Zosakaniza zachilengedwe zikuchulukirachulukira m'makampani amasiku ano ofufuza asayansi ndi azamankhwala. 7,8-Dihydroxyflavone (7,8-Dihydroxyflavone), monga chinthu chofunika kwambiri chochokera ku zomera, chakopa chidwi cha anthu ambiri chifukwa cha ntchito yake yofunika kwambiri yamoyo. Kwa ofufuza asayansi ndi mabizinesi, ndikofunikira kupeza ogulitsa odalirika a 7,8-Dihydroxyflavone Powder. Ufa wa 7,8-Dihydroxyflavone woperekedwa ndi Suzhou Myland uli nawochiwerengero cha CAS cha 38183-03-8 ndi chiyero mpaka 98%, kukupatsani chosankha chodalirika.
7,8-Dihydroxyflavone(yomwe imadziwikanso kuti 7,8-DHF kapena proflavonoid) ndi molekyulu yochitika mwachilengedwe yomwe ili m'gulu la ma flavonoid. Amapezeka m'masamba a Godmania aesculifolia, Tridax procumbens ndi primula.
7,8-DHF ndi organic pawiri ndi molecular formula C15H10O4. Imasungunuka mu zosungunulira za organic ndipo imakhala ndi mtundu, fungo ndi kukoma kogwirizana ndi ma flavonoid.
7,8-DHF yatulukira ngati gulu lodalirika la nootropic. Zawonetsa zotsatira zingapo za neuropharmacological mu maphunziro a preclinical, kuphatikiza kuwongolera kukumbukira, kulimbikitsa neurogenesis ndi kupewa neurodegeneration.
Monga agonist yamphamvu komanso yosankha ya mamolekyu ang'onoang'ono a tropomyosin receptor kinase B (TrkB), proflavin yawonetsa mphamvu mu zitsanzo za nyama motsutsana ndi matenda osiyanasiyana, kuphatikiza matenda a Alzheimer's.
Flavonoids ndi gulu la mankhwala a polyphenolic omwe amapezeka mumitundu yosiyanasiyana ya zipatso, masamba, ndi zomera zina. M'zaka zaposachedwa, adalandira chidwi kwambiri chifukwa cha antioxidant, anti-inflammatory, and neuroprotective properties.
Mankhwalawa awonetsedwa kuti ali ndi phindu paubongo, kuphatikizapo kupititsa patsogolo chidziwitso komanso kupewa matenda a neurodegenerative. 7,8-DHF ndi imodzi mwazinthu zodziwika bwino za polyphenolic zomwe zimalandira chidwi chowonjezereka ngati nootropic. Zaphunziridwa chifukwa cha zotsatira zake pamalingaliro, kukumbukira, kuphunzira, nkhawa, ndi ntchito zina zanzeru.
Zotsatira za minyewa za 7,8-DHF zimaganiziridwa kuti zimalumikizidwa ndi kuyanjana kwake ndi zolandilira zenizeni. Zapezeka kuti ndi TrkA, cholandirira chomwe chimakhudzidwa ndi chizindikiro cha kukula kwa mitsempha komanso chofunikira pakupulumuka kwa neuronal ndi pulasitiki.
7,8-DHF imachita mwa kuwongolera mafotokozedwe a zolandilira zosiyanasiyana, kuphatikiza ma glutamate receptor subunits ndi BDNF. Zimakhudzanso mapangidwe a synapse, mphamvu ya metabolism, ndi kutulutsidwa kwa acetylcholine m'madera ena a ubongo.
Kafukufuku wa 7,8-dihydroxyflavone wakula kukhala zotsatira zake pa thanzi la munthu, makamaka kuyang'ana momwe amatsanzira ntchito ya ubongo-derived neurotrophic factor (BDNF), puloteni yofunikira kuti ubongo ukhale ndi moyo ndi ntchito. cha protein.
Pakugwiritsiridwa ntchito kwake, 7,8-DHF yafufuzidwa kuti igwiritsidwe ntchito pochiza matenda a ubongo chifukwa cha mphamvu yake yodutsa malire a ubongo.
7,8-Dihydroxyflavone imapezeka mwachilengedwe mumitundu yosiyanasiyana yazakudya, kuphatikiza:
●Zipatso: maapulo, zipatso, mphesa ndi zipatso za citrus
●Zamasamba: anyezi, kale, broccoli ndi sipinachi
● Zitsamba: Parsley, thyme ndi oregano
Kuphatikiza pa zinthu zachilengedwe izi, 7,8-DHF ikupezekanso mu fomu yowonjezera kuti idye mosavuta komanso yokonzekera.
