Kodi NAD + Ndi Chiyani Ndipo Mumafunikira Chifukwa Chathanzi Lanu?

M'dziko lomwe likukulirakulirabe lazaumoyo ndi thanzi, NAD+ yakhala mawu omveka, okopa chidwi cha asayansi komanso okonda zaumoyo chimodzimodzi. Koma NAD+ ndi chiyani kwenikweni? N’chifukwa chiyani kuli kofunika kwambiri pa thanzi lanu? Tiyeni tiphunzire zambiri zokhudzana ndi zomwe zili pansipa!

NAD+ ndi chiyani?

Dzina la sayansi la NAD ndi nicotinamide adenine dinucleotide. NAD + ilipo mu selo lililonse la thupi lathu. Ndi metabolite yofunika kwambiri komanso coenzyme munjira zosiyanasiyana za metabolic. Imayimira pakati ndikuchita nawo njira zosiyanasiyana zamoyo. Ma enzymes opitilira 300 amadalira NAD + Kuti agwire ntchito.

NAD +ndi chidule cha Chingerezi cha Nicotinamide adenine dinucleotide. Dzina lake lonse m'Chitchaina ndi nicotinamide adenine dinucleotide, kapena Coenzyme I mwachidule. Monga coenzyme yomwe imatumiza ma hydrogen ions, NAD + imathandizira mbali zambiri za metabolism yaumunthu, kuphatikizapo glycolysis, Gluconeogenesis, tricarboxylic acid cycle, etc. ndi NAD + zimagwirizana ndi ukalamba, matenda a metabolic, minyewa ndi khansa, kuphatikizapo kuyang'anira ma cell homeostasis, sirtuins omwe amadziwika kuti "majini a moyo wautali", kukonza DNA, mapuloteni a banja la PARPs okhudzana ndi necroptosis ndi CD38 zomwe zimathandiza posonyeza calcium.

NAD + imagwira ntchito ngati basi, yonyamula ma elekitironi kuchokera ku cell molekyu kupita ku ina. Pamodzi ndi mnzake wa NADH, imatenga nawo gawo pazosintha zosiyanasiyana za kagayidwe kachakudya kudzera pakusinthana kwa ma elekitironi komwe kumatulutsa adenosine triphosphate (ATP), molekyulu ya "mphamvu" yamthupi.

Mwachidule, NAD + ndiyofunikira kuti thupi likhale ndi thanzi labwino komanso moyenera. Metabolism, redox, kukonza ndi kukonza DNA, kukhazikika kwa majini, epigenetic regulation, etc. zonse zimafuna kutenga nawo mbali kwa NAD +.

Chifukwa chake, thupi lathu limafunikira kwambiri NAD +. NAD + imapangidwa mosalekeza, yophwanyidwa ndikusinthidwanso m'maselo kuti ikhale yokhazikika pama cell a NAD +.

NAD + ndi gawo lofunikira pamachitidwe am'manja ndipo limakhudzidwa ndikupereka mphamvu ndi kukonza kwa DNA, zonse zomwe zimagwirizana kwambiri ndi ukalamba wathanzi.

1) Imagawidwa kwambiri m'maselo onse a thupi la munthu ndipo imatenga nawo gawo pazochita masauzande a biocatalytic. Ikhoza kulimbikitsa kagayidwe ka shuga, mafuta ndi amino acid, komanso kutenga nawo mbali pakupanga mphamvu. Ndi coenzyme yofunika kwambiri m'thupi la munthu.

2) NAD + ndi gawo lokhalo la ma enzymes owononga coI (gawo lokhalo la DNA kukonza enzyme PARP, gawo lokhalo la mapuloteni a moyo wautali Sirtuins, ndi gawo lokhalo la cyclic ADP ribose synthase CD38/157).

Komabe, zaka zikamakula, mulingo wa NAD + m'thupi umachepa kwambiri. Idzatsika ndi 50% zaka 20 zilizonse. Pafupifupi zaka 40, zomwe NAD + zili m'thupi la munthu zimangokhala 25% ya zomwe zinali mwa ana.

Ngati maselo aumunthu alibe NAD +, kusokonezeka kwa mitochondrial kumachepetsedwa, mphamvu yokonzanso kuwonongeka kwa DNA imachepetsedwa, ndipo moyo wautali wa jini wa banja la Sirtuin umakhalanso wosagwira ntchito, etc. Zinthu zoipazi zingayambitse apoptosis, matenda a anthu, ukalamba komanso imfa.

Udindo wa NAD+ mu Thanzi Lanu Lonse

Anti-kukalamba

NAD + imasunga kulumikizana kwamankhwala pakati pa nyukiliyasi ndi mitochondria, ndipo kulumikizana kofooka ndikofunikira chifukwa chakukalamba kwa ma cell.

NAD+ imatha kuchotsa kuchuluka kwa manambala olakwika a DNA panthawi ya kagayidwe kazinthu, kusunga mawonekedwe abwino a majini, kusunga magwiridwe antchito a cell, ndikuchepetsa kukalamba kwa maselo amunthu.

Konzani kuwonongeka kwa DNA

NAD+ ndi gawo lapansi lofunikira la DNA kukonza enzyme PARP, yomwe imakhudza kwambiri kukonza kwa DNA, mawonekedwe a jini, kukula kwa maselo, kupulumuka kwa maselo, kumangidwanso kwa chromosome, komanso kukhazikika kwa majini.

