Ukalamba ndi njira yachilengedwe yosapeŵeka ya zamoyo, yomwe imadziwika ndi kuchepa pang'onopang'ono kwa kapangidwe ka thupi ndi ntchito zake pakapita nthawi. Njirayi ndi yovuta kwambiri ndipo imakhudzidwa kwambiri ndi zinthu zosiyanasiyana zakunja monga chilengedwe. Pofuna kumvetsetsa bwino liwiro la ukalamba, asayansi asiya njira yachikhalidwe yoyezera zaka kapena masiku ndipo m'malo mwake ayang'ana kwambiri nthawi yovuta kwambiri, akuyesetsa kupeza chidziwitso chobisika cha njira yokalamba.
Mu kafukufukuyu, asayansi apanga mndandanda wa zizindikiro za ukalamba zomwe zili ndi luso lapamwamba, zomwe pakati pazotsatira za DNA methylation zimakopa kwambiri maso. Monga njira yofunika kwambiri yowongolera ma epigenetic, zizindikiro za DNA methylation zimatha kulongosola molondola mbiri ya ukalamba wa munthu, osati kungowulula kusintha kwa chidziwitso cha majini mu ukalamba, komanso kukhala kofunikira kwambiri pa kafukufuku wa sayansi yokalamba. Kudzera mu kusanthula mozama kwa zizindikiro izi, asayansi amatha kuwona momwe mamolekyu alili kumbuyo kwa ukalamba, ndikutsegula njira zatsopano zochedwetsera ukalamba ndikulimbikitsa ukalamba wathanzi.
Mu thambo lalikulu la nyenyezi la sayansi yolimbana ndi ukalamba, NMN (nicotinamide mononucleotide) inali ngati nyenyezi yowala kwambiri. Kudziwika kwake monga woyambitsa NAD+ (nicotinamide adenine dinucleotide) kunalimbikitsa asayansi ambiri kuti azichita kafukufuku. Komabe, pakupita kwa nthawi, nyenyezi ina yowala kwambiri, AKG (alpha-ketoglutarate), pang'onopang'ono inayamba kuonekera ndipo inadziwika kwambiri pankhani yolimbana ndi ukalamba chifukwa cha kukongola kwake kwapadera komanso maziko asayansi.
Mu kafukufuku wofalitsidwa mu magazini ya Nature Metabolism, asayansi adafotokoza bwino momwe AKG imagwirira ntchito pa kagayidwe ka mphamvu, ntchito ya mitochondrial ndi anti-ukalamba. Kafukufukuyu adawonetsa kuti AKG imatha kulimbikitsa mwachindunji kayendedwe ka tricarboxylic acid ndikuwonjezera mphamvu zomwe zimachokera m'maselo, motero kumawonjezera mphamvu zonse za maselo. Kuphatikiza apo, magazini ya "Cell Metabolism" idasindikizanso zotsatira za kafukufuku pa kuthekera kwa AKG kulimbikitsa kapangidwe ka collagen ndikuwonjezera kusinthasintha kwa khungu, zomwe zikutsimikiziranso kuthekera kwake pantchito yoletsa ukalamba.
Kutembenuza zizindikiro za nthawi
Kafukufuku wa zachipatala wochokera ku Japan akutipatsa chitsanzo chomveka bwino. Mayi wazaka zapakati yemwe wakhala akusamala kwambiri za mankhwala oletsa ukalamba kwa nthawi yayitali, atamwa mankhwala owonjezera a AKG kwa theka la chaka, sikuti khungu lake lokha linasintha kwambiri, kukhala lolimba komanso lolimba, komanso thanzi lake lonse la thupi komanso mkhalidwe wake wamaganizo zinasinthanso kwambiri. Poyerekeza zizindikiro za thupi asanayambe komanso atatha kuyesera, ofufuza adapeza kuti ntchito ya mayiyo ya mitochondrial inakula kwambiri, zomwe zikugwirizana kwambiri ndi ntchito ya AKG polimbikitsa kagayidwe ka mphamvu.
Woteteza thanzi la mitsempha
Kafukufuku wina wochokera ku United States anayang'ana kwambiri ntchito ya AKG yoteteza mitsempha. Atalandira chithandizo cha AKG, mwamuna wina wachikulire yemwe anali ndi vuto lochepa la kuzindikira anawonetsa kusintha kwakukulu mu luso lake la kuzindikira, kuphatikizapo kukumbukira bwino ndi kuyang'ana kwambiri. Ofufuzawo adawona kudzera muukadaulo wa kujambula ubongo kuti ntchito ya mitochondrial ya mitsempha ya wodwalayo yabwezeretsedwa, zomwe zimathandiza kwambiri AKG popewa ndikuchiza matenda owononga mitsempha.
Ubwino wapadera wa AKG
1. Mphamvu yotsutsana ndi ukalamba yamitundu yambiri
Mosiyana ndi NMN, yomwe imagwira ntchito yolimbana ndi ukalamba powonjezera kuchuluka kwa NAD+, AKG imagwira ntchito yokwanira polimbana ndi ukalamba. Sikuti imangolimbikitsa kagayidwe ka mphamvu ndikuwonjezera ntchito ya mitochondrial, komanso imawongolera ukalamba wa thupi kuchokera mbali zosiyanasiyana pokhudza kagayidwe ka amino acid ndikulimbikitsa kapangidwe ka collagen.
2. Kugwirizana kwambiri ndi zamoyo komanso chitetezo
Popeza AKG ndi chinthu chachilengedwe chomwe chimapezeka m'thupi la munthu, imakhala ndi mgwirizano wabwino kwambiri komanso chitetezo. Imatha kuyamwa mwachindunji ndikugwiritsidwa ntchito ndi thupi la munthu popanda kudutsa njira yovuta yosinthira, zomwe zimachepetsa chiopsezo cha zotsatira zoyipa. Izi zimapangitsa kuti kugwiritsa ntchito AKG m'munda woletsa kukalamba kukhale kotetezeka komanso kodalirika.
