Salidroside: Kuvumbulutsa chinsinsi cha mphamvu ya Rhodiola rosea yolimbana ndi ma antioxidants

Salidroside ndi antioxidant yachilengedwe yomwe imateteza maselo amitsempha mwa kuchotsa ROS ndikuletsa apoptosis ya maselo.

Kuchuluka kwa calcium m'maselo ndi chimodzi mwa zifukwa zazikulu zomwe zimayambitsa apoptosis ya mitsempha ya m'magazi. Chotsitsa cha Rhodiola rosea ndi salidroside zimatha kuchepetsa kuchuluka kwa calcium yaulere m'maselo chifukwa cha kupsinjika kwa okosijeni ndikuteteza maselo a cortical a anthu ku glutamate. Salidroside imatha kuletsa kuyambika kwa microglial yomwe imayambitsa lipopolysaccharide, kuletsa kupanga kwa NO, kuletsa ntchito ya inducible nitric oxide synthase (iNOS), ndikuchepetsa milingo ya TNF-α ndi IL-1β, IL-6.

Salidroside imaletsa NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) ndi response response of development ndi DNA damage 1 (REDD1)/mammalian target ya rapamycin (mTOR)/p70 ribosome. Njira yolumikizirana ya puloteni ya S6 kinase imayendetsa njira yolumikizirana ya AMP-dependent protein kinase/silent information 1, RAS homologous gene member A/MAPK ndi PI3K/Akt signaling pathways.

1. Salidroside imaletsa kuwonongeka kwa ma free radicals ndipo imateteza thupi

Thupi limatha kupanga ma free radicals enaake panthawi ya kayendetsedwe ka thupi, ndipo mlingo winawake wa ma free radicals ndi wofunikira kuti thupi lizigwira ntchito bwino. Palinso njira yochotsera ma free radicals m'thupi kuti achotse ma free radicals omwe amaposa mlingo wa thupi kuti asawononge thanzi la thupi.

Komabe, motsogozedwa ndi zinthu zina zapadera zachilengedwe, ma free radicals a m'thupi amakhala ochuluka kwambiri ndipo amaposa kuchuluka kwa ma free radicals a m'thupi, zomwe zimapangitsa kuti pakhale kusalinganika mu dongosolo lopanga ma oxygen free radicals m'thupi, zomwe zimapangitsa kuti ma oxygen free radicals adziunjikane m'thupi, zomwe zimapangitsa kuti nembanemba ya selo iwonongeke.

Kafukufuku akusonyeza kuti malo okhala ndi mpweya woipa m'malo otsetsereka angayambitse kusalinganika kwa kagayidwe ka okosijeni kopanda mpweya, kusonkhanitsa ma free radicals mkati mwa maselo ndikuwonjezera zinthu zosungunuka m'mafuta. Kafukufuku wasonyeza kuti salidroside imatha kuteteza maselo a minofu mwa kuchotsa ma free radicals m'thupi.

2. Salidroside imaletsa hypoxia kuti isunge bata la ntchito ya mitochondrial

Pafupifupi 80-90% ya okosijeni wamkati mwa maselo imagwiritsidwa ntchito popangira okosijeni wachilengedwe mu mitochondria kuti ipange ATP ndikupanga mitundu ya ROS yogwira ntchito kuti maselo azikhala ndi moyo wabwinobwino. 10-20% yokha ya okosijeni ndi yaulere kunja kwa mitochondria kuti ipange biosynthesis, degradation, biotransformation (detoxification), ndi zina zotero. Ntchito ya kupuma kwa mitochondria imakulitsidwa mu hypoxia yofatsa kapena pachiyambi cha hypoxia, yomwe imawonekera ngati yankho lobwezera la dongosolo la kupuma la thupi.

