Dzina la sayansi la NAD ndi nicotinamide adenine dinucleotide. NAD+ imapezeka mu selo iliyonse ya thupi lathu. Ndi metabolite yofunika kwambiri komanso coenzyme m'njira zosiyanasiyana za kagayidwe kachakudya. Imagwira ntchito ndikuchita nawo machitidwe osiyanasiyana a zamoyo. Ma enzyme opitilira 300 amadalira NAD+ kuti igwire ntchito. Komabe, kuchuluka kwa NAD+ sikusinthasintha. Pamene tikukalamba, kuchuluka kwa NAD+ m'maselo kumachepa. Makamaka tikakwanitsa zaka 30, kuchuluka kwa NAD+ kumatsika kwambiri, zomwe zimapangitsa kuti ntchito zambiri zichepe ndipo motero zimasonyeza zizindikiro za ukalamba. Nicotinamide riboside chloride ndi mtundu wa vitamini B3. Nicotinamide riboside chloride imatha kusinthidwa kukhala NAD+ (nicotinamide adenine dinucleotide). Ndi imodzi mwa zinthu zomwe zimaphunziridwa kwambiri za NAD+. Imayamwa mosavuta ndi thupi ndikugwiritsa ntchito. Kafukufuku wambiri wasonyeza kuti kuwonjezera NRC kumatha kuwonjezera kuchuluka kwa NAD+, komwe kungabweretse phindu ku kagayidwe kachakudya, mtima ndi mitsempha. Nthawi zambiri imagwiritsidwa ntchito ngati chowonjezera pazakudya kuti ilimbikitse thanzi lonse komanso thanzi labwino.
Nicotinamide riboside chloride (NRC) ndi chinthu chochokera ku vitamini B3 komanso chinthu chatsopano chomwe chimagwira ntchito m'thupi. Chimapangidwa ndi ribose ya shuga ndi nicotinamide yomwe ili mu vitamini B3 (yomwe imadziwikanso kuti nicotinic acid kapena vitamini B3). Itha kudyedwa podya nyama, nsomba, chimanga ndi zakudya zina kapena kudzera mu zowonjezera za NRC.
Nicotinamide ribose chloride ikhoza kusinthidwa kukhala NAD+ (nicotinamide adenine dinucleotide) ndikuchita ntchito zamoyo mkati mwa maselo. NAD+ ndi coenzyme yofunika kwambiri yamkati mwa maselo yomwe imagwira ntchito zosiyanasiyana m'maselo, kuphatikizapo kupanga mphamvu, kukonza DNA, kuchulukana kwa maselo, ndi zina zotero. Pa nthawi ya ukalamba wa thupi la munthu, kuchuluka kwa NAD+ kumachepa pang'onopang'ono. Kuwonjezera kwa Nicotinamide riboside chloride kumatha kuwonjezera kuchuluka kwa NAD+, komwe kukuyembekezeka kuchedwetsa kukalamba kwa maselo ndi matenda ena okhudzana nawo.
Kafukufuku wokhudza nicotinamide riboside chloride wasonyeza kuti ili ndi zochita zambiri zamoyo, monga:
Kupititsa patsogolo kagayidwe ka mphamvu, kulimbitsa kupirira ndi kuchita masewera olimbitsa thupi;
Kupititsa patsogolo ntchito ya mitsempha ndi kukumbukira;
Kulimbitsa ntchito ya chitetezo chamthupi.
Ponseponse, nicotinamide riboside chloride ndi chosakaniza chabwino kwambiri cha zakudya chomwe chingagwiritsidwe ntchito m'njira zosiyanasiyana.
Kuphatikiza apo, nicotinamide ribose chloride imagwiritsidwanso ntchito kwambiri mu kafukufuku wa sayansi. Monga chinthu choyambirira cha NAD+, ingagwiritsidwe ntchito kuphunzira za biosynthesis ndi njira za kagayidwe kachakudya ka NAD+ ndi zina zokhudzana nazo. Nthawi yomweyo, nicotinamide riboside chloride imagwiritsidwanso ntchito ngati chosakaniza mu zinthu zaumoyo ndi zodzoladzola kuti ilimbikitse thanzi la maselo ndikuchepetsa ukalamba wa khungu.
