Zipangizo zotetezeka za mitophagy ndi zosakaniza zatsopano zoletsa ukalamba - Urolithin A

Mbiri yaurolithin A (UA)Ikhoza kutsatiridwa kuyambira mu 2005. Ndi chinthu chomwe chimapezeka m'matumbo ndipo sichingawonjezeredwe mwachindunji kudzera munjira zodyera. Komabe, ma ellagitannins omwe amatsogolera ali ndi zipatso zosiyanasiyana monga mapomegranate ndi sitiroberi.

Udindo wa urolithin A

Pa Marichi 25, 2016, kafukufuku wamkulu mu magazini ya "Nature Medicine" adakopa chidwi cha omvera ku kulumikizana kwake ndi kuchedwa kwa ukalamba wa anthu. Kuyambira pomwe zidapezeka mu 2016 kuti UA imatha kukulitsa bwino nthawi ya moyo wa C. elegans, UA yakhala ikugwiritsidwa ntchito pamlingo uliwonse (maselo oyambira a hematopoietic, minofu ya khungu, ubongo (ziwalo), chitetezo chamthupi, nthawi ya moyo wa munthu aliyense) komanso m'mitundu yosiyanasiyana (C. elegans, melanogaster). Zotsatira zotsutsana ndi ukalamba zawonetsedwa bwino mu ntchentche za zipatso, mbewa, ndi anthu.

(1) Kuletsa ukalamba ndikuwongolera kugwira ntchito kwa minofu
Kafukufuku wochitidwa mwachisawawa wofalitsidwa mu JAMA Network Open, magazini yocheperako ya Journal of the American Medical Association, adawonetsa kuti kwa okalamba kapena anthu omwe ali ndi vuto losamuka chifukwa cha matenda, ma UA supplements angathandize kukonza thanzi la minofu ndikuchita masewera olimbitsa thupi ofunikira.

(2) Kuthandiza pakulimbikitsa mphamvu ya immunotherapy yolimbana ndi chotupa
Mu 2022, gulu lofufuza la Florian R. Greten kuchokera ku Georg-Speyer-Haus Institute of Tumor Biology and Experimental Therapeutics ku Germany linapeza kuti UA ikhoza kuyambitsa mitophagy mu maselo a T, kulimbikitsa kutulutsidwa kwa PGAM5, kuyambitsa njira yolumikizirana ya Wnt, ndikulimbikitsa kupangidwa kwa maselo oyambira a T, motero kulimbikitsa chitetezo chamthupi cholimbana ndi chotupa.

(3) Kuchepetsa ukalamba wa maselo oyambira a magazi ndi chitetezo chamthupi
Mu kafukufuku wa 2023, Yunivesite ya Lausanne ku Switzerland inaphunzira momwe imakhudzira dongosolo la magazi mwa kulola mbewa za miyezi 18 kudya chakudya cholemera mu urolithin A kwa miyezi 4 ndikuyang'anira kusintha kwa maselo awo amagazi mwezi uliwonse.
Zotsatira zake zinasonyeza kuti zakudya za UA zinawonjezera kuchuluka kwa maselo oyambira a hematopoietic ndi maselo oyambira a lymphoid, ndipo zinachepetsa kuchuluka kwa maselo oyambira a erythroid. Izi zikusonyeza kuti zakudyazi zitha kusintha zina mwa kusintha kwa dongosolo la hematopoietic komwe kumakhudzana ndi ukalamba.

(4) Mphamvu yoletsa kutupa
Mphamvu yoletsa kutupa ya UA ndi yamphamvu kwambiri ndipo imatha kuletsa kwambiri zinthu zosiyanasiyana zotupa monga TNF-α. Ndi chifukwa chake UA imagwira ntchito m'njira zosiyanasiyana zochizira kutupa kuphatikizapo ubongo, mafuta, mtima, matumbo ndi chiwindi. Imatha kuchepetsa kutupa m'minofu yosiyanasiyana.

