Kodi Alpha GPC Ingakuthandizeni Kuyang'ana Kwambiri? Nazi Zomwe Muyenera Kudziwa

Ponena za kukonza kukumbukira ndi kuphunzira, kafukufuku waposachedwapa akusonyeza kuti alpha GPC ingakhale yopindulitsa kwambiri. Izi zili choncho chifukwa A-GPC imanyamula choline kupita ku ubongo, zomwe zimapangitsa kuti neurotransmitter yofunika kwambiri ilimbikitse thanzi la ubongo.

Kafukufuku akusonyeza kuti alpha GPC ndi imodzi mwa mankhwala abwino kwambiri a nootropic muubongo omwe alipo pamsika. Ndi molekyulu yolimbitsa ubongo yomwe yawonetsedwa kuti ndi yotetezeka komanso yovomerezeka bwino ndi odwala okalamba omwe akufuna kuchepetsa zizindikiro za matenda a dementia, komanso othamanga achinyamata omwe akufuna kuwonjezera kupirira kwawo komanso mphamvu zawo.
Mofanana ndi zotsatira za phosphatidylserine zomwe zimapangitsa ubongo kukhala wosangalala, a-GPC ingagwiritsidwe ntchito ngati mankhwala achilengedwe a matenda a Alzheimer's ndipo ingachepetse kuchepa kwa chidziwitso chifukwa cha ukalamba.

Kodi Alpha GPC ndi chiyani?

Alpha GPC kapena alpha glycerylphosphorylcholine ndi molekyulu yomwe imagwira ntchito ngati gwero la choline. Ndi mafuta acid omwe amapezeka mu soy lecithin ndi zomera zina ndipo amagwiritsidwa ntchito ngati zowonjezera thanzi la ubongo komanso kumanga mphamvu za minofu.
Alpha GPC, yomwe imadziwikanso kuti choline alfoscerate, imayamikiridwa chifukwa cha kuthekera kwake kunyamula choline kupita ku ubongo ndikuthandizira thupi kupanga acetylcholine ya neurotransmitter, yomwe imayang'anira zabwino zambiri za choline paumoyo. Acetylcholine imagwirizana ndi kuphunzira ndi kukumbukira, ndipo ndi imodzi mwa ma neurotransmitter ofunikira kwambiri pakuchepetsa minofu.
Mosiyana ndi choline bitartrate, chowonjezera china chodziwika bwino cha choline chomwe chili pamsika, A-GPC imatha kudutsa chotchinga cha magazi ndi ubongo. Ichi ndichifukwa chake imakhala ndi zotsatira zabwino pa ubongo ndipo chifukwa chake imagwiritsidwa ntchito pochiza matenda a dementia, kuphatikizapo matenda a Alzheimer's.

Ubwino ndi ntchito za Alpha GPC

1. Kuchepetsa vuto la kukumbukira zinthu

Alpha GPC imagwiritsidwa ntchito popititsa patsogolo luso lokumbukira, kuphunzira, ndi kuganiza. Imachita izi mwa kuwonjezera acetylcholine muubongo, mankhwala omwe amagwira ntchito yofunika kwambiri pa kukumbukira ndi kuphunzira. Ofufuzawo adawona kuti alpha GPC ili ndi kuthekera kowonjezera zizindikiro zamaganizo zokhudzana ndi matenda a Alzheimer's ndi dementia.
Kafukufuku wochitidwa ndi anthu awiri osawona, mwachisawawa, komanso wolamulidwa ndi placebo womwe unafalitsidwa mu Clinical Therapeutics mu 2003 unayesa momwe alpha GPC imagwirira ntchito komanso momwe imalolera pochiza matenda amisala omwe amayamba chifukwa cha matenda a Alzheimer's.
Odwala adamwa makapisozi a 400 mg a-GPC kapena makapisozi a placebo katatu patsiku kwa masiku 180. Odwala onse adawunikidwa kumayambiriro kwa mayeso, atatha masiku 90 a chithandizo, ndipo kumapeto kwa mayesowo patatha masiku 180.
Mu gulu la alpha GPC, magawo onse oyesedwa, kuphatikizapo Alzheimer's Disease Assessment Scale ndi Behavioral and Mini-Mental State Examination, adapitilirabe kukhala bwino pambuyo pa masiku 90 ndi 180 a chithandizo, pomwe mu gulu la placebo sanasinthe kapena kuipiraipira.
Ofufuzawo adatsimikiza kuti a-GPC ndi yothandiza kwambiri pachipatala ndipo imalekerera bwino pochiza zizindikiro za matenda a dementia ndipo imatha kukhala ngati chithandizo chachilengedwe cha matenda a Alzheimer's.