Ukalamba ndi nkhani yosatha kwa anthu. Malinga ndi kafukufuku wa asayansi, ukalamba wa maselo umagwirizana kwambiri ndi kuchepa kwa nicotinamide adenine dinucleotide (NAD). NAD ndi chinthu chofunikira kwambiri pa kagayidwe kachakudya ndi kukonzanso maselo m'thupi la munthu. Sikuti imangochedwetsa ukalamba, komanso imasunga mphamvu za maselo ndikusunga thanzi la thupi ndi maganizo. Koma pamene tikukalamba, kuchuluka kwa NAD m'matupi athu kumachepa mofulumira komanso mofulumira, ndipo kungachepe ndi theka la zaka zapakati pa 40 ndi 80.
Pali enzyme yofunika kwambiri m'thupi lathu, yomwe ndi gawo lalikulu la kagayidwe ka mphamvu m'maselo. Kodi ndi yofunika bwanji? Pafupifupi njira zonse zomwe zimasunga magwiridwe antchito abwinobwino a thupi, monga kagayidwe kachakudya, kukonzanso, ndi chitetezo chamthupi, zimafuna kuti enzyme iyi igwire ntchito. Pamene kuchuluka kwa enzyme iyi kumachepa, zizindikiro zambiri ndi matenda okhudzana ndi ukalamba zimatha kuchitika, monga matenda a kagayidwe kachakudya, kufooka kwa chitetezo chamthupi, kuchepa kwa chidziwitso, ndi zina zotero. Enzyme yofunikayi ili ndi dzina lalitali: nicotinamide adenine dinucleotide, kapena NAD+.
Mwachidule, kuchepa kwa NAD+ m'thupi kumatanthauza kukalamba. Ndiye, kodi tingawonjezere NAD+ m'thupi kuti tichedwetse kukalamba? Ngati muwonjezera NAD+ mwachindunji, thupi la munthu silingathe kuyamwa, ndipo lidzakhala ndi zotsatirapo zoyipa kwambiri. Chifukwa chake, anthu adatembenukira ku chinthu choyambirira cha NAD+: nicotinamide ribose chloride (NRC).
Nicotinamide riboside chloride ndi mtundu wa vitamini B3 ndipo ndi imodzi mwa zinthu zomwe zimaphunziridwa kwambiri za NAD+ precursors. Imayamwa mosavuta ndikugwiritsidwa ntchito ndi thupi. Kafukufuku wambiri wasonyeza kuti kuwonjezera NR kumatha kuwonjezera kuchuluka kwa NAD+, zomwe zingabweretse phindu ku kagayidwe kachakudya, mtima ndi mitsempha.
Mawu oti "kuletsa ukalamba" amamveka ngati osayenera. Zikumveka ngati tikuyesera kuletsa chinthu chomwe chikuchitika kale, kapena sitingathe kuvomereza ziwalo zathu zomwe tiyenera kukonda. Koma zoona zake n'zakuti kusintha kwa kagayidwe kachakudya kumachitika pansi pa khungu tisanaone zotsatira za ukalamba. Kusankha kuyang'ana thanzi lathu kuchokera mkati kungakhale chomwe tikufunikira kuti tiwongolere momwe timakalamba.
Ndipotu, chimodzi mwa zizindikiro za ukalamba ndi njira yotchedwa "mitochondrial dysfunction," mawu omwe amatanthauza kutayika kwa mphamvu ndi magwiridwe antchito a maselo athu pakapita nthawi. Ichi chikhoza kukhala chimodzi mwa zifukwa zomwe timakalamba. Ngati mitochondria ndi yomwe imayambitsa ukalamba wathu, ndikofunikira kufufuza njira zonse zomwe zingatheke kuti zipitirize kugwira ntchito kwa nthawi yayitali.
Dziwani zambiri za mitochondria.
Mkati mwa selo lililonse muli tinthu tating'onoting'ono tomwe timaoneka modabwitsa totchedwa mitochondria—“malo amphamvu a selo.” Tizilombo tating'onoting'onoti ndi tomwe timapanga 90% ya mphamvu zomwe matupi athu amafunikira. Mitochondria ndi chifukwa chake masiku ano tili ngati nyama zovuta osati mabakiteriya.
