Urolithin A ndi mankhwala achilengedwe omwe ndi mankhwala a metabolite opangidwa ndi mabakiteriya am'mimba omwe amasintha ellagitannins kuti akhale ndi thanzi labwino pama cell. Urolithin B wapeza chidwi ndi ofufuza chifukwa cha kuthekera kwake kopititsa patsogolo thanzi lamatumbo komanso kuchepetsa kutupa. Urolithin A ndi urolithin B ali ndi zofananira, koma ali ndi zosiyana. Ndi kusiyana kotani komwe inu, tiyeni tipeze!
M'zaka zaposachedwa, asayansi akhala akuphunzira za thanzi la urolithin, mankhwala achilengedwe omwe ndi mankhwala a metabolite opangidwa ndi kutembenuka kwa ellagitannins ndi mabakiteriya a m'mimba. Zoyambira zake ndi ellagic acid ndi ellagitannins, zomwe zimapezeka mwachilengedwe m'zakudya zingapo monga makangaza, magwava, tiyi, pecans, mtedza, ndi zipatso monga sitiroberi, ma raspberries akuda, ndi mabulosi akuda. Kuonjezera apo, urolithin A, polyphenol wachilengedwe, ndi wokondweretsa ngati antioxidant wamphamvu ndi anti-inflammatory agent omwe ali ndi thanzi labwino.
Smaphunziro ofufuza the zotsatira za UA pa ntchito zama cell ndi njira zamoyo zawonetsa kuti ili ndi njira zingapo zogwirira ntchito. Kafukufuku wapezanso kuti UA imayendetsa mitochondrial autophagy, njira yomwe imachotsa mitochondria yowonongeka m'selo ndikuwonjezera kupanga mphamvu. Izi ndizofunikira makamaka ku matenda okhudzana ndi ukalamba, chifukwa mitochondria yosagwira ntchito imayambitsa kudzikundikira kwa kupsinjika kwa okosijeni ndi kutupa. UA imayang'aniranso mafotokozedwe a majini omwe amakhudzidwa ndi kupsinjika kwa okosijeni, kukonza kwa DNA ndi apoptosis, zomwe ndizofunikira kuti zisawonongeke komanso kupewa khansa.
Zinar chidwi mbali ya UA ndikuthekera kwake ngati senescence mkangaziwisi, kutanthauza kuti akhoza kusankha kuchititsa apoptosis m'maselo senescent, amene kuonongeka maselo kuti salinso kugawanitsa koma secrete zinthu zoipa zimene kuvulaza oyandikana maselo ndi zimakhala. Maselo a Senescent amalumikizidwa ndi matenda osiyanasiyana okhudzana ndi ukalamba, monga nyamakazi, atherosclerosis ndi neurodegeneration. Posankha kuchotsa maselowa, UA ikhoza kuchedwetsa kapena kulepheretsa kuyambika kwa matendawa ndikukhala ndi thanzi labwino.
Urolithins ndi gulu la mankhwala omwe amadziwika kuti ellagitannin metabolites, omwe amapangidwa makamaka ndi matumbo a microbiota. Mwa iwo, mamolekyu awiri, urolithin A ndi urolithin B, apeza chidwi chachikulu pazabwino zawo paumoyo. Mankhwalawa amapezeka mu zipatso zosiyanasiyana monga makangaza, sitiroberi, ndi raspberries. Mu blog iyi, tiyang'ana mwatsatanetsatane za urolithin A ndi urolithin B.
Urolithin A ndi molekyu yochuluka kwambiri ya banja la urolithin, ndipo yafufuzidwa bwino chifukwa cha antioxidant ndi anti-inflammatory properties. Komanso, kafukufuku wasonyeza kuti UA ikhoza kusintha ntchito ya mitochondrial ndikuletsa kuwonongeka kwa minofu. UA imadziwikanso chifukwa cha mphamvu zake zolimbana ndi khansa. Kafukufuku wasonyeza kuti UA imatha kuletsa kuchulukana kwa ma cell ndikupangitsa kufa kwa maselo m'maselo osiyanasiyana a khansa, kuphatikiza ma cell a prostate, m'mawere, ndi m'matumbo.
Kumbali inayi, urolithin B yapeza chidwi cha ofufuza chifukwa chakutha kwake kukonza thanzi lamatumbo ndikuchepetsa kutupa. Kafukufuku wasonyeza kuti UB ikhoza kupititsa patsogolo kusiyanasiyana kwa tizilombo toyambitsa matenda komanso kuchepetsa ma cytokines oyambitsa kutupa, monga interleukin-6 ndi tumor necrosis factor-alpha. Kuphatikiza apo, UB yapezekanso kuti ili ndi mphamvu zoteteza ubongo, monga kafukufuku wasonyeza kuti zitha kuthandiza kupewa matenda a neurodegenerative monga Parkinson's ndi Alzheimer's.
Ngakhale zili zofananira, UA ndi UB zili ndi zosiyana zina. Mwachitsanzo, UA yawonetsedwa kuti ndi yamphamvu kwambiri ngati anti-inflammatory and antioxidant agent kuposa UB. Kumbali ina, UB yapezeka kuti ndi yothandiza kwambiri popewa zovuta zokhudzana ndi kunenepa kwambiri, monga insulin kukana ndi kusiyana kwa adipocyte. Kuphatikiza apo, mosiyana ndi UA, UB sinaphunziridwe mozama ngati wothandizira khansa.
Njira yochitira UA ndi UB ndiyosiyananso. UA imayendetsa njira ya Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) njira, yomwe imagwira ntchito mu mitochondrial biogenesis, pamene UB imapangitsa AMP-activated protein kinase (AMPK) njira, yomwe imakhudzidwa ndi mphamvu ya homeostasis. Njirazi zimathandizira ku zotsatira zopindulitsa za mankhwalawa pa thanzi.
Ngakhale mapindu osangalatsa a UA ndi UB, akadali ndi malire pakugwiritsa ntchito kwawo. Mwachitsanzo, bioavailability wa mankhwalawa akadali otsika, ndipo pharmacokinetics yawo sakumveka bwino. Komanso, zotsatira za mankhwalawa pa anthu sizidziwika bwino, monga momwe kafukufuku wambiri wachitikira mu vitro kapena zinyama. Komabe, kafukufuku omwe alipo akuwonetsa kuti UA ndi UB atha kukhala akulonjeza ofuna kupanga zakudya zogwira ntchito kapena zowonjezera kuti zithandizire thanzi komanso kupewa matenda.
Urolithin A. Kamolekyu kakang'ono kameneka kamapezeka mwachilengedwe mu zipatso zina ndi mtedza ndi yotchuka chifukwa cha kuthekera kwake kukonza chilichonse kuyambira kukula kwa minofu kupita ku ubongo. Urolithin A ndi metabolite, kutanthauza kuti amapangidwa ndi zinthu zina m'thupi. Makamaka, amapangidwa pamene mabakiteriya a m'mimba amathyola ellagitannins, omwe amapezeka muzakudya zina monga makangaza, sitiroberi ndi walnuts. Koma apa pali gawo losangalatsa: si aliyense amene ali ndi mabakiteriya a m'matumbo omwe amafunikira kuti apange urolithin A. Ndipotu, kafukufuku wasonyeza kuti pafupifupi 30-50% ya anthu akhoza kupanga molekyuluyi mwachibadwa. Apa ndipamene zowonjezