Kodi Choline Alfoscerate ndi Chiyani Ndipo Ingathandize Bwanji Ubongo Wanu?

Monga chinthu chokhazikika m'thupi la munthu, L-α-glycerophosphocholine imatha kulowa chotchinga chamagazi ndi ubongo ndipo imakhala ndi bioavailability yapamwamba kwambiri. Ndi mchere wapamwamba kwambiri womwe ndi wofunika kwambiri m'thupi la munthu. "Chotchinga chamagazi-muubongo ndi cholimba, chofanana ndi "khoma" pakati pa ma capillary plexuses a ubongo. L-α-glycerophosphocholine imatha kuloŵa chotchinga chamagazi ndi ubongo ndikuthandizira kukulitsa kukumbukira, kuwongolera kuganiza, komanso ali ndi mapindu omwe angakhalepo pothetsa nkhawa, kukhazikika maganizo, ndi kuwonjezera mphamvu za minofu ndi kupirira "Zotsatira za zakudya za L-α-glycerophosphocholine zimawonekera makamaka muzinthu za 5.

Chimodzi ndicho kupititsa patsogolo ntchito za ubongo. Kuchuluka kwa ma cell a mitsempha muubongo, mphamvu yawo imakhala yamphamvu, imatumiza mwachangu zizindikiro za minyewa, komanso mphamvu yaubongo yokonza zinthu. L-α-glycerophosphocholine imatha kupititsa patsogolo ntchito zaubongo polimbikitsa mphamvu zama cell amitsempha komanso kufalikira kwa ma sign a mitsempha. Pankhani yopititsa patsogolo cholinergic neurotransication, kufalikira kwa ma cell pakati pa mitsempha ya mitsempha kumadalira kufalikira kwa ma neurotransmitters, ndipo acetylcholine ndi messenger wofunikira wamankhwala ndi ma neurotransmitter omwe amatsimikizira kuganiza mozama ndikusunga mgwirizano pakati pa ubongo ndi thupi lonse.

L-α-glycerophosphocholine imatha kuwola kukhala 3-glycerol phosphate ndi choline mu ubongo ndipo ndiyomwe imathandizira kwambiri acetylcholine. Ikhoza kupititsa patsogolo kukumbukira ndikuwongolera kuganiza mwa kulimbikitsa kaphatikizidwe ndi kutulutsidwa kwa acetylcholine mu ubongo. Ponena za kupititsa patsogolo kukhazikika ndi kusungunuka kwa ma membrane am'maselo, L-α-glycerophosphocholine imatha kulimbikitsa kaphatikizidwe ka phosphoinositide, potero kumathandizira kukhazikika ndi kutulutsa madzi kwa ma cell. Ma neurons okhala ndi mawonekedwe osasinthika amatha kufalitsa zambiri. Limbikitsani kuganiza bwino kwa thupi.

Chachiwiri ndi zakudya ndi chitetezo cha mitsempha. Zinthu za neurotrophic, kukula kwa minofu yamanjenje, zimatha kuwongolera kusiyanasiyana kwa ma cell a stem ndikulimbikitsa mapangidwe a kulumikizana kwatsopano kwa neural. L-α-glycerophosphocholine ikhoza kulimbikitsa kutulutsidwa kwa zinthu zosiyanasiyana za neurotrophic ndikuyambitsa njira zowonetsera zokhudzana ndi kupulumuka kwa maselo, motero Zimakhala ndi zotsatira za neuroprotective komanso zimapangitsa kuti thupi likhale ndi chidziwitso. Panthawi imodzimodziyo, L-α-glycerophosphocholine ikhoza kulimbikitsanso kutulutsidwa kwa hormone ya kukula ndikukhala ndi thanzi labwino la thupi powonjezera kukula kwa hormone.

Chachitatu ndi antioxidant. Oxidation ndi kutupa ndizomwe zimayambitsa kukalamba ndi kufa kwa maselo aubongo. L-α-glycerophosphocholine imatha kuwononga ma radicals aulere m'thupi, kuthana ndi kupsinjika kwa okosijeni, komanso kuchepetsa nyukiliya NF-κB, tumor necrosis factor TNF-α, ndi interleukins. Kutulutsidwa kwa zinthu zotupa monga IL-6 kumalimbana ndi kutupa kwaubongo, motero kumachepetsa kwambiri kuchepa kwa chidziwitso ndikuletsa kuchitika komanso kukula kwa matenda a neurodegenerative.

Zotsatira zoyenera zathandizidwa ndi zotsatira zachipatala. Mu phunziro la "Mchitidwe wa L-α-glycerophosphocholine pa kuwonongeka kwa kukumbukira zaka", maphunziro a 4 anapatsidwa placebo, ndi maphunziro ena a 5 anapatsidwa Pambuyo pa kutenga L-α-glycerophosphocholine (1200 mg / tsiku) pamlomo kwa miyezi 3. , Ma electrode a 16 anagwiritsidwa ntchito kulemba mafunde a ubongo kwa mphindi 5 pamene maphunzirowo anali maso ndi kupuma. Zotsatira zake zidawonetsa kuti poyerekeza ndi placebo, L-alpha-glycerophosphocholine idakulitsa kwambiri kuchuluka kwa mafunde othamanga kwambiri muubongo pomwe amakhala ndi chizolowezi chochepetsa ma frequency ocheperako. Ndiko kuti, imatha kukulitsa nyonga yaubongo ya anthu azaka zapakati ndikuchedwetsa kukalamba kwa thupi.

