Kodi muyenera kudziwa chiyani chokhudza nicotinamide adenine dinucleotide (NAD+)?

NAD+ imatchedwanso coenzyme, ndipo dzina lake lonse ndi nicotinamide adenine dinucleotide. Ndi coenzyme yofunika kwambiri mu tricarboxylic acid cycle. Imalimbikitsa kagayidwe ka shuga, mafuta, ndi amino acid, imatenga nawo mbali popanga mphamvu, komanso imatenga nawo mbali pazinthu zambirimbiri mu selo iliyonse. Deta yambiri yoyesera ikuwonetsa kuti NAD+ imagwira ntchito kwambiri m'zinthu zosiyanasiyana zofunika pa thupi m'thupi, motero imalowerera mu ntchito zofunika kwambiri zamaselo monga kagayidwe ka mphamvu, kukonza DNA, kusintha majini, kutupa, kayimbidwe ka zamoyo, komanso kukana kupsinjika.

Malinga ndi kafukufuku wofunikira, kuchuluka kwa NAD+ m'thupi la munthu kumachepa ndi ukalamba. Kuchepa kwa kuchuluka kwa NAD+ kungayambitse kuchepa kwa mitsempha, kutayika kwa masomphenya, kunenepa kwambiri, kuchepa kwa magwiridwe antchito a mtima ndi kuchepa kwina kwa magwiridwe antchito. Chifukwa chake, momwe mungakulitsire kuchuluka kwa NAD+ m'thupi la munthu nthawi zonse kwakhala funso. Nkhani yofufuza kwambiri m'gulu la akatswiri azachipatala.

Chifukwa chiyani NAD+ imachepa?

Chifukwa, pamene tikukalamba, kuwonongeka kwa DNA kumawonjezeka. Panthawi yokonza DNA, kufunikira kwa PARP1 kumawonjezeka, ntchito ya SIRT imakhala yochepa, kugwiritsa ntchito NAD+ kumawonjezeka, ndipo kuchuluka kwa NAD+ kumachepa mwachibadwa.

Ngati tiwonjezera zokwaniraNAD+, tidzapeza kuti ntchito zambiri za thupi zimayamba kubwezeretsa unyamata.

Maselo ali ndi NAD+. Kodi tikufunikabe kuwonjezera pa izi?

Thupi lathu limapangidwa ndi maselo pafupifupi 37 thililiyoni. Maselo ayenera kumaliza ntchito zambiri kapena zochita zamaselo kuti adzisunge okha. Selo lililonse la maselo anu 37 thililiyoni limadalira NAD+ kuti ligwire ntchito yake yopitilira.

Pamene anthu padziko lonse lapansi akukalamba, matenda okhudzana ndi ukalamba monga matenda a Alzheimer's, matenda a mtima, mavuto a mafupa, tulo ndi matenda a mtima akhala matenda ofunikira omwe amaopseza thanzi la anthu.

Chifukwa chake, kuyambira pomwe NAD idapezeka ndi asayansi aku America, NAD yalowa m'miyoyo ya anthu, ndipo NAD+ ndi zowonjezera zake zawonetsa mwayi waukulu wogwiritsidwa ntchito popewa matenda okhudzana ndi ukalamba.

① NAD+ imagwira ntchito ngati coenzyme mu mitochondria kuti ilimbikitse kagayidwe kachakudya. NAD+ imagwira ntchito yofunika kwambiri mu kagayidwe kachakudya monga glycolysis, TCA cycle (yomwe imadziwikanso kuti Krebs cycle kapena citric acid cycle) komanso unyolo woyendera ma electron. Ndi momwe maselo amapezera mphamvu. Kukalamba ndi zakudya zama calorie ambiri zimachepetsa kuchuluka kwa NAD+ m'thupi.

Kafukufuku wasonyeza kuti m'makoswe akale, kumwa mankhwala owonjezera a NAD+ kumachepetsa kulemera chifukwa cha zakudya kapena ukalamba komanso kukulitsa luso lochita masewera olimbitsa thupi. Kuphatikiza apo, kafukufuku wasintha zotsatira za matenda a shuga m'makoswe achikazi, zomwe zasonyeza njira zatsopano zothanirana ndi matenda a kagayidwe kachakudya monga kunenepa kwambiri.

