Kukalamba ndi njira yachilengedwe yosapeŵeka ya zamoyo, yodziwika ndi kuchepa kwapang'onopang'ono kwa thupi ndi ntchito yake pakapita nthawi. Njirayi ndi yovuta kwambiri ndipo imatha kutengeka kwambiri ndi zinthu zosawoneka bwino zochokera kuzinthu zosiyanasiyana zakunja monga chilengedwe. Kuti amvetse bwino momwe ukalamba ukuyendera, asayansi asiya njira yanthawi zonse yoyezera zaka kapena masiku ndipo m'malo mwake amayang'ana kwambiri za nthawi yovuta kwambiri, kuyesetsa kupeza chidziwitso chobisika cha ukalamba.
Pakufufuza uku, asayansi apanga zolembera zaukalamba zokhala ndi luntha, zomwe ma DNA methylation amawonetsa chidwi kwambiri. Monga njira yayikulu yoyendetsera epigenetic, machitidwe a DNA methylation amatha kujambula bwino momwe munthu akukalamba, osati kungowonetsa kusintha kwakusintha kwa majini paukalamba, komanso kukhala wofunikira pakukalamba kafukufuku wasayansi. zida zolondola. Kupyolera mu kusanthula mozama kwa ma biomarkers awa, asayansi atha kudziwa pang'ono momwe maselo amapangira ukalamba, kutsegulira njira zatsopano zochepetsera kukalamba komanso kulimbikitsa ukalamba wabwino.
M’mlengalenga waukulu wa nyenyezi wa sayansi yoletsa kukalamba, NMN (nicotinamide mononucleotide) nthawi ina inadutsa ngati meteor yonyezimira. Kudziwika kwake monga kalambulabwalo wa NAD + (nicotinamide adenine dinucleotide) kudalimbikitsa asayansi ambiri. chidwi chofufuza. Komabe, m'kupita kwa nthawi, nyenyezi ina yowala kwambiri, AKG (alpha-ketoglutarate), idawonekera pang'onopang'ono ndikuzindikirika kwambiri pankhani yolimbana ndi ukalamba ndi chithumwa chake chapadera komanso maziko asayansi. .
Pakafukufuku wofalitsidwa mu nyuzipepala ya Nature Metabolism, asayansi adafotokoza zambiri za momwe AKG imagwirira ntchito mu metabolism yamphamvu, ntchito ya mitochondrial ndi anti-kukalamba. Kafukufukuyu adawonetsa kuti AKG imatha kulimbikitsa mwachindunji kuzungulira kwa tricarboxylic acid ndikuwonjezera mphamvu zamagetsi m'maselo, motero kumapangitsa kuti ma cell azikhala ndi mphamvu. Kuphatikiza apo, magazini ya "Cell Metabolism" idasindikizanso zotsatira za kafukufuku pa kuthekera kwa AKG kulimbikitsa kaphatikizidwe ka collagen ndikuwongolera kukhazikika kwa khungu, kutsimikiziranso kuthekera kwake pankhani yoletsa kukalamba.
Kubwerera kumayendedwe a nthawi
Kafukufuku wachipatala wochokera ku Japan amatipatsa chitsanzo chowoneka bwino. Mayi wina wazaka zapakati yemwe wakhala akuyang'anitsitsa zotsutsana ndi ukalamba kwa nthawi yayitali, atatenga zowonjezera za AKG kwa theka la chaka, osati kokha kuti khungu lake linali labwino kwambiri, kukhala lolimba komanso lolimba, koma thupi lake lonse. ndipo mkhalidwe wamaganizo unawongoleredwanso kwambiri. Poyerekeza zizindikiro za thupi asanayesedwe komanso atatha, ofufuzawo adapeza kuti ntchito ya mitochondrial ya mayiyo idalimbikitsidwa kwambiri, zomwe zimagwirizana kwambiri ndi ntchito ya AKG yolimbikitsa mphamvu ya metabolism.
Guardian wa thanzi la mitsempha
Kafukufuku wina wochokera ku United States adayang'ana kwambiri ntchito ya neuroprotective ya AKG. Atalandira chithandizo cha AKG, bambo wina wachikulire yemwe anali ndi vuto la kuzindikira pang'ono, adawonetsa kusintha kwakukulu mu luso lake la kuzindikira, kuphatikiza kukumbukira bwino komanso kukhazikika. Ofufuzawo adawona kudzera muukadaulo wojambula muubongo kuti ntchito ya neuron mitochondrial ya wodwalayo idabwezeretsedwa, zomwe zimapereka chithandizo champhamvu kwa AKG popewa komanso kuchiza matenda a neurodegenerative.
Ubwino wapadera wa AKG
1. Multi-dimensional anti-aging effect
Mosiyana ndi NMN, yomwe makamaka imalimbana ndi ukalamba powonjezera milingo ya NAD+, AKG imagwira ntchito yoletsa kukalamba. Sizingangolimbikitsa kagayidwe ka mphamvu ndi kupititsa patsogolo ntchito ya mitochondrial, komanso kupititsa patsogolo ukalamba wa thupi kuchokera kumagulu angapo pokhudza kagayidwe ka amino acid ndi kulimbikitsa kaphatikizidwe ka collagen.
2. Biocompatibility yapamwamba ndi chitetezo
Monga metabolite yochitika mwachilengedwe m'thupi la munthu, AKG ili ndi biocompatibility yabwino kwambiri komanso chitetezo. Itha kutengeka mwachindunji ndikugwiritsidwa ntchito ndi thupi la munthu popanda kudutsa njira yovuta yosinthira, kuchepetsa chiopsezo cha zovuta zomwe zingachitike. Izi zimapangitsa kugwiritsa ntchito AKG m'munda woletsa kukalamba kukhala otetezeka komanso odalirika.
