Salidroside: Kuwulula chinsinsi cha antioxidant ya Rhodiola rosea

Salidroside ndi antioxidant yachilengedwe yomwe imateteza maselo amitsempha mwa kuwononga ROS ndikuletsa ma cell apoptosis.

Kuchulukira kwa calcium m'thupi ndi chimodzi mwazomwe zimayambitsa neuronal apoptosis. Kutulutsa kwa Rhodiola rosea ndi salidroside kumatha kuchepetsa kuchuluka kwa calcium yaulere ya intracellular yomwe imayambitsidwa ndi kupsinjika kwa okosijeni ndikuteteza maselo amtundu wamunthu ku glutamate. Salidroside imatha kuletsa lipopolysaccharide-induced microglial activation, kuletsa NO kupanga, kuletsa inducible nitric oxide synthase (iNOS) ntchito, ndi kuchepetsa TNF-α ndi IL-1β, IL-6.

Salidroside inhibits NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) ndi regulator reaction of development and DNA damage 1 (REDD1)/mammalian target of rapamycin (mTOR)/p70 ribosome Protein S6 kinase signing pathway imayambitsa kudalira kwa AMP protein kinase/silent information regulator 1, RAS homologous gene membala wabanja A/MAPK ndi PI3K/Akt signing pathways.

1. Salidroside amatsutsana ndi kuwonongeka kwakukulu kwaufulu ndikuteteza thupi

Thupi likhoza kutulutsa kuchuluka kwa ma radicals amtundu waulere panthawi yachilengedwe, ndipo mlingo wina wokhudzana ndi ma free radicals ndiwofunikira kuti thupi lizigwira ntchito bwino. Palinso dongosolo laufulu losakaza m'thupi kuti lichotse ma radicals aulere omwe amapitilira kuchuluka kwa thupi kuti asawononge thanzi la thupi.

Komabe, mchikakamizo cha zinthu zina zapadera zachilengedwe, thupi amkati ufulu ankafuna kusintha zinthu mopitirira adzakhala mopitirira muyeso ndi kupitirira dongosolo ufulu ankafuna scavenging mlingo, kuchititsa kusalinganizika mu thupi mpweya ufulu ankafuna kusintha kwambiri dongosolo kupanga-scaveng, kumabweretsa kudzikundikira mpweya free radicals. m'thupi, potero kuwononga nembanemba ya maselo. kuwonongeka.

Kafukufuku akuwonetsa kuti chilengedwe cha hypoxic pansi pamapiri atha kuyambitsa kusalinganika kwa metabolism yopanda okosijeni, kusonkhanitsa ma intracellular free radicals ndikuwonjezera zinthu za lipid peroxidation. Kafukufuku wawonetsa kuti salidroside imatha kuteteza maselo am'minyewa pochotsa ma free radicals m'thupi.

2. Salidroside imatsutsana ndi hypoxia kuti ikhalebe yokhazikika ya mitochondrial ntchito

Pafupifupi 80-90% ya okosijeni wa intracellular amagwiritsidwa ntchito ngati okosijeni wachilengedwe mu mitochondria kupanga ATP ndikupanga mtundu wa okosijeni wa ROS kuti asunge magwiridwe antchito amoyo wama cell. 10-20% yokha ya okosijeni ndi yaulere kunja kwa mitochondria chifukwa cha biosynthesis, kuwonongeka, biotransformation (detoxification), etc. Mitochondrial kupuma kwa mpweya kumawonjezeka mu hypoxia yofatsa kapena kumayambiriro kwa hypoxia, yomwe imasonyezedwa ngati kuyankha kobwezera. thupi kupuma dongosolo.

Hypoxia yoopsa imakhudza kaye mpweya wakunja wa mitochondria ndi zovuta za kagayidwe kachakudya m'thupi, kuchepetsa kupanga ma neurotransmitters, ndikufooketsa mphamvu za biotransformation, potero zimakhudza magwiridwe antchito a minofu ndi ziwalo. Kafukufuku wasonyeza kuti salidroside ikhoza kuteteza kusungirako ntchito ya mitochondrial mwa kuchepetsa zomwe zili mu ROS mu mitochondria, kuonjezera ntchito za SOD, ndi kuonjezera chiwerengero cha mitochondria.

3. Myocardial zoteteza zotsatira za salidroside

Kafukufuku wasonyeza kuti dongosolo la mtima ndi dongosolo lalikulu lomwe limasintha malo a hypoxic. Chilengedwe cha hypoxic chidzapangitsa kuti kagayidwe ka aerobic kathupi kake kafooke komanso kusakwanira kwa mphamvu, zomwe zimapangitsa kuti pakhale zizindikiro monga hypoxia, ischemia, ndi apoptosis ya maselo a myocardial. Kafukufuku wasonyeza kuti salidroside imatha kupititsa patsogolo kugwira ntchito kwa mtima ndikusintha ma microcirculation mwa kukulitsa mitsempha yamagazi ndi venous, kuwongolera kutulutsa kwamagazi a myocardial, kusintha ma hemodynamics amtima, kuchepetsa kuchuluka kwa mtima, ndikuchepetsa kuwonongeka kwa myocardial ischemic.
Mwachidule, salidroside imatha kuchitapo kanthu pamayendedwe amtima kudzera m'njira zingapo, njira, ndi zolinga, kuteteza apoptosis ya myocardial cell chifukwa cha zifukwa zingapo, ndikuwongolera ischemia ndi hypoxia ya thupi. M'malo a hypoxic, kulowererapo kwa Rhodiola rosea ndikofunikira kwambiri kuteteza minyewa ya thupi ndi ziwalo ndikusunga kukhazikika kwa magwiridwe antchito a cell. Zimagwira ntchito yofunika kwambiri popewa komanso kuchepetsa matenda okwera.
Mkhalidwe wamakono wa kupanga salidroside

1) Muzidalira kwambiri kuchotsa mbewu

Rhodiola rosea ndi zopangira zasalidroside.Monga mtundu wa chomera chosatha cha herbaceous, Rhodiola rosea imamera makamaka m'malo omwe kuzizira kwambiri, anoxia, kuuma, komanso kusiyana kwakukulu kwa kutentha pakati pa usana ndi usiku pamtunda wa 1600-4000 metres. Ichi ndi chimodzi mwa zomera zakutchire. China ndi amodzi mwa madera omwe amapanga Rhodiola rosea padziko lapansi, koma zikhalidwe za Rhodiola rosea ndizopadera kwambiri. Sikovuta kulima mongoyerekeza, koma zokolola za mitundu yakuthengo ndizochepa kwambiri. Kusiyana kwapachaka komwe kumafuna Rhodiola rosea kumafika matani 2,200.

2) Chemical synthesis ndi kwachilengedwenso nayonso mphamvu

Chifukwa cha otsika okhutira ndi mkulu kupanga mtengo mu zomera, kuwonjezera njira m'zigawo zachilengedwe, njira kupanga salidroside monga mankhwala kaphatikizidwe njira, biological nayonso mphamvu njira, etc. Pakati pawo, monga teknoloji ikupitiriza kukhwima, kwachilengedwenso nayonso mphamvu yakhala yofala kwambiri. Njira zamakono zopangira kafukufuku ndi kupanga salidroside. Pakali pano, Suzhou Mailun wapeza zotsatira zafukufuku ndi chitukuko ndipo wapeza mafakitale.