Kodi Alpha GPC Ingakulimbikitseni Kuyikira Kwambiri? Nazi Zomwe Muyenera Kudziwa

Zikafika pakuwongolera kukumbukira ndi kuphunzira, kafukufuku waposachedwa akuwonetsa kuti alpha GPC ikhoza kukhala yopindulitsa kwambiri. Izi ndichifukwa choti A-GPC imanyamula choline kupita ku ubongo, ndikuyambitsa neurotransmitter yofunikira yomwe imalimbikitsa thanzi lachidziwitso.

Kafukufuku akuwonetsa kuti alpha GPC ndi imodzi mwazabwino kwambiri zaubongo za nootropic pamsika. Ndi molekyulu yolimbikitsa ubongo yomwe yasonyezedwa kuti ndi yotetezeka komanso yololedwa bwino ndi odwala okalamba omwe akuyang'ana kuti athetse zizindikiro za dementia, komanso othamanga achinyamata omwe akuyang'ana kuti apititse patsogolo kupirira ndi mphamvu zawo.
Mofanana ndi zotsatira zowonjezeretsa ubongo za phosphatidylserine, a-GPC ikhoza kukhala ngati mankhwala achilengedwe a matenda a Alzheimer's ndipo ingachepetse kuchepa kwa chidziwitso chokhudzana ndi ukalamba.

Kodi Alpha GPC ndi chiyani?

Alpha GPC kapena alpha glycerylphosphorylcholine ndi molekyulu yomwe imakhala ngati gwero la choline. Ndi mafuta acid omwe amapezeka mu soy lecithin ndi zomera zina ndipo amagwiritsidwa ntchito muzowonjezera thanzi lachidziwitso komanso kupanga mphamvu za minofu.
Alpha GPC, yomwe imadziwikanso kuti choline alfoscerate, imayamikiridwa chifukwa cha kuthekera kwake kunyamula choline kupita ku ubongo ndikuthandizira thupi kupanga neurotransmitter acetylcholine, yomwe imayang'anira zabwino zambiri zathanzi la choline. Acetylcholine imagwirizanitsidwa ndi kuphunzira ndi kukumbukira, ndipo ndi imodzi mwama neurotransmitters ofunikira kwambiri pakupanga minofu.
Mosiyana ndi choline bitartrate, choline chowonjezera china chodziwika pamsika, A-GPC imatha kuwoloka chotchinga chamagazi-muubongo. Ichi ndichifukwa chake imakhala ndi zotsatira zabwino paubongo komanso chifukwa chake imagwiritsidwa ntchito pochiza matenda a dementia, kuphatikiza matenda a Alzheimer's.

Alpha GPC imapindula ndikugwiritsa ntchito

1. Kupititsa patsogolo kuwonongeka kwa kukumbukira

Alpha GPC imagwiritsidwa ntchito kukonza kukumbukira, kuphunzira ndi luso loganiza. Zimachita izi powonjezera acetylcholine mu ubongo, mankhwala omwe amathandiza kwambiri kukumbukira ndi kuphunzira ntchito. Ofufuzawo adawona kuti alpha GPC imatha kupititsa patsogolo chidziwitso chazidziwitso chokhudzana ndi matenda a Alzheimer's and dementia.
Mayesero akhungu awiri, osasinthika, oyendetsedwa ndi placebo omwe adasindikizidwa mu Clinical Therapeutics mu 2003 adawunikira mphamvu ndi kulekerera kwa alpha GPC pochiza kusokonezeka kwa chidziwitso komwe kumachitika chifukwa cha matenda a Alzheimer's wofatsa mpaka ochepa.
Odwala adatenga makapisozi a 400 mg a-GPC kapena makapisozi a placebo katatu tsiku lililonse kwa masiku 180. Odwala onse adawunikidwa kumayambiriro kwa mayesero, pambuyo pa masiku 90 akulandira chithandizo, ndipo kumapeto kwa mayesero patatha masiku 180.
Mu gulu la alpha GPC, magawo onse oyesedwa, kuphatikizapo chidziwitso ndi khalidwe la Alzheimer's Disease Assessment Scale ndi Mini-Mental State Examination, zinapitirizabe kusintha pambuyo pa 90 ndi 180 masiku a chithandizo, pamene mu gulu la placebo iwo sanasinthe. kusintha kapena kuipiraipira.
Ofufuzawo adatsimikiza kuti a-GPC ndi yothandiza komanso yololera bwino pochiza zizindikiro zachidziwitso cha dementia ndipo imatha kukhala ngati chithandizo chachilengedwe cha matenda a Alzheimer's.

