Zida zotetezedwa za mitophagy & zowonjezera zotsutsana ndi ukalamba-Urolithin A

Mbiri yaurolithin A (UA)ikhoza kutsatiridwa ku 2005. Ndi metabolite ya tizilombo tating'onoting'ono ta m'mimba ndipo sitingathe kuthandizidwa mwachindunji kudzera mu njira za zakudya. Komabe, kalambulabwalo wake ellagitannins ali wolemera mu zipatso zosiyanasiyana monga makangaza ndi sitiroberi.

Udindo wa urolithin A

Pa Marichi 25, 2016, kafukufuku wamkulu m'magazini ya "Nature Medicine" adakopa chidwi cha omvera kuti agwirizane ndi kuchedwetsa kukalamba kwa anthu. Popeza zinadziwika mu 2016 kuti UA imatha kukulitsa moyo wa C. elegans, UA yakhala ikugwiritsidwa ntchito pamagulu onse (ma cell a hematopoietic stem, minyewa yapakhungu, ubongo (ziwalo), chitetezo chamthupi, moyo wamunthu aliyense) komanso zamoyo zosiyanasiyana. (C. elegans, melanogaster Zotsatira zotsutsana ndi ukalamba zasonyezedwa kwambiri mu ntchentche za zipatso, mbewa, ndi anthu.

(1) Anti-kukalamba ndi kupititsa patsogolo minofu ntchito
Chiyeso chachipatala chosasinthika chomwe chinafalitsidwa mu JAMA Network Open, nyuzipepala yothandizira ya Journal of the American Medical Association, inasonyeza kuti kwa okalamba kapena anthu omwe amavutika kuyenda chifukwa cha matenda, UA supplements angathandize kusintha thanzi la minofu ndi kuchita masewera olimbitsa thupi ofunikira.

(2) Thandizani kukulitsa luso la anti-chotupa la immunotherapy
Mu 2022, gulu lofufuza la Florian R. Greten wochokera ku Georg-Speyer-Haus Institute of Tumor Biology and Experimental Therapeutics ku Germany adapeza kuti UA ikhoza kuyambitsa mitophagy m'maselo a T, kulimbikitsa kumasulidwa kwa PGAM5, kuyambitsa njira yowonetsera Wnt, ndi kulimbikitsa maselo a T memory stem. kupanga, potero kulimbikitsa chitetezo chokwanira cha anti-chotupa.

(3) Sinthani kukalamba kwa maselo amtundu wa hematopoietic ndi chitetezo chamthupi
Mu kafukufuku wa 2023, yunivesite ya Lausanne ku Switzerland inaphunzira momwe imakhudzira dongosolo la hematopoietic polola mbewa za miyezi 18 kudya chakudya cholemera cha urolithin A kwa miyezi 4 ndikuwunika kusintha kwa maselo awo a magazi mwezi uliwonse. Chikoka.
Zotsatira zake zidawonetsa kuti zakudya za UA zimachulukitsa kuchuluka kwa maselo amtundu wa hematopoietic ndi ma lymphoid progenitor cell, ndikuchepetsa kuchuluka kwa maselo a erythroid. Kupeza uku kumasonyeza kuti chakudyachi chikhoza kusintha kusintha kwina kwa hematopoietic system yokhudzana ndi ukalamba.

(4) Anti-inflammatory effect
Ntchito yotsutsa-kutupa ya UA ndi yamphamvu kwambiri ndipo imatha kuletsa kwambiri zinthu zosiyanasiyana zotupa monga TNF-α. Ndi chifukwa chake UA imagwira ntchito pazamankhwala osiyanasiyana otupa kuphatikiza ubongo, mafuta, mtima, matumbo ndi chiwindi. Ikhoza kuthetsa kutupa m'magulu osiyanasiyana.

(5) Neuroprotection
Akatswiri ena atsimikizira kuti UA imatha kuletsa njira ya apoptosis yokhudzana ndi mitochondria ndikuwongolera njira yolozera ya p-38 MAPK, potero kuletsa apoptosis yoyambitsa kupsinjika kwa okosijeni. Mwachitsanzo, UA imatha kusintha kuchuluka kwa kupulumuka kwa ma neuron omwe amalimbikitsidwa ndi kupsinjika kwa okosijeni ndipo amakhala ndi ntchito yabwino yoteteza mitsempha.

(6) Zotsatira zamafuta
UA imatha kukhudza lipid metabolism ndi lipogenesis. Kafukufuku wasonyeza kuti UA ikhoza kuyambitsa kuyambitsa kwamafuta a bulauni ndi kuyanika kwamafuta oyera, ndikuletsa kudzikundikira kwamafuta chifukwa cha zakudya.

(7) Kuchepetsa kunenepa kwambiri
UA imathanso kuchepetsa kudzikundikira kwamafuta mu adipocytes ndi maselo a chiwindi otukuka mu vitro ndikuwonjezera okosijeni wamafuta. Itha kusintha T4 yocheperako mu thyroxine kukhala T3 yogwira kwambiri, kupititsa patsogolo kagayidwe kachakudya ndi kupanga kutentha kudzera mu siginecha ya thyroxine. , motero kumathandiza kuchepetsa kunenepa.

(8) Tetezani maso
The mitophagy inducer UA ikhoza kuchepetsa kupsinjika kwa okosijeni mu retina wokalamba; imachepetsa mulingo wa cytosolic cGAS ndikuchepetsa kuyatsa kwa ma cell a glial mu retina yakale.

(9) Kusamalira khungu
Pakati pa zonse zomwe zimapezeka m'matumbo a mammalian metabolites, UA ili ndi antioxidant yamphamvu kwambiri, yachiwiri ku proanthocyanidin oligomers, katekisimu, epicatechin ndi 3,4-dihydroxyphenylacetic acid. dikirani.

Urolithin A zochitika zogwiritsira ntchito

Mu 2018, UA idasankhidwa ndi US Food and Drug Administration ngati chinthu chodyedwa "chodziwika kuti ndi chotetezeka" ndipo chitha kuwonjezeredwa ku ma protein, zakumwa zolowa m'malo, oatmeal pompopompo, zopatsa thanzi zama protein ndi zakumwa zamkaka (mpaka 500 mg). / kutumikira) ), yogati yachi Greek, yoghurt yokhala ndi mapuloteni ambiri komanso mapuloteni amkaka (mpaka 1000 mg / kutumikira).

UA ikhoza kuwonjezeredwa kuzinthu zosamalira khungu, kuphatikizapo zodzoladzola zamasiku, zopaka usiku ndi zosakaniza za seramu, zomwe zimapangidwira kupititsa patsogolo madzi a khungu ndi kuchepetsa kwambiri makwinya, kusintha khungu kuchokera mkati, ndikumenyana bwino ndi zizindikiro zowoneka za ukalamba. , kuthandiza khungu kukhala lachinyamata.

Njira yopanga Urolithin A

(1) Njira yowotchera
Kupanga malonda kwa UA kumachitika koyamba kudzera muukadaulo wa fermentation, womwe umakhala wofufumitsa kuchokera ku ma peel a makangaza ndipo uli ndi urolithin A woposa 10%.
(2) Chemical synthesis process
Ndi kupitilira kwatsopano komanso chitukuko cha kafukufuku, kaphatikizidwe ka mankhwala ndi njira yofunikira yopangira mafakitale a urolithin A. Suzhou Myland Pharm ndi njira yowonjezera ya sayansi ya moyo, kaphatikizidwe kazinthu ndi kampani yopanga ntchito zomwe zimatha kupereka urolithin A wapamwamba kwambiri, wochuluka kwambiri. ufa zopangira.