Lithium orotateZakudya zowonjezera zatchuka m'zaka zaposachedwa chifukwa cha ubwino wawo pa thanzi. Komabe, pali chisokonezo chachikulu ndi zolakwika zokhudzana ndi mchere uwu ndi kagwiritsidwe ntchito kake mu mawonekedwe owonjezera. Mu bukhuli lathunthu, tikambirana zonse zomwe muyenera kudziwa zokhudza zakudya zowonjezera za lithiamu orotate. Choyamba, ndikofunikira kumvetsetsa kuti lithiamu orotate ndi mchere wachilengedwe womwe umagwiritsidwa ntchito pothandizira thanzi la maganizo ndi thanzi lonse. Ndi mtundu wa lithiamu womwe umaphatikizidwa ndi orotic acid, womwe umathandiza mchere kulowa m'maselo a maselo bwino. Izi zikutanthauza kuti mlingo wochepa wa lithiamu orotate ungagwiritsidwe ntchito poyerekeza ndi mitundu ina ya lithiamu, kuchepetsa chiopsezo cha zotsatirapo zoyipa.
Kodi ubwino wa lithiamu pa ubongo ndi wotani?
Lithium orotate ndi mchere wopangidwa ndi orotic acid ndi lithiamu. Dzina lake lonse ndi lithiamu orotate monohydrate (Orotic acid lithium salt monohydrate), ndipo formula yake ya molekyulu ndi C5H3LIN2O4H2O. Ma ioni a lithiamu ndi orotic acid sali ogwirizana koma amatha kugawanika mu yankho kuti apange ma ioni a lithiamu aulere. Kafukufuku akuwonetsa kuti lithiamu orotate imapezeka kwambiri kuposa mankhwala operekedwa ndi dokotala a lithiamu carbonate kapena lithiamu citrate (mankhwala ovomerezeka ndi US FDA).
Lithium ndi mankhwala omwe amagwiritsidwa ntchito kwambiri mu zamankhwala pochiza kuvutika maganizo, matenda a bipolar, ndi matenda ena amisala. Komabe, kuchuluka kwa lithiamu carbonate kapena lithiamu citrate komwe kumayamwa ndi kochepa, ndipo mlingo waukulu umafunika kuti pakhale zotsatirapo zochiritsira. Chifukwa chake, ali ndi zotsatirapo zazikulu ndipo ndi oopsa. Komabe, lithiamu orotate yochepa imakhala ndi zotsatirapo zochiritsira zofanana ndipo ili ndi zotsatirapo zochepa.
Kale m'ma 1970, lithiamu orotate inkagulitsidwa ngati chowonjezera pazakudya pa matenda ena amisala, monga uchidakwa ndi matenda a Alzheimer's.
Gawo la umboni ndi ili:
Matenda a Alzheimer's: Kafukufuku akuwonetsa kuti lithiamu orotate ili ndi bioavailability yambiri ndipo imatha kugwira ntchito mwachindunji pa mitochondria ndi glial cell membranes kuti ipereke chithandizo ndi chitetezo cha ma neuron ndikuchedwetsa kapena kukonza matenda owononga mitsempha monga matenda a Alzheimer's.
Kuteteza ubongo ndi kukumbukira bwino: Kafukufuku waposachedwa wa zamankhwala aku America wapeza kuti lithiamu sikuti imangothandiza kuteteza maselo a ubongo ku imfa isanakwane, komanso ingathandizenso kubwezeretsanso maselo a ubongo. Chifukwa chake, lithiamu ikhoza kuteteza hippocampus ku kuwonongeka ndikusunga kapena kuwonjezera ntchito yokumbukira.
Zolimbitsa Maganizo: Lithium (lithium carbonate kapena lithium citrate) imagwiritsidwa ntchito pachipatala pochiza kuvutika maganizo ndi matenda a bipolar. Mofananamo, lithium orotate ili ndi zotsatira izi. Chifukwa chakuti mlingo womwe umagwiritsidwa ntchito ndi wochepa kwambiri poyerekeza ndi nthawi yomweyi chaka chatha, umaloledwa bwino ndipo uli ndi zotsatirapo zochepa.
Kodi lithiamu orotate ndi yabwino chifukwa chiyani?
Matenda a Alzheimer's ndi matenda owononga mitsempha. Mwachipatala, odwala amakumana ndi zizindikiro monga kulephera kukumbukira, kulephera kukumbukira, komanso kulephera kugwira ntchito bwino kwa thupi. Chifukwa chachikulu cha matendawa sichinapezekebe. Pakati pawo, matenda a Alzheimer's amatchedwanso matenda a Alzheimer's. Odwala ambiri amadwala matendawa asanakwanitse zaka 65. Ili ndi gulu la matenda osiyanasiyana omwe amayamba chifukwa cha zinthu zosiyanasiyana. Kuphatikiza apo, odwala ambiri amadwala matendawa atakwanitsa zaka 50. Matendawa ndi obisika ndipo amakula pang'onopang'ono matendawa akayamba kukula. Pazizindikiro zoyambirira, padzakhala kuiwala kwambiri.