Phunzirani za flavonoids
Flavonoids ndi mankhwala a polyphenolic omwe amagwira ntchito yofunika kwambiri pakupanga mtundu wamtundu, kusefa kwa UV, komanso kukana matenda. Amagawidwa m'magulu angapo, kuphatikizapo flavonols, flavones, isoflavones, flavanones, ndi anthocyanins. Kagulu kakang'ono kalikonse kali ndi mitundu yosiyanasiyana yamankhwala ndi zochitika zamoyo, zomwe zimapangitsa kuti pakhale mapindu osiyanasiyana azaumoyo.
7,8-dihydroxyflavone ndi chiyani?
7,8-Dihydroxyflavone ndi mtundu wapadera wa flavonoid womwe uli wa flavonoid subclass. Kapangidwe kake kake kamakhala ndi magulu awiri a hydroxyl pamalo 7 ndi 8 a msana wa flavonoid, womwe umayang'anira mawonekedwe ake apadera. Pawiriyi imapezeka makamaka muzomera monga dioscorea (yam) ndipo yaphunziridwa chifukwa cha zotsatira zake za neuroprotective, anti-inflammatory properties, ndi chidziwitso cha chidziwitso.
Kusiyana Kwakukulu Pakati pa 7,8-DHF ndi Flavonoids Zina
1. Kapangidwe ka mankhwala
Kusiyana koonekeratu pakati pa 7,8-DHF ndi ma flavonoid ena ndi kapangidwe kake ka mankhwala. Ngakhale ma flavonoids ambiri amagawana msana wofanana, kupezeka kwa magulu a hydroxyl pamalo enaake kumatha kukhudza kwambiri ntchito yawo yachilengedwe. Mwachitsanzo, quercetin, flavonol yodziwika bwino, ili ndi makonzedwe osiyanasiyana a magulu a hydroxyl, omwe amakhudza kusungunuka kwake ndi kugwirizana ndi zolinga zamoyo.
2. Zochitika zamoyo
7,8-DHF yawonetsedwa kuti ili ndi zochitika zapadera zachilengedwe poyerekeza ndi ma flavonoids ena. Kafukufuku akuwonetsa kuti imayambitsa njira yolozera ya neurotrophic factor (BDNF) yochokera ku ubongo, yomwe ndi yofunika kwambiri kuti ma neuron apulumuke, kukula ndi kusiyanitsa. Njirayi ndiyofunikira makamaka pankhani ya matenda a neurodegenerative komanso kuchepa kwa chidziwitso.
Mosiyana ndi izi, ma flavonoid ena monga makatekini (omwe amapezeka mu tiyi wobiriwira) ndi anthocyanins (omwe amapezeka mu zipatso) amagwira ntchito makamaka kudzera muzochita za antioxidant, kuwononga ma radicals aulere komanso kuchepetsa kupsinjika kwa okosijeni. Ngakhale kuti zinthuzi ndi zothandiza, sizingakhudze mwachindunji zinthu za neurotrophic monga momwe 7,8-DHF imachitira.
3. Bioavailability
Kupezeka kwa bioavailability kumatanthawuza kuchuluka ndi kuchuluka komwe chinthu chogwira ntchito kapena gawo logwira ntchito limatengedwa ndikupezeka pamalo ochitirapo kanthu. 7,8-DHF yasonyeza bioavailability wabwino mu maphunziro a nyama, kusonyeza kuti akhoza efficiently kuwoloka chotchinga magazi-muubongo, amene n'kofunika kwambiri chifukwa neuroprotective zotsatira zake.
Mosiyana ndi izi, bioavailability ya flavonoids ina imatha kusiyanasiyana. Mwachitsanzo, ngakhale kuti quercetin imagwiritsidwa ntchito kwambiri, kuyamwa kwake nthawi zambiri kumakhala kochepa chifukwa cha metabolism yake yofulumira. Kusiyana kumeneku kwa bioavailability kumakhudza mphamvu ya mankhwalawa kuti akwaniritse zotsatira zomwe akufuna.
7,8-DHF Njira yochitira: BDNF regulation ndi Trkb receptor activation
Pogwiritsa ntchito njira zogwirira ntchito, 7,8-DHF imadziwika kuti imalimbikitsa kupanga BDNF (brain-derived neurotrophic factor) pomangirira ndi kuyambitsa receptor yake TrkB. Popanda ukadaulo kwambiri, izi zimabweretsa kuchulukira kwa zochitika zama cell zomwe zimakhala zopindulitsa pakusunga magwiridwe antchito a neuronal ndikulimbikitsa neurogenesis.