Sitidziwa nthawi zonse kufunika kwa mitochondria pa thanzi lathu. Njira yofunika kwambiri yosungira mitochondria yanu kukhala yathanzi ndi molekyulu yotchedwa NAD+ (nicotinamide adenine dinucleotide). Maselo athu amapanga NAD+ mwachibadwa ndipo timaigwiritsa ntchito mosalekeza tsiku lonse.
Tikudziwanso kuti kuchuluka kwa NAD+ komwe timapeza kumachepa tikamakalamba. Ofufuza atazindikira kuti NAD+ ikhoza kukhala chinsinsi chosunga maselo athu athanzi, adayesetsa kupeza njira yogwiritsira ntchito bwino.
Ofufuza akudziwa kale kuti mavitamini awiri amayamba chifukwa cha kuchuluka kwa NAD+: niacin ndi niacinamide. Izi zinapezeka m'zaka za m'ma 1930 kuti zithandize kuchiza pellagra, kusowa kwa vitamini B3 komwe kungayambitse imfa.
Niacin inakhalanso mankhwala a cholesterol yambiri m'zaka za m'ma 1950. Komabe, zapezeka kuti kudya niacin yambiri nthawi zina kungayambitse khungu losasangalatsa lomwe limakwiyitsa komanso losakongola.
Niacinamide siimayambitsa khungu kutsuka ndipo mwachiphunzitso ingapereke zabwino zambiri zomwezo, koma imaletsa kuyambika kwa mapuloteni ofunikira okonzanso maselo otchedwa sirtuins. Niacinamide kapena niacin sizinali zogwira mtima monga momwe ofufuza ankayembekezera.
Ngakhale mavitamini awiriwa ndi oyambitsa matenda a NAD+, si njira yabwino yothetsera vutoli. Chifukwa cha zotsatirapo zoyipa za niacin komanso mphamvu ya nicotinamide, ofufuza alibebe vitamini yowonjezera yokwanira kuti awonjezere kuchuluka kwa NAD+.
Kupezeka kwa nicotinamide riboside.
Mtundu wina wa vitamini B3 wotchedwa nicotinamide riboside unapezeka mu yisiti m'zaka za m'ma 1940. Koma mpaka kumayambiriro kwa zaka za m'ma 2000 asayansi anayamba kuona kuthekera kwa vitamini wachitatu uyu, B3, osati kungowonjezera NAD+ komanso kukonza thanzi la anthu. Mu 2004, gulu lofufuza la Dartmouth College linapeza kuti nicotinamide riboside, monga m'bale wake wa vitamini B3, ndi chiyambi cha NAD+.
Gulu lofufuza lotsogozedwa ndi Dr. Charles Brenner linapeza kuti nicotinamide riboside inawonjezera NAD+ m'makoswe, ndipo mbewazo zinapeza ubwino wambiri pa thanzi chifukwa cha zimenezi.
Makoswewo adawonetsa chilichonse kuyambira kuwonjezeka kwa shuga m'magazi ndi kuchuluka kwa cholesterol mpaka kuchepa kwa kuwonongeka kwa mitsempha komanso kukana kunenepa. Dr. Charles Brenner adapeza kuti zotsatirazi zinali zolimbikitsa kwambiri kotero kuti adatenga gawo lotsatira kuti amvetsetse tanthauzo la nicotinamide riboside pa thanzi la anthu.
Mu 2014, Dr. Brenner anakhala munthu woyamba kumwa nicotinamide riboside ngati chowonjezera. Zotsatira zake n'zolimbikitsanso. Mtundu wosadziwika bwino wa vitamini B3 umenewu unawonjezera kwambiri milingo yake ya NAD+ mosamala, mwachangu, komanso popanda zotsatirapo zoyipa zilizonse.
Nicotinamide riboside imagwiritsa ntchito njira yapadera yopangira NAD+ yomwe palibe vitamini B3 ina yomwe imagwiritsa ntchito.
Nicotinamide riboside imathanso kuyambitsa mapuloteni olimbikitsa kukonzanso maselo otchedwa sirtuins. Pamene tikukalamba, ma sirtuins amenewa amagwira ntchito nthawi yayitali kuti athandize maselo kukhala olimba.