Chachinayi ndi kulamulira maganizo. Dopamine imapangitsa anthu kukhala osangalala, ndipo serotonin ndi gamma-aminobutyric acid zimatha kuwongolera momwe thupi likuyendera. L-α-glycerophosphocholine imatha kulimbikitsa kutulutsidwa kwa dopamine, kuwongolera mafotokozedwe a onyamula dopamine, kusintha dopamine neurotransmission muubongo, ndikuwonjezera milingo ya serotonin mu striatum ndi prefrontal cortex; Zingathenso kulimbikitsa endogenous Kutulutsidwa kwa γ-aminobutyric acid mu minofu yokhudzana ndi kugonana kumachepetsa kusowa tulo, motero kumakhala ndi zotsatira zotsutsa-depressant, nkhawa komanso kukhazikika maganizo.

Chachisanu ndikusintha masewera olimbitsa thupi. Panthawi yochita masewera olimbitsa thupi, L-alpha-glycerophosphocholine imathandizanso kuti thupi likhale lopangidwa mwa kuwonjezera minofu ndikuwongolera zochitika zonse za kagayidwe kachakudya poonjezera kupanga kwambiri kukula kwa hormone ndi kutulutsa mphamvu. Kuphatikiza apo, L-α-glycerophosphocholine imathanso kufulumizitsa kufalikira kwa ma neurotransmitter, kumapangitsa kuti kulumikizana kwa neuromuscular kukhale kothandiza, kukulitsa kugundana ndi kupirira kwa minofu ya chigoba, potero kumathandizira kulimbitsa thupi, kudana ndi kutopa, komanso kulimbikitsa kukula kwa minofu. . mphamvu.

Ndiye kodi anthu angapeze kuti chopatsa thanzi chimenechi chokhala ndi mapindu ochuluka chonchi? M'malo mwake, L-α-glycerophosphocholine ili muzakudya zambiri monga mazira, nkhuku, ndi utawaleza, koma zomwe zilimo nthawi zambiri zimakhala zazing'ono. Malinga ndi "Second Edition of the US General Food Choline Content Database" lofalitsidwa ndi United States Department of Agriculture, zomwe zili mu L-α-glycerophosphocholine muzakudya zonse za 630 m'magulu 22 zidawonetsa kuti L-α-glycerophosphocholine pa 100 iliyonse. magalamu a chakudya Zomwe zili mu glycerophosphocholine zimachokera ku 0 mpaka 190 mg. Choncho, pofuna kukwaniritsa zosowa za kukula kwa thupi laumunthu, chitukuko ndi kagayidwe kake, zowonjezera zowonjezera zingathe kupangidwa moyenera.

Kaphatikizidwe ka mankhwala ndi imodzi mwa njira zazikulu zopangira L-α-glycerophosphocholine. Pogwiritsa ntchito polyphosphoric acid, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide ndi madzi monga zopangira, pambuyo pa condensation ndi esterification anachita, ndi decolorized, zonyansa zimachotsedwa, zimayikirapo, zoyengedwa ndi zouma. L-α-glycerophosphocholine yopangidwa ndi njira zina imatha kuwonjezeredwa ku zakumwa zoziziritsa kukhosi, zakumwa zamasewera, khofi, ma gummies, oatmeal energy bar, ndi zina zambiri, ndipo zimatha kuwonetsa zotsatira zake zopatsa thanzi m'njira yolunjika kuti akwaniritse thanzi la ogula. chosowa.

Ku United States, Japan, Canada ndi mayiko ena, L-α-glycerophosphocholine yagwiritsidwa ntchito kwambiri muzakudya. Zogulitsa zogwirizana zimaphimba zakudya zowonjezera, zakumwa, ma gummies ndi magulu ena, ndipo chilichonse chimakhala ndi Ntchito zomveka bwino, mlingo wovomerezeka ndi magulu ovomerezeka.

Suzhou Myland Pharm & Nutrition Inc.ndi wopanga olembetsedwa ndi FDA yemwe amapereka ufa wapamwamba kwambiri komanso woyeretsedwa wa Alpha GPC.

Ku Suzhou Myland Pharm tadzipereka kupereka zinthu zapamwamba kwambiri pamitengo yabwino kwambiri. Ufa wathu wa Alpha GPC umayesedwa mwamphamvu kuti ukhale woyera ndi potency, kuonetsetsa kuti mumapeza chowonjezera chapamwamba chomwe mungakhulupirire. Kaya mukufuna kuthandizira thanzi la ma cell, kulimbikitsa chitetezo chamthupi kapena kukulitsa thanzi labwino, ufa wathu wa Alpha GPC ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira zokongoletsedwa bwino za R&D, Suzhou Myland Pharm yapanga zinthu zambiri zampikisano ndikukhala kampani yotsogola ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.

Kuphatikiza apo, Suzhou Myland Pharm ndiwopanganso zolembedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira zinthu, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani mumlingo, ndikutsata miyezo ya ISO 9001 ndi zopangira GMP.