Yambitsani mapuloteni a moyo wautali

Sirtuin nthawi zambiri amatchedwa banja la mapuloteni amoyo wautali ndipo amatenga gawo lofunikira pakuwongolera magwiridwe antchito a cell, monga kutupa, kukula kwa ma cell, circadian rhythm, metabolism yamphamvu, ntchito ya neuronal, komanso kukana kupsinjika, ndipo NAD + ndi puloteni yofunikira pakuphatikizika kwa mapuloteni amoyo wautali. .

Imayatsa mapuloteni onse 7 a moyo wautali m'thupi la munthu, amatenga gawo lofunikira pakukana kupsinjika kwa ma cell, metabolism yamphamvu, kupewa kusintha kwa ma cell, apoptosis ndi kukalamba.

Perekani mphamvu

Imathandizira kupanga mphamvu zopitilira 95% zomwe zimafunikira pazochitika zamoyo. Mitochondria m'maselo aumunthu ndi zomera zamphamvu za maselo. NAD+ ndi coenzyme yofunikira mu mitochondria kuti ipange molekyu yamphamvu ya ATP, ndikusintha michere kukhala mphamvu yofunikira mthupi la munthu.

Limbikitsani kusinthika kwa mitsempha yamagazi ndikusunga zotumphukira zamagazi

Mitsempha yamagazi ndi minofu yofunika kwambiri pazochitika zamoyo. Tikamakalamba, mitsempha yamagazi imasiya kusinthasintha pang'onopang'ono ndipo imakhala yolimba, yowonjezereka, komanso yopapatiza, zomwe zimayambitsa "arteriosclerosis."

NAD + imatha kukulitsa zochitika za elastin m'mitsempha yamagazi, potero kusunga kukhazikika kwa mitsempha yamagazi ndikusunga thanzi la mitsempha yamagazi.

Kulimbikitsa metabolism

Metabolism ndi kuchuluka kwa zinthu zosiyanasiyana zomwe zimachitika mthupi. Thupi lidzapitiriza kusinthanitsa zinthu ndi mphamvu. Kusinthana uku kukayima, moyo wa thupi nawonso utha.

Pulofesa Anthony ndi gulu lake lofufuza ku yunivesite ya California, USA, adapeza kuti NAD+ ikhoza kupititsa patsogolo kuchepa kwa kagayidwe kachakudya komwe kumakhudzana ndi ukalamba, potero kumapangitsa thanzi la anthu ndikutalikitsa moyo.

Tetezani thanzi la mtima

Mtima ndiye chiwalo chofunikira kwambiri mwa anthu, ndipo mulingo wa NAD + m'thupi umagwira ntchito yofunika kwambiri kuti mtima ugwire bwino ntchito.

Kuchepetsa kwa NAD + kungakhale kogwirizana ndi matenda ambiri amtima, ndipo maphunziro ambiri oyambira adatsimikiziranso zotsatira za kuwonjezera NAD + pa matenda amtima.

Kupewa matenda amtima ndi cerebrovascular

Kafukufuku wasonyeza kuti pafupifupi ma subtypes asanu ndi awiri a sirtuins (SIRT1-SIRT7) amakhudzana ndi kuyambika kwa matenda amtima. Sirtuins amaonedwa kuti ndi agonistic zolinga zochizira matenda amtima, makamaka SIRT1.

NAD+ ndiye gawo lokhalo la Sirtuins. Kuphatikizika kwanthawi yake kwa NAD + m'thupi la munthu kumatha kuyambitsa zochitika zamtundu uliwonse wa Sirtuins, potero kuteteza thanzi lamtima komanso kupewa matenda amtima.

Limbikitsani kukula kwa tsitsi

Chomwe chimapangitsa tsitsi kutayika ndikutha kwa mphamvu ya cell ya amayi, ndipo kutayika kwa mphamvu ya cell ya amayi ndi chifukwa mulingo wa NAD + m'thupi la munthu umachepa. Ma cell amayi atsitsi alibe ATP yokwanira kuti azitha kupanga mapuloteni atsitsi, motero amataya mphamvu zawo ndikupangitsa tsitsi kutayika.

Chifukwa chake, kuwonjezera NAD + kumatha kulimbikitsa kuzungulira kwa asidi ndikupanga ATP, kuti ma cell amayi atsitsi akhale ndi kuthekera kokwanira kupanga mapuloteni atsitsi, potero kuwongolera tsitsi.

Komwe Mungagule Beta-NAD+ Supplement Motetezedwa Paintaneti

Suzhou Myland Pharm & Nutrition Inc. ndi wopanga olembetsedwa ndi FDA yemwe amapereka ufa wapamwamba kwambiri komanso woyeretsedwa kwambiri wa NAD + Supplement powder.

Ku Suzhou Myland Pharm tadzipereka kupereka zinthu zapamwamba kwambiri pamitengo yabwino kwambiri. NAD + Supplement yathu ya ufa imayesedwa mwamphamvu kuti ikhale yoyera komanso yamphamvu, kuonetsetsa kuti mumapeza chowonjezera chapamwamba chomwe mungakhulupirire. Kaya mukufuna kuthandizira thanzi la ma cell, kulimbikitsa chitetezo chamthupi kapena kukulitsa thanzi labwino, NAD + Supplement powder yathu ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira zokongoletsedwa bwino za R&D, Suzhou Myland Pharm yapanga zinthu zambiri zampikisano ndikukhala kampani yotsogola ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.

Kuphatikiza apo, Suzhou Myland Pharm ndiwopanganso zolembedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira zinthu, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani mumlingo, ndikutsata miyezo ya ISO 9001 ndi zopangira GMP.