NAD+ imamangirira ku ma enzyme ndikusamutsa ma elekitironi pakati pa mamolekyu. Ma elekitironi ndiye maziko a mphamvu ya maselo. NAD+ imagwira ntchito pa maselo monga kubwezeretsanso batire. Ma elekitironi akatha, batire imafa. M'maselo, NAD+ imatha kulimbikitsa kusamutsa ma elekitironi ndikupereka mphamvu ku maselo. Mwanjira imeneyi, NAD+ imatha kuchepetsa kapena kuwonjezera ntchito ya ma enzyme, kulimbikitsa kufotokozera majini ndi ma signaling a maselo.

② NAD+ imathandiza kuwongolera kuwonongeka kwa DNA

Pamene zamoyo zikukalamba, zinthu zoipa zachilengedwe monga kuwala kwa dzuwa, kuipitsa chilengedwe, ndi kubwerezabwereza kwa DNA kolakwika zimatha kuwononga DNA. Iyi ndi imodzi mwa mfundo za ukalamba. Pafupifupi maselo onse ali ndi "makina a mamolekyu" okonzera kuwonongeka kumeneku.

Kukonza kumeneku kumafuna NAD+ ndi mphamvu, kotero kuwonongeka kwakukulu kwa DNA kumawononga zinthu zofunika kwambiri m'maselo. Ntchito ya PARP, puloteni yofunika kwambiri yokonzanso DNA, imadaliranso NAD+. Kukalamba kwabwinobwino kumapangitsa kuti kuwonongeka kwa DNA kuchuluke m'thupi, RARP imawonjezeka, motero kuchuluka kwa NAD+ kumachepa. Kuwonongeka kwa DNA ya Mitochondrial pa sitepe iliyonse kudzawonjezera kuchepa kumeneku.

③ NAD+imakhudza ntchito ya jini ya Sirtuins yokhala ndi moyo wautali ndipo imaletsa ukalamba

Majini opangidwa kumene otchedwa sirtuins, omwe amadziwikanso kuti "alonda a majini," amachita gawo lofunika kwambiri pakusunga thanzi la maselo. Sirtuins ndi banja la ma enzyme omwe amagwira ntchito poyankha kupsinjika kwa maselo komanso kukonza kuwonongeka. Amathandizanso kutulutsa insulin, ukalamba, komanso matenda okhudzana ndi ukalamba monga matenda amitsempha ndi matenda a shuga.

NAD+ ndi mafuta omwe amathandiza ma sirtuin kusunga umphumphu wa majini ndikulimbikitsa kukonzanso kwa DNA. Monga momwe galimoto singakhalire popanda mafuta, ma Sirtuin amafunikira NAD+ kuti ayambe kugwira ntchito. Zotsatira za kafukufuku wa nyama zikuwonetsa kuti kuwonjezeka kwa kuchuluka kwa NAD+ m'thupi kumayendetsa mapuloteni a sirtuin ndikuwonjezera moyo wamoyo mu yisiti ndi mbewa.

④ Ntchito ya mtima

Kukweza kuchuluka kwa NAD+ kumateteza mtima ndikuwongolera magwiridwe antchito a mtima. Kuthamanga kwa magazi kungayambitse kukula kwa mtima ndi kutsekeka kwa mitsempha, zomwe zingayambitse sitiroko. Pambuyo powonjezera kuchuluka kwa NAD+ mumtima kudzera mu zowonjezera za NAD+, kuwonongeka kwa mtima komwe kumachitika chifukwa cha kubwereranso kwa magazi kumalepheretsedwa. Kafukufuku wina wasonyeza kuti zowonjezera za NAD+ zimatetezanso mbewa ku kukula kwa mtima kosazolowereka.

⑤ Kuwonongeka kwa mitsempha

Mu mbewa zomwe zili ndi matenda a Alzheimer's, kuwonjezera kuchuluka kwa NAD+ kumawonjezera ntchito ya ubongo mwa kuchepetsa kuchuluka kwa mapuloteni omwe amasokoneza kulumikizana kwa ubongo. Kukweza kuchuluka kwa NAD+ kumatetezanso maselo a ubongo kuti asafe pamene magazi sakuyenda mokwanira kupita ku ubongo. NAD+ ikuwoneka kuti ili ndi lonjezo latsopano loteteza ku kuwonongeka kwa mitsempha ndikuwongolera kukumbukira.