Kukhala ndi thanzi labwino pamene mukukalamba sikudzakhala kosavuta ngati vitamini imodzi, ngakhale ndi vitamini yabwino ngati nicotinamide riboside. Pali maphunziro opitilira 100 ofufuza nicotinamide riboside, ambiri mwa iwo akuwonetsa kuti kuchuluka kwa NAD+ kumalumikizidwa ndi thanzi la kagayidwe kachakudya ndi minofu m'makoswe. Kafukufuku wowonjezera akupitilira kuti amvetsetse ntchito ya NAD+ pothandizira mavuto ena okhudzana ndi thanzi okhudzana ndi ukalamba, kuphatikizapo kuchepa kwa ntchito ya chiwindi, kunenepa, kuchuluka kwa insulin ndi ntchito ya ubongo m'makoswe.
Kodi NAD ndi chiyani?
NAD+ ndi coenzyme I, yomwe ndi coenzyme yomwe imasamutsa ma proton (molondola kwambiri, ma hydrogen ions) ndipo imagwira ntchito zambiri zokhudzana ndi thupi monga kagayidwe ka zinthu zamaselo, kupanga mphamvu, ndi kukonzanso DNA. NAD+ ndi michere yofunika kwambiri pa ntchito ya puloteni ya Sirtuin, yomwe asayansi amaitcha "chinthu chokhalitsa nthawi yayitali". Makamaka, imatha kusunga kutalika kwa ma telomere ofunikira, kuchepetsa ukalamba ndikuwonjezera moyo.
NAD+ ingathandizenso kukonza majini ndikuchedwetsa kukalamba kwa maselo. NAD+ imalimbikitsa kusinthika kwa maselo komanso imateteza matenda a chitetezo chamthupi. NAD+ imapangitsa kuti ma chromosome akhale olimba komanso imachepetsa chiopsezo cha khansa.
Ndi mabwenzi apamtima a ma enzyme, omwe amathandiza kupatsa mphamvu "makina a maselo" omwe amapanga mphamvu yofunikira pa ntchito iliyonse yayikulu m'thupi lanu pamlingo wa maselo.
Chifukwa chiyani NAD+ ndi yofunika?
Chifukwa cha ntchito yake yofunika kwambiri pakupanga mphamvu zamaselo, kusowa kwa NAD+ m'thupi lanu kumapangitsa kuti ntchito zambiri za thupi zisakhale zothandiza. Popanda NAD, mapapo anu sadzatha kulandira mpweya, mtima wanu sungathe kupopa magazi, ndipo ma synapses a ubongo wanu sadzagwira ntchito.
NAD+ imathandizanso kulimbikitsa kukonzanso kwa DNA ndikuwongolera ntchito ya maselo pogwiritsa ntchito ma sirtuins ndi poly(ADP-ribose) polymerases (PARPs), omwe ndi ofunikira kwambiri pakulamulira mayankho a maselo ku zilakolako monga kudya mopitirira muyeso, kumwa mowa, kugona movutikira, komanso machitidwe osakhala chete. Ma enzyme.
NAD+ ndi kukalamba
Kafukufuku wochitidwa mu 2012 ndi gulu lochokera ku Dipatimenti ya Zamankhwala ku Yunivesite ya New South Wales adawonetsa kuti kagayidwe ka NAD kamagwirizana ndi ukalamba. Kafukufukuyu akuwonetsa kuti kuchuluka kwa NAD+ m'mitsempha ya khungu la munthu kumachepa ndi 50% pakati pa zaka 40 ndi 60, ndipo kuchepa kwa NAD+ kungakhale ndi gawo lofunikira pakukalamba.
"Kugwirizana kwakukulu koipa kunawonedwa pakati pa milingo ya NAD+ ndi zaka mwa amuna ndi akazi," ofufuzawo adatero mu pepalalo.
Kuphatikiza apo, NAD imagwira ntchito yopuma m'maselo, makamaka mu mitochondria, ndipo imathandizira pa thanzi la mitochondria yonse. Pali chidwi chachikulu cha asayansi pa momwe NAD imakhudzira kusokonekera kwa mitochondria, chimodzi mwa zizindikiro za ukalamba.
M'zaka zaposachedwapa, kafukufuku wayang'ana kwambiri kumvetsetsa udindo wa NAD pothana ndi kuchepa kwa magwiridwe antchito okhudzana ndi ukalamba.
Nicotinamide Ribose Chloride imawonjezera milingo ya NAD+.
