Urolithin A ndi molekyu yosangalatsa pantchito yofufuza zoletsa kukalamba. Kuthekera kwake kubwezeretsa ntchito zama cell ndikuwongolera thanzi lakhala likulonjeza mu maphunziro a nyama. Komabe, kafukufuku wochulukirapo akufunika kuti adziwe momwe zimagwirira ntchito mwa anthu.Ngakhale kuti sitinapeze kasupe wa unyamata, Urolithin A imatifikitsa pafupi ndi kumvetsetsa zinsinsi za ukalamba ndikutsegula chinsinsi cha moyo wautali, wathanzi.
Urolithin A ndi mankhwala achilengedwe omwe adalandira chidwi kwambiri m'zaka zaposachedwa chifukwa cha mapindu ake azaumoyo. Kafukufuku waposachedwapa akusonyeza kuti akhoza kukhala ndi anti-inflammatory, anti-cancer ndi anti-aging properties.
●Urolithin A ndi metabolite yopangidwa ndi kuwonongeka kwa ellagitannins, gulu la polyphenolic lomwe limapezeka mu zipatso ndi mtedza wina. Kutembenuka kwa ellagitannins kukhala urolithin A kumachitika makamaka m'matumbo chifukwa cha zochita za mabakiteriya ena am'matumbo.
●Makangaza ndi amodzi mwa magwero olemera kwambiri a ellagitannins ndipo motero urolithin A. Machiritso ofiira owala, kapena mbewu, za makangaza amakhala ndi kuchuluka kwa ellagitannins, komwe kumasinthidwa kukhala urolithin A panthawi ya chimbudzi. Madzi a makangaza ndi zowonjezera ndizomwe zimapangira urolithin A.
●Chipatso china chomwe chili ndi urolithin A ndi raspberries. Mofanana ndi makangaza, raspberries ndi olemera mu ellagitannins, makamaka mu mbewu zawo. Kumwa ma raspberries atsopano kapena oundana pafupipafupi kumatha kukulitsa milingo ya urolithin A m'thupi.
●Mtedza wina, monga walnuts ndi pistachios, umakhalanso ndi urolithin A. Ngakhale kuti urolithin A imapezeka pang'onopang'ono poyerekeza ndi zipatso monga makangaza, kuphatikizapo mtedzawu muzakudya zanu zingathandize kuonjezera kuchuluka kwa urolithin A.
Ngakhale zipatso zatsopano ndi mtedza ndi zakudya zabwino kwambiri za urolithin A, ndiyenera kunena kuti urolithin A zowonjezera zilipo. Zowonjezera izi zitha kukupatsirani njira yabwino yowonjezerera kumwa urolithin A.
Urolithin A ndi mankhwala opangidwa kuchokera ku zinthu zachilengedwe zotchedwa ellagitannin, zomwe zimapezeka mu zipatso zina monga makangaza ndi zipatso. Tikamadya zipatsozi, mabakiteriya athu am'matumbo amathyola ellagitannins kukhala urolithin A, kulola matupi athu kupindula ndi mankhwalawa.
Chimodzi mwazinthu zosangalatsa zomwe zapezedwa za urolithin A ndikutha kukonzanso mitochondria, mphamvu zama cell athu. Tikamakalamba, mitochondria yathu imakhala yocheperako, zomwe zimapangitsa kuchepa kwa kupanga mphamvu zama cell. Kafukufuku wasonyeza kuti urolithin A imatha kuyambitsa njira yotchedwa mitophagy, yomwe imachotsa mitochondria yosagwira ntchito ndikulimbikitsa kupanga zatsopano zathanzi. Njirayi imabweretsa kusintha kwa kupanga mphamvu komanso ntchito zonse zama cell.
Kuphatikiza apo, urolithin A wapezeka kuti amathandizira thanzi la minofu ndi mphamvu. Pamene tikukalamba, timakonda kutaya minofu, zomwe zimayambitsa kufooka ndi kuchepetsa kuyenda. Komabe, kafukufuku wa nyama zakale awonetsa kuti kuphatikizika ndi urolithin A kumathandizira kukula kwa minofu ndikuletsa kuwonongeka kwa minofu.
Ubwino winanso wodabwitsa wa Urolithin A ndikuteteza ku matenda a neurodegenerative monga Alzheimer's ndi Parkinson's. Matendawa amadziwika ndi kudzikundikira kwa mapuloteni oopsa mu ubongo, zomwe zimayambitsa kuchepa kwa chidziwitso komanso kusokonezeka kwa kayendedwe. Kafukufuku waposachedwa wawonetsa kuti urolithin A imatha kuthandizira kuchotsa mapuloteni owopsawa, kuchepetsa chiwopsezo ndi kupitilira kwa matenda a neurodegenerative.
