Pamene tikukalamba, mwachibadwa timayamba kuganizira za momwe tingakhalire athanzi komanso achangu kwa nthawi yayitali. Chisankho chimodzi chabwino ndi urolithin A, yomwe yasonyezedwa kuti imayambitsa njira yotchedwa mitophagy, yomwe imathandiza kuchotsa mitochondria yowonongeka ndikulimbikitsa kupangidwa kwa mitochondria yatsopano, yathanzi. Pothandizira thanzi la mitochondrial, urolithin A ingathandize kuchepetsa ukalamba pamlingo wa ma cell. Kafukufuku akuwonetsanso kuti urolithin A ikhoza kukhala ndi maubwino ena, monga kuthandizira thanzi la minofu ndi magwiridwe antchito ndipo imatha kuchepetsa kutupa m'thupi.
Ma microbiome a m'matumbo a anthu amasiyanasiyana. Zinthu monga zakudya, zaka, ndi ma genetics zonse zimakhudzidwa ndipo zimabweretsa kusiyana kwa kupanga milingo yosiyanasiyana ya urolithin A. Anthu omwe alibe mabakiteriya m'matumbo awo sangathe kupanga UA. Ngakhale omwe amatha kupanga urolithin A sangathe kupanga urolithin A wokwanira. Tinganene kuti gawo limodzi mwa magawo atatu a anthu ali ndi urolithin A wokwanira.
Ndiye, magwero abwino kwambiri a urolithin A ndi ati?
Makangaza: Makangaza ndi amodzi mwazinthu zachilengedwe zolemera kwambiriurolithin A.Chipatsochi chimakhala ndi ellagitannins, yomwe imasinthidwa kukhala urolithin A ndi matumbo a microbiota. Kudya madzi a makangaza kapena mbewu zonse za makangaza kumapereka urolithin A wambiri, zomwe zimapangitsa kukhala gwero labwino kwambiri lazakudya zamtunduwu.
Ellagic acid supplements: Ellagic acid supplements ndi njira ina yopezera urolithin A. Pambuyo pa kumwa, ellagic acid imasandulika urolithin A ndi matumbo a microbiota. Zowonjezera izi ndizopindulitsa makamaka kwa anthu omwe sakonda kudya zakudya zolemera za urolithin A.
Zipatso: Zipatso zina, monga raspberries, sitiroberi, ndi mabulosi akuda, zimakhala ndi ellagic acid, zomwe zimathandizira kupanga urolithin A m'thupi. Kuphatikizira mitundu yosiyanasiyana ya zipatso muzakudya kumatha kuthandizira kukulitsa kudya kwa ellagic acid ndikuwonjezera urolithin A.
Zakudya zowonjezera zakudya: Zakudya zina zopatsa thanzi zimapangidwa mwapadera kuti zipereke urolithin A mwachindunji. Zowonjezera izi nthawi zambiri zimakhala ndi zowonjezera zachilengedwe zokhala ndi urolithin A, zomwe zimapereka njira yokhazikika komanso yabwino yowonjezerera kumwa urolithin A.
Gut Microbiota: Kapangidwe ka m'matumbo a microbiota amagwira ntchito yofunika kwambiri popanga urolithin A. Mitundu ina ya mabakiteriya m'matumbo ndi yomwe imapangitsa kusintha ellagitannins ndi ellagic acid kukhala urolithin A. Kuthandizira m'matumbo athanzi komanso osiyanasiyana kudzera m'ma probiotics, prebiotics. , ndi ulusi wa zakudya ukhoza kupititsa patsogolo kupanga urolithin A m'thupi.
Dziwani kuti bioavailability ndi mphamvu ya urolithin A imatha kusiyanasiyana kutengera komwe kumachokera komanso zinthu zina. Ngakhale magwero achilengedwe monga makangaza ndi zipatso amapereka zakudya zowonjezera, zowonjezera zimatha kupereka mulingo wodalirika, wokhazikika wa urolithin A.
Tikamakalamba, matupi athu mwachibadwa amatulutsa urolithin wochepa, zomwe zinapangitsa kuti pakhale urolithin zowonjezera monga njira yothandizira thanzi la ma cell ndi ukalamba.