Poyamba, luso la wodwalayo lokumbukira zinthu limachepa pang'onopang'ono, mwachitsanzo, posachedwa adzaiwala zomwe wangonena kapena zomwe wachita, ndipo luso la wodwalayo lofufuza kuganiza komanso luso lake loweruza zinthu limachepanso, koma nthawi yomweyo, zinthu zina zomwe adaphunzira kale zidzachepanso. Wodwalayo adzakhalabe ndi zokumbukira za ntchito kapena luso lake. Matendawa akakula, zizindikiro za wodwalayo za gawo loyamba zidzakhala vuto lodziwikiratu la kuzindikira ndi kuwona, ndipo zidzakhala zovuta kuvala.
Makamaka, kugwiritsa ntchito lithiamu kunagwirizanitsidwa ndi chiopsezo chotsika cha 44% cha matenda a dementia, chiopsezo chotsika cha 45% cha matenda a Alzheimer's (AD), ndi chiopsezo chotsika cha 64% cha matenda a vascular dementia (VD).
Izi zikutanthauza kuti mchere wa lithiamu ukhoza kukhala njira yopewera matenda a dementia monga AD.
Matenda a dementia amatanthauza vuto lalikulu komanso losatha la kuzindikira. Mwachipatala, limadziwika ndi kuchepa kwa maganizo pang'onopang'ono, limodzi ndi kusintha kwa umunthu mosiyanasiyana, koma palibe kuwonongeka kwa chidziwitso. Ndi gulu la matenda amisala osati matenda odziyimira pawokha. Pali zifukwa zambiri zomwe zimayambitsa matenda a dementia, koma nthawi zambiri matenda a dementia amayamba chifukwa cha kuwonongeka kwa ubongo kapena zilonda za ubongo, monga matenda a Alzheimer's, matenda a Parkinson, kuvulala kwa ubongo koopsa, ndi zina zotero.
Mphamvu yoteteza mitsempha ya mchere wa lithiamu
Kuwunikanso zotsatira za lithiamu pa ubongo ndi magazi (Kuwunikanso zotsatira za lithiamu pa ubongo ndi magazi) Kuwunikaku kumati: “Mu nyama, lithiamu imawonjezera mphamvu ya neurotrophins, kuphatikizapo neurotrophic factor (BDNF) yochokera mu ubongo, nerve growth factor, nerve Trophin 3 (NT3), ndi ma receptor a zinthu izi zomwe zikukula mu ubongo.
Lithium imalimbikitsanso kuchulukana kwa maselo oyambira, kuphatikizapo mafupa ndi maselo oyambira a mitsempha m'dera la subventricular, striatum, ndi forebrain. Kulimbikitsidwa kwa maselo oyambira a mitsempha yamkati kungapereke chifukwa chake lithiamu imawonjezera kuchuluka kwa maselo a muubongo ndi kuchuluka kwa odwala omwe ali ndi vuto la bipolar.
Kuwonjezera pa zotsatira zomwe zili pamwambapa, lithiamu ingathandizenso kulimbitsa chitetezo chamthupi, kulamulira ntchito ya mitsempha yapakati, kupereka mpumulo, bata, kuteteza mitsempha, ndi kuwongolera matenda amitsempha. Kusanthula kawiri ndi kuyesa kolamulidwa mwachisawawa kwatsegula zitseko zatsopano mu mankhwala oletsa matenda a dementia, kusonyeza kuti lithiamu ili ndi zotsatira zabwino pa magwiridwe antchito a ubongo mwa odwala omwe ali ndi vuto lochepa la chidziwitso (MCI) ndi AD.
Ndani sayenera kumwa lithiamu orotate?
Azimayi Oyembekezera ndi Oyamwitsa
Amayi oyembekezera ndi oyamwitsa ayenera kupewa kumwa lithiamu orotate. Kugwiritsa ntchito lithiamu orotate panthawi ya mimba ndi kuyamwitsa sikunaphunziridwe mokwanira, ndipo pali zambiri zochepa zokhudzana ndi chitetezo chake kwa anthu awa. Ndikofunikira kuti amayi omwe ali ndi pakati kapena oyamwitsa alankhule ndi dokotala wawo asanagwiritse ntchito mankhwala enaake, kuphatikizapo lithiamu orotate, kuti atsimikizire kuti mayi ndi mwana ali otetezeka.
Anthu omwe ali ndi Matenda a Impso
Lithium imatulutsidwa makamaka kudzera mu impso, ndipo anthu omwe ali ndi matenda a impso akhoza kukhala pachiwopsezo chachikulu cha kuchuluka kwa lithiamu m'thupi. Izi zitha kubweretsa poizoni wa lithiamu, zomwe zitha kupha anthu. Chifukwa chake, anthu omwe ali ndi matenda a impso ayenera kupewa kumwa lithiamu orotate pokhapokha ngati akuyang'aniridwa ndi dokotala yemwe angathe kuyang'anira ntchito ya impso zawo ndikusintha mlingo moyenerera.