7,8-DHF njira yayikulu yochitira:
(1) Ubongo-derived neurotrophic factor (BDNF) ndi gawo lake mu neuroplasticity
Kupeza kuti mawu opangidwa ndi ubongo wa neurotrophic factor (BDNF) amachepetsedwa m'matenda a neurodegenerative, makamaka matenda a Alzheimer's (AD), kufunika kwake pakusunga ndi kupititsa patsogolo thanzi laubongo kukuwonekera kwambiri.
BDNF ndi yofunika kwambiri pa ntchito zosiyanasiyana za neuronal monga momwe imathandizira kufalitsa kwa synaptic, synaptogenesis, ndi synaptic plasticity kupyolera mu chizindikiro ndi TrkB receptors. Izi zimapangitsa njira yowonetsera BDNF-TrkB kukhala chandamale chothandizira pakupanga njira zochiritsira zomwe cholinga chake ndi kuthana ndi matenda a neurodegenerative.
(2) Tropomyosin receptor kinase B (Trkb) receptor chizindikiro njira
The tropomyosin receptor kinase B (TrkB) receptor imagwira ntchito yofunika kwambiri pakuyanjanitsa zotsatira za BDNF pa neurons. Monga transmembrane tyrosine kinase receptor, TrkB ndiye cholandilira chachikulu cha BDNF ndipo imayambitsa kuchulukira kwa zochitika zamasiginidwe amkati mwa cell zikamangika ku neurotrophic factor.
BDNF imayatsa TrkB kuyambitsa njira zingapo zofunika zamkati mwa cell, kuphatikiza phosphatidylinositol 3-kinase (PI3K)-Akt, mitogen-activated protein kinase (MAPK) -extracellular signal-regulated kinase (ERK), ndi phospholipase Cγ (PLCγ) -protein kinase ( PKC) njira. Iliyonse mwa njirazi imathandizira mbali yosiyana ya ntchito ya neuronal ndikukhala bwino.
Njira ya PI3K-Akt ndiyofunikira pakulimbikitsa kupulumuka kwa neuronal ndikuletsa apoptosis. Kuzindikiritsa kwa BDNF-TrkB kumayambitsa njira iyi kuti iwonjezere kupulumuka kwa ma cell poletsa zinthu zomwe zimathandizira pa apoptotic ndikulimbikitsa anti-apoptotic factor, potero kuonetsetsa kuti ma neuron athanzi asungidwa.
Kumbali inayi, njira ya MAPK-ERK imakhala ndi gawo lofunikira pakusiyanitsa ndi kufalikira kwa ma neuronal. Kuzindikiritsa kwa BDNF-TrkB kumalimbikitsa kuyambitsa kwa njira ya MAPK-ERK, yomwe imathandizira kusasitsa kwa neuronal ndi kusiyanitsa komanso kuphatikiza kwawo mu maukonde omwe alipo kale.
Njira ya PLCγ-PKC ndiyofunikira pakuwongolera pulasitiki ya synaptic, njira yofunikira yophunzirira ndi kukumbukira. BDNF-TrkB siginecha imasintha machitidwe anjirayi, zomwe zimapangitsa kusintha kwa mphamvu ya synaptic ndi kulumikizana.
Kusinthasintha uku kumalimbikitsa kusintha ndi kukonzanso kwa ma neural circuits potsatira zochitika zatsopano komanso zolimbikitsa zachilengedwe.
Pochita ngati TrkB agonist, 7,8-DHF imakhala ndi zotsatira zake za nootropic makamaka poyang'anira njira zowonetsera zokhudzana ndi BDNF, motero zimalimbikitsa neurogenesis ndi kupititsa patsogolo synaptic plasticity.
Mwa kutsanzira zotsatira za BDNF, 7,8-DHF imathandiza kuteteza ma neuroni kuti asawonongeke, amalimbikitsa kupulumuka kwawo, ndikulimbikitsa kukula ndi kukonzanso kwa ma neuronal atsopano. Kuthekera kumeneku kolimbikitsa neuroplasticity, kupititsa patsogolo ntchito zachidziwitso, komanso kuthetsa zizindikiro za matenda amisempha kumapangitsa 7,8-DHF kukhala munthu wodalirika pakupanga mankhwala ndi kufufuza kwina.
