Urolithin A ndi metabolite wachilengedwe wopangidwa pamene thupi limagaya zinthu zina mu zipatso monga makangaza, sitiroberi, ndi raspberries. Metabolite iyi yasonyezedwa kuti ili ndi ubwino wambiri wathanzi komanso ndi mankhwala oletsa kukalamba omwe amatha kusintha momwe timachitira ndi ukalamba. Kukhoza kwake kuthandizira ntchito ya mitochondrial, thanzi la minofu, ndi chidziwitso chazidziwitso zimapangitsa kuti zikhale zowonjezera kwa iwo omwe akufuna kusunga unyamata ndi nyonga. Pamene kafukufuku wa urolithin A akupitilirabe kusinthika, akuyenera kukhala mwala wapangodya wa njira zothana ndi ukalamba m'tsogolomu. Yang'anirani gulu lamphamvu limeneli—lingakhale mfungulo yotsegula kasupe wa unyamata.
Urolithin A ndi metabolite yopangidwa m'matumbo mutadya zakudya zina, monga makangaza, zipatso zokhala ndi ellagitannin, ndi mtedza. Kafukufuku akuwonetsa kuti urolithin A ili ndi mphamvu zoletsa kukalamba ndipo imatha kukhala ndi gawo lalikulu polimbikitsa thanzi la ma cell ndi moyo wautali.
Urolithin A imayendetsa njira yotchedwa mitophagy. Mitophagy ndi njira yachilengedwe ya thupi yochotsera mitochondria yowonongeka kapena yosagwira ntchito, mphamvu zama cell. Tikamakalamba, mitochondria yathu imakhala yochepa kwambiri ndipo imadziunjikira zowonongeka, zomwe zimayambitsa kuchepa kwa maselo ndi thanzi labwino. Polimbikitsa mitophagy, urolithin A imathandizira kubwezeretsa ndikubwezeretsanso mafakitale athu amphamvu zama cell, zomwe zimachepetsa kukalamba.
Kuphatikiza pa kulimbikitsa thanzi la mitochondrial, urolithin A imakhalanso ndi antioxidant ndi anti-inflammatory properties. Kupsinjika kwa okosijeni ndi kutupa kosatha ndizomwe zimayambitsa matenda okalamba komanso okhudzana ndi ukalamba. Urolithin A imathandizira kuthana ndi njirazi, kuteteza maselo athu ndi minofu kuti isawonongeke ndi ukalamba.
Kuphatikiza apo, urolithin A yawonetsedwa kuti imathandizira kugwira ntchito kwa minofu ndikulimbikitsa thanzi la minofu, zomwe zimakhala zofunika kwambiri tikamakalamba. Sarcopenia, kapena kuwonongeka kwa minofu yokhudzana ndi ukalamba, ndi vuto lofala kwa okalamba ndipo lingayambitse kufooka ndi kuchepa kwa moyo wonse. Pothandizira kugwira ntchito kwa minofu, urolithin A ikhoza kuthandizira kukhalabe ndi mphamvu ndi kuyenda pamene tikukalamba.
Choyamba, tiyeni tione mwatsatanetsatane zomwe urolithin ndi momwe zimagwirira ntchito m'thupi. Urolithins ndi metabolites opangidwa pamene tizilombo toyambitsa matenda timaphwanya ellagitannins, omwe amapezeka mu zipatso monga makangaza ndi zipatso. Izi ndizofunikira chifukwa urolithin sangathe kupezeka mwachindunji podya zipatsozi. Akapangidwa, urolithins amaganiziridwa kuti ali ndi ubwino wambiri wathanzi, kuphatikizapo kupititsa patsogolo ntchito ya mitochondrial (yomwe ndi yofunika kwambiri pakupanga mphamvu zamagetsi) ndikulimbikitsa thanzi la minofu ndi moyo wautali.
Kafukufuku wofalitsidwa mu nyuzipepala ya Nature Metabolism anapeza kuti urolithin A, imodzi mwa mitundu yophunzira kwambiri ya urolithin, imapangitsa kuti minofu igwire bwino ntchito komanso kupirira kwa mbewa zachikulire. Kupeza uku ndikulonjeza chifukwa zikuwonetsa kuti urolithin ikhoza kukhala ndi phindu pakuchepa kwa minofu yokhudzana ndi ukalamba.