3. Ubwino wosiyanasiyana pa thanzi
Kuwonjezera pa kuchepetsa ukalamba, AKG imakhalanso ndi ubwino wambiri pa thanzi polimbikitsa thanzi la mitsempha ndi kulimbitsa chitetezo chamthupi. Ubwino wowonjezerawu pa thanzi umapangitsa AKG kukhala yokongola kwambiri pakugwiritsa ntchito mankhwala oletsa ukalamba.
Ndi kuzama kosalekeza kwa kafukufuku wa sayansi komanso kupita patsogolo kwa ukadaulo, mwayi wogwiritsa ntchito AKG m'munda woletsa ukalamba udzakhala waukulu. Tikuyembekezera kafukufuku wapamwamba kwambiri mtsogolo kuti tiwulule zinsinsi zambiri za AKG, komanso tikuyembekezera kuthekera kwake kuphatikizidwa ndi njira zina zoletsa ukalamba monga NMN kuti tithandizire pamodzi nzeru ndi mphamvu zambiri pa thanzi la anthu komanso moyo wautali. Mu mpikisanowu motsutsana ndi nthawi, AKG mosakayikira yawonetsa mpikisano wamphamvu komanso mwayi wopanda malire.
Ntchito zazikulu ndi izi:
Kuletsa ukalamba: Kungathe kuchedwetsa kwambiri ukalamba wa maselo mwa kuwongolera njira yolumikizirana ya mTOR, kulimbikitsa autophagy, kukonza zolakwika mu kagayidwe ka mapuloteni, ndikuwongolera epigenetics. Kuphatikiza apo, kumatha kulimbikitsa kapangidwe ka collagen, kuthandizira kuchotsa poizoni m'maselo, kuthandiza kubwezeretsa kuchuluka kwa calcium m'magazi, kufulumizitsa kuchira kwa mabala, kulimbikitsa kukonzanso minofu, ndi zina zotero.
Konzani matenda osatha: Kuyesa kwachipatala kwasonyeza kuti kumakhudza kwambiri matenda osiyanasiyana osatha, kuphatikizapo koma osati kokha matenda a osteoporosis, matenda a neurodegenerative (monga matenda a Parkinson), matenda a mtima, matenda a shuga, ndi khansa. Kumathetsa zomwe zimayambitsa matenda osatha mwa kuyambitsa mapuloteni okhala ndi moyo wautali m'thupi ndikukonzanso DNA yowonongeka.
Kulimbitsa chitetezo chamthupi: Kungawonjezere ntchito ndi kuchuluka kwa maselo oteteza thupi ku matenda, kukulitsa chitetezo chamthupi chonse, motero kumathandiza thupi kulimbana bwino ndi matenda ndi matenda.
Limbikitsani thanzi: Mankhwalawa alinso ndi ubwino monga kulimbikitsa kagayidwe ka shuga m'magazi ndi mafuta m'thupi komanso kuthandizira ubongo kugwira ntchito bwino, zomwe zimathandiza kuti thupi lonse likhale ndi thanzi labwino.
Zotsatira zotsutsana ndi ukalamba zimathandizidwa ndi kafukufuku wa sayansi. Mwachitsanzo, mu 2014, magazini yapamwamba ya "Nature" inanena koyamba kuti ukalamba ukhoza kuchedwa poletsa ntchito ya mTOR; kafukufuku wokhudza maselo a osteosarcoma a anthu watsimikiziranso kuti ukhoza kulimbikitsa autophagy; kuphatikiza apo, ukhozanso kutenga nawo mbali pakupanga ma amino acid ndikuchepetsa kagayidwe ka mapuloteni. Zinthu zosazolowereka zimachitika ndipo zimakhudzana ndi njira zowongolera ma epigenetic monga DNA demethylation.
Mayeso azachipatala adatsimikiziranso kuti ndi otetezeka komanso ogwira ntchito. Mwachitsanzo, lipoti la mayeso azachipatala a Phase I lomwe linaperekedwa ndi Chipatala cha NewMed ku California likuwonetsa kuti lili ndi mphamvu yochiritsa kwambiri pa zizindikiro zosiyanasiyana za matenda osatha monga kusowa tulo, kuiwala, kulephera kwa impso, matenda a sitiroko, komanso lingathe kuchiza kupuma movutikira, kutopa, ndi zizindikiro zina zomwe zimayambitsidwa ndi kachilombo ka corona. Lilinso ndi mphamvu yabwino kwambiri yochiritsira matenda ena monga chifuwa.
Ndi mphamvu zake zodabwitsa komanso chitetezo chake, chatchuka kwambiri pamsika. Ogwiritsa ntchito ambiri anena kuti ali ndi kusintha kwakukulu pa thanzi lawo atamwa, monga mphamvu zambiri, khungu lolimba komanso lofewa, ndi zina zotero. Nthawi yomweyo, mankhwalawa adziwika ndi kuthandizidwa ndi mabungwe ndi akatswiri ambiri odalirika.
Mwachidule, Calcium Alpha ketoglutarate ndi mankhwala asayansi, otetezeka komanso ogwira mtima oletsa ukalamba. Amathandiza poletsa ukalamba komanso amawongolera zizindikiro za matenda osiyanasiyana osatha kudzera m'njira zosiyanasiyana. Ndi chisankho chabwino kwambiri kwa anthu omwe amafunafuna thanzi komanso moyo wautali.
Nthawi yotumizira: Julayi-08-2024