7,8-DHF Mapindu a Nootropic: Kupititsa patsogolo Chidziwitso ndi Neuroprotection
Ponena za maubwino ake a nootropic, 7,8-DHF imagwira ntchito kudzera munjira zazikulu zinayi:
Kuphatikiza kukumbukira ndi kubwezanso: ntchito yodalira hippocampus
7,8-DHF yapezeka kuti imathandizira kuphatikiza kukumbukira ndi kubwezanso m'maphunziro osiyanasiyana odalira hippocampus ndi kukumbukira ntchito zamakoswe. Zotsatirazi zikusonyeza kuti 7,8-DHF ikhoza kukhala nootropic yodalirika, Ikhoza kugwiritsidwa ntchito kupititsa patsogolo ntchito ya kukumbukira kwa anthu athanzi komanso omwe ali ndi vuto la kukumbukira.
Synaptic plasticity: kuthekera kwanthawi yayitali komanso kukhumudwa
7,8-DHF yasonyezedwa kuti imayendetsa pulasitiki ya synaptic polimbikitsa LTP ndi kuchepetsa LTD mu hippocampus. Zotsatirazi zimaganiziridwa kuti zimayanjanitsidwa ndi kuthekera kwake kuyambitsa zolandilira za TrkB kenako ndikukulitsa njira yolumikizira ya BDNF. Kusinthika kwa synaptic plasticity kumathandizira kuwongolera kwachidziwitso komwe kumawonedwa kutsatira 7,8-DHF.
Antioxidant katundu: ROS scavenging ndi lipid peroxidation
7,8-DHF ili ndi antioxidant katundu monga umboni ndi mphamvu yake scavenge reactive oxygen mitundu (ROS) ndi kuchepetsa lipid peroxidation. Zotsatirazi zimathandizira ku zotsatira zake za neuroprotective pochepetsa kuwonongeka kwa neuronal komwe kumayambitsidwa ndi okosijeni komanso kusagwira ntchito bwino.
Anti-inflammatory effect: imayang'anira kuyambitsa kwa microglial ndi kupanga cytokine
Kuphatikiza pa antioxidant katundu wake, 7,8-DHF yapezeka kuti imakhala ndi zotsatira zotsutsa-kutupa mwa kusintha ma microglial activation ndi kuchepetsa kupanga ma cytokines oyambitsa kutupa monga TNF-α ndi IL-1β. Izi zimathandiziranso ku zotsatira zake za neuroprotective ndi nootropic poletsa kuwonongeka kwapakatikati kwa neuronal.
Pamene mukuyang'ana wogulitsa wa7,8-DihydroxyflavonePowder, mutha kuganizira izi:
1. Mbiri ya ogulitsa
Kusankha wogulitsa yemwe ali ndi mbiri yabwino ndikofunikira. Mutha kudziwa mbiri ya ogulitsa poyang'ana ndemanga zamakasitomala, malipoti amakampani, ndi mabwalo akatswiri. Suzhou Myland ali ndi mbiri yabwino pamsika, ndi mayankho abwino amakasitomala komanso mtundu wazinthu zodziwika bwino.
2. Makhalidwe abwino
Onetsetsani kuti zinthu zoperekedwa ndi ogulitsa zikugwirizana ndi miyezo yapadziko lonse lapansi komanso zofunikira pakuwongolera khalidwe. Suzhou Myland 7,8-Dihydroxyflavone Powder yayesedwa kwambiri ndipo ili ndi chiyero mpaka 98%, kuwonetsetsa kuti malondawo akuyenda bwino komanso otetezeka.
3. Chitsimikizo ndi Kutsatira
Kusankha wogulitsa ndi GMP (Good Manufacturing Practice) ndi satifiketi ya ISO kumawonetsetsa kuti kupanga kwake kumakwaniritsa miyezo yapadziko lonse lapansi. Suzhou Myland imatsatira mosamalitsa mfundo izi kuti zitsimikizire kukhazikika komanso kusasinthika kwa gulu lililonse lazinthu.
4. Thandizo laukadaulo ndi ntchito
Wothandizira wodalirika ayenera kupereka chithandizo chaukadaulo chaukadaulo komanso ntchito yamakasitomala. Suzhou Myland ili ndi gulu laukadaulo lomwe limatha kupatsa makasitomala malingaliro ogwiritsira ntchito malonda ndi chitsogozo chaukadaulo kuthandiza makasitomala kupeza zotsatira zabwino pakufufuza ndi kugwiritsa ntchito.
