Urolithin A ndi mankhwala achilengedwe omwe ndi mankhwala a metabolite opangidwa ndi mabakiteriya am'mimba omwe amasintha ma ellagitannins kuti akhale ndi thanzi labwino pamlingo wa maselo. Urolithin B yatchuka ndi ofufuza chifukwa cha kuthekera kwake kokweza thanzi la m'mimba ndikuchepetsa kutupa. Urolithin A ndi urolithin B zili ndi makhalidwe ofanana, koma ali ndi kusiyana kosiyana. Tiyeni tiwone kusiyana kwake kwenikweni!
M'zaka zaposachedwapa, asayansi akhala akuphunzira za ubwino wa urolithin pa thanzi, mankhwala achilengedwe omwe ndi mankhwala a metabolite omwe amapangidwa ndi kusintha kwa ellagitannins ndi mabakiteriya am'mimba. Zomwe zimayambitsa izi ndi ellagic acid ndi ellagitannins, zomwe zimapezeka mwachilengedwe m'magwero angapo azakudya monga makangaza, guava, tiyi, pecans, mtedza, ndi zipatso monga sitiroberi, rasiberi wakuda, ndi mabulosi akuda. Kuphatikiza apo, urolithin A, polyphenol yachilengedwe, ndi yofunika kwambiri ngati antioxidant yamphamvu komanso mankhwala oletsa kutupa omwe ali ndi ubwino wabwino pa thanzi.
Smaphunziro ofufuza zaZotsatira za UA pa ntchito za maselo ndi njira zamoyo zasonyeza kuti ili ndi njira zambiri zogwirira ntchito. Kafukufuku wapezanso kuti UA imayambitsa autophagy ya mitochondrial, njira yomwe imachotsa mitochondria yowonongeka kuchokera mu selo ndikuwonjezera kupanga mphamvu. Kuchita izi ndikofunikira kwambiri pa matenda okhudzana ndi ukalamba, chifukwa mitochondria yosagwira ntchito bwino imabweretsa kusonkhanitsa kwa oxidative stress ndi kutupa. UA imawongoleranso kufotokozera kwa majini omwe amakhudzidwa ndi yankho la oxidative stress, kukonza DNA ndi apoptosis, zomwe ndizofunikira kwambiri kuti maselo azikhala olimba komanso kupewa khansa.
EnatheMbali yosangalatsa ya UA ndikuthekera kwake ngati chofufutira ukalamba, zomwe zikutanthauza kuti imatha kuyambitsa apoptosis m'maselo okalamba, omwe ndi maselo owonongeka omwe sagawanitsanso koma amatulutsa zinthu zovulaza zomwe zimavulaza maselo ndi minofu yoyandikana nayo. Maselo okalamba amagwirizanitsidwa ndi matenda osiyanasiyana okhudzana ndi ukalamba, monga nyamakazi, atherosclerosis ndi neKuchuluka kwa urodegeneration. Mwa kuchotsa maselo amenewa mwachisawawa, UA ikhoza kuchedwetsa kapena kuletsa kuyamba kwa matenda amenewa ndikukweza thanzi lonse.
Ma Urolithin ndi gulu la mankhwala omwe amadziwika kuti ellagitannin metabolites, omwe amapangidwa makamaka ndi gut microbiota. Pakati pawo, mamolekyu awiri, urolithin A ndi urolithin B, atchuka kwambiri chifukwa cha ubwino wawo pa thanzi. Mankhwalawa amapezeka mu zipatso zosiyanasiyana monga mapomegranate, sitiroberi, ndi raspberries. Mu blog iyi, tiwona bwino kwambiri makhalidwe ofanana a urolithin A ndi urolithin B.
Urolithin A ndi molekyulu yochuluka kwambiri m'banja la urolithin, ndipo yafufuzidwa bwino chifukwa cha mphamvu zake zotsutsana ndi kutupa komanso antioxidant. Komanso, kafukufuku wasonyeza kuti UA ikhoza kukonza ntchito ya mitochondrial ndikuletsa kuwonongeka kwa minofu. UA imadziwikanso chifukwa cha mphamvu zake zotsutsana ndi khansa. Kafukufuku wasonyeza kuti UA ikhoza kuletsa kuchulukana kwa maselo ndikuyambitsa kufa kwa maselo m'maselo osiyanasiyana a khansa, kuphatikizapo maselo a khansa ya prostate, mawere, ndi matumbo.
Kumbali inayi, urolithin B yakopa chidwi cha ofufuza chifukwa cha kuthekera kwake kokweza thanzi la m'mimba ndikuchepetsa kutupa. Kafukufuku wasonyeza kuti UB ikhoza kuwonjezera kusiyanasiyana kwa tizilombo toyambitsa matenda m'matumbo ndikuchepetsa ma cytokines omwe amayambitsa kutupa, monga interleukin-6 ndi tumor necrosis factor-alpha. Kuphatikiza apo, UB yapezekanso kuti ili ndi mphamvu zoteteza mitsempha, chifukwa kafukufuku wasonyeza kuti ingathandize kupewa matenda owononga mitsempha monga Parkinson's ndi Alzheimer's.
