Palmitoylethanolamide ndi endogenous fatty acid amide yomwe ili m'gulu la nuclear factor agonists. Ndi imodzi mwazinthu zofunika kwambiri zamkati za analgesic ndi anti-inflammatory compounds zomwe zasonyezedwa kuti ndizothandiza osati pazovuta komanso zowawa zopweteka. Monga mankhwala opweteka achilengedwe, ndi njira yabwino yopangira mankhwala achikhalidwe omwe angayambitse mavuto.
PEA yasonyezedwa kuti ili ndi anti-inflammatory, antinociceptive, neuroprotective, ndi anticonvulsant properties. PEA yakhala ikuyang'ana anthu omwe ali ndi zowawa zosiyanasiyana, kutupa ndi ma syndromes opweteka m'mayesero osiyanasiyana azachipatala. Mapulogalamu: Palmitoylethanolamide ndi organic synthesis wapakatikati ndi mankhwala apakatikati, omwe angagwiritsidwe ntchito pofufuza ma laboratory ndi njira zachitukuko ndi kafukufuku wamankhwala ndi mankhwala ndi chitukuko.
M'mafukufuku amasiku ano asayansi ndi mafakitale, Palmitoylethanolamide, monga chinthu chofunika kwambiri cha mankhwala, yalandira chidwi chofala chifukwa cha mankhwala ake apadera komanso chiyembekezo chogwiritsa ntchito.
1. Kukonzekera kwa Palmitoylethanolamide
Kukonzekera kwa Palmitoylethanolamide nthawi zambiri kumaphatikizapo kuchitapo kanthu kwa esterification. Pokonzekera, palmitadecanoic acid ndi ethanol amakumana ndi esterification reaction pansi pa chothandizira kupanga palmitadecanamide ethanol. Pakukonzekera ndondomeko, zinthu monga anachita kutentha, chothandizira mtundu ndi mlingo, ndi zochita nthawi zimakhudza kwambiri khalidwe ndi zokolola za mankhwala. Chifukwa chake, kukhathamiritsa njira yokonzekera ndiye chinsinsi chowongolera zinthu komanso kuchepetsa ndalama.
2. Katundu wa Palmitoylethanolamide
Palmitoylethanolamide ndi yoyera mpaka yachikasu pang'ono yokhala ndi kusungunuka kwabwino komanso kukhazikika. Ndiwolimba kutentha kwa firiji, koma amasungunuka mumitundu yosiyanasiyana yamadzimadzi pa kutentha kwina, monga ethanol, acetone, ndi zina zotero. kutentha kwambiri ndi malo ovuta.
3. Kugwiritsa ntchito Palmitoylethanolamide
1. Kafukufuku wamankhwala ndi labotale ndi chitukuko:
● PEA ndi mankhwala ofunikira apakati, omwe amagwiritsidwa ntchito pofufuza kafukufuku wa labotale ndi njira zachitukuko ndi kafukufuku wamankhwala a mankhwala ndi njira zachitukuko.
● Zasonyezedwa kuti zili ndi anti-inflammatory, analgesic, neuroprotective and anticonvulsant properties ndipo ndizoyenera kuchiza kupweteka kosalekeza, khunyu, cerebral ischemia ndi sitiroko.
2. Makampani opanga zodzoladzola:
●PEA ili ndi ntchito yopangira surfactant ndi foam accelerator ndipo imagwiritsidwa ntchito popanga zodzoladzola monga moisturizer ndi shampoo.
● Ikhoza kupititsa patsogolo kusinthasintha ndi kukhazikika kwa mankhwala, pamene ikuwongolera mphamvu ya mankhwala.
3. Makampani opanga nsalu:
● PEA imagwiritsidwa ntchito ngati chofewa, antistatic agent ndi lubricant kuti ikhale yofewa komanso yonyezimira ya nsalu komanso kuchepetsa kugundana kwamphamvu ndi zotsatira za electrostatic.
4. Makampani apulasitiki:
● Monga plasticizer, lubricant ndi dispersant, PEA imapangitsa kufewa ndi kulimba kwa mapulasitiki ndikuchepetsa kutentha kwa processing ndi kugwiritsa ntchito mphamvu.
5. Anti-kutupa ndi analgesic:
● PEA imachepetsa zizindikiro za kutupa mwa kusintha maonekedwe a majini, imakhala ndi zotsatira zotsutsa kutupa ndi zochepetsera ululu, ndipo ndi yoyenera kuchiza matenda osiyanasiyana opweteka ndi otupa.