2. Limbikitsani kuphunzira ndi kuganizira kwambiri

Pali kafukufuku wambiri wotsimikizira ubwino wa alpha GPC kwa anthu omwe ali ndi vuto la kuzindikira, koma kodi ndi yothandiza bwanji kwa anthu omwe alibe matenda a dementia? Kafukufuku akuwonetsa kuti Alpha GPC ingathandizenso achinyamata athanzi kukhala ndi chidwi, kukumbukira, komanso luso lophunzira.
Nyuzipepala ya American Journal of Clinical Nutrition inafalitsa kafukufuku wa gulu la anthu omwe analibe matenda a dementia ndipo inapeza kuti kudya kwambiri choline kunkagwirizana ndi kugwira bwino ntchito kwa ubongo. Magawo a chidziwitso omwe adawunikidwa ndi monga kukumbukira mawu, kukumbukira maso, kuphunzira mawu, ndi ntchito yogwira ntchito.
Kafukufuku wofalitsidwa mu Journal of the International Society of Sports Nutrition adapeza kuti achinyamata akamagwiritsa ntchito zowonjezera za alpha GPC, zinali zothandiza pa ntchito zina zakuthupi ndi zamaganizo. Iwo omwe adalandira 400 mg ya a-GPC adapeza 18% mwachangu pa mayeso ochotsera serial kuposa omwe adalandira 200 mg ya caffeine. Kuphatikiza apo, gulu lodya caffeine lidapeza bwino kwambiri pa neuroticism poyerekeza ndi gulu la alpha GPC.

3. Kupititsa patsogolo luso la masewera

Kafukufuku akuchirikiza mphamvu ya alpha GPC yogwirizana. Pachifukwa ichi, othamanga akukonda kwambiri a-GPC chifukwa cha kuthekera kwake kowonjezera kupirira, kutulutsa mphamvu, ndi mphamvu ya minofu. Kuonjezera a-GPC kumadziwika kuti kumathandiza kuwonjezera mphamvu zakuthupi, kulimbikitsa kumanga minofu yowonda, ndikufupikitsa nthawi yochira pambuyo pa masewera olimbitsa thupi.
Kafukufuku akusonyeza kuti alpha GPC imawonjezera mahomoni okula kwa munthu, omwe amathandiza pakukonzanso maselo, kukula ndi kusamalira minofu yathanzi ya munthu. Homoni yokula imadziwika chifukwa cha luso lake lokulitsa luso la thupi komanso kuchita bwino masewera.
Pakhala maphunziro ambiri ofufuza momwe alpha GPC imagwirira ntchito pa kupirira thupi ndi mphamvu. Kafukufuku wa 2008 wochitidwa mwachisawawa, wolamulidwa ndi placebo, wokhudza amuna asanu ndi awiri omwe adaphunzira za kukana mankhwala adawonetsa kuti a-GPC imakhudza kuchuluka kwa mahomoni okulira. Ophunzira omwe adatenga nawo mbali mu gulu loyesera adapatsidwa 600 mg ya alpha GPC mphindi 90 masewera olimbitsa thupi asanayambe.
Ofufuzawo adapeza kuti poyerekeza ndi chiyambi, kuchuluka kwa mahomoni okulirapo kunawonjezeka ndi 44 ndi alpha GPC ndi 2.6 ndi placebo. Kugwiritsa ntchito A-GPC kunawonjezeranso mphamvu zakuthupi, ndipo mphamvu yokakamiza ya bench pressure inawonjezeka ndi 14% poyerekeza ndi placebo.
Kuwonjezera pa kulimbitsa minofu ndi mphamvu, mahomoni okulitsa amatha kuchepetsa thupi, kulimbitsa mafupa, kusintha momwe munthu akumvera, komanso kukonza tulo tabwino.