2. Limbikitsani kuphunzira ndi kukhazikika

Pali kafukufuku wochuluka wochirikiza ubwino wa alpha GPC kwa anthu omwe ali ndi vuto lachidziwitso, koma ndi othandiza bwanji kwa anthu omwe alibe dementia? Kafukufuku akuwonetsa kuti Alpha GPC imathanso kupititsa patsogolo chidwi, kukumbukira komanso luso la kuphunzira mwa achinyamata athanzi.
Nyuzipepala ya American Journal of Clinical Nutrition inafalitsa kafukufuku wamagulu okhudza anthu omwe alibe dementia ndipo adapeza kuti kudya kwambiri kwa choline kumagwirizanitsidwa ndi chidziwitso chabwinoko. Madera ozindikira omwe amawunikiridwa amaphatikiza kukumbukira mawu, kukumbukira kowonekera, kuphunzira pakamwa, ndi ntchito yayikulu.
Kafukufuku wofalitsidwa mu Journal of the International Society of Sports Nutrition anapeza kuti pamene achinyamata achikulire amagwiritsa ntchito zowonjezera za alpha GPC, zinali zopindulitsa pa ntchito zina zakuthupi ndi zamaganizo. Omwe adalandira 400 mg ya a-GPC adapeza 18% mwachangu pamayeso ochotsa ambiri kuposa omwe adalandira 200 mg ya caffeine. Kuphatikiza apo, gulu logwiritsa ntchito caffeine lidachita bwino kwambiri pa neuroticism poyerekeza ndi gulu la alpha GPC.

3. Kupititsa patsogolo masewera olimbitsa thupi

Kafukufuku amathandizira ma synergistic a alpha GPC. Pachifukwa ichi, othamanga akukhudzidwa kwambiri ndi a-GPC chifukwa cha kuthekera kwake kupititsa patsogolo kupirira, kutulutsa mphamvu, ndi mphamvu za minofu. Kuphatikizira ndi a-GPC kumadziwika kuti kumathandizira kuwonjezera mphamvu zathupi, kulimbikitsa kumanga minofu yowonda, ndikufupikitsa nthawi yobwezeretsa pambuyo polimbitsa thupi.
Kafukufuku amasonyeza kuti alpha GPC imawonjezera kukula kwa hormone yaumunthu, yomwe imathandizira kusinthika kwa maselo, kukula ndi kusamalira minofu yaumunthu yathanzi. Hormone yakukula imadziwika chifukwa cha kuthekera kwake kukulitsa luso lakuthupi komanso kuchita masewera olimbitsa thupi.
Pakhala pali maphunziro ambiri akuwunika mphamvu ya alpha GPC pa kupirira kwakuthupi ndi mphamvu. Kafukufuku wopangidwa mwachisawawa wa 2008, woyendetsedwa ndi placebo, wophatikiza amuna asanu ndi awiri omwe ali ndi chidziwitso chotsutsana ndi maphunziro adawonetsa kuti a-GPC imakhudza kukula kwa mahomoni. Ophunzira mu gulu loyesera anapatsidwa 600 mg ya alpha GPC 90 maminiti asanayambe kuchita masewera olimbitsa thupi.
Ofufuzawa adapeza kuti poyerekeza ndi zoyambira, kuchuluka kwa mahomoni okula kumawonjezeka 44-fold ndi alpha GPC ndi 2.6-fold ndi placebo. Kugwiritsa ntchito kwa A-GPC kumawonjezeranso mphamvu zakuthupi, pomwe mphamvu yosindikizira ya benchi yapamwamba ikuwonjezeka ndi 14% poyerekeza ndi placebo.
Kuphatikiza pa kukulitsa mphamvu ya minofu ndi mphamvu, kukula kwa hormone kungathandize kuchepetsa thupi, kulimbitsa mafupa, kusintha maganizo, ndi kukonza kugona.