Ubwino umodzi waukulu wa urolithin ndikutha kupititsa patsogolo ntchito ya mitochondrial, yomwe ndi yofunika kwambiri pakupanga mphamvu komanso thanzi la ma cell. Mitochondria ndi mphamvu zama cell athu, timagulu ting'onoting'ono tomwe timasinthira shuga ndi okosijeni kukhala adenosine triphosphate (ATP) kuti apange mphamvu. Tikamakalamba, ntchito yawo imatha kuchepa, zomwe zimayambitsa matenda osiyanasiyana. Urolithins awonetsedwa kuti amathandizira kukonza magwiridwe antchito a mitochondrial, zomwe zitha kukulitsa mphamvu komanso mphamvu zonse.
Kwa anthu omwe ali ndi mphamvu zochepa, urolithin A angagwiritsidwe ntchito kulimbikitsa thanzi la mitochondrial popanda kufunikira kochita masewera olimbitsa thupi. Urolithin A, yomwe ingapezeke kuchokera ku zakudya kapena, mogwira mtima, kudzera mu zakudya zowonjezera zakudya, zasonyezedwa kuti zimalimbikitsa thanzi la mitochondrial ndi kupirira kwa minofu. Imachita izi popititsa patsogolo ntchito ya mitochondrial, makamaka poyambitsa njira ya mitophagy.
Kuphatikiza pa zotsatira zake pa ntchito ya mitochondrial, urolithin adaphunziridwa chifukwa cha mphamvu zawo zotsutsa-kutupa ndi antioxidant. Kutupa kosatha komanso kupsinjika kwa okosijeni ndizomwe zimayambitsa matenda ambiri osatha, kotero kuthekera kwa urolithin kuthana ndi izi kungakhale ndi phindu lalikulu paumoyo wonse. Kafukufuku wina amasonyezanso kuti urolithin ikhoza kukhala ndi zotsatira zabwino pa thanzi la minofu ndi machitidwe a thupi, zomwe zimapangitsa kukhala njira yabwino kwa othamanga ndi okonda masewera olimbitsa thupi.
Urolithin Andi mankhwala achilengedwe omwe amachokera ku ellagic acid, yomwe imapezeka mu zipatso ndi mtedza wina. Zasonyezedwa kuti ziyambitsa njira yotchedwa mitophagy, njira yachilengedwe ya thupi yochotsera mitochondria yowonongeka ndikulimbikitsa kugwira ntchito kwa maselo athanzi. Njirayi ndi yofunikira kuti mukhale ndi thanzi labwino la ma cell ndipo zakhala zikugwirizana ndi moyo wautali komanso kuchepetsa chiopsezo cha matenda okhudzana ndi ukalamba.
NMN, kumbali ina, ndiye kalambulabwalo wa NAD + (nicotinamide adenine dinucleotide), coenzyme yomwe imagwira ntchito yofunika kwambiri pakupanga ma cell ndi kupanga mphamvu. Tikamakalamba, milingo ya NAD + imachepa, zomwe zimapangitsa kuti ma cell achepe komanso chiwopsezo cha matenda obwera chifukwa cha ukalamba. Powonjezera ndi NMN, timakhulupirira kuti titha kukulitsa milingo ya NAD+ ndikuthandizira thanzi la ma cell ndi moyo wautali.
Kotero, ndi iti yomwe ili bwino? Chowonadi ndi chakuti, si yankho losavuta. Onse urolithin A ndi NMN awonetsa zotsatira zabwino mu maphunziro a preclinical ndipo onse ali ndi njira zapadera zochitira. Urolithin A imayambitsa mitophagy, pomwe NMN imawonjezera milingo ya NAD +. Ndizotheka kwathunthu kuti zinthu ziwirizi zimathandizirana ndipo zimapindulitsa kwambiri zikaphatikizidwa.
Kuyerekeza kwachindunji kwa urolithin A ndi NMN sikunachitike m'maphunziro aumunthu, choncho n'zovuta kunena motsimikiza kuti ndi ndani amene ali bwino. Komabe, mankhwala onsewa awonetsedwa kuti ali ndi mphamvu zolimbikitsa ukalamba wathanzi ndipo akhoza kukhala ndi zotsatira za synergistic akagwiritsidwa ntchito pamodzi.