4. Kuthandiza kuti munthu ayambe kuchira matenda a sitiroko

Kafukufuku woyambirira akusonyeza kuti a-GPC ingathandize odwala omwe adadwala sitiroko kapena kuukira kwa ischemic kwakanthawi kochepa, komwe kumadziwika kuti "mini-stroke." Izi zimachitika chifukwa cha kuthekera kwa alpha GPC kugwira ntchito ngati choteteza mitsempha ndikuthandizira neuroplasticity kudzera mu zolandirira kukula kwa mitsempha.
Mu kafukufuku wa mu 1994, ofufuza aku Italy adapeza kuti alpha GPC inathandiza kuti odwala omwe ali ndi sitiroko yapakhungu kapena yaying'ono ayambenso kuzindikira. Pambuyo pa sitiroko, odwala adalandira 1,000 mg ya alpha GPC mwa jakisoni kwa masiku 28, kenako 400 mg pakamwa katatu patsiku kwa miyezi 5 yotsatira.
Ofufuzawo adanenanso kuti kumapeto kwa kafukufukuyu, 71% ya odwala sanasonyeze kuchepa kwa chidziwitso kapena kuiwalika. Kuphatikiza apo, zigoli za odwala pa Mini-Mental State Examination zinakwera kwambiri. Kuphatikiza pa zomwe zapezekazi, kuchuluka kwa zochitika zoyipa pambuyo pogwiritsa ntchito alpha GPC kunali kochepa ndipo ofufuzawo adatsimikiza kuti ndi yolekerera bwino kwambiri.

5. Zingathandize anthu omwe ali ndi khunyu

Kafukufuku wa nyama wofalitsidwa mu Brain Research mu 2017 cholinga chake chinali kuwunika momwe chithandizo cha alpha GPC chimakhudzira kusokonezeka kwa chidziwitso pambuyo pa khunyu. Ofufuzawo adapeza kuti makoswe akalandira jakisoni wa a-GPC milungu itatu pambuyo pa khunyu, mankhwalawa adathandizira magwiridwe antchito a chidziwitso ndikuwonjezera kukula kwa mitsempha, kukula kwa minofu ya mitsempha.
Kafukufukuyu akusonyeza kuti alpha GPC ikhoza kukhala yothandiza kwa odwala matenda a khunyu chifukwa cha mphamvu zake zoteteza mitsempha ndipo ikhoza kuchepetsa kusokonezeka kwa chidziwitso komwe kumachitika chifukwa cha khunyu komanso kuwonongeka kwa mitsempha.

Alpha GPC ndi Choline

Choline ndi michere yofunika kwambiri pa ntchito zambiri za thupi, makamaka ubongo. Imafunika kuti neurotransmitter yofunika kwambiri ya acetylcholine, yomwe imagwira ntchito bwino ngati neurotransmitter yoletsa ukalamba ndipo imathandiza mitsempha yathu kulankhulana.
Ngakhale thupi limapanga choline pang'ono lokha, tiyenera kupeza michere kuchokera muzakudya. Zakudya zina zomwe zili ndi choline yambiri ndi monga chiwindi cha ng'ombe, nsomba ya salimoni, nsawawa, mazira, ndi bere la nkhuku. Komabe, malipoti ena akusonyeza kuti choline yochokera ku chakudya siilowedwa bwino ndi thupi, ndichifukwa chake anthu ena amavutika ndi kusowa kwa choline. Izi zili choncho chifukwa choline imakonzedwa pang'ono m'chiwindi, ndipo anthu omwe ali ndi vuto la chiwindi sadzatha kuyamwa.
Apa ndi pomwe zowonjezera za alpha GPC zimagwira ntchito. Akatswiri ena amalimbikitsa kugwiritsa ntchito zowonjezera za choline, monga a-GPC, kuti ziwonjezere kugwira ntchito kwa ubongo ndikuthandizira kukumbukira kukumbukira. Alpha GPC ndi CDP choline zimaganiziridwa kuti ndizothandiza kwambiri m'thupi chifukwa zimafanana kwambiri ndi momwe choline imachitikira mwachilengedwe mu chakudya. Monga choline yomwe imayamwa mwachilengedwe kuchokera ku chakudya chomwe timadya, alpha GPC imadziwika kuti imatha kudutsa chotchinga cha magazi ndi ubongo ikadyedwa, zomwe zimathandiza thupi kusintha choline kukhala neurotransmitter acetylcholine yofunika kwambiri.
Alpha GPC ndi mtundu wamphamvu wa choline. Mlingo wa 1,000 mg wa a-GPC ndi wofanana ndi pafupifupi 400 mg wa choline yazakudya. Kapena, mwa kuyankhula kwina, alpha GPC ndi pafupifupi 40% ya choline polemera.