NR ndi chiyambi cha NAD, zomwe zikutanthauza kuti ndi "chomangira" chomwe mamolekyu a NAD+ amapangidwa. Inapezeka mu 2004 ngati chiyambi cha vitamini ku NAD+, zomwe zimapangitsa kuti ikhale imodzi mwa njira zatsopano zofufuzira za NAD+.
NR ndi vitamini yopezeka mwachilengedwe komanso mtundu watsopano wa vitamini B3, koma kugwiritsidwa ntchito kwake ngati chowonjezera kwakhudzidwa kwambiri ndi mavitamini "okalamba bwino". Ndi othandiza kwambiri pakuwonjezera NAD, zomwe zimapangitsa kuti ikhale imodzi mwa njira zosangalatsa kwambiri zothetsera ukalamba wathanzi.
NR imatha kukweza bwino milingo ya NAD+. Mayeso azachipatala omwe adasindikizidwa mu Scientific Reports adawonetsa kuti adakweza NAD+ ndi 50% patatha milungu iwiri atamwa.
Ngakhale kuti kuwonjezera kwa NR kwatsimikiziridwa kuti kumawonjezera milingo ya NAD+, kuwonjezera kwa NAD+ ngati chosakaniza chodziyimira pachokha sikuthandiza kwenikweni.
NAD+ ndi molekyulu yaikulu kwambiri ndipo singalowe m'maselo mwachindunji. M'malo mwake, thupi lanu liyenera kuigawa m'zidutswa zing'onozing'ono lisanadutse nembanemba ya selo. Zigawo zimenezi zimasonkhanitsidwanso mkati mwa batri.
Nicotinamide riboside (NR) ndi nicotinamide riboside chloride (NRC) Zonsezi ndi mitundu ya vitamini B3, yomwe imadziwikanso kuti niacin. Vitamini B3 ndi michere yofunika kwambiri yomwe imagwira ntchito yofunika kwambiri m'thupi, kuphatikizapo kupanga mphamvu, kukonza DNA, ndi kagayidwe ka maselo. NR ndi NRC zonse ndi zoyambira za nicotinamide adenine dinucleotide (NAD+), coenzyme yomwe imakhudzidwa ndi njira zosiyanasiyana zamoyo, monga kuwongolera kupanga mphamvu zamaselo ndikuthandizira kukonza DNA.
Nicotinamide riboside (NR) ndi mtundu wa vitamini B3 womwe watchuka chifukwa cha mphamvu zake zoletsa ukalamba komanso mphamvu. Ndi chinthu chachilengedwe chomwe chimapezeka muzakudya zina, komanso chimapezeka ngati chowonjezera pazakudya. NR imadziwika chifukwa cha kuthekera kwake kuwonjezera kuchuluka kwa NAD+ m'thupi, zomwe zimathandiza kugwira ntchito kwa mitochondrial, kuwonjezera kupanga mphamvu zamaselo, komanso kuteteza ku kuchepa kwa ukalamba.
Komano, Nicotinamide riboside chloride (NRC) ndi mchere wa NR ndipo umagwiritsidwa ntchito kwambiri mu zakudya zowonjezera. Kuwonjezera chloride ku NR kumapanga NRC, yomwe imakhulupirira kuti imawonjezera kukhazikika kwa mankhwalawa komanso kupezeka kwake m'thupi. Izi zikutanthauza kuti NRC ikhoza kuyamwa bwino ndikugwiritsidwa ntchito bwino m'thupi kuposa NR yokha ndipo ikhoza kukhala ndi zotsatira zabwino kwambiri pa milingo ya NAD+ ndi ntchito ya maselo.
Kusiyana kwakukulu pakati pa NR ndi NRC ndi kapangidwe kake ka mankhwala. NR ndiye maziko a mankhwalawa, pomwe NRC ndi mtundu wosinthidwa wokhala ndi chloride yowonjezera. Kusintha kumeneku cholinga chake ndi kuwonjezera kusungunuka kwa mankhwalawa komanso kupezeka kwake, zomwe zimapangitsa kuti thupi lizitha kuyamwa mosavuta ndikugwiritsa ntchito.
Ponena za ubwino wawo pa thanzi, NR ndi NRC akuganiziridwa kuti ali ndi zotsatira zofanana chifukwa cha kuthekera kwawo kukulitsaNAD+milingo. Zotsatirazi zingaphatikizepo kusintha kwa ntchito ya mitochondrial, kukulitsa kagayidwe ka mphamvu, komanso kuthandizira thanzi la maselo onse. Komabe, kugwiritsa ntchito NRC mu chowonjezera kungabweretse ubwino wowonjezera wa kuyamwa bwino ndi kugwiritsidwa ntchito, zomwe zingapangitse kuti pakhale zabwino zambiri poyerekeza ndi kugwiritsa ntchito NR yokha.