Kuchepa kwa mpweya m'thupi kwambiri kudzakhudza mpweya wakunja kwa mitochondria ndi matenda a kagayidwe kachakudya m'thupi, kuchepetsa kupanga ma neurotransmitters, ndikufooketsa mphamvu za biotransformation, motero kukhudza ntchito za minofu ndi ziwalo. Kafukufuku wasonyeza kuti salidroside ikhoza kuteteza ntchito ya mitochondria pochepetsa kuchuluka kwa ROS mu mitochondria ya maselo, kuwonjezera ntchito ya SOD, ndikuwonjezera kuchuluka kwa mitochondria.

3. Mphamvu yoteteza mtima ya salidroside

Kafukufuku wasonyeza kuti dongosolo la mtima ndi dongosolo lalikulu lomwe limasintha malo omwe ali ndi mpweya wochepa. Malo omwe ali ndi mpweya wochepa amachititsa kuti kagayidwe ka thupi m'thupi kachepe komanso mphamvu zake zisakwanire, zomwe zimapangitsa kuti zizindikiro monga kuchepa kwa mpweya m'thupi, kuchepa kwa magazi m'thupi, komanso kuchepa kwa maselo a mtima. Kafukufuku wasonyeza kuti salidroside imatha kupititsa patsogolo ntchito ya mtima ndikuwongolera kuyenda kwa magazi m'mitsempha mwa kukulitsa mitsempha yamagazi ndi mitsempha, kusintha magazi m'mitsempha, kusintha kayendedwe ka magazi m'mtima, kuchepetsa kuchuluka kwa magazi m'mtima, komanso kuchepetsa kuwonongeka kwa mtima.
Mwachidule, salidroside imatha kugwira ntchito pa dongosolo la mtima pogwiritsa ntchito njira zosiyanasiyana, njira, ndi zolinga, kuteteza apoptosis ya maselo a myocardial omwe amayamba chifukwa cha zifukwa zosiyanasiyana, ndikukonzanso vuto la ischemia ndi hypoxia m'thupi. Mu malo opanda mpweya wambiri, kulowererapo kwa Rhodiola rosea ndikofunikira kwambiri poteteza minofu ndi ziwalo za thupi ndikusunga kukhazikika kwa ntchito za maselo. Imagwira ntchito yofunika kwambiri popewa ndikuchepetsa matenda okwera.
Momwe kupanga salidroside kulili panopa

1) Kudalira kwambiri kuchotsa zomera

Rhodiola rosea ndi chinthu chopangidwa ndisalidroside.Monga mtundu wa chomera chosatha cha zomera, Rhodiola rosea imakula makamaka m'madera ozizira kwambiri, osakhala ndi mpweya wokwanira, ouma, komanso kutentha kwakukulu pakati pa usana ndi usiku pamalo okwera mamita 1600-4000. Ndi imodzi mwa zomera zakuthengo zakuthengo. China ndi imodzi mwa madera akuluakulu opanga Rhodiola rosea padziko lonse lapansi, koma moyo wa Rhodiola rosea ndi wapadera kwambiri. Sikuti zimangovuta kulima mwaluso, komanso zokolola za mitundu yakuthengo ndizochepa kwambiri. Kusiyana kwa kufunikira kwa Rhodiola rosea pachaka ndi matani 2,200.

2) Kupanga mankhwala ndi kuwiritsa kwachilengedwe

Chifukwa cha kuchuluka kochepa komanso mtengo wokwera wa zinthu zomwe zimapangidwa m'zomera, kuwonjezera pa njira zachilengedwe zochotsera zinthu, njira zopangira salidroside zimaphatikizaponso njira zopangira mankhwala, njira zopangira zinthu zamoyo, ndi zina zotero. Pakati pawo, pamene ukadaulo ukupitirira kukula, kupangira zinthu zamoyo kwakhala njira yayikulu yaukadaulo yopangira kafukufuku ndi kupanga salidroside. Pakadali pano, Suzhou Mailun wapeza zotsatira za kafukufuku ndi chitukuko ndipo wapanga mafakitale.