1. Idyani zakudya zokhala ndi ellagitannins: Kuti mwachilengedwe muwonjezere kuchuluka kwa urolithin, kudya zakudya zokhala ndi ellagitannins ndikofunikira. Makangaza, sitiroberi, raspberries, ndi mabulosi akuda ndi magwero abwino kwambiri a ellagitannins. Kuphatikizira zipatso izi muzakudya zanu kumatha kulimbikitsa kupanga urolithin m'matumbo anu.
2. Kupititsa patsogolo Thanzi la M'matumbo: Kukhala ndi matumbo athanzi a microbiota ndikofunikira pakupanga urolithin. Kuti muthandizire kusiyanasiyana komanso koyenera m'matumbo a microbiome, phatikizani zakudya zofufumitsa monga yogati, kefir, sauerkraut, ndi kimchi muzakudya zanu. Zakudya izi zimabweretsa mabakiteriya abwino m'matumbo anu, omwe amathandizira kupanga urolithin.
3. Tengani zowonjezera za urolithin: Kuphatikiza pazakudya, zowonjezera za urolithin zimapezekanso pamsika. Zowonjezera izi zimapereka Mlingo wokhazikika wa urolithin, womwe ungakhale wopindulitsa kwa iwo omwe amavutika kudya zakudya zokwanira zokhala ndi ellagitannin pafupipafupi kapena omwe ali ndi vuto la thanzi lamatumbo.
4. Phatikizani ellagitannins ndi magwero amafuta: Ellagitannins amatengedwa mosavuta ndi thupi akamadyedwa ndi mafuta abwino. Ganizirani kuwonjezera mtedza, mbewu, kapena mafuta pang'ono a azitona ku chipatsocho kuti muwonjezere kuyamwa kwa ellagitannins ndikuwonjezera kupanga urolithin.
Nthawi yomwe imatengera urolithin A kugwira ntchito imasiyanasiyana ndi zinthu zingapo. Chofunikira kwambiri ndi metabolism yamunthu. Thupi la munthu aliyense limagwiritsa ntchito zinthu mosiyana, zomwe zimakhudzanso momwe thupi limayankhira ndikugwiritsa ntchito urolithin A. Kuphatikiza apo, mlingo ndi mawonekedwe omwe urolithin A amadyedwa amathanso kukhudza nthawi yomwe amayamba kuchitapo kanthu.
Kafukufuku wasonyeza kuti kudya mitundu yachilengedwe ya urolithin A, monga madzi a makangaza kapena zipatso zina, kumatha kutulutsa milingo yamagazi m'magazi mkati mwa maola angapo. Komabe, zotsatira za urolithin A sizingawonekere nthawi yomweyo, chifukwa zochita za pawirizi zimayang'ana kwambiri pazaumoyo wanthawi yayitali.
Ndikofunikira kudziwa kuti urolithin A sichiritso chofulumira cha matenda aliwonse. M'malo mwake, amalingaliridwa kuti ali ndi zotsatira zake poyambitsa njira yobwezeretsanso maselo a thupi yotchedwa autophagy. Njirayi imaphatikizapo kuphwanya ndi kuchotsa maselo owonongeka ndi mapuloteni, omwe angakhale ndi zotsatira za nthawi yaitali pa thanzi labwino ndi thanzi. Kafukufuku akupitilirabe kuti zitenga nthawi yayitali bwanji kuti apeze mapindu a urolithin A.
Kafukufuku wokhudza zotsatira za urolithin A akadali ochepa, chifukwa ndi gawo la kafukufuku watsopano. Maphunziro ambiri omwe achitika mpaka pano ayang'ana kwambiri zotsatira zake osati zoyipa zilizonse. Komabe, ndikofunikira kusamala ndikumvetsetsa zoopsa zomwe zingachitike.
Vuto lomwe lingakhalepo ndi kugwiritsa ntchito urolithin A ndikuti limatha kuyanjana ndi mankhwala ena. Monga chowonjezera chazakudya, chimatha kuyanjana ndi mankhwala opangidwa ndi ma enzymes a chiwindi omwewo. Izi zitha kusintha momwe mankhwalawa alili othandiza kapena otetezeka. Chifukwa chake, ndikofunikira kukaonana ndi akatswiri azachipatala musanamwe urolithin A ngati mukumwa mankhwala ena aliwonse.
Chinthu china choyenera kuganizira ndi mlingo wa urolithin A. Pakalipano, palibe zovomerezeka za tsiku ndi tsiku kapena ndondomeko za mlingo wa mankhwalawa. Choncho, n'zovuta kudziwa ngati pali mlingo woyenera, kapena ngati pali zotsatira zina zomwe zingagwirizane ndi mlingo waukulu. Ndikoyenera kutsatira malangizo omwe ali patsamba lazogulitsa kapena kukaonana ndi chipatala kuti mudziwe mlingo woyenera.
Nthawi yotumiza: Jun-21-2023