1. Kuonjezera kupanga mphamvu zamaselo
Chimodzi mwa zabwino kwambiri zanicotinamide riboside chloride Ndi udindo wake pakuwonjezera kupanga mphamvu zamaselo. NR ndiye chimake cha nicotinamide adenine dinucleotide (NAD+), coenzyme yomwe imagwira ntchito popanga adenosine triphosphate (ATP), ndalama yayikulu ya mphamvu ya selo. udindo wofunikira. Pamene tikukalamba, kuchuluka kwa NAD+ kumachepa, zomwe zimapangitsa kuti kupanga mphamvu zamaselo kuchepe. Mwa kuwonjezera NR, amakhulupirira kuti kuchuluka kwa NAD+ kumatha kubwezeretsedwanso, potero kumathandizira kagayidwe kabwino ka mphamvu zamaselo.
2. Ntchito ya Mitochondria ndi nthawi ya moyo
Mitochondria ndi malo amphamvu a selo, omwe ali ndi udindo wopanga mphamvu ndikuwongolera machitidwe a maselo. Kafukufuku akuwonetsa kuti Nicotinamide Riboside Chloride imatha kuthandizira ntchito ya mitochondria mwa kulimbikitsa biogenesis ya mitochondria yatsopano ndikuwonjezera magwiridwe antchito ake. Izi zimakhudza moyo wonse komanso ukalamba wathanzi, chifukwa mitochondria yogwira ntchito bwino ndiyofunikira kwambiri kuti maselo azikhala ndi thanzi labwino komanso kulimba.
3. Thanzi la kagayidwe kachakudya ndi kasamalidwe ka kulemera
NAD+ ndi coenzyme, kapena molekyulu yowonjezera, yomwe imagwira ntchito m'machitidwe ambiri a zamoyo. Kafukufuku waposachedwapa adapeza kuti kuwonjezera kwa nicotinamide ribose kumatha kulimbikitsa kagayidwe ka NAD+ mwa achikulire azaka zapakati ndi okalamba omwe ali ndi thanzi labwino. Sikuti kokha kuti ma NR supplements adalandiridwa bwino ndi omwe adachita nawo, komanso mwina adathandiza kuchepetsa kuthamanga kwa magazi ndi kuuma kwa mitsempha. Kusowa kwa NAD+ ndi chifukwa chachikulu cha ukalamba ndi matenda ambiri, ndipo kafukufuku akuwonetsa kuti kubwezeretsa milingo ya NAD+ kuli ndi phindu lalikulu pamankhwala komanso zakudya.
Mwa kuwonjezera milingo ya NAD+, nicotinamide ribose imapindulitsa kagayidwe kachakudya, mphamvu zosungira, kapangidwe ka DNA, ndi ntchito zina za thupi.
Kuphatikiza apo, kafukufuku wasonyeza kuti kuwonjezera NR kungathandize kuchepetsa insulin, kuchepetsa kutupa, komanso kusinthasintha kwa kagayidwe kachakudya. Zotsatirazi zitha kukhala zothandiza makamaka kwa anthu omwe akufuna kuwongolera kulemera kwawo ndikuthandizira thanzi lonse la kagayidwe kachakudya.
4. Ntchito ya ubongo ndi thanzi la ubongo
Monga chiyambi cha NAD+, nicotinamide ribose imateteza maselo a muubongo ku kupsinjika kwa okosijeni, zomwe zingayambitse matenda a muubongo okhudzana ndi ukalamba. Mkati mwa maselo a muubongo, NAD+ imathandiza kuwongolera kupanga PGC-1-alpha, puloteni yomwe imawoneka kuti imathandiza kuteteza maselo ku kupsinjika kwa okosijeni komanso ntchito yolakwika ya mitochondrial.