(5) Chitetezo cha mitsempha
Akatswiri ena atsimikiza kuti UA imatha kuletsa njira yolumikizirana ndi mitochondria ndikuwongolera njira yolumikizirana ya p-38 MAPK, motero kuletsa apoptosis yomwe imayambitsa kupsinjika kwa okosijeni. Mwachitsanzo, UA imatha kupititsa patsogolo kuchuluka kwa ma neuron omwe amalimbikitsidwa ndi kupsinjika kwa okosijeni ndipo ili ndi ntchito yabwino yoteteza mitsempha.

(6) Zotsatira za mafuta
UA ingakhudze kagayidwe ka mafuta m'maselo ndi kupanga mafuta m'thupi. Kafukufuku wasonyeza kuti UA ingayambitse kuyambika kwa mafuta a bulauni ndi kufiira kwa mafuta oyera, pomwe imaletsa kusonkhanitsa mafuta chifukwa cha zakudya.

(7) Kuchepetsa kunenepa kwambiri
UA ingachepetsenso kuchulukana kwa mafuta m'maselo a adipocytes ndi chiwindi omwe amakula mu vitro ndikuwonjezera kukhuthala kwa mafuta. Ikhoza kusintha T4 yomwe sigwira ntchito kwambiri mu thyroxine kukhala T3 yogwira ntchito kwambiri, kukulitsa kuchuluka kwa kagayidwe kachakudya ndi kupanga kutentha kudzera mu thyroxine signaling. , motero imagwira ntchito yoletsa kunenepa kwambiri.

(8) Tetezani maso
Choyambitsa mitophagy UA chingachepetse kupsinjika kwa okosijeni mu retina yokalamba; chimachepetsa kuchuluka kwa cytosolic cGAS ndikuchepetsa kuyambitsa kwa maselo a glial mu retina yokalamba.

(9) Kusamalira khungu
Pakati pa zinthu zonse zomwe zimapezeka m'matumbo a nyama zoyamwitsa, UA ili ndi mphamvu yolimbana ndi ma antioxidants, yachiwiri pambuyo pa proanthocyanidin oligomers, catechins, epicatechin ndi 3,4-dihydroxyphenylacetic acid.

Zitsanzo za kugwiritsa ntchito Urolithin A

Mu 2018, UA idasankhidwa ndi US Food and Drug Administration ngati chinthu chodyedwa "chodziwika kuti ndi chotetezeka" ndipo chitha kuwonjezeredwa ku ma protein shake, zakumwa zosinthira chakudya, oatmeal yomweyo, ma protein bar ndi zakumwa za mkaka (mpaka 500 mg/kutumikira)), Greek yogurt, yogurt yokhala ndi mapuloteni ambiri ndi ma milk protein shake (mpaka 1000 mg/kutumikira).

UA ikhozanso kuwonjezeredwa ku zinthu zosamalira khungu, kuphatikizapo mafuta odzola masana, mafuta odzola usiku ndi seramu, zomwe zimapangidwa kuti ziwonjezere madzi m'thupi la khungu ndikuchepetsa kwambiri makwinya, kukonza kapangidwe ka khungu kuyambira mkati mpaka kunja, komanso kuthana ndi zizindikiro zooneka za ukalamba. , zomwe zimathandiza khungu kukhala lachinyamata.

Njira yopangira Urolithin A

(1) Njira yowiritsa
Kupanga kwa malonda kwa UA kumachitika koyamba kudzera muukadaulo wa fermentation, womwe umapangidwa makamaka kuchokera ku makoko a mapomegranate ndipo uli ndi urolithin A yoposa 10%.
(2) Njira yopangira mankhwala
Ndi luso lopitilira komanso chitukuko cha kafukufuku, kupanga mankhwala ndi njira yofunika kwambiri yopangira urolithin A m'mafakitale. Suzhou Myland Pharm ndi kampani yatsopano yowonjezera zamoyo, yopanga zinthu mwamakonda komanso yopangira zinthu yomwe ingapereke ufa wa urolithin A woyeretsedwa kwambiri komanso waukulu.