Lithium orotatezowonjezera zapeza kutchuka m'zaka zaposachedwapa chifukwa cha ubwino wawo wathanzi. Komabe, padakali chisokonezo chochuluka komanso zabodza zozungulira mcherewu komanso kugwiritsa ntchito mawonekedwe owonjezera. Mu bukhuli lathunthu, tidzakambirana zonse zomwe muyenera kudziwa zokhudza lithiamu orotate supplements.Choyamba, ndikofunika kumvetsetsa kuti lithiamu orotate ndi mchere wachilengedwe womwe umagwiritsidwa ntchito kuthandizira thanzi labwino komanso thanzi labwino. Ndi mtundu wa lithiamu womwe umaphatikizidwa ndi orotic acid, womwe umathandizira kuti mcherewo ulowe m'maselo a cell mogwira mtima. Izi zikutanthauza kuti mlingo wochepa wa lithiamu orotate ungagwiritsidwe ntchito poyerekeza ndi mitundu ina ya lithiamu, kuchepetsa chiopsezo cha zotsatirapo.
Kodi ubwino wa lithiamu ku ubongo ndi chiyani?
Lithium orotate ndi mchere wopangidwa ndi orotic acid ndi lithiamu. Dzina lake lonse ndi lithiamu orotate monohydrate (Orotic acid lithium salt monohydrate), ndipo mawonekedwe ake a maselo ndi C5H3LIN2O4H2O. Lithium ndi orotic acid ma ion samamangidwa molumikizana koma amatha kupatukana munjira kuti apange ma ion a lithiamu aulere. Kafukufuku akuwonetsa kuti lithiamu orotate ndi bioavailable kwambiri kuposa mankhwala lithiamu carbonate kapena lithiamu citrate (US FDA-approved drugs).
Lithium ndi mankhwala omwe amagwiritsidwa ntchito kwambiri ngati mankhwala pochiza kuvutika maganizo, matenda a bipolar, ndi matenda ena amisala. Komabe, mayamwidwe a lithiamu carbonate kapena lithiamu citrate ndi otsika, ndipo mlingo waukulu umayenera kupanga zotsatira zochiritsira. Choncho, ali ndi mavuto aakulu ndipo ndi poizoni. Komabe, mlingo wochepa wa lithiamu orotate uli ndi zotsatira zofanana zochiritsira ndipo uli ndi zotsatira zochepa.
Kumayambiriro kwa zaka za m'ma 1970, lithiamu orotate idagulitsidwa ngati chakudya chowonjezera pa matenda ena amisala, monga uchidakwa ndi matenda a Alzheimer's.
Umboni wina uli motere:
Matenda a Alzheimer's: Kafukufuku akuwonetsa kuti lithiamu orotate ili ndi bioavailability yayikulu ndipo imatha kuchitapo kanthu mwachindunji pamitochondria ndi nembanemba ya cell ya glial kuti ipereke chithandizo ndi chitetezo cha ma neuron ndikuchedwetsa kapena kupititsa patsogolo matenda a neurodegenerative monga matenda a Alzheimer's.
Neuroprotection ndi kukumbukira kukumbukira: Kafukufuku waposachedwa mu zamankhwala aku America apeza kuti lithiamu sikungothandiza kuteteza ma cell aubongo kuti asafe msanga, imatha kulimbikitsa kusinthika kwa maselo a ubongo. Chifukwa chake, lithiamu imatha kuteteza hippocampus kuti isawonongeke ndikusunga kapena kupititsa patsogolo kukumbukira.
Zolimbitsa thupi: Lithium (lithium carbonate kapena lithium citrate) amagwiritsidwa ntchito pochiza matenda ovutika maganizo ndi bipolar. Mofananamo, lithiamu orotate ili ndi izi. Chifukwa mlingo wogwiritsidwa ntchito ndi wochepa kwambiri poyerekeza ndi nthawi yomweyi chaka chatha, umalekerera bwino ndipo umakhala ndi zotsatirapo zochepa.
Kodi lithiamu orotate ndi chiyani?
Matenda a Alzheimer ndi matenda osachiritsika a dongosolo lamanjenje. Zachipatala, odwala amakumana ndi zizindikiro monga kulephera kukumbukira, amnesia, ndi kusagwira bwino ntchito. Choyambitsa chachikulu cha matendawa sichinadziwikebe. Pakati pawo, matenda a Alzheimer amatchedwanso matenda a Alzheimer. Odwala ambiri amadwala matendawa asanakwanitse zaka 65. Ichi ndi gulu la matenda osiyanasiyana omwe amayamba chifukwa cha zinthu zosiyanasiyana. Komanso, odwala ambiri amadwala matendawa akakwanitsa zaka 50. Matendawa saoneka bwino ndipo amayamba pang’onopang’ono matendawa akayamba. Pazizindikiro zoyambirira, kuyiwala kokulirapo kumakhala kokulirapo.