Ofufuza adapeza kuti m'makoswe, kuchepa kwa NAD+ kumachita gawo lofunika kwambiri pakutupa kwa mitsempha, kuwonongeka kwa DNA, komanso kuwonongeka kwa mitsempha mu matenda a Alzheimer's. Komanso mu kafukufuku wa chubu choyesera, nicotinamide riboside idakulitsa kuchuluka kwa NAD+ komanso idasintha kwambiri ntchito ya mitochondrial m'maselo oyambira a odwala matenda a Parkinson.
Kafukufuku watsopano akuwonetsanso ubwino wa nicotinamide riboside chloride m'maganizo. NAD+ imagwira ntchito zosiyanasiyana zokhudzana ndi thanzi la ubongo, kuphatikizapo kuonetsa zizindikiro za mitsempha, kukonza DNA, ndi kuchotsa mapuloteni owonongeka. Mwa kuthandizira milingo ya NAD+, NR ingathandize kusunga ntchito ya ubongo ndikuletsa kuchepa kwa chidziwitso chokhudzana ndi ukalamba.
5. Kuchita Masewera ndi Kuchira
Kafukufuku wa 2019 wofalitsidwa mu European Journal of Nutrient Impurities adapeza kuti kugwiritsa ntchito zowonjezera za nicotinamide ribose kumawonjezera luso la thupi komanso kuchepetsa kupsinjika kwa okosijeni mwa okalamba.
Ofufuzawo adatsimikiza kuti kuwonjezera kwa NR kunali kothandiza kwa anthu omwe ali ndi vuto la NAD+, pofotokoza chifukwa chake kunali kothandiza kwambiri kwa okalamba kuposa achinyamata.
Ochita masewera olimbitsa thupi ndi okonda masewera olimbitsa thupi angafune kudziwa kuti nicotinamide riboside chloride imatha kukhudza bwino magwiridwe antchito amasewera ndi kuchira. NAD+ imagwira ntchito yofunika kwambiri pakulamulira njira zama cell zomwe zimakhudzidwa ndi kupanga mphamvu ndi magwiridwe antchito a minofu. Mwa kuthandizira milingo ya NAD+, NR imatha kukulitsa kupirira, kukulitsa kuchira kwa minofu, komanso kukulitsa magwiridwe antchito amasewera.
Ubwino ndi Chiyero
Mukamagula ufa wa nicotinamide riboside chloride, ubwino ndi kuyera ziyenera kukhala patsogolo panu. Yang'anani zinthu zopangidwa ndi makampani odziwika bwino komanso anthu ena omwe ayesedwa kuti aone ngati zili zoyera komanso zamphamvu. Mwachiyembekezo, zinthuzo ziyenera kukhala zopanda zodetsa ndi zodzaza kuti muwonetsetse kuti mukupeza chowonjezera chapamwamba chomwe chimapereka zabwino zomwe mukufuna.
Mlingo ndi kagwiritsidwe ntchito
Musanagwiritse ntchito ufa wa nicotinamide riboside chloride mu zochita zanu za tsiku ndi tsiku, ndikofunikira kumvetsetsa mlingo woyenera ndi malangizo ogwiritsira ntchito. Ndikofunikira kuyamba ndi mlingo wochepa ndikuwonjezera pang'onopang'ono momwe mukufunira, chifukwa kuchuluka kwa mlingo sikungafanane ndi zotsatira zabwino ndipo kungayambitse zotsatira zoyipa. Kuphatikiza apo, chonde ganizirani kufunsa katswiri wazachipatala kuti mudziwe mlingo woyenera zolinga zanu zaumoyo ndi zosowa zanu.
Ubwino ndi zinthu zomwe zingaganizidwe
Ufa wa Nicotinamide Riboside Chloride nthawi zambiri umatamandidwa chifukwa cha ubwino wake, kuphatikizapo kuthandizira mphamvu, ntchito ya mitochondrial, komanso thanzi la maselo onse. Kafukufuku akusonyeza kuti ungakhalenso ndi zotsatira pa ukalamba ndi matenda okhudzana ndi ukalamba.
Chitetezo ndi zodzitetezera
Monga momwe zimakhalira ndi mankhwala ena aliwonse owonjezera, ndikofunikira kuika patsogolo chitetezo ndikumvetsetsa njira zodzitetezera zomwe zingachitike. Ngakhale kuti nicotinamide riboside chloride nthawi zambiri imalekerera bwino, anthu ena amatha kukhala ndi zotsatirapo zochepa, monga kusapeza bwino m'mimba. Kuphatikiza apo, ngati muli ndi matenda enaake kapena mukumwa mankhwala, onetsetsani kuti mwafunsana ndi katswiri wa zaumoyo musanagwiritse ntchito mankhwalawa kuti muwonetsetse kuti ndi otetezeka komanso oyenera pa vuto lanu.
