Kodi muyenera kudziwa chiyani za nicotinamide adenine dinucleotide (NAD+)?

NAD+ imatchedwanso coenzyme, ndipo dzina lake lonse ndi nicotinamide adenine dinucleotide. Ndiwofunikira coenzyme mu tricarboxylic acid cycle. Imalimbikitsa kagayidwe ka shuga, mafuta, ndi ma amino acid, imatenga nawo gawo pakupanga mphamvu, ndipo imachita nawo masauzande ambiri mu cell iliyonse. Zambiri zoyeserera zikuwonetsa kuti NAD + imakhudzidwa kwambiri ndi zochitika zosiyanasiyana zakuthupi m'thupi, motero imalowererapo pazantchito zazikulu zama cell monga mphamvu ya metabolism, kukonza kwa DNA, kusintha kwa ma genetic, kutupa, ma biological rhythms, komanso kukana kupsinjika.

Malinga ndi kafukufuku wofunikira, mulingo wa NAD + m'thupi la munthu utsika ndi zaka. Kutsika kwa milingo ya NAD + kungayambitse kuchepa kwa minyewa, kuwonongeka kwa masomphenya, kunenepa kwambiri, kuchepa kwa ntchito ya mtima ndi kuchepa kwa magwiridwe antchito. Chifukwa chake, momwe mungakulitsire mulingo wa NAD + m'thupi la munthu nthawi zonse lakhala funso. Mutu wotentha wofufuza m'magulu azachipatala.

Chifukwa chiyani NAD + imachepa?

Chifukwa, pamene tikukalamba, kuwonongeka kwa DNA kumawonjezeka. Panthawi yokonza DNA, kufunikira kwa PARP1 kumawonjezeka, ntchito ya SIRT imakhala yochepa, kugwiritsa ntchito NAD + kumawonjezeka, ndipo kuchuluka kwa NAD + kumachepa mwachibadwa.

Ngati tiwonjezera mokwaniraNAD +, tidzapeza kuti ntchito zambiri za thupi zimayamba kubwezeretsa unyamata.

Maselo ali NAD+. Kodi tikufunikabe kuwonjezera?

Thupi lathu limapangidwa ndi maselo pafupifupi 37 thililiyoni. Maselo amayenera kumaliza "ntchito" zambiri kapena ma cell kuti adzisamalira okha. Selo lililonse la 37 thililiyoni limadalira NAD + kuti igwire ntchito yake yopitilira.

Pamene chiwerengero cha anthu padziko lapansi chikukalamba, matenda okalamba okhudzana ndi ukalamba monga matenda a Alzheimer's, matenda a mtima, matenda a mafupa, kugona ndi matenda a mtima asanduka matenda ofunika kwambiri omwe amaopseza thanzi la anthu.

Chifukwa chake, popeza NAD idapezeka ndi asayansi aku America, NAD yalowa m'miyoyo ya anthu, ndipo NAD + ndi zowonjezera zake zawonetsa chiyembekezo chachikulu chogwiritsa ntchito popewa matenda okhudzana ndi ukalamba.

① NAD + imagwira ntchito ngati coenzyme mu mitochondria kuti ilimbikitse metabolism. NAD+ imatenga gawo lofunikira kwambiri pamayendedwe a metabolic monga glycolysis, TCA cycle (aka Krebs cycle kapena citric acid cycle) ndi unyolo wonyamula ma elekitironi. Ndi mmene maselo amapezera mphamvu. Kukalamba komanso zakudya zama calorie ambiri zimachepetsa milingo ya NAD + m'thupi.

Kafukufuku wasonyeza kuti mu mbewa zakale, kutenga NAD + zowonjezera kumachepetsa kudya- kapena kulemera kwa zaka zokhudzana ndi zaka komanso kuchita masewera olimbitsa thupi. Kuphatikiza apo, kafukufuku wasinthanso zotsatira za matenda a shuga mwa mbewa zazikazi, kuwonetsa njira zatsopano zothana ndi matenda a metabolic monga kunenepa kwambiri.

