Mitochondria ndi yofunika kwambiri monga mphamvu ya maselo a thupi lathu, kupereka mphamvu zambiri kuti mtima wathu uzigunda, mapapu athu kupuma ndi thupi lathu likugwira ntchito mwa kukonzanso tsiku ndi tsiku.Komabe, m'kupita kwanthawi, komanso ndi zaka, zida zathu zopanga mphamvu, mitochondria, zimatha kuwonongeka ndikutaya mphamvu zawo zogwira ntchito bwino.Mitochondria yogwira ntchito mokwanira ndizofunikira pa moyo wa munthu.Komabe, mitochondria imakondanso kuwonongeka kuchokera kuzinthu zosiyanasiyana, kuphatikizapo kupsinjika kwa okosijeni, kutupa, ndi poizoni wa chilengedwe.Zinthu izi zimatha kuwononga DNA ya mitochondrial, kusokoneza luso lawo lopanga ATP ndi zinthu zina zofunika.
Mwamwayi, thupi lathu limachotsa mitochondria yowonongeka komanso yosagwira ntchito m'maselo athu kudzera mu mitochondrial autophagy kuti tikhalebe ndi thanzi labwino komanso kupewa zotsatira zina zoipa za mitochondria yowonongeka, malinga ndi kafukufuku wosonyeza kuti njira ya mitochondrial autophagy imakhala ndi ntchito yotsutsa- kukalamba.Tiyeni timvetsetse kulumikizana pakati pa mitochondria ndi anti-kukalamba!
Kodi ntchito za mitochondria ndi ziti?
Mitochondria ndi organelles ofunikira omwe amapanga mphamvu m'maselo athu.Ntchito yawo yayikulu ndikutulutsa adenosine triphosphate (ATP), yomwe ndi ndalama zamphamvu zama cell athu.Tikakhala ndi mitochondria yambiri, timatha kupanga ATP yambiri, zomwe zimapangitsa kuti tiwonjezere mphamvu komanso kuchepetsa kutopa.Zina mwa maudindo akuluakulu omwe amasewera ndi awa:
(1)kupereka mphamvu ndi njira za metabolic m'thupi
(2)Mitochondrial autophagy imazindikira mitochondria yowonongeka ndikuichotsa mwasankha, ndipo kuchotsedwa kwa mitochondria yowonongekayi kumalimbikitsa biosynthesis ya mitochondria yatsopano.
(3)Imatha kukhala ndi gawo loletsa kufa kwa maselo pochotsa mitochondria
(4)Zakhala zikugwirizana ndi chitukuko cha matenda osiyanasiyana, kuphatikizapo matenda a mtima, matenda a neurodegenerative komanso mitundu ina ya khansa.
Kodi pali kulumikizana kotani pakati pa mitochondria ndi anti-kukalamba?
Kafukufuku wasonyeza kuti pamene tikukalamba, chilolezo kudzera mu mitochondrial autophagy ndi dysregulated, kutanthauza kuti maselo a mitochondrial sangathe kuchotsa ntchito zawo.Popanda njira zowongolera bwino monga mitochondrial autophagy, kuwonongeka kwa ma cell kumatha kufulumizitsa.
M'maphunziro a nyama, nthawi yayitali ya moyo idawoneka pamene majini omwe amawongolera mitochondrial autophagy amawonetsedwa, kutanthauza kuti mitochondrial autophagy ndi moyo wautali zimalumikizana.Kuphatikiza apo, kuwonongeka kwa mitochondrial autophagy kumawonedwa kawirikawiri m'matenda angapo okhudzana ndi ukalamba, kuphatikiza matenda a Parkinson ndi Alzheimer's, matenda amtima, ndi khansa, kutanthauza kuti njira zomwe zimayang'ana mitochondrial autophagy zitha kukhala ndi gawo popewa komanso kuchiza matenda.Pamapeto pake, chinsinsi cha ukalamba mwachisomo chagona pakumvetsetsa ndi kuthandizira njira zovuta kwambiri zomwe zimapangitsa kuti thupi lizigwira ntchito.Mwa kuyesetsa kulimbikitsa thanzi la mitochondrial autophagy ndikupanga zisankho za moyo zomwe zimayika patsogolo kukhala ndi moyo wabwino, titha kuvumbulutsa zinsinsi za moyo wautali komanso wathanzi!
Momwe mungakulitsire mitochondrial autophagy
(1)Ganizirani kusala kudya kwapang'onopang'ono komanso kuletsa ma calorie
Kafukufuku wasonyeza kuti mitochondrial autophagy ikhoza kusonkhezeredwa ndi njira zosiyanasiyana za moyo.Mwachitsanzo, masewera olimbitsa thupi awonetsedwa kuti akuwonjezera mitochondrial autophagy, potero kupititsa patsogolo ntchito ya mitochondrial.Kuphatikiza apo, kulowererapo pazakudya monga kusala kudya kwakanthawi kapena kuletsa ma calorie kungayambitsenso mitochondrial autophagy, zomwe zimapangitsa kuti mitochondria yathanzi ichuluke.