Kuphatikiza pa zabwino zomwe zingakhalepo pa thanzi la minofu, urolithin adaphunziridwanso chifukwa cha anti-kukalamba. Kafukufuku wina yemwe adasindikizidwa mu nyuzipepala ya Nature Medicine mu 2016 adawonetsa kuti urolithin A imatha kutsitsimutsa mitochondria m'maselo okalamba, potero imathandizira magwiridwe antchito a cell ndikuchepetsa kukalamba.
Imodzi mwa mitundu yodziwika bwino ya urolithin A imakhala ngati chowonjezera chazakudya. Zowonjezera izi nthawi zambiri zimachokera ku makangaza kapena ellagic acid ndipo zimatengedwa ngati kapisozi. Komabe, bioavailability ya urolithin A mu mawonekedwe owonjezera imatha kusiyana, ndipo kafukufuku wina akuwonetsa kuti ikhoza kukhala yocheperako kuposa mitundu ina.
Mtundu wina wa urolithin A uli ngati chakudya chogwira ntchito. Makampani ena ayamba kuwonjezera urolithin A kuzinthu zosiyanasiyana zazakudya ndi zakumwa, monga zopangira mapuloteni, zakumwa ndi ufa. Zogulitsazi zimapereka njira yabwino komanso yokoma yogwiritsira ntchito urolithin A.
Chimodzi mwazinthu zodalirika kwambiri za urolithin A ndi monga chowonjezera chamankhwala. Zogulitsazi zimayesedwa mozama ndikuwongolera kuti zitsimikizire chiyero ndi potency. Mankhwala a urolithin A amapereka bioavailability yapamwamba kwambiri komanso yogwira mtima, zomwe zimapangitsa kukhala njira yabwino kwambiri yopezera ubwino wathanzi wa mankhwalawa.
Kuphatikiza pa mawonekedwewa, kafukufuku akupitirirabe pakupanga ma analogues a urolithin A, omwe ndi opangidwa ndi mankhwala opangidwa kuti atsanzire zotsatira za urolithin A. Mafananidwewa angapereke ubwino wapadera pokhudzana ndi bioavailability, kukhazikika, ndi potency.
1. Anti-kukalamba katundu
Mitochondria ndi mphamvu zama cell athu, omwe ali ndi udindo wopanga mphamvu ndikuwongolera ma cell. Tikamakalamba, mitochondria yathu imakhala yochepa kwambiri, zomwe zimapangitsa kuti ma cell agwire ntchito. Urolithin A wawonetsedwa kuti amatsitsimutsa mitochondria yokalamba, potero imathandizira kupanga mphamvu komanso thanzi la ma cell. Kuphatikiza pa zabwino zake pa mitochondria, urolithin A yapezeka kuti imayambitsa njira yotchedwa autophagy. Autophagy ndi njira yachilengedwe ya thupi yochotsera ma cell owonongeka kapena osokonekera, potero kulimbikitsa kukonzanso kwa maselo ndi thanzi labwino. Mwa kupititsa patsogolo autophagy, Urolithin A imathandiza kuchotsa maselo akale, otopa m'thupi ndikuwalowetsa m'malo mwa maselo atsopano, athanzi, potero amawongolera kugwira ntchito kwa minofu ndi mphamvu zonse.
2. Anti-kutupa katundu
Kutupa kosatha ndi kupsinjika kwa okosijeni ndizo zomwe zimayambitsa ukalamba, zomwe zimayambitsa matenda okhudzana ndi ukalamba. Pochepetsa kutupa ndi kupsinjika kwa okosijeni, urolithin A imatha kuletsa kupanga mamolekyu otupa ndikuthandizira kupewa matenda okhudzana ndi ukalamba. matenda, ndipo amalimbikitsa thanzi lonse ndi moyo wautali.
3. Thanzi la minofu
Urolithin A yapezekanso kuti imalimbikitsa thanzi la minofu ndi ntchito. Tikamakalamba, minofu ndi mphamvu zathu zimachepa mwachibadwa. Komabe, urolithin A imatha kupititsa patsogolo kusintha kwa maselo a minofu ndikuwongolera magwiridwe antchito a minofu, zomwe zingathandize kuchepetsa kuwonongeka kwa minofu yokhudzana ndi ukalamba.