Sankhani wogulitsa wodalirika
Mukamagula Nicotinamide Riboside Chloride Powder, ndikofunikira kusankha wogulitsa wodalirika amene amaika patsogolo ubwino, kuwonekera poyera, komanso kukhutitsa makasitomala. Yang'anani makampani omwe amapereka tsatanetsatane wa njira zawo zopangira, kupeza zinthu, ndi kuyesa kwa anthu ena. Kuphatikiza apo, ganizirani kuwerenga ndemanga za makasitomala ndikupempha malingaliro kuchokera ku magwero odalirika kuti muwonetsetse kuti mukugula kuchokera kwa wogulitsa wodalirika komanso wodalirika.
Suzhou Myland Pharm & Nutrition Inc. yakhala ikugwira ntchito mu bizinesi yowonjezera zakudya kuyambira mu 1992. Ndi kampani yoyamba ku China kupanga ndikugulitsa zotulutsa za mbewu za mphesa.
Kampaniyi, yomwe ili ndi zaka 30 zokumana nazo komanso yoyendetsedwa ndi ukadaulo wapamwamba komanso njira yabwino kwambiri yofufuzira ndi chitukuko, yapanga zinthu zosiyanasiyana zopikisana ndipo yakhala kampani yatsopano yopereka chithandizo cha sayansi ya moyo, kupanga zinthu mwamakonda komanso kupanga zinthu.
Kuphatikiza apo, Suzhou Myland Pharm & Nutrition Inc. ndi kampani yodziwika bwino yopanga mankhwala yomwe ili ndi dzina la FDA. Zipangizo za kafukufuku ndi chitukuko cha kampaniyi, malo opangira mankhwala, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri ndipo zimatha kupanga mankhwala kuyambira mamiligalamu mpaka matani ambiri, komanso zimagwirizana ndi miyezo ya ISO 9001 ndi zomwe zimapangidwa ndi GMP.
Q: Kodi ufa wa nicotinamide riboside chloride ndi chiyani?
A: Nicotinamide Riboside Chloride Powder ndi mtundu wa vitamini B3 womwe waphunziridwa kuti ungathandize kupanga mphamvu zamaselo ndi kagayidwe kachakudya. Nthawi zambiri umagwiritsidwa ntchito ngati chowonjezera pazakudya kuti ulimbikitse thanzi labwino komanso thanzi.
Q: Kodi ubwino wa nicotinamide riboside chloride powder ndi wotani?
A: Ubwino wina womwe ungabwere chifukwa cha Nicotinamide Riboside Chloride Powder ndi monga kuthandizira ntchito ya mitochondrial, kulimbikitsa ukalamba wathanzi, komanso kulimbitsa kupirira komanso magwiridwe antchito akuthupi. Zingathandizenso kuthandizira ntchito ya ubongo komanso thanzi la maselo onse.
Q: Kodi ndingapeze kuti ufa wa nicotinamide riboside chloride?
A: Ufa wa Nicotinamide Riboside Chloride umapezeka m'masitolo osiyanasiyana komanso m'masitolo apaintaneti. Mukamagula chowonjezera ichi, ndikofunikira kusankha gwero lodalirika kuti muwonetsetse kuti ndi chapamwamba komanso chotetezeka.
Chodzikanira: Nkhaniyi ndi yongofuna kudziwa zambiri ndipo siyenera kuonedwa ngati upangiri uliwonse wa zachipatala. Zina mwa zomwe zili mu blog iyi zimachokera pa intaneti ndipo si zaukadaulo. Webusaitiyi ili ndi udindo wosankha, kupanga ndi kusintha nkhani zokha. Cholinga chopereka zambiri sichikutanthauza kuti mukugwirizana ndi malingaliro ake kapena kutsimikizira kuti zomwe zili mkati mwake ndi zoona. Nthawi zonse funsani katswiri wa zaumoyo musanagwiritse ntchito zowonjezera zilizonse kapena kusintha njira yanu yazaumoyo.
Nthawi yotumizira: Ogasiti-14-2024