NAD + imamanga ku michere ndikusamutsa ma elekitironi pakati pa mamolekyu. Ma electron ndiye maziko a mphamvu zama cell. NAD + imagwira ntchito pama cell ngati kulipiritsa batire. Ma electron akagwiritsidwa ntchito, batire imafa. M'maselo, NAD + imatha kulimbikitsa kusamutsa kwa ma elekitironi ndikupereka mphamvu kumaselo. Mwanjira iyi, NAD + imatha kuchepetsa kapena kukulitsa zochitika za enzyme, kulimbikitsa mawonekedwe a jini ndi ma cell signing.

② NAD + imathandizira kuwongolera kuwonongeka kwa DNA

Pamene zamoyo zimakalamba, zinthu zoipa za chilengedwe monga kuwala kwa dzuwa, kuipitsa, ndi kubwerezabwereza kwa DNA molakwika kungawononge DNA. Ichi ndi chimodzi mwa ziphunzitso za ukalamba. Pafupifupi maselo onse ali ndi "makina a mamolekyu" kuti akonze zowonongekazi.

Kukonza uku kumafuna NAD + ndi mphamvu, kotero kuwonongeka kwakukulu kwa DNA kumawononga ma cell amtengo wapatali. Ntchito ya PARP, puloteni yofunika yokonza DNA, imadaliranso NAD +. Ukalamba wamba kumapangitsa kuwonongeka kwa DNA m'thupi, RARP imawonjezeka, chifukwa chake kuchuluka kwa NAD + kumachepa. Kuwonongeka kwa DNA ya Mitochondrial pa sitepe iliyonse kudzakulitsa kuchepa uku.

③ NAD+zimakhudza ntchito ya moyo wautali jini Sirtuins ndi kuletsa kukalamba

Ma jini omwe angopezedwa kumene a sirtuin, omwe amadziwikanso kuti "oteteza majini," amagwira ntchito yofunika kwambiri kuti ma cell akhale ndi thanzi. Sirtuins ndi gulu la ma enzyme omwe amakhudzidwa ndi kupsinjika kwa ma cell ndikukonza zowonongeka. Amakhalanso ndi insulin secretion, ukalamba, komanso matenda okhudzana ndi ukalamba monga matenda a neurodegenerative ndi matenda a shuga.

NAD + ndiye mafuta omwe amathandiza kuti ma sirtuin asunge umphumphu wa genome ndikulimbikitsa kukonza kwa DNA. Monga momwe galimoto singakhalire popanda mafuta, Sirtuins amafuna NAD + kuti ayambitse. Zotsatira za kafukufuku wa nyama zikuwonetsa kuti kuchuluka kwa NAD + m'thupi kumayambitsa mapuloteni a sirtuin ndikukulitsa moyo wa yisiti ndi mbewa.

④ Ntchito ya mtima

Kukweza milingo ya NAD + kumateteza mtima ndikuwongolera magwiridwe antchito amtima. Kuthamanga kwa magazi kungayambitse kukulitsa mtima ndi kutsekeka kwa mitsempha, zomwe zingayambitse sitiroko. Pambuyo pobwezeretsanso mulingo wa NAD+ mu mtima kudzera muzowonjezera za NAD+, kuwonongeka kwa mtima komwe kumachitika chifukwa chobwezeretsanso kumaletsedwa. Kafukufuku wina wasonyeza kuti zowonjezera za NAD + zimatetezanso mbewa kuti zisakule molakwika mtima.

⑤ Neurodegeneration

Mu mbewa zomwe zili ndi matenda a Alzheimer's, kuchuluka kwa NAD + kumakulitsa magwiridwe antchito anzeru pochepetsa kuchuluka kwa mapuloteni omwe amasokoneza kulumikizana kwaubongo. Kukweza milingo ya NAD + kumatetezanso ma cell aubongo kuti asafe ngati palibe magazi okwanira opita ku ubongo. NAD + ikuwoneka kuti ili ndi lonjezo latsopano poteteza ku neurodegeneration ndikuwongolera kukumbukira.

