YDL223C (HBT1) wopanga ufa CAS No.: 489408-02-8 99% chiyero min. kwa zowonjezera zowonjezera

HBT1 imamangiriza ku ligand-binding domain ya α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) m'njira yodalira glutamate. Izi zikutanthauza kuti HBT1 ndi molekyu yomwe imatha kumangiriza kumalo enaake a puloteni ya AMPA-R pamene glutamate ilipo, ndipo kumanga kumeneku kumathandiza kuyendetsa bwino ntchito ya mapuloteni. Ma receptor a AMPA amawonetsedwa mu dongosolo lonse lamanjenje ndipo amatenga gawo lofunikira pakuyankhulirana kwa neuronal, kukonza zomverera, kuphunzira, kukumbukira, ndi synaptic plasticity. Ma receptor a AMPA ndi omwe amathandizira kwambiri pakutulutsa kosangalatsa kwa ma neurotransmission, amalumikizana mwachangu, mofulumizitsa chisangalalo pama synapses ambiri, ndipo amatenga nawo gawo pakuyankha koyambirira kwa glutamate m'magawo a synaptic. Ma receptor a AMPA nthawi zambiri amawonetsedwa limodzi ndi ma NMDA receptors pa ma synapses, ndipo palimodzi amalimbikitsa njira za synaptic plasticity zomwe zimakhudzidwa ndi kuphunzira, kukumbukira, chisangalalo, ndi neuroprotection. Ubongo wamtundu wa neurotrophic factor (BDNF) ndi neurotrophic factor yomwe imagwira ntchito yofunika kwambiri pakukonza ndi kukulitsa ma neurons ndipo imakhala ndi zotsatira zamphamvu komanso zambiri pakukula, kusiyanitsa, kupulumuka ndi kufa kwa maselo a neuronal ndi osakhala a neuronal. , moduli ya neurotransmitter yomwe imathandizira ku neuronal plasticity pophunzira ndi kukumbukira. Choncho, ndizofunikira pa thanzi komanso thanzi la mitsempha ya mitsempha.