Ngakhale kuti ali ndi makhalidwe ofanana, UA ndi UB ali ndi kusiyana koonekeratu. Mwachitsanzo, UA yawonetsedwa kuti ndi yamphamvu kwambiri ngati mankhwala oletsa kutupa komanso oletsa kupha tizilombo toyambitsa matenda kuposa UB. Kumbali ina, UB yapezeka kuti ndi yothandiza kwambiri popewa mavuto okhudzana ndi kunenepa kwambiri, monga kukana insulin ndi kusiyana kwa mafuta m'thupi. Kuphatikiza apo, mosiyana ndi UA, UB sinaphunziridwe kwambiri ngati mankhwala oletsa khansa.
Kagwiridwe ka ntchito ka UA ndi UB nakonso n’kosiyana. UA imayambitsa njira ya Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), yomwe imagwira ntchito mu mitochondrial biogenesis, pomwe UB imawonjezera njira ya AMP-activated protein kinase (AMPK), yomwe imakhudzidwa ndi energy homeostasis. Njirazi zimathandiza kuti zinthuzi zikhale ndi phindu pa thanzi.
Ngakhale kuti UA ndi UB zili ndi ubwino wosangalatsa, pali zoletsa pakugwiritsa ntchito kwawo. Mwachitsanzo, kupezeka kwa mankhwala amenewa kudakali kochepa, ndipo mankhwala ake sakumveka bwino. Kuphatikiza apo, zotsatira za mankhwala amenewa pa anthu sizinadziwike bwino, chifukwa kafukufuku wambiri wachitika mu vitro kapena mu zitsanzo za nyama. Komabe, kafukufuku amene alipo akusonyeza kuti UA ndi UB zitha kukhala zabwino popanga zakudya zogwira ntchito kapena zowonjezera kuti zithandize thanzi lonse ndikupewa matenda.
Urolithin A. Molekyu kakang'ono aka kamapezeka mwachilengedwe mu zipatso ndi mtedza wina ndi kotchuka chifukwa chakuti kamatha kukonza chilichonse kuyambira kukula kwa minofu mpaka kugwira ntchito kwa ubongo. Urolithin A ndi metabolite, zomwe zikutanthauza kuti ndi chinthu chochokera ku zinthu zina m'thupi. Makamaka, kamapangidwa pamene mabakiteriya am'mimba amawononga ma ellagitannins, omwe amapezeka muzakudya zina monga mapomegranate, sitiroberi ndi mtedza. Koma nayi gawo losangalatsa: si aliyense amene ali ndi mabakiteriya am'mimba omwe amafunikira kuti apange urolithin A. Ndipotu, kafukufuku wasonyeza kuti pafupifupi 30-50% ya anthu ndi omwe angapange molekyu iyi mwachilengedwe. Apa ndi pomwe zowonjezera zimakhala zothandiza.
Kotero, ndi chiyaniUbwino wa urolithin A? Chabwino, chimodzi mwa zifukwa zazikulu ndikuti zingathandize kukonza thanzi la minofu. Kafukufuku wofalitsidwa mu magazini ya Nature Medicine adapeza kuti makoswe atapatsidwa urolithin A, anali ndi kuwonjezeka kwa 42% pa kupirira komanso kuwonjezeka kwa 70% pa minofu. Ngakhale kuti zotsatirazi ndizodabwitsa, ndikofunikira kudziwa kuti uwu unali kafukufuku waung'ono ndipo kafukufuku wambiri akufunika kuti atsimikizire zomwe zapezeka mwa anthu.
Koma si zokhazo zomwe urolithin A imanena kuti imachita. Zawonetsedwanso kuti imapangitsa kuti ntchito ya mitochondrial igwire bwino ntchito. Mitochondria kwenikweni ndi malo amphamvu a maselo, omwe ali ndi udindo wopanga mphamvu zomwe thupi lingagwiritse ntchito. Pamene tikukalamba, ntchito yathu ya mitochondrial imayamba kuchepa, zomwe zingayambitse mavuto ambiri azaumoyo. Komabe, kafukufuku woyambirira akusonyeza kuti urolithin A ingathandize kuchepetsa kuchepa kumeneku, zomwe zingawongolere thanzi lonse ndikuwonjezera nthawi ya moyo.
Ngati kuti zimenezo sizinali zokwanira, urolithin A yawonetsedwanso kuti ili ndi ubwino wozindikira. Kafukufuku wofalitsidwa mu magazini ya Scientific Reports adapeza kuti makoswe akapatsidwa urolithin A, luso lawo lokumbukira ndi kuphunzira linakula. Ofufuza amakhulupirira kuti izi zitha kukhala chifukwa cha mphamvu ya molekyuluyi yolimbana ndi kutupa, yomwe imathandiza kuteteza maselo a ubongo ku kuwonongeka.
Urolithin B, yomwe imapezeka mu zipatso zosiyanasiyana ndi mapomegranate, imadziwika chifukwa cha ubwino wake wothandiza pa thanzi la kagayidwe kachakudya m'thupi komanso kutalikitsa moyo. Kafukufuku waposachedwapa wasonyeza kuti urolithin B ili ndi mphamvu zotsutsana ndi kutupa komanso zoteteza ku ma antioxidants zomwe zingathandize kupewa matenda osatha komanso kukonza thanzi lonse.