⑥ Chitetezo cha mthupi

Tikamakalamba, chitetezo chathu cha mthupi chimachepa ndipo timayamba kudwala. Kafukufuku waposachedwa akuwonetsa kuti milingo ya NAD + imatenga gawo lofunikira pakuwongolera mayankho a chitetezo chamthupi komanso kutupa komanso kupulumuka kwa maselo akamakalamba. Kafukufukuyu akuwunikira kuthekera kochizira kwa NAD + pakulephera kwa chitetezo chamthupi.

Ubale pakati pa udindo wa NAD + ndi kukalamba

Ma Coenzymes amatenga nawo gawo mu metabolism ya zinthu zofunika monga shuga, mafuta, ndi mapuloteni m'thupi la munthu, ndipo amatenga gawo lalikulu pakuwongolera kagayidwe kazinthu zam'thupi ndi mphamvu ndikusunga magwiridwe antchito amthupi. NAD ndiye coenzyme yofunika kwambiri m'thupi la munthu, yomwe imatchedwanso coenzyme I. Imagwira nawo masauzande ambiri a redox enzymatic reaction m'thupi la munthu. Ndi chinthu chofunikira kwambiri pa metabolism ya cell iliyonse. Ili ndi ntchito zambiri, ntchito zazikulu ndi izi:

1. Limbikitsani kupanga bioenergy

NAD+ imapanga ATP kudzera mu kupuma kwa ma cell, kumawonjezera mwachindunji mphamvu zama cell ndikuwonjezera magwiridwe antchito a cell;

2. Konzani majini

NAD+ ndiye gawo lokhalo la DNA kukonza enzyme PARP. Mtundu uwu wa enzyme umagwira nawo ntchito yokonza DNA, umathandizira kukonza DNA ndi maselo owonongeka, amachepetsa mwayi wa kusintha kwa maselo, ndikuletsa kuchitika kwa khansa;

3. Yambitsani mapuloteni onse a moyo wautali

NAD + imatha kuyambitsa mapuloteni onse 7 a moyo wautali, kotero NAD + imakhudza kwambiri kuletsa kukalamba komanso kukulitsa moyo;

4. Kulimbitsa chitetezo cha mthupi

NAD + imalimbitsa chitetezo chamthupi ndikuwongolera chitetezo cham'manja mwa kusankha kupulumuka ndikugwira ntchito kwa ma T cell owongolera.

5. Limbikitsani kukula kwa tsitsi

Chomwe chimapangitsa tsitsi kutayika ndikutha kwa mphamvu ya cell ya amayi, ndipo kutayika kwa mphamvu ya cell ya amayi ndi chifukwa mulingo wa NAD + m'thupi la munthu umachepa. Ma cell amayi atsitsi alibe ATP yokwanira kuti azitha kupanga mapuloteni atsitsi, motero amataya mphamvu zawo ndikupangitsa tsitsi kutayika.

6. Kuwongolera kulemera, kulimbikitsa kagayidwe kake

Mu 2017, Pulofesa David Sinclair wa ku Harvard Medical School ndi gulu lochokera ku Australian Medical College adayesa kuyesa mbewa zazikazi zonenepa kwambiri zomwe zikuchita masewera olimbitsa thupi kwa milungu 9 ndikutenga NMN tsiku lililonse kwa masiku 18. Kafukufukuyu adapeza kuti NMN imakhudza kagayidwe ka mafuta a chiwindi. Ndipo zotsatira za kaphatikizidwe mwachiwonekere ndi zazikulu kuposa zolimbitsa thupi.

Makamaka, kukalamba kumatsagana ndi kuchepa kwapang'onopang'ono kwa minofu ndi ma cell a NAD+ muzamoyo zosiyanasiyana, kuphatikiza makoswe ndi anthu. Kutsika kwa milingo ya NAD + kumalumikizidwa ndi matenda ambiri okhudzana ndi ukalamba, kuphatikiza kuchepa kwa chidziwitso, khansa, matenda a metabolic, sarcopenia, ndi kufooka.