4. Thanzi la M'matumbo
Kafukufuku watsopano akuwonetsa kuti urolithin A ikhoza kukhala ndi gawo lolimbikitsa thanzi lamatumbo. Zapezeka kuti zili ndi prebiotic zotsatira, kutanthauza kuti zimathandizira kukula kwa mabakiteriya abwino m'matumbo. Kukhala ndi thanzi labwino m'matumbo a microbiome ndikofunikira paumoyo wonse, chifukwa kumatha kukhudza chilichonse kuyambira chimbudzi mpaka chitetezo chamthupi.
5. Thanzi lachidziwitso
Palinso umboni wosonyeza kuti urolithin A ikhoza kukhala ndi zotsatira zabwino pa thanzi lachidziwitso. Kafukufuku akuwonetsa kuti zitha kuthandiza kupewa matenda a neurodegenerative monga Alzheimer's pochepetsa kuchuluka kwa mapuloteni oyipa muubongo. Izi zikuwonetsa phindu lomwe lingakhalepo pa thanzi laubongo komanso kugwira ntchito kwachidziwitso.
Ndi njere zake zofiira za ruby ndi kukoma kwa tart, makangaza ndi amtengo wapatali chifukwa cha ubwino wawo wambiri wathanzi. Kuchokera kuzinthu zambiri za antioxidant mpaka ku mphamvu zake zotsutsa-kutupa, chipatsochi chakhala chikuwoneka ngati chopatsa mphamvu m'dziko lazakudya. Chimodzi mwazinthu zosangalatsa kwambiri zomwe zimapezeka m'makangaza ndi urolithin, metabolite yomwe yakhala ikuphunziridwa zambiri chifukwa cha zotsatira zake zolimbikitsa thanzi.
Kuti timvetsetse yankho la funsoli, m'pofunika kufufuza mozama mu sayansi ya urolithin ndi momwe amapangidwira. Tikamadya zakudya zokhala ndi ellagitannins, monga makangaza, mankhwalawa amaphwanyidwa kukhala urolithins ndi matumbo a microbiota. Komabe, si onse omwe ali ndi mawonekedwe ofanana a m'matumbo a microbiota, zomwe zimapangitsa kusiyana kwa kupanga urolithin pakati pa anthu.
Ngakhale makangaza ndi gwero lambiri la ellagitannins, kuchuluka kwa urolithin komwe kumapangidwa m'thupi kumatha kusiyanasiyana. Kusiyanasiyana kumeneku kunapangitsa kuti pakhale zowonjezera zowonjezera za urolithin zomwe zimachokera ku makangaza a makangaza, kuonetsetsa kuti kupitiriza kudya kwa metabolite yopindulitsa iyi. Zowonjezera izi zikupeza chidwi chifukwa cha kuthekera kwawo kuthandizira thanzi la minofu, kupititsa patsogolo ntchito ya mitochondrial, ndikuwonjezera thanzi labwino.
Kutuluka kwa zowonjezera za urolithin kwadzetsa chidwi pa kuthekera kwawo kogwiritsa ntchito mapindu a makangaza popanda kudalira kusiyana kwa kupanga urolithin. Kwa iwo omwe sangadye makangaza pafupipafupi kapena sangapindule mokwanira ndi urolithin yake chifukwa cha kapangidwe kake ka m'matumbo a microbiota.
Funso loti chotsitsa cha makangaza chili ndi urolithin chingayankhidwe motsimikiza. Ngakhale kuti urolithin ndi mankhwala achilengedwe omwe amadya makangaza, kusiyanasiyana kwa kapangidwe kake m'thupi kunapangitsa kuti urolithin apangidwe kuti apitirize kudya metabolite yopindulitsayi.
Pamene kafukufuku akupitiriza kuwulula zotsatira zolimbikitsa thanzi za urolithin, kugwiritsa ntchito makangaza monga gwero la mankhwalawa kuli ndi kuthekera kwakukulu. Kaya kudzera mukudya makangaza okha kapena kugwiritsa ntchito zowonjezera za urolithin, kugwiritsa ntchito mphamvu ya urolithin ndi njira yodalirika yothandizira thanzi labwino komanso thanzi.
Posankha chowonjezera cha urolithin A, pali zinthu zingapo zofunika kuziganizira. Choyamba, ndikofunikira kupeza wopanga zodziwika bwino yemwe amagwiritsa ntchito zosakaniza zapamwamba kwambiri komanso kutsatira malamulo okhwima. Yang'anani zowonjezera zomwe zimayesedwa ndi chipani chachitatu kuti zikhale zoyera ndi potency kuti muwonetsetse kuti mukupeza mankhwala otetezeka komanso ogwira mtima.