5. Mtengo ndi nthawi yobweretsera
Mtengo ndi nthawi yobweretsera ndizofunikanso kuganizira posankha wogulitsa. Mutha kupempha ma quotes kuchokera kwa ogulitsa angapo ndikuyerekeza mitengo yawo ndi nthawi yobweretsera kuti mupeze njira yoyenera kwambiri. Suzhou Myland
imapereka mitengo yopikisana komanso nthawi zosinthika zoperekera ndikuwonetsetsa kuti zinthu zili bwino.
Momwe Mungapezere Ufa wa 7,8-Dihydroxyflavone
Ngati mukuyang'ana Ufa wapamwamba kwambiri wa 7,8-Dihydroxyflavone, Suzhou Myland ndiye chisankho chanu chabwino. Mutha kulumikizana nafe kudzera:
Webusaiti yovomerezeka: Pitani kutsamba lovomerezeka la Suzhou Mylandkuti mudziwe zambiri zamalonda ndi chithandizo chaukadaulo.
Kufunsira pa intaneti: Lumikizanani mwachindunji ndi gulu lathu lothandizira makasitomala kudzera munjira yolumikizirana pa intaneti yoperekedwa ndi webusayiti kuti mupeze zambiri zamalonda ndi mawu omwe mukufuna.
Kuyimba foni: Imbani nambala yathu kuti mulankhule ndi akatswiri ogulitsa ndikupeza zambiri zamalonda ndi malingaliro ogula.
Kufunsa pa imelo: Mutha kutifunsanso zambiri zamalonda kudzera pa imelo, ndipo tidzakuyankhani posachedwa.
Kupeza odalirika a 7,8-Dihydroxyflavone Powder ogulitsa sikophweka, koma mwa kumvetsera mbiri ya wogulitsa, khalidwe la mankhwala, chivomerezo ndi kutsata, chithandizo chaumisiri ndi ntchito, komanso mtengo ndi nthawi yobweretsera, mukhoza kupanga chisankho chanzeru. kusankha. Suzhou Myland ndi mnzako wabwino kwambiri wokhala ndi Ufa woyenga kwambiri wa 7,8-Dihydroxyflavone komanso ntchito yabwino kwambiri yamakasitomala. Tikuyembekezera kugwira ntchito nanu kuti tiwone momwe mungagwiritsire ntchito 7,8-Dihydroxyflavone.
Q:Kodi proflavin imathandizira kuphunzira?
A: Inde, proflavin yasonyezedwa kuti imakulitsa luso la kuphunzira m'maphunziro a nyama polimbikitsa kulumikizana kwa neurogenesis ndi synaptic. Imawongolera machitidwe a neurotransmitter omwe ndi ofunikira kwambiri pakuphunzira, makamaka mu hippocampus, gawo lofunikira muubongo pophunzira.
Q: Kodi 7,8-DHF imathandizira kuchira kwachidziwitso pambuyo povulala?
A: Inde, kafukufuku wachipatala amasonyeza kuti 7,8-DHF ingathandize kuchira kwachidziwitso pambuyo pa kuvulala kwa ubongo mwa kulimbikitsa chitetezo cha mitsempha ndi kusinthika kwa ubongo. Amachepetsa kufa kwa neuronal ndipo amathandizira kukula kwa ma neuroni atsopano, zomwe zitha kupititsa patsogolo chidziwitso chosokonekera chifukwa cha kuvulala kapena kuvulala kwa ischemic.
Q:Kodi 7,8-dihydroxyflavone imagwira ntchito yanji pakuchepa kwa chidziwitso chokhudzana ndi ukalamba?
A: Kafukufuku wotulukapo akuwonetsa kuti 7,8-DHF ikhoza kuchedwetsa kuchepa kwachidziwitso komwe kumakhudzana ndi ukalamba poteteza kupsinjika kwa okosijeni ndi kutupa, zomwe zimafala m'matenda okhudzana ndi ukalamba.
Mwa kukulitsa milingo ya BDNF ndi kuyambitsa kwa TrkB receptor, kumathandizira kukhalabe olimba mtima, ngakhale maphunziro ochulukirapo aumunthu amafunikira kuti afufuze bwino izi.
Q:Kodi 7,8-DHF imathandizira chidwi ndi ntchito yayikulu?
A: Maphunziro oyambirira a zinyama akusonyeza kuti 7,8-DHF ikhoza kupititsa patsogolo chidwi ndi ntchito yaikulu mwa kupititsa patsogolo malamulo a neurotransmitter ndi kugwirizana kwa mitsempha m'madera a ubongo omwe akukhudzidwa ndi izi.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Oct-16-2024