Atangoyamba kumene, luso la kukumbukira la wodwalayo limachepa pang’onopang’ono, mwachitsanzo, posachedwapa adzaiwala zimene wangonena kumene kapena zimene wachita, ndipo luso la kusanthula kaganizidwe ka wodwalayo ndi luso lake lotha kusankha zinthu zidzachepa, koma panthawi imodzimodziyo, zinthu zina. waphunzira kale adzachepanso. Wodwalayo adzakumbukirabe za ntchitoyo kapena luso lake. Matendawa akamakula, zizindikiro za gawo loyamba la wodwalayo zidzakhala zoonekeratu kuwonongeka kwa chidziwitso cha malo, ndipo kudzakhala kovuta kuvala.
Makamaka, kugwiritsa ntchito lithiamu kumalumikizidwa ndi 44% kutsika kwachiwopsezo cha dementia, 45% kutsika kwachiwopsezo cha matenda a Alzheimer's (AD), ndi 64% kutsika kwachiwopsezo cha vascular dementia (VD).
Izi zikutanthauza kuti mchere wa lithiamu ukhoza kukhala njira yodzitetezera ku dementia monga AD.
Dementia imatanthawuza kuwonongeka kwachidziwitso koopsa komanso kosalekeza. Kachipatala, imadziwika ndi kuchepa kwapang'onopang'ono kwamalingaliro, komwe kumatsagana ndi kusintha kosiyanasiyana kwa umunthu, koma palibe kuwonongeka kwa chidziwitso. Ndi gulu la matenda a syndromes osati matenda odziimira okha. Pali zinthu zambiri zomwe zimayambitsa matenda a dementia, koma nthawi zambiri matenda a dementia amayamba chifukwa cha kuwonongeka kwa ubongo kapena kuwonongeka kwa ubongo, monga matenda a Alzheimer's, Parkinson's disease, kuvulala koopsa kwa ubongo, ndi zina zotero.
Mphamvu ya neuroprotective ya mchere wa lithiamu
Ndemanga ya zotsatira za lithiamu pa ubongo ndi magazi (Kuwunika kwa lithiamu zotsatira pa ubongo ndi magazi) Ndemanga iyi imati: "Mu zinyama, lithiamu imayendetsa neurotrophins, kuphatikizapo ubongo-derived neurotrophic factor (BDNF), mitsempha ya kukula kwa mitsempha, mitsempha Trophin 3 (NT3) , ndi zolandilira zinthu izi kukula mu ubongo.
Lithium imalimbikitsanso kuchuluka kwa maselo oyambira, kuphatikiza ma cell a mafupa ndi neural stem cell mu subventricular zone, striatum, ndi forebrain. Kukondoweza kwa endogenous neural stem cell kungafotokozere chifukwa chake lithiamu imachulukitsa kuchuluka kwa maselo aubongo mwa odwala omwe ali ndi vuto la bipolar. “
Kuphatikiza pa zomwe zili pamwambazi, lithiamu imathanso kupititsa patsogolo chitetezo chamthupi, kuwongolera zochitika zapakati pamitsempha, kuchita masewera olimbitsa thupi, bata, chitetezo chamthupi, ndikuwongolera kusokonezeka kwa mitsempha. Kusanthula kwa meta kuwiri ndi kuyesa kosasinthika kwatsegula zitseko zatsopano zochiritsira zotsutsana ndi dementia, kusonyeza kuti lithiamu ili ndi zotsatira zabwino pakuchita bwino kwa chidziwitso kwa odwala omwe ali ndi vuto lochepa lachidziwitso (MCI) ndi AD.
Ndani sayenera kumwa lithiamu orotate?
Amayi Oyembekezera ndi Oyamwitsa
Amayi oyembekezera ndi oyamwitsa sayenera kumwa lithiamu orotate. Kugwiritsiridwa ntchito kwa lithiamu orotate pa nthawi ya mimba ndi kuyamwitsa sikunaphunzire mozama, ndipo pali chidziwitso chochepa chopezeka pa chitetezo chake kwa anthuwa. Ndikofunikira kuti amayi omwe ali ndi pakati kapena oyamwitsa akambirane ndi wothandizira zaumoyo asanagwiritse ntchito zowonjezera zowonjezera, kuphatikizapo lithiamu orotate, kuti atsimikizire chitetezo cha amayi ndi mwana.