4. Sinthani kuchira kwa sitiroko

Kafukufuku woyambirira akusonyeza kuti a-GPC ikhoza kupindulitsa odwala omwe ali ndi sitiroko kapena osakhalitsa ischemic attack, yotchedwa "mini-stroke." Izi ndichifukwa cha kuthekera kwa alpha GPC kuchita ngati neuroprotectant ndikuthandizira neuroplasticity kudzera muzolandilira mitsempha ya kukula kwa mitsempha.
Mu kafukufuku wa 1994, ofufuza a ku Italy adapeza kuti alpha GPC imathandizira kuchira kwachidziwitso kwa odwala omwe ali ndi zikwapu zazikulu kapena zazing'ono. Pambuyo pa sitiroko, odwala adalandira 1,000 mg ya alpha GPC ndi jekeseni kwa masiku 28, ndikutsatiridwa ndi 400 mg pakamwa katatu tsiku lililonse kwa miyezi yotsatira ya 5.
Pamapeto pa mayeserowo, 71% ya odwala sanawonetse kuchepa kwa chidziwitso kapena amnesia, ofufuzawo adanena. Kuphatikiza apo, zotsatira za odwala pa Mini-Mental State Examination zidayenda bwino kwambiri. Kuphatikiza pa zomwe apezazi, kuchuluka kwa zochitika zoyipa zomwe zidachitika pambuyo pa kugwiritsa ntchito alpha GPC zinali zotsika ndipo ochita kafukufuku adatsimikizira kulekerera kwake kwakukulu.

5. Ikhoza kupindulitsa anthu omwe ali ndi khunyu

Kafukufuku wa nyama wofalitsidwa mu Brain Research mu 2017 cholinga chake ndikuwunika momwe chithandizo cha alpha GPC chimakhudzira chidziwitso pambuyo pa khunyu. Ofufuzawo adapeza kuti makoswe atabayidwa ndi a-GPC patatha milungu itatu atagwidwa, chigawocho chinapangitsa kuti chidziwitso chikhale bwino komanso kuwonjezeka kwa neurogenesis, kukula kwa mitsempha ya mitsempha.
Kafukufukuyu akuwonetsa kuti alpha GPC ikhoza kukhala yothandiza kwa odwala khunyu chifukwa cha zotsatira zake za neuroprotective ndipo imatha kuwongolera kuwonongeka kwa chidziwitso chifukwa cha khunyu komanso kuwonongeka kwa neuronal.

Alpha GPC ndi Choline

Choline ndi gawo laling'ono lofunikira pazakudya zambiri zathupi, makamaka ubongo. Ndikofunikira kuti mugwire bwino ntchito yofunika ya neurotransmitter acetylcholine, yomwe imakhala ngati anti-aging neurotransmitter ndipo imathandizira minyewa yathu kulankhulana.
Ngakhale kuti thupi limapanga choline pang'ono palokha, tiyenera kupeza michere kuchokera ku chakudya. Zakudya zina zomwe zili ndi choline zimaphatikizapo chiwindi cha ng'ombe, nsomba, nandolo, mazira, ndi chifuwa cha nkhuku. Komabe, malipoti ena amasonyeza kuti choline kuchokera ku chakudya sichimatengedwa bwino ndi thupi, chifukwa chake anthu ena amavutika ndi vuto la choline. Izi ndichifukwa choti choline imapangidwa pang'ono m'chiwindi, ndipo anthu omwe ali ndi vuto la chiwindi sangathe kuyamwa.
Apa ndipamene zowonjezera za alpha GPC zimalowa. Akatswiri ena amalimbikitsa kugwiritsa ntchito choline supplements, monga a-GPC, kuti apititse patsogolo ntchito ya ubongo ndikuthandizira kukumbukira kukumbukira. Alpha GPC ndi CDP choline amaganiziridwa kuti ndi opindulitsa kwambiri kwa thupi chifukwa ali ofanana kwambiri ndi momwe choline imachitikira mwachibadwa mu chakudya. Monga choline chomwe mwachibadwa chimatengedwa kuchokera ku chakudya chomwe timadya, alpha GPC imadziwika kuti imatha kuwoloka chotchinga cha magazi-ubongo ikalowetsedwa, kuthandiza thupi kutembenuza choline kukhala neurotransmitter yofunika kwambiri ya acetylcholine.
Alpha GPC ndi mtundu wamphamvu wa choline. Mlingo wa 1,000 mg wa a-GPC ndi wofanana ndi pafupifupi 400 mg ya choline yazakudya. Kapena, mwa kuyankhula kwina, alpha GPC ndi pafupifupi 40% choline ndi kulemera.