1. Mphamvu zotsutsa kutupa
Kutupa kosatha ndi chifukwa chachikulu cha matenda ambiri, kuphatikizapo matenda a mtima, matenda a shuga ndi khansa. Urolithin B ili ndi mphamvu zotsutsana ndi kutupa zomwe zimathandiza kuchepetsa kutupa m'thupi, motero kuchepetsa chiopsezo cha matenda osatha. Kafukufuku wina adapeza kuti urolithin B imachepetsa kwambiri kutupa m'makoswe omwe ali ndi matenda otupa m'matumbo, zomwe zikusonyeza kuti ingathandize kwambiri pochiza anthu omwe ali ndi matenda ofanana.
2. Mphamvu zoletsa kukalamba kwa maselo ofiira a m'magazi
Urolithin B ndi antioxidant yamphamvu, zomwe zikutanthauza kuti ingathandize kuteteza thupi ku kupsinjika kwa okosijeni, njira yomwe imawononga maselo ndikulimbikitsa kukalamba. Urolithin B imathandiza kupewa kuwonongeka kwa okosijeni mwa kuletsa ma free radicals, omwe angayambitse kuwonongeka kwa maselo ndikuyambitsa matenda osatha. Kafukufuku wina adapeza kuti urolithin B imachepetsa kupsinjika kwa okosijeni m'makoswe, zomwe zimathandizira kwambiri kuthekera kwake ngati chowonjezera choletsa kukalamba.
3. Kulimbikitsa thanzi la minofu
Urolithin B yawonetsedwa kuti imalimbikitsa autophagy ya mitochondrial, njira ya maselo yomwe imathandiza kuchotsa mitochondria yowonongeka m'maselo. Njirayi imathandiza kukonza thanzi la minofu yonse ndi magwiridwe antchito, zomwe zimapangitsa kuti ikhale yowonjezera kwa iwo omwe akufuna kukonza magwiridwe antchito a thupi. Kafukufuku wina adapeza kuti urolithin B imathandizira magwiridwe antchito a minofu ndi mphamvu mwa mbewa ndi anthu.
4. Zimathandiza thanzi la maganizo
Urolithin B yawonetsedwa kuti imathandizira thanzi la ubongo mwa kulimbikitsa neuroplasticity, njira yomwe imathandiza ubongo kuzolowera chidziwitso chatsopano komanso imatha kukonza magwiridwe antchito a ubongo. Kafukufuku wina adapeza kuti urolithin B imasintha magwiridwe antchito a ubongo ndikuwonjezera kukumbukira mwa makoswe.
5. Ubwino wokhalitsa
Kafukufuku waposachedwapa wasonyeza kuti urolithin B ili ndi kuthekera kolimbikitsa moyo wautali mwa kukonza thanzi la kagayidwe kachakudya, kuchepetsa kutupa, komanso kuteteza kupsinjika kwa okosijeni. Kafukufuku wina adapeza kuti urolithin B imawonjezera moyo wautali mu C. elegans, mtundu wa nyongolotsi ya nematode, zomwe zimathandiza kuti ikhale ndi ubwino wolimbikitsa moyo wautali.
1. Makangaza
Pomegranate ndi imodzi mwa magwero abwino kwambiri a urolithin. Ofufuza apeza kuti madzi a pomegranate amatha kuwonjezera kuchuluka kwa urolithin A ndi B m'magazi. Kuphatikiza apo, ma pomegranate ali ndi maubwino ena paumoyo, kuphatikizapo mphamvu zotsutsana ndi kutupa komanso zotsutsana ndi ma antioxidants.
2. Zipatso
Zipatso monga sitiroberi, rasiberi ndi mabulosi akuda nazonso ndi magwero abwino a urolithin. Kafukufuku wasonyeza kuti kudya zipatso kungapangitse kuchuluka kwa urolithin A ndi B m'magazi.
3. Mtedza
Ma Walnuts ndi ma pecans ndi mtedza wina ndi gwero labwino la urolithin. Kafukufuku wina adapeza kuti kudya mtedza kumawonjezera kuchuluka kwa urolithin A ndi B m'magazi.
Urolithin A ndi B ndi mankhwala achilengedwe omwe amapezeka muzakudya zina, ali ndi maubwino ambiri paumoyo. Mankhwalawa ali ndi mphamvu zotsutsana ndi kutupa, amathandiza thanzi la mitochondrial ndi minofu, komanso amalimbikitsa thanzi la ubongo. Mapomegranate, zipatso, mtedza ndi zowonjezera za ellagitannin ndi zina mwazakudya zabwino kwambiri zomwe zingapereke urolithin. Kuphatikiza zakudya izi muzakudya zanu kungakuthandizeni kuzindikira ubwino wa urolithin A ndi B ndikulimbikitsa ukalamba wathanzi.
Nthawi yotumizira: Juni-05-2023