Anthu Amene Ali ndi Matenda a Impso
Lithium imatulutsidwa kudzera mu impso, ndipo anthu omwe ali ndi matenda a impso akhoza kukhala pachiwopsezo chowonjezeka cha lithiamu m'thupi. Izi zitha kuyambitsa poizoni wa lithiamu, zomwe zitha kuyika moyo pachiwopsezo. Chifukwa chake, anthu omwe ali ndi matenda a impso ayenera kupewa kumwa lithiamu orotate pokhapokha atayang'aniridwa ndi dokotala yemwe angayang'anire momwe impso zawo zimagwirira ntchito ndikusintha mlingo moyenerera.
Anthu Omwe Ali ndi Matenda a Mtima
Lithium orotate yanenedwa kuti ili ndi zotsatira zomwe zingatheke pamtima, kuphatikizapo kusintha kwa kugunda kwa mtima ndi rhythm. Anthu omwe ali ndi matenda a mtima omwe analipo kale, monga arrhythmias kapena matenda a mtima, ayenera kusamala poganizira za kugwiritsa ntchito lithiamu orotate. Anthu omwe ali ndi vuto la mtima ayenera kukaonana ndi dokotala asanagwiritse ntchito lithiamu orotate kuti awone zoopsa zomwe zingatheke komanso ubwino wake malinga ndi mbiri yawo yachipatala.
Ana ndi Achinyamata
Chitetezo ndi mphamvu ya lithiamu orotate mwa ana ndi achinyamata sizinakhazikitsidwe bwino. Zotsatira zake, nthawi zambiri amalangizidwa kuti anthu osakwana zaka 18 apewe kugwiritsa ntchito lithiamu orotate pokhapokha motsogozedwa ndi wothandizira zaumoyo yemwe angayang'ane momwe angagwiritsire ntchito pazochitika zinazake. Ana ndi achinyamata ali ndi malingaliro apadera a thupi ndi chitukuko omwe amayenera kuganiziridwa poganizira kugwiritsa ntchito chowonjezera chilichonse, kuphatikizapo lithiamu orotate.
Anthu Amene Ali ndi Matenda a Chithokomiro
Lithium imadziwika kuti imasokoneza ntchito ya chithokomiro, ndipo anthu omwe ali ndi vuto la chithokomiro, monga hypothyroidism kapena hyperthyroidism, ayenera kusamala akamaganizira za kugwiritsa ntchito lithiamu orotate. Zotsatira za lithiamu pa ntchito ya chithokomiro zimatha kusiyana pakati pa munthu ndi munthu, ndipo anthu omwe ali ndi vuto la chithokomiro ayenera kugwirira ntchito limodzi ndi wothandizira zaumoyo wawo kuti ayang'ane ntchito ya chithokomiro ngati akuganiza za kugwiritsa ntchito lithiamu orotate.
Momwe Mungawonjezere Lithium
Chifukwa chake, zitha kuwoneka kuchokera pazomwe tafotokozazi kuti mchere wa lithiamu umakhala ndi chitetezo pama cell a mitsempha mu vivo komanso mu vitro. Ikhoza kukhazika mtima pansi ndi kukhazikika maganizo, kulamulira matenda a ubongo, ndipo ingagwiritsidwe ntchito kupewa matenda a Alzheimer, matenda a Huntington, cerebral ischemia, etc. Cerebrovascular disease. Nthawi yomweyo, imatha kupititsa patsogolo ntchito ya hematopoietic ndikuwonjezera chitetezo chamthupi chamunthu.
Lithium ndi chinthu chachilengedwe chomwe chimapezeka m'chilengedwe, makamaka chochokera kumbewu ndi ndiwo zamasamba. Kuonjezera apo, madzi akumwa m'madera ena ali ndi lithiamu yapamwamba, yomwe ingaperekenso zowonjezera za lithiamu.
Kuphatikiza pa kupeza kachulukidwe ka lithiamu muzakudya zanu zatsiku ndi tsiku, muthanso kuzipeza muzowonjezera.
Suzhou Myland Pharm & Nutrition Inc. yakhala ikuchita bizinesi yazakudya zopatsa thanzi kuyambira 1992. Ndi kampani yoyamba ku China kupanga ndi kugulitsa zokolola za mphesa.
Pokhala ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira yokongoletsedwa kwambiri ya R&D, kampaniyo yapanga zinthu zambiri zopikisana ndikukhala kampani yowonjezera ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.
Kuphatikiza apo, Suzhou Myland Pharm & Nutrition Inc. ndiwopanganso zolembedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani pamlingo, ndikutsata miyezo ya ISO 9001 ndi kufotokozedwa kwa GMP.
Nthawi yotumiza: Aug-01-2024