Kodi ndingawonjezere bwanji NAD + tsiku lililonse?

Palibe kuchuluka kwa NAD + kosatha m'thupi lathu. Zomwe zili ndi zochita za NAD + m'thupi la munthu zidzacheperachepera ndi zaka, ndipo zimachepa kwambiri akakwanitsa zaka 30, zomwe zimapangitsa kukalamba kwa ma cell, apoptosis komanso kutayika kwa kubadwanso. .

Kuphatikiza apo, kuchepetsedwa kwa NAD + kudzadzetsanso mavuto angapo azaumoyo, kotero ngati NAD + singathe kubwezeredwa munthawi yake, zotsatira zake zitha kuganiziridwa.

1.Kuwonjezera kuchokera ku chakudya

Zakudya monga kabichi, broccoli, avocado, steak, bowa, ndi edamame zili ndi NAD + precursors, zomwe zimatha kusinthidwa kukhala NAD * yogwira m'thupi pambuyo poyamwa.

2.Kuletsa zakudya ndi zopatsa mphamvu

Kuletsa kwapakatikati kwa caloric kumatha kuyambitsa njira zowona mphamvu m'maselo ndikuwonjezera milingo ya NAD* mwanjira ina. Koma onetsetsani kuti mumadya zakudya zopatsa thanzi kuti mukwaniritse zosowa za thupi lanu

3. Khalani otanganidwa ndi kuchita masewera olimbitsa thupi

Zochita zolimbitsa thupi zolimbitsa thupi monga kuthamanga ndi kusambira zimatha kukulitsa milingo ya NAD +, kuthandizira kuchulukitsa mpweya m'thupi komanso kusintha mphamvu zamagetsi.

4. Tsatirani chizolowezi chogona mokwanira

Tikagona, thupi la munthu limachita zinthu zambiri zofunika kwambiri za kagayidwe kachakudya ndi kukonza zinthu, kuphatikizapo kaphatikizidwe ka NAD*. Kugona mokwanira kumathandiza kuti NAD ikhale yabwino

5. Wonjezerani NAD + zinthu zam'mbuyo

Nicotinic acid (NA) ndi nicotinamide (NAM) onse ndi otsogola a NAD +. Atha kupangidwa ndikusinthidwa kukhala NAD m'thupi la munthu, potero akuwonjezera zomwe zili. Komabe, chifukwa cha kuchepa kwa njira yophatikizira komanso kuchepetsa kuchuluka kwa ma enzymes, bioavailability ndiyotsika. .

6 Onjezani mwachindunji NAD +

Kuphatikizika kwachilendo kwa NAD + kumatha kubwezeretsa mwachangu milingo ya NAD + m'thupi, kulola ziwalo zofunika monga mtima ndi ubongo kupeza zowonjezera zowonjezera za NAD +.

Suzhou Myland Pharm & Nutrition Inc. ndi wopanga olembetsedwa ndi FDA yemwe amapereka ufa wapamwamba kwambiri komanso woyeretsedwa kwambiri wa NAD +.

Ku Suzhou Myland Pharm tadzipereka kupereka zinthu zapamwamba kwambiri pamitengo yabwino kwambiri. Mafuta athu owonjezera a NAD + amayesedwa mwamphamvu kuti akhale oyera komanso amphamvu, kuwonetsetsa kuti mumapeza chowonjezera chapamwamba chomwe mungakhulupirire. Kaya mukufuna kuthandizira thanzi la ma cell, kulimbikitsa chitetezo chamthupi kapena kukulitsa thanzi labwino, NAD + yathu yowonjezera ufa ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira zokongoletsedwa bwino za R&D, Suzhou Myland Pharm yapanga zinthu zambiri zampikisano ndikukhala kampani yotsogola ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.

Kuphatikiza apo, Suzhou Myland Pharm ndiwopanganso zolembedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira zinthu, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani mumlingo, ndikutsata miyezo ya ISO 9001 ndi zopangira GMP.