Anthu Odwala Matenda a Mtima
Zanenedwa kuti lithiamu orotate ikhoza kukhala ndi zotsatirapo pa matenda a mtima, kuphatikizapo kusintha kwa kugunda kwa mtima ndi kayimbidwe kake. Anthu omwe ali ndi matenda a mtima omwe analipo kale, monga arrhythmias kapena matenda a mtima, ayenera kusamala akamaganizira zogwiritsa ntchito lithiamu orotate. Anthu omwe ali ndi matenda a mtima ayenera kufunsa dokotala asanagwiritse ntchito lithiamu orotate kuti awone zoopsa zomwe zingachitike komanso ubwino wake kutengera mbiri yawo yachipatala.
Ana ndi Achinyamata
Chitetezo ndi mphamvu ya lithiamu orotate mwa ana ndi achinyamata sizinakhazikitsidwe bwino. Chifukwa chake, nthawi zambiri amalangizidwa kuti anthu osakwana zaka 18 apewe kugwiritsa ntchito lithiamu orotate pokhapokha ngati atsogoleredwa ndi dokotala yemwe angawone ngati ikugwiritsidwa ntchito moyenera nthawi zina. Ana ndi achinyamata ali ndi zinthu zapadera zokhudza thupi ndi chitukuko zomwe ziyenera kuganiziridwa poganizira kugwiritsa ntchito chowonjezera chilichonse, kuphatikizapo lithiamu orotate.
Anthu omwe ali ndi Matenda a Chithokomiro
Mankhwala a Lithium amadziwika kuti amasokoneza ntchito ya chithokomiro, ndipo anthu omwe ali ndi matenda a chithokomiro, monga hypothyroidism kapena hyperthyroidism, ayenera kusamala akamaganizira zogwiritsa ntchito lithiamu orotate. Zotsatira za lithiamu pa ntchito ya chithokomiro zimatha kusiyana malinga ndi munthu, ndipo anthu omwe ali ndi matenda a chithokomiro ayenera kugwira ntchito limodzi ndi dokotala wawo kuti azitha kuyang'anira ntchito ya chithokomiro chawo ngati akuganiza zogwiritsa ntchito lithiamu orotate.
Momwe Mungawonjezere Lithium
Chifukwa chake, zitha kuwoneka kuchokera pazokambirana zomwe zili pamwambapa kuti mchere wa lithiamu umateteza maselo amitsempha m'thupi komanso m'thupi. Umatha kutonthoza ndikukhazikitsa malingaliro, kuwongolera matenda amitsempha, ndipo ungagwiritsidwe ntchito popewa matenda a Alzheimer's, matenda a Huntington, ischemia ya ubongo, ndi zina zotero. Matenda a mitsempha yamagazi. Nthawi yomweyo, umathanso kukonza magwiridwe antchito a hematopoietic ndikuwonjezera magwiridwe antchito a chitetezo chamthupi cha munthu.
Lithium ndi chinthu chachilengedwe chomwe chimapezeka m'chilengedwe, makamaka chochokera ku tirigu ndi ndiwo zamasamba. Kuphatikiza apo, madzi akumwa m'madera ena ali ndi lithiamu yambiri, zomwe zingaperekenso kuchuluka kwa lithiamu.
Kuwonjezera pa kupeza pang'ono lithiamu muzakudya zanu za tsiku ndi tsiku, muthanso kuipeza mu zowonjezera.
Suzhou Myland Pharm & Nutrition Inc. yakhala ikugwira ntchito mu bizinesi yowonjezera zakudya kuyambira mu 1992. Ndi kampani yoyamba ku China kupanga ndikugulitsa zotulutsa za mbewu za mphesa.
Kampaniyi, yomwe ili ndi zaka 30 zokumana nazo komanso yoyendetsedwa ndi ukadaulo wapamwamba komanso njira yabwino kwambiri yofufuzira ndi chitukuko, yapanga zinthu zosiyanasiyana zopikisana ndipo yakhala kampani yatsopano yopereka chithandizo cha sayansi ya moyo, kupanga zinthu mwamakonda komanso kupanga zinthu.
Kuphatikiza apo, Suzhou Myland Pharm & Nutrition Inc. ndi kampani yodziwika bwino yopanga mankhwala yomwe ili ndi dzina la FDA. Zipangizo za kafukufuku ndi chitukuko cha kampaniyi, malo opangira mankhwala, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri ndipo zimatha kupanga mankhwala kuyambira mamiligalamu mpaka matani ambiri, komanso zimagwirizana ndi miyezo ya ISO 9001 ndi zomwe zimapangidwa ndi GMP.
Nthawi yotumizira: Ogasiti-01-2024