⑥ Chitetezo cha mthupi

Pamene tikukalamba, chitetezo chathu chamthupi chimachepa ndipo timakhala pachiwopsezo chachikulu cha matenda. Kafukufuku waposachedwapa akusonyeza kuti kuchuluka kwa NAD+ kumathandiza kwambiri pakulamulira momwe chitetezo chamthupi chimayankhira komanso kutupa komanso kupulumuka kwa maselo panthawi ya ukalamba. Kafukufukuyu akuwonetsa kuthekera kwa NAD+ kuchiza matenda osagwirizana ndi chitetezo chamthupi.

Ubale pakati pa ntchito ya NAD+ ndi ukalamba

Ma coenzymes amagwira ntchito yokonza zinthu zofunika monga shuga, mafuta, ndi mapuloteni m'thupi la munthu, ndipo amagwira ntchito yofunika kwambiri pakulamulira kagayidwe ka zinthu ndi mphamvu m'thupi komanso kusunga magwiridwe antchito abwinobwino a thupi. NAD ndiye coenzyme yofunika kwambiri m'thupi la munthu, yomwe imatchedwanso coenzyme I. Imagwira ntchito m'machitidwe ambirimbiri a redox enzyme m'thupi la munthu. Ndi chinthu chofunikira kwambiri pa kagayidwe ka maselo onse. Ili ndi ntchito zambiri, ntchito zazikulu ndi izi:

1. Kulimbikitsa kupanga mphamvu zamagetsi

NAD+ imapanga ATP kudzera mu kupuma kwa maselo, kuwonjezera mphamvu ya maselo mwachindunji ndikuwonjezera magwiridwe antchito a maselo;

2. Kukonza majini

NAD+ ndiye chinthu chokhacho chomwe chimagwiritsidwa ntchito pokonza DNA enzyme PARP. Mtundu uwu wa enzyme umagwira ntchito yokonza DNA, umathandiza kukonza DNA ndi maselo owonongeka, umachepetsa mwayi wosintha maselo, komanso umaletsa khansa;

3. Yambitsani mapuloteni onse okhala ndi moyo wautali

NAD+ imatha kuyambitsa mapuloteni onse 7 okhala ndi moyo wautali, kotero NAD+ ili ndi mphamvu yofunika kwambiri pakulimbana ndi ukalamba ndikuwonjezera moyo;

4. Limbitsani chitetezo cha mthupi

NAD+ imalimbitsa chitetezo chamthupi ndikuwonjezera chitetezo chamthupi mwa kusintha mosamalitsa kupulumuka ndi kugwira ntchito kwa maselo olamulira a T.

5. Kulimbikitsa kukula kwa tsitsi

Chifukwa chachikulu chomwe chimayambitsa kutayika kwa tsitsi ndi kutayika kwa mphamvu ya maselo a amayi a tsitsi, ndipo kutayika kwa mphamvu ya maselo a amayi a tsitsi ndi chifukwa chakuti kuchuluka kwa NAD+ m'thupi la munthu kumachepa. Maselo a amayi a tsitsi alibe ATP yokwanira yopangira mapuloteni a tsitsi, motero amataya mphamvu zawo ndikupangitsa kuti tsitsi litayike.

6. Kusamalira kulemera, kulimbikitsa kagayidwe kachakudya m'thupi

Mu 2017, Pulofesa David Sinclair wa ku Harvard Medical School ndi gulu lochokera ku Australian Medical College adachita kafukufuku woyerekeza pa mbewa zazikazi zonenepa kwambiri zomwe zimachita masewera olimbitsa thupi pa treadmill kwa milungu 9 ndikugwiritsa ntchito NMN tsiku lililonse kwa masiku 18. Kafukufukuyu adapeza kuti NMN imakhudza kagayidwe ka mafuta m'chiwindi. Ndipo zotsatira za kupanga mafuta mwachionekere zimakhala zazikulu kuposa za masewera olimbitsa thupi.

Chodziwika bwino n'chakuti, ukalamba umayenderana ndi kuchepa pang'onopang'ono kwa milingo ya NAD+ m'maselo ndi minofu m'mitundu yosiyanasiyana ya zamoyo, kuphatikizapo makoswe ndi anthu. Kutsika kwa milingo ya NAD+ kumalumikizidwa ndi matenda ambiri okhudzana ndi ukalamba, kuphatikizapo kuchepa kwa chidziwitso, khansa, matenda a kagayidwe kachakudya, sarcopenia, ndi kufooka.

Kodi ndingatani kuti ndiwonjezere NAD+ tsiku lililonse?

