Wopanga ufa wa YDL223C (HBT1) Nambala ya CAS: 489408-02-8 99% kuyera kwa zosakaniza zowonjezera
Kanema wa Zamalonda
Magawo a Zamalonda
| Dzina la chinthu | HBT1 |
| Dzina lina | YDL223C |
| Nambala ya CAS | 489408-02-8 |
| Fomula ya maselo | C16H17F3N4O2S |
| Kulemera kwa maselo | 386.40 |
| Chiyero | 99.0% |
| Maonekedwe | Cholimba chachikasu chopepuka |
| Kulongedza | 1kg pa thumba 25kg pa ng'oma |
| Kugwiritsa ntchito | mankhwala a nootropic |
Chiyambi cha malonda
HBT1 imalumikizana ndi gawo lomangirira la α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) motsatira glutamate. Izi zikutanthauza kuti HBT1 ndi molekyulu yomwe imangolumikizana ndi malo enaake pa puloteni ya AMPA-R pamene glutamate ilipo, ndipo kumangiriza kumeneku kumathandiza kuwongolera ntchito ya puloteni. Ma AMPA receptors amawonetsedwa mu dongosolo lonse la mitsempha ndipo amachita ntchito zofunika kwambiri pakulankhulana kwa mitsempha, kukonza zomverera, kuphunzira, kukumbukira, ndi pulasitiki ya synaptic. Ma AMPA receptors ndi omwe amathandizira kwambiri pakufalitsa mauthenga a mitsempha, amathandizira kusuntha mwachangu komanso mwachangu pa ma synapses ambiri, ndipo amagwira ntchito poyankha koyambirira kwa glutamate m'madera a synaptic. Ma AMPA receptors nthawi zambiri amawonetsedwa pamodzi ndi ma NMDA receptors pa ma synapses, ndipo pamodzi amalimbikitsa njira za synaptic plasticity zomwe zimakhudzidwa ndi kuphunzira, kukumbukira, poizoni, komanso kuteteza mitsempha. Chida chochokera mu ubongo (BDNF) ndi chida chochokera mu ubongo chomwe chimagwira ntchito yofunika kwambiri pakusunga ndi kukulitsa ma neuron ndipo chimakhala ndi zotsatira zamphamvu komanso zambiri pa kuchulukana, kusiyanitsa, kupulumuka ndi kufa kwa maselo a neuronal ndi omwe si a neuronal. , chosinthira ma neurotransmitter chomwe chimathandizira kuti ma neuron azitha kuphunzira komanso kukumbukira. Chifukwa chake, ndikofunikira pa thanzi ndi ubwino wa dongosolo lamanjenje.
Mbali
(1) Kuyera kwambiri: HBT1 imatha kupeza zinthu zoyera kwambiri kudzera mu njira zopangira zinthu zoyeretsera. Kuyera kwambiri kumatanthauza kupezeka bwino kwa bioavailability komanso kuchepetsa zotsatirapo zoyipa.
(2) Chitetezo: HBT1 yatsimikiziridwa kuti ndi yotetezeka ku thupi la munthu.
(3) Kukhazikika: HBT1 ili ndi kukhazikika kwabwino ndipo imatha kusunga ntchito yake ndi mphamvu zake pansi pa malo osiyanasiyana komanso malo osungiramo zinthu zosiyanasiyana.
Mapulogalamu
HBT1 ndi chowonjezera chatsopano cha AMPA receptor chomwe chili ndi agonism yochepa, chomwe chimayambitsa kupanga kwa neurotrophic factor (BDNF) yochokera muubongo ndipo sichimakhudza kwambiri ma neuron oyambira. HBT1 imagwirizana ndi AMPA-R yomwe imamanga ligand modalira glutamate. Pamodzi, amalimbikitsa njira zolumikizirana za synaptic zomwe zimakhudzidwa ndi kuphunzira, kukumbukira, kusangalala, komanso kuteteza mitsempha. Ikhoza kupititsa patsogolo luso la ubongo lozindikira komanso kukumbukira, ndikuwonjezera luso la anthu lophunzira. Nthawi zambiri imawonjezeredwa ku zakudya za tsiku ndi tsiku monga zowonjezera zakudya.
