali pakupanga mphamvu. Ndi coenzyme yofunika kwambiri m'thupi la munthu.

2) NAD+ ndiye gawo lokhalo la ma enzymes odya coI (gawo lokhalo la enzyme yokonzanso DNA PARP, gawo lokhalo la protein ya Sirtuins yokhalitsa, komanso gawo lokhalo la cyclic ADP ribose synthase CD38/157).

Komabe, pamene ukalamba ukukwera, kuchuluka kwa NAD+ m'thupi kumachepa mofulumira. Kumachepa ndi 50% pazaka 20 zilizonse. Ali ndi zaka pafupifupi 40, kuchuluka kwa NAD+ m'thupi la munthu ndi 25% yokha ya momwe kunalili mwa ana.

Ngati maselo a anthu alibe NAD+, kusokonekera kwa mitochondrial kumachepa, mphamvu yokonzanso kuwonongeka kwa DNA imachepa, ndipo banja la mapuloteni a majini a Sirtuin lomwe ndi lokhalitsa nthawi yayitali siligwiranso ntchito, ndi zina zotero. Zinthu zoipa izi zingayambitse apoptosis, matenda a anthu, ukalamba komanso imfa.

Udindo wa NAD+ pa Thanzi Lanu Lonse

Kuletsa kukalamba

NAD+ imasunga kulumikizana kwa mankhwala pakati pa nyukiliyasi ndi mitochondria, ndipo kufooka kwa kulumikizana ndi chifukwa chachikulu cha ukalamba wa maselo.

NAD+ imatha kuchotsa kuchuluka kwa ma code olakwika a DNA panthawi ya kagayidwe ka maselo, kusunga mawonekedwe abwinobwino a majini, kusunga magwiridwe antchito abwinobwino a maselo, ndikuchepetsa kukalamba kwa maselo a anthu.

Konzani kuwonongeka kwa DNA

NAD+ ndi gawo lofunikira la enzyme yokonza DNA ya PARP, yomwe imakhudza kwambiri kukonzanso DNA, kufotokozera majini, kukula kwa maselo, kupulumuka kwa maselo, kumanganso ma chromosome, ndi kukhazikika kwa majini.

Yambitsani puloteni yokhalitsa

Ma Sirtuin nthawi zambiri amatchedwa banja la mapuloteni okhala ndi moyo wautali ndipo amagwira ntchito yofunika kwambiri pakuwongolera ntchito za maselo, monga kutupa, kukula kwa maselo, kayendedwe ka circadian, kagayidwe ka mphamvu, ntchito ya mitsempha, komanso kukana kupsinjika, ndipo NAD+ ndi enzyme yofunika kwambiri popanga mapuloteni okhala ndi moyo wautali.

Imayendetsa mapuloteni onse 7 okhala ndi moyo wautali m'thupi la munthu, imagwira ntchito yofunika kwambiri pakukana kupsinjika kwa maselo, kagayidwe ka mphamvu, kupewa kusintha kwa maselo, apoptosis ndi ukalamba.

Perekani mphamvu

Zimathandizira kupanga mphamvu zoposa 95% zomwe zimafunika pa moyo. Mitochondria m'maselo a anthu ndi malo opangira mphamvu m'maselo. NAD+ ndi coenzyme yofunika kwambiri mu mitochondria yopanga molekyulu yamphamvu ya ATP, yomwe imasintha michere kukhala mphamvu yomwe thupi la munthu limafuna.

Kulimbikitsa kukonzanso kwa mitsempha yamagazi ndikusunga kusinthasintha kwa mitsempha yamagazi

Mitsempha ya magazi ndi minofu yofunika kwambiri pa moyo wathu. Pamene tikukalamba, mitsempha ya magazi imataya kusinthasintha kwake pang'onopang'ono ndipo imakhala yolimba, yokhuthala, komanso yopapatiza, zomwe zimayambitsa "arteriosclerosis."

NAD+ imatha kuwonjezera ntchito ya elastin m'mitsempha yamagazi, motero kusunga kulimba kwa mitsempha yamagazi ndikusunga thanzi la mitsempha yamagazi.

Limbikitsani kagayidwe kachakudya

Kagayidwe kachakudya ndi kuchuluka kwa zochita zosiyanasiyana za mankhwala m'thupi. Thupi lidzapitiriza kusinthana zinthu ndi mphamvu. Kusinthana kumeneku kukatha, moyo wa thupi nawonso udzatha.