Palibe kuchuluka kosatha kwa NAD+ m'thupi lathu. Zomwe zili ndi ntchito ya NAD+ m'thupi la munthu zimachepa ndi ukalamba, ndipo zimachepa mofulumira munthu akakwanitsa zaka 30, zomwe zimapangitsa kuti maselo azikalamba, apoptosis ichitike komanso kuti munthu asamaberekenso.

Kuphatikiza apo, kuchepetsa kwa NAD+ kudzayambitsanso mavuto ambiri azaumoyo, kotero ngati NAD+ singadzabwezeretsedwe pakapita nthawi, zotsatira zake zitha kuganiziridwa.

1. Zowonjezera kuchokera ku chakudya

Zakudya monga kabichi, broccoli, avocado, steak, bowa, ndi edamame zili ndi zinthu zoyambira za NAD+, zomwe zimatha kusinthidwa kukhala NAD* yogwira ntchito m'thupi mutamwa.

2. Chepetsani zakudya ndi ma calories

Kuchepetsa ma calories pang'ono kungayambitse njira zowunikira mphamvu mkati mwa maselo ndikuwonjezera milingo ya NAD* mwanjira ina. Koma onetsetsani kuti mukudya zakudya zopatsa thanzi kuti mukwaniritse zosowa za thupi lanu.

3. Khalani otanganidwa komanso ochita masewera olimbitsa thupi

Kuchita masewera olimbitsa thupi pang'ono monga kuthamanga ndi kusambira kungathandize kuwonjezera kuchuluka kwa NAD+ m'maselo, kuthandiza kuwonjezera mpweya m'thupi komanso kukonza kagayidwe ka mphamvu.

4. Tsatirani zizolowezi zabwino zogona

Pa nthawi yogona, thupi la munthu limachita zinthu zambiri zofunika kwambiri monga kagayidwe kachakudya ndi kukonzanso, kuphatikizapo kupanga NAD*. Kugona mokwanira kumathandiza kuti NAD ikhale yofanana ndi yachibadwa.

5. Onjezani zinthu zoyambira za NAD+

Nicotinic acid (NA) ndi nicotinamide (NAM) zonse ndi zoyambira za NAD+. Zitha kupangidwa ndikusinthidwa kukhala NAD m'thupi la munthu, motero zimawonjezera kuchuluka kwake. Komabe, chifukwa cha zoletsa za njira yopangira ndi ma enzyme ochepetsa liwiro, bioavailability ndi yotsika.

6 Chowonjezera mwachindunji cha NAD+

Kupatsa NAD+ chakudya chakunja kungabwezeretse msanga kuchuluka kwa NAD+ m'thupi, zomwe zimathandiza ziwalo zofunika monga mtima ndi ubongo kupeza NAD+ yowonjezera yogwira mtima.

Suzhou Myland Pharm & Nutrition Inc. ndi kampani yolembetsedwa ndi FDA yomwe imapereka ufa wowonjezera wa NAD+ wapamwamba komanso woyera kwambiri.

Ku Suzhou Myland Pharm, tadzipereka kupereka zinthu zabwino kwambiri pamitengo yabwino kwambiri. Ufa wathu wa NAD+ umayesedwa bwino kuti ukhale woyera komanso wamphamvu, zomwe zimakutsimikizirani kuti mumapeza chowonjezera chapamwamba chomwe mungachidalire. Kaya mukufuna kuthandiza thanzi la maselo, kulimbitsa chitetezo cha mthupi lanu kapena kulimbitsa thanzi lonse, ufa wathu wa NAD+ ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zakuchitikira komanso kutsogoleredwa ndi ukadaulo wapamwamba komanso njira zabwino kwambiri zofufuzira ndi chitukuko, Suzhou Myland Pharm yapanga zinthu zosiyanasiyana zopikisana ndipo yakhala kampani yatsopano yopereka chithandizo cha sayansi ya moyo, kupanga zinthu mwamakonda komanso kupanga zinthu.

Kuphatikiza apo, Suzhou Myland Pharm ndi kampani yodziwika bwino yopanga mankhwala yomwe ili ndi dzina la FDA. Zipangizo za kafukufuku ndi chitukuko cha kampaniyi, malo opangira mankhwala, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuyambira mamiligalamu mpaka matani ambiri, komanso zimagwirizana ndi miyezo ya ISO 9001 ndi zomwe zimapangidwa ndi GMP.