3. Zopindulitsa zambiri zathanzi
Kuphatikiza pa anti-kukalamba, AKG imawonetsanso zabwino zambiri zathanzi polimbikitsa thanzi lamanjenje ndikulimbikitsa chitetezo chamthupi. Zowonjezera izi zaumoyo zimapangitsa AKG kukhala yokongola kwambiri pamapulogalamu oletsa kukalamba.
Ndikukula kosalekeza kwa kafukufuku wa sayansi komanso kupita patsogolo kwaukadaulo, chiyembekezo chogwiritsa ntchito AKG pankhani yoletsa kukalamba chidzakhala chokulirapo. Tikuyembekezera kufufuza kwapamwamba kwambiri m'tsogolomu kuti tiwulule zinsinsi zambiri za AKG, komanso tikuyembekezera kutha kwake kuphatikizika ndi njira zina zotsutsana ndi ukalamba monga NMN kuti tithandizire pamodzi nzeru zambiri ndi mphamvu ku thanzi laumunthu ndi moyo wautali. . Mu mpikisano wolimbana ndi nthawi, AKG mosakayikira yawonetsa kupikisana kwamphamvu komanso mwayi wopanda malire.
Ntchito zazikuluzikulu ndi:
Anti-aging: Ikhoza kuchedwetsa kwambiri kukalamba kwa ma cell poyendetsa njira yowonetsera mTOR, kulimbikitsa autophagy, kukonza zolakwika za protein metabolism, ndikuwongolera epigenetics. Kuphatikiza apo, imatha kulimbikitsa kaphatikizidwe ka collagen, kuthandizira kutulutsa maselo, kuthandizira kubwezeretsa kuchuluka kwa calcium m'magazi, kufulumizitsa machiritso a bala, kulimbikitsa kukonza minofu, ndi zina zambiri.
Limbikitsani matenda aakulu: Kuyesa kwachipatala kwasonyeza kuti ili ndi kusintha kwakukulu pa matenda osiyanasiyana osatha, kuphatikizapo koma osati kokha ku osteoporosis, matenda a neurodegenerative (monga Parkinson's disease), matenda a mtima, shuga, ndi khansa. Imathetsa zomwe zimayambitsa matenda osachiritsika mwa kuyambitsa mapuloteni amoyo wautali m'thupi ndikukonzanso DNA yowonongeka.
Kupititsa patsogolo chitetezo chokwanira: Ikhoza kupititsa patsogolo ntchito ndi kuchuluka kwa maselo a chitetezo cha mthupi, kusintha chitetezo chokwanira cha thupi lonse, motero kumathandiza thupi kulimbana bwino ndi matenda ndi matenda.
Limbikitsani thanzi: Izi zilinso ndi zopindulitsa monga kulimbikitsa kagayidwe ka shuga wamagazi ndi mafuta m'thupi komanso kuthandizira chidziwitso chaubongo, zomwe zimathandiza kuti thupi lonse likhale ndi thanzi labwino.
Zotsatira zotsutsana ndi ukalamba zimathandizidwa ndi kafukufuku wa sayansi. Mwachitsanzo, mu 2014, magazini yapamwamba yotchedwa "Nature" inanena kwa nthawi yoyamba kuti ukalamba ukhoza kuchedwa kulepheretsa ntchito ya mTOR; kafukufuku pa maselo osteosarcoma anthu watsimikiziranso kuti akhoza kulimbikitsa autophagy; Kuphatikiza apo, imathanso kutenga nawo gawo pakupanga ma amino acid ndikuchepetsa kagayidwe ka mapuloteni. Zolakwika zimachitika ndipo zimakhudzidwa ndi njira zoyendetsera epigenetic monga DNA demethylation.
Mayesero azachipatala adatsimikiziranso chitetezo chake komanso mphamvu zake. Mwachitsanzo, lipoti lachipatala la anthu la Phase I lomwe linaperekedwa ndi NewMed Hospital ku California limasonyeza kuti limakhala ndi zotsatira zochiritsira pamitundu yosiyanasiyana ya matenda aakulu monga kusowa tulo, kukumbukira kukumbukira, kulephera kwa aimpso, stroke sequelae, komanso amatha kuchiza kupuma, kutopa, ndi zizindikiro zina zoyambitsidwa ndi coronavirus yatsopano. Imakhalanso ndi zotsatira zabwino kwambiri pa sequelae monga chifuwa.
Ndi mphamvu yake yodabwitsa komanso chitetezo, yapambana chidwi ndi matamando ambiri pamsika. Ogwiritsa ntchito ambiri awonetsa kusintha kwakukulu kwa thupi lawo atatenga, monga mphamvu zowonjezera, khungu lolimba komanso losalala, ndi zina zotero. Panthawi imodzimodziyo, mankhwalawa adziwikanso ndikuthandizidwa ndi mabungwe ambiri ovomerezeka ndi akatswiri.
Mwachidule, Calcium Alpha ketoglutarate ndi mankhwala asayansi, otetezeka komanso othandiza oletsa kukalamba. Imakwaniritsa zotsutsana ndi ukalamba ndikuwongolera zizindikiro za matenda osiyanasiyana osachiritsika kudzera m'njira zingapo. Ndi chisankho choyenera kwa anthu omwe amatsata thanzi komanso moyo wautali.
Nthawi yotumiza: Jul-08-2024