Pulofesa Anthony ndi gulu lake lofufuza ku Yunivesite ya California, USA, adapeza kuti NAD+ imatha kusintha bwino kuchepa kwa kagayidwe ka maselo komwe kumakhudzana ndi ukalamba, motero kukonza thanzi la anthu ndikuwonjezera moyo wawo.

Tetezani thanzi la mtima

Mtima ndi chiwalo chofunikira kwambiri cha anthu, ndipo mulingo wa NAD+ m'thupi umachita gawo lofunika kwambiri pakusunga magwiridwe antchito a mtima.

Kuchepa kwa NAD+ kungakhale kogwirizana ndi matenda ambiri a mtima, ndipo kafukufuku wambiri woyambira watsimikiziranso zotsatira za kuwonjezera NAD+ pa matenda a mtima.

Kuteteza matenda a mtima ndi mitsempha yamagazi

Kafukufuku wasonyeza kuti mitundu yonse isanu ndi iwiri ya sirtuins (SIRT1-SIRT7) imagwirizana ndi kufalikira kwa matenda a mtima. Sirtuins amaonedwa kuti ndi mankhwala ochizira matenda a mtima, makamaka SIRT1.

NAD+ ndiye chinthu chokhacho chomwe chimagwiritsidwa ntchito ndi Sirtuins. Kuonjezera NAD+ pa nthawi yake m'thupi la munthu kungathandize kuti ntchito ya mtundu uliwonse wa Sirtuins iyambe kugwira ntchito, motero kuteteza thanzi la mtima ndi kupewa matenda a mtima.

Limbikitsani kukula kwa tsitsi

Chifukwa chachikulu chomwe chimayambitsa kutayika kwa tsitsi ndi kutayika kwa mphamvu ya maselo a amayi a tsitsi, ndipo kutayika kwa mphamvu ya maselo a amayi a tsitsi ndi chifukwa chakuti kuchuluka kwa NAD+ m'thupi la munthu kumachepa. Maselo a amayi a tsitsi alibe ATP yokwanira yopangira mapuloteni a tsitsi, motero amataya mphamvu zawo ndikupangitsa kuti tsitsi litayike.

Chifukwa chake, kuwonjezera NAD+ kumatha kulimbitsa kayendedwe ka asidi ndikupanga ATP, kotero kuti maselo a tsitsi amakhala ndi mphamvu zokwanira zopangira mapuloteni a tsitsi, motero zimathandiza kuti tsitsi litayike bwino.

Komwe Mungagule Beta-NAD+ Supplement Motetezeka Pa intaneti

Suzhou Myland Pharm & Nutrition Inc. ndi kampani yolembetsedwa ndi FDA yomwe imapereka ufa wa NAD+ Supplement wapamwamba komanso woyera kwambiri.

Ku Suzhou Myland Pharm, tadzipereka kupereka zinthu zabwino kwambiri pamitengo yabwino kwambiri. Ufa wathu wa NAD+ Supplement umayesedwa bwino kuti ukhale woyera komanso wamphamvu, zomwe zimakutsimikizirani kuti mumapeza chowonjezera chapamwamba chomwe mungachidalire. Kaya mukufuna kuthandiza thanzi la maselo, kulimbitsa chitetezo cha mthupi lanu kapena kulimbitsa thanzi lonse, ufa wathu wa NAD+ Supplement ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zakuchitikira komanso kutsogoleredwa ndi ukadaulo wapamwamba komanso njira zabwino kwambiri zofufuzira ndi chitukuko, Suzhou Myland Pharm yapanga zinthu zosiyanasiyana zopikisana ndipo yakhala kampani yatsopano yowonjezera sayansi ya moyo, kupanga zinthu mwamakonda komanso kupanga zinthu.

Kuphatikiza apo, Suzhou Myland Pharm ndi kampani yodziwika bwino yopanga mankhwala yomwe ili ndi dzina la FDA. Zipangizo za kafukufuku ndi chitukuko cha kampaniyi, malo opangira mankhwala, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuyambira mamiligalamu mpaka matani ambiri, komanso zimagwirizana ndi miyezo ya ISO 9001 ndi zomwe zimapangidwa ndi GMP.