Ndikofunikiranso kuganizira za kusiyana kwa anthu komanso momwe munthu aliyense angayankhire mosiyana ndi mankhwalawa. Anthu ena akhoza kukhala ndi mayankho omveka bwino a urolithin A, pamene ena angapindule kwambiri ndi NMN. Genetics, moyo, ndi zinthu zina zingakhudze momwe munthu aliyense amayankhira pamagulu awa, zomwe zimapangitsa kuti zikhale zovuta kufotokoza momveka bwino kuti ndi gulu liti lomwe ndi lapamwamba.
Pamapeto pake, funso loti urolithin A ndi wabwino kuposa NMN silosavuta kuyankha. Mankhwala onsewa awonetsa kuthekera kolimbikitsa ukalamba wathanzi ndipo onse ali ndi njira zapadera zochitira. Njira yabwino ingakhale kulingalira kutenga zowonjezera zonse ziwiri panthawi imodzi kuti muwonjezere phindu lawo.
1. Thanzi la Minofu: Chimodzi mwa ubwino waukulu wa urolithin A ndi mphamvu yake yothandizira thanzi la minofu. Pamene tikukalamba, matupi athu mwachibadwa amawona kuchepa kwa minofu ndi mphamvu. Komabe, kafukufuku akuwonetsa kuti urolithin A imatha kuthandizira kuthana ndi njirayi powonjezera ntchito ya mitochondria, nyumba zopangira mphamvu zama cell. Pochita izi, zingathandize kupititsa patsogolo ntchito ya minofu ndikulimbikitsa kugwira ntchito kwa thupi lonse.
2. Moyo Wautali: Chifukwa china choyenera kuganizira urolithin A supplementation ndi kuthekera kwake kulimbikitsa moyo wautali. Kafukufuku akuwonetsa kuti chigawo ichi chikhoza kuyambitsa njira yotchedwa mitophagy, yomwe imayambitsa kuchotsa mitochondria yowonongeka. Pochotsa zinthu zosokonekerazi, Urolithin A ikhoza kuthandizira kutalikitsa moyo ndikuthandizira moyo wathanzi wonse.
3. Umoyo Wama cell: Urolithin A yasonyezedwanso kuti imathandizira thanzi la maselo ndi ntchito. Mwa kukonza ntchito ya mitochondrial ndikulimbikitsa mitophagy, chigawo ichi chingathandize kupititsa patsogolo thanzi labwino komanso kubwezeretsa maselo. Izi, zikhoza kukhala ndi zotsatira zabwino pazochitika zonse za thanzi, kuyambira kupanga mphamvu mpaka ku chitetezo cha mthupi.
4. Zinthu Zotsutsana ndi Kutupa: Kutupa kwanthawi yaitali ndi chinthu chofala kwambiri pazochitika zambiri za thanzi, ndipo Urolithin A wasonyezedwa kuti ali ndi zotsutsana ndi zotupa zomwe zingathandize kuchepetsa chiopsezo cha matenda ena ndikuthandizira thanzi labwino ndi thanzi.
5. Thanzi laubongo: Kafukufuku wotulukapo akuwonetsa kuti urolithin A ikhoza kukhalanso ndi mapindu a thanzi laubongo. Pothandizira ntchito ya mitochondrial ndikulimbikitsa thanzi la ma cell, chigawo ichi chingathandize kupewa kuchepa kwa chidziwitso chokhudzana ndi ukalamba komanso matenda a neurodegenerative.
Choyamba, ndikofunikira kumvetsetsa kuti si onsezowonjezera urolithin Aamapangidwa mofanana. Ubwino ndi kuyera kwa Urolithin A kumatha kusiyanasiyana pakati pa zinthu zosiyanasiyana, kotero ndikofunikira kuti mufufuze ndikusankha chowonjezera kuchokera kwa wopanga odziwika. Yang'anani zowonjezera zomwe zimayesedwa ndi gulu lachitatu kuti zikhale zoyera ndi potency kuti muwonetsetse kuti mukupeza mankhwala apamwamba.