Choline ya A-GPC ndi CDP

CDP Choline, yomwe imadziwikanso kuti cytidine diphosphate choline ndi citicoline, ndi mankhwala opangidwa ndi choline ndi cytidine. CDP Choline imadziwika ndi luso lake lothandiza kunyamula dopamine muubongo. Monga alpha GPC, Citicoline imayamikiridwa chifukwa cha luso lake lodutsa chotchinga cha magazi ndi ubongo ikamezedwa, zomwe zimapangitsa kuti ikumbukire bwino komanso iwonjezere chidziwitso.
Ngakhale kuti alpha GPC ili ndi pafupifupi 40% ya choline polemera, CDP choline ili ndi pafupifupi 18% ya choline. Koma CDP choline ilinso ndi cytidine, yomwe imatsogolera ku nucleotide uridine. Uridine wodziwika kuti amatha kuwonjezera kapangidwe ka maselo, ali ndi mphamvu zowonjezera chidziwitso.
Onse a-GPC ndi CDP choline amadziwika chifukwa cha ubwino wawo wamaganizo, kuphatikizapo udindo wawo pothandizira kukumbukira, kugwira ntchito kwamaganizo, ndi kuganizira.

Komwe mungapeze ndi momwe mungagwiritsire ntchito

Ma supplements a A-GPC amagwiritsidwa ntchito kwambiri popititsa patsogolo kukumbukira ndi luso la kuzindikira. Angagwiritsidwenso ntchito popititsa patsogolo kupirira kwa thupi ndi magwiridwe antchito. Alpha GPC imapezeka ngati chowonjezera cha zakudya chakumwa. Ma supplements a Alpha GPC ndi osavuta kupeza pa intaneti kapena kuchokera kwa ogulitsa. Mupeza mu mawonekedwe a kapisozi ndi ufa. Mankhwala ambiri okhala ndi a-GPC amalimbikitsa kumwa chowonjezeracho ndi chakudya kuti chikhale chothandiza kwambiri.
Suzhou Myland Pharm & Nutrition Inc. ndi kampani yolembetsedwa ndi FDA yomwe imapereka ufa wa alpha GPC wapamwamba komanso woyera kwambiri.

Ku Suzhou Myland Pharm, tadzipereka kupereka zinthu zabwino kwambiri pamitengo yabwino kwambiri. Ufa wathu wa alpha GPC umayesedwa bwino kuti ukhale woyera komanso wamphamvu, zomwe zimakutsimikizirani kuti mumapeza chowonjezera chabwino chomwe mungachikhulupirire. Kaya mukufuna kuthandiza thanzi la maselo, kulimbitsa chitetezo cha mthupi lanu kapena kulimbitsa thanzi lonse, ufa wathu wa alpha GPC ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zakuchitikira komanso kutsogoleredwa ndi ukadaulo wapamwamba komanso njira zabwino kwambiri zofufuzira ndi chitukuko, Suzhou Myland Pharm yapanga zinthu zosiyanasiyana zopikisana ndipo yakhala kampani yatsopano yowonjezera sayansi ya moyo, kupanga zinthu mwamakonda komanso kupanga zinthu.

Kuphatikiza apo, Suzhou Myland Pharm ndi kampani yodziwika bwino yopanga mankhwala yomwe ili ndi dzina la FDA. Zipangizo za kafukufuku ndi chitukuko cha kampaniyi, malo opangira mankhwala, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuyambira mamiligalamu mpaka matani ambiri, komanso zimagwirizana ndi miyezo ya ISO 9001 ndi zomwe zimapangidwa ndi GMP.
A-GPC imadziwika kuti ndi yosalala, zomwe zikutanthauza kuti imayamwa chinyezi kuchokera mumlengalenga wozungulira. Pachifukwa ichi, zowonjezera ziyenera kusungidwa m'zidebe zosalowa mpweya ndipo siziyenera kuyikidwa mumlengalenga kwa nthawi yayitali.

Maganizo omaliza

Alpha GPC imagwiritsidwa ntchito kupereka choline ku ubongo kudutsa chotchinga cha magazi ndi ubongo. Ndi chiyambi cha acetylcholine, neurotransmitter yomwe imalimbikitsa thanzi la ubongo. Zowonjezera za Alpha GPC zingagwiritsidwe ntchito kupindulitsa thanzi lanu la ubongo mwa kukonza kukumbukira, kuphunzira, ndi kuyang'ana kwambiri. Kafukufuku akuwonetsanso kuti a-GPC imathandiza kuwonjezera mphamvu zakuthupi ndi minofu.