6. Ntchito zina zomwe zingatheke:
● Pankhani ya mphamvu zatsopano, PEA ikhoza kugwiritsidwa ntchito popanga zipangizo zatsopano zamagetsi monga ma cell a dzuwa ndi mabatire a lithiamu-ion.
● Pankhani yoteteza chilengedwe, itha kugwiritsidwa ntchito popanga mapulasitiki osawonongeka, zokutira zoteteza zachilengedwe ndi zinthu zina zoteteza chilengedwe.
● Pazamankhwala, atha kugwiritsidwa ntchito popanga zinthu zopangira mankhwala monga zonyamulira mankhwala komanso zotulutsa zokhazikika.
Kugwiritsa ntchito uku kukuwonetsa kugwiritsidwa ntchito kwakukulu komanso kufunikira kwa ethanol ya palmitamide m'mafakitale angapo.
4. Zochitika zamtsogolo za Palmitoylethanolamide
Ndi kupita patsogolo kosalekeza kwa sayansi ndi ukadaulo komanso kukula kwachangu kwamakampani, magawo ogwiritsira ntchito Palmitoylethanolamide apitiliza kukula. M'tsogolomu, kugwiritsa ntchito Palmitoylethanolamide mu mphamvu zatsopano, kuteteza chilengedwe, mankhwala ndi zina zidzawonjezeka pang'onopang'ono. Mwachitsanzo, m'munda wa mphamvu zatsopano, Palmitoylethanolamide ingagwiritsidwe ntchito kupanga zipangizo zatsopano zamagetsi monga maselo a dzuwa ndi mabatire a lithiamu-ion; pankhani yachitetezo cha chilengedwe, itha kugwiritsidwa ntchito popanga zinthu zoteteza zachilengedwe monga mapulasitiki osawonongeka komanso zokutira zoteteza zachilengedwe; m'munda wamankhwala, zitha kugwiritsidwa ntchito Kupanga zida zamankhwala monga zonyamulira mankhwala ndi othandizira omasulidwa.
Kuonjezera apo, pamene kuzindikira kwa anthu za thanzi ndi chitetezo cha chilengedwe kukukulirakulirabe, ubwino ndi zofunikira za Palmitoylethanolamide zidzakhalanso zapamwamba. Choncho, kafukufuku wamtsogolo ndi chitukuko ndi kupanga Palmitoylethanolamide adzapereka chidwi kwambiri pa kuteteza chilengedwe, chitetezo ndi kukhazikika. Panthawi imodzimodziyo, kuti akwaniritse zosowa za madera osiyanasiyana, kufufuza ndi chitukuko cha zotumphukira zatsopano za Palmitoylethanolamide kudzakhalanso chitsogozo chofunikira m'tsogolomu.
PEA ndi endogenous fatty acid amide yomwe ili m'gulu la nuclear factor agonists. PEA yasonyezedwa kuti imamangiriza ku ma receptor mu nyukiliya (nyukiliya receptors) ndikuchita ntchito zosiyanasiyana zamoyo zokhudzana ndi ululu wosatha ndi kutupa. Cholinga chachikulu chimaganiziridwa kuti ndi peroxisome proliferator-activated receptor alpha (PPAR-alpha).
Suzhou Myland Pharm & Nutrition Inc. ndi wopanga olembetsedwa ndi FDA yemwe amapereka ufa wapamwamba kwambiri komanso woyeretsedwa kwambiri wa Oleoylethanolamide (OEA).
Ku Suzhou Myland Pharm tadzipereka kupereka zinthu zapamwamba kwambiri pamitengo yabwino kwambiri. Oleoylethanolamide (OEA) ufa wathu umayesedwa mwamphamvu kuti ukhale woyera ndi potency, kuonetsetsa kuti mumapeza chowonjezera chapamwamba chomwe mungakhulupirire. Kaya mukufuna kuthandizira thanzi la ma cell, kulimbikitsa chitetezo chamthupi kapena kukulitsa thanzi labwino, Oleoylethanolamide (OEA) ufa wathu ndiye chisankho chabwino kwambiri.
Ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira zokongoletsedwa bwino za R&D, Suzhou Myland Pharm yapanga zinthu zambiri zampikisano ndikukhala kampani yotsogola ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.
Kuphatikiza apo, Suzhou Myland Pharm ndiwopanganso zolembedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira zinthu, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani mumlingo, ndikutsata miyezo ya ISO 9001 ndi zopangira GMP.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Sep-27-2024