Kuphatikiza apo, lingalirani za mawonekedwe a urolithin A omwe amagwiritsidwa ntchito pazowonjezera. Urolithin A nthawi zambiri amaphatikizidwa ndi mankhwala ena, monga urolithin B kapena ellagic acid, omwe angapangitse zotsatira zake. Yang'anani zowonjezera zomwe zimagwiritsa ntchito mawonekedwe a bioavailable a urolithin A kuti muwonjezere kuyamwa kwake ndikuchita bwino m'thupi.
Pomaliza, ganizirani zosowa zanu paumoyo wanu komanso zolinga zanu zenizeni zotengera urolithin A zowonjezera. Mwachitsanzo, ngati ndinu wothamanga yemwe akufuna kupititsa patsogolo ntchito ya minofu, mungakonde zowonjezera zomwe zimapangidwira kuti mukhale ndi thanzi labwino la minofu ndi kuchira.
Suzhou Myland Pharm & Nutrition Inc. yakhala ikuchita bizinesi yazakudya zopatsa thanzi kuyambira 1992. Ndi kampani yoyamba ku China kupanga ndi kugulitsa zokolola za mphesa.
Pokhala ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira yokongoletsedwa kwambiri ya R&D, kampaniyo yapanga zinthu zambiri zopikisana ndikukhala kampani yowonjezera ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.
Kuphatikiza apo, kampaniyo ndinso wopanga olembetsedwa ndi FDA, kuwonetsetsa kuti thanzi la anthu likhale lokhazikika komanso kukula kosatha. Zipangizo zamakampani za R&D ndi zida zopangira ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala pa milligram mpaka ton motsatira miyezo ya ISO 9001 ndi machitidwe opanga GMP.
Q: Kodi ketone ester ndi chiyani ndipo imagwira ntchito bwanji?
A: Ketone ester ndi yowonjezera yomwe imapatsa thupi ma ketoni, omwe amapangidwa mwachibadwa ndi chiwindi panthawi ya kusala kudya kapena kuchepa kwa carbohydrate. Mukalowetsedwa, ketone ester imatha kukweza mwachangu kuchuluka kwa matupi a ketone m'magazi, ndikupangitsa thupi kukhala ndi mafuta ena opangira shuga.
Q: Kodi ndingaphatikize bwanji ketone ester muzochita zanga za tsiku ndi tsiku?
A: Ketone ester ikhoza kuphatikizidwa muzochita zanu za tsiku ndi tsiku mwa kuitenga m'mawa ngati chowonjezera chokonzekera kulimbitsa thupi, kugwiritsira ntchito kupititsa patsogolo ntchito yamaganizo ndi kuika maganizo pa nthawi ya ntchito kapena maphunziro, kapena kuigwiritsa ntchito ngati chithandizo chobwezeretsa pambuyo pochita masewera olimbitsa thupi. Itha kugwiritsidwanso ntchito ngati chida chosinthira ku zakudya za ketogenic kapena kusala kwapakatikati.
Q: Kodi pali zovuta kapena zodzitetezera zomwe muyenera kuziganizira mukamagwiritsa ntchito ketone ester?
A: Ngakhale kuti ketone ester nthawi zambiri imatengedwa kuti ndi yotetezeka kwa anthu ambiri, anthu ena amatha kukhala ndi vuto laling'ono la m'mimba akayamba kugwiritsa ntchito. Ndikofunikanso kukaonana ndi dokotala musanaphatikizepo ketone ester muzochita zanu, makamaka ngati muli ndi vuto linalake kapena mukumwa mankhwala.
Q: Kodi ndingawonjezere bwanji zotsatira zogwiritsira ntchito ketone ester?
A: Kuti muwonjezere zotsatira zogwiritsira ntchito ketone ester, ndikofunika kugwirizanitsa kudya kwake ndi moyo wathanzi womwe umaphatikizapo kuchita masewera olimbitsa thupi nthawi zonse, madzi okwanira okwanira, ndi zakudya zopatsa thanzi. Kuphatikiza apo, kulabadira nthawi yogwiritsira ntchito ketone ester pokhudzana ndi zochita zanu ndi zolinga zanu kungathandize kukulitsa zotsatira zake.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Jan-15-2024