A-GPC ndi CDP Choline

CDP Choline, yomwe imadziwikanso kuti cytidine diphosphate choline ndi citicoline, ndi gulu lopangidwa ndi choline ndi cytidine. CDP Choline imadziwika kuti imatha kuthandiza kunyamula dopamine mu ubongo. Monga alpha GPC, Citicoline imayamikiridwa chifukwa cha kuthekera kwake kuwoloka chotchinga chamagazi-muubongo ikalowetsedwa, ndikupangitsa kukumbukira kukumbukira komanso kukulitsa chidziwitso.
Ngakhale alpha GPC ili ndi pafupifupi 40% choline ndi kulemera kwake, CDP choline ili ndi pafupifupi 18% choline. Koma CDP choline ilinso ndi cytidine, kalambulabwalo wa nucleotide uridine. Uridine amadziwika chifukwa cha mphamvu yake yowonjezeretsa kaphatikizidwe ka cell membrane, imakhalanso ndi chidziwitso chothandizira kuzindikira.
Onse a-GPC ndi CDP choline amadziwika chifukwa cha ubwino wawo wachidziwitso, kuphatikizapo ntchito yawo yothandizira kukumbukira, kugwira ntchito m'maganizo, ndi kuika maganizo.

Komwe mungapeze komanso momwe mungagwiritsire ntchito

Zowonjezera za A-GPC zimagwiritsidwa ntchito kwambiri kupititsa patsogolo kukumbukira ndi kuzindikira. Itha kugwiritsidwanso ntchito kupititsa patsogolo kupirira kwakuthupi ndi magwiridwe antchito. Alpha GPC imapezeka ngati chowonjezera chazakudya chapakamwa. Zowonjezera za Alpha GPC ndizosavuta kupeza pa intaneti kapena kwa ogulitsa. Mudzazipeza mu kapisozi ndi mawonekedwe a ufa. Zogulitsa zambiri zomwe zili ndi a-GPC zimalimbikitsa kutenga chowonjezeracho ndi chakudya kuti chikhale chothandiza kwambiri.
Suzhou Myland Pharm & Nutrition Inc. ndi wopanga olembetsedwa ndi FDA yemwe amapereka ufa wapamwamba kwambiri komanso wachiyero wa alpha GPC.

Ku Suzhou Myland Pharm tadzipereka kupereka zinthu zapamwamba kwambiri pamitengo yabwino kwambiri. Ufa wathu wa alpha GPC umayesedwa mwamphamvu kuti ukhale woyera ndi potency, kuonetsetsa kuti mumapeza zowonjezera zomwe mungakhulupirire. Kaya mukufuna kuthandizira thanzi la ma cell, kulimbikitsa chitetezo chamthupi kapena kuwonjezera thanzi lanu, alpha GPC ufa wathu ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira zokongoletsedwa bwino za R&D, Suzhou Myland Pharm yapanga zinthu zambiri zampikisano ndikukhala kampani yotsogola ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.

Kuphatikiza apo, Suzhou Myland Pharm ndiwopanganso zolembedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira zinthu, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani mumlingo, ndikutsata miyezo ya ISO 9001 ndi zopangira GMP.
A-GPC imadziwika kuti ndi hygroscopic, kutanthauza kuti imatenga chinyezi kuchokera kumlengalenga wozungulira. Pachifukwa ichi, zowonjezera ziyenera kusungidwa m'mitsuko yopanda mpweya ndipo sayenera kuwululidwa ndi mpweya kwa nthawi yaitali.

Malingaliro omaliza

Alpha GPC imagwiritsidwa ntchito popereka choline ku ubongo kudutsa chotchinga chamagazi-ubongo. Ndi kalambulabwalo wa acetylcholine, neurotransmitter yomwe imalimbikitsa thanzi lachidziwitso. Zowonjezera za Alpha GPC zitha kugwiritsidwa ntchito kupindulitsa thanzi lanu lachidziwitso mwa kukonza kukumbukira, kuphunzira, ndi kukhazikika. Kafukufuku akuwonetsanso kuti a-GPC imathandizira kuwonjezera mphamvu zakuthupi ndi mphamvu za minofu.