(2)Kusachita masewera olimbitsa thupi nthawi zonse
Kuchita masewera olimbitsa thupi ndikosavuta komanso kosavuta kumamatira.Zingathe kulimbikitsa thanzi ndi moyo wautali komanso kupititsa patsogolo ntchito ya mitochondrial komanso kuyambitsa mitochondrial autophagy, kotero kuchita masewera olimbitsa thupi kungathe kukonzedwa momveka bwino ndi mphamvu, aerobic ndi kupirira maphunziro kuti awonjezere mitochondrial autophagy.
(3)Urolithin A ndi molekyu yomwe imayambitsa mitochondrial autophagy
Urolithin A ndi mankhwala a metabolite opangidwa ndi kutembenuka kwa ellagic tannins ndi mabakiteriya am'mimba.Zitsanzo zake ndi ellagic acid ndi ellagitannin, zomwe zimapezeka mu zomera zambiri zodyedwa, monga makangaza, sitiroberi, raspberries, walnuts, ndi zina zotero, koma osati kuti zilipo mu chakudya, chifukwa mabakiteriya ena amatha kusintha ellagitannin ku urolithin.Ndipo urolithin A, organic pawiri wopangidwa kuchokera ku kalambulabwalo wazakudya, ndiye chinthu chomwe chawonetsedwa kuti chimayambitsa mitochondrial autophagy.
Kufunika kwa mitochondrial autophagy
Mitochondrial autophagy ndi njira yachilengedwe komanso yofunika yomwe imathandizira kukhala ndi thanzi la mitochondria mkati mwa maselo athu.Izi zimaphatikizapo kuzindikira mitochondria yomwe yawonongeka kapena yosagwira ntchito ndikuwachotsa m'selo kuti apange mitochondria yatsopano, yotheka kuti ilowe m'malo mwake.Panthawi imodzimodziyo, njira ya mitochondrial autophagy imathandizira kuti mphamvu za thupi lathu zikhale zokhazikika komanso kuti maselo athu ndi minofu ikhale yathanzi komanso yogwira ntchito.
Pomaliza, kukhala ndi mitochondria yathanzi ndikofunikira kwambiri pa thanzi lathu lonse komanso moyo wathu wonse, ndipo maselo athu asintha njira yotchedwa mitochondrial autophagy kuti titsimikizire kuti timakhala ndi mitochondria yathanzi mosalekeza.Komabe, njira zothandizira moyo (monga masewera olimbitsa thupi) ndi zakudya zowonjezera (monga zakudya za ketogenic) ndi kugwiritsa ntchito zowonjezera zowonjezera zingathandize ntchito ya mitochondrial ndikuthandizira kupewa matenda okhudzana ndi ukalamba.Posamalira mitochondria yathu, titha kutsimikizira kuti tili ndi mphamvu komanso nyonga zomwe timafunikira kuti tikhale ndi moyo wathunthu.
Kuphatikiza apo, titha kudziwa bwino kugwirizana pakati pa mitochondria ndi anti-kukalamba, tikamakalamba, njira ya mitochondrial autophagy imasokonekera, ndiye kuti, imayambitsa kudzikundikira kwa mitochondria m'maselo, omwe kusala kudya, kuletsa kalori, urolithin A. , ndi zina zotero zingayambitse mitochondrial autophagy ndipo zimatha kusintha thanzi ndi kukalamba, kumene NAD + ndi urolithin A zimathandizira kupanga mitochondria yatsopano kudzera mu njira yotchedwa biogenesis process yotchedwa biogenesis;komabe, urolithin A ali ndi ntchito ina yofunika.Imakulitsa njira yotchedwa mitochondrial autophagy, momwe mitochondria yowonongeka imachotsedwa ndikusinthidwa kukhala mitochondria yatsopano, yogwira mtima kwambiri.Anthu ambiri m'miyoyo yathu sangathe kuchita masewera olimbitsa thupi kwa nthawi yayitali, koma mankhwala omwe timapereka, Urolithin A, amatha kukhala ndi thanzi labwino.
Funso: Kodi pali zakudya zenizeni pamoyo wanu zomwe zingathandize kupewa kukalamba msanga?
A: Inde, zakudya zina zokhala ndi antioxidants, mavitamini ndi mchere zingathandize kulimbikitsa khungu lathanzi komanso kuchepetsa ukalamba.Zitsanzo ndi zipatso, ndiwo zamasamba, zomanga thupi zowonda ndi mafuta athanzi.
Nthawi yotumiza: Jun-01-2023