Kuphatikiza pa khalidwe la urolithin A Tingafinye, ndikofunikanso kuganizira mawonekedwe a zowonjezera. Urolithin A imapezeka m'mitundu yosiyanasiyana, kuphatikiza makapisozi, ufa, ndi madzi. Ganizirani zomwe mumakonda komanso moyo wanu posankha mtundu womwe ndi wosavuta kuphatikizira m'moyo wanu watsiku ndi tsiku.
Chinthu china choyenera kuganizira posankha chowonjezera cha urolithin A ndi mlingo. Zowonjezera zosiyanasiyana zitha kukhala ndi milingo yosiyana ya urolithin A pa kutumikira, kotero ndikofunikira kuganizira zosowa zanu ndi zolinga zanu pozindikira mlingo womwe ukuyenerani. Ngati simukutsimikiza za mlingo womwe uli woyenera kwa inu, funsani katswiri wazachipatala kuti akuthandizeni payekha.
Kuphatikiza apo, ganizirani ngati pali zosakaniza zina zomwe zilipo muzowonjezera za urolithin A. Zina zowonjezera zingakhale ndi zowonjezera zowonjezera, monga antioxidants kapena mankhwala ena a bioactive, omwe angapangitse zotsatira za urolithin A. Komabe, ndikofunika kuonetsetsa kuti zosakaniza zina ziri zotetezeka komanso zopindulitsa pa zosowa zanu zenizeni za thanzi.
Kuphatikiza apo, posankha chowonjezera cha urolithin A, chonde ganizirani za thanzi lanu komanso matenda aliwonse omwe analipo kale. Ngati muli ndi vuto linalake la thanzi kapena mukumwa mankhwala, nkofunika kuti muyang'ane ndi wothandizira zaumoyo wanu musanayambe mankhwala atsopano kuti muwonetsetse kuti ndi otetezeka komanso oyenera kwa inu.
Pomaliza, ndikofunikira kuwongolera zomwe mukuyembekezera mukatenga urolithin A zowonjezera. Ngakhale urolithin A akuwonetsa lonjezo lalikulu pakuwongolera magwiridwe antchito a minofu, kuchuluka kwa mphamvu, komanso thanzi la ma cell, zotsatira zamunthu aliyense zimatha kusiyana. Ndikofunikira kupatsa chowonjezeracho nthawi yokwanira yogwira ntchito ndikugwirizana ndi kugwiritsa ntchito kwanu kuti muwone zotsatira zabwino.
Suzhou Myland Pharm & Nutrition Inc. yakhala ikuchita bizinesi yazakudya zopatsa thanzi kuyambira 1992. Ndi kampani yoyamba ku China kupanga ndi kugulitsa zokolola za mphesa.
Pokhala ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira yokongoletsedwa kwambiri ya R&D, kampaniyo yapanga zinthu zambiri zopikisana ndikukhala kampani yowonjezera ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.
Kuphatikiza apo, kampaniyo ndinso wopanga olembetsedwa ndi FDA, kuwonetsetsa kuti thanzi la anthu likhale lokhazikika komanso kukula kosatha. Zipangizo zamakampani za R&D ndi zida zopangira ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala pa milligram mpaka ton motsatira miyezo ya ISO 9001 ndi machitidwe opanga GMP.
Q: Kodi urolithin A ndi chiyani?
A: Urolithin A ndi mankhwala achilengedwe omwe amapangidwa m'thupi atadya zakudya zina, monga makangaza ndi zipatso. Imapezekanso ngati chowonjezera.
Q: Kodi urolithin A amagwira ntchito bwanji?
A: Urolithin A amagwira ntchito poyambitsa njira yama cell yotchedwa mitophagy, yomwe imathandiza kuchotsa mitochondria yowonongeka m'maselo. Izi, nazonso, zimathandizira kukonza magwiridwe antchito a ma cell komanso thanzi lonse.
Q: Ndi maubwino ati a urolithin A supplementation?
A: Ubwino wina wa urolithin A wowonjezera umaphatikizira kugwira ntchito bwino kwa minofu, kupanga mphamvu zambiri, komanso kukhala ndi moyo wautali. Zingathandizenso kuthandizira thanzi labwino ndi thanzi pamene tikukalamba.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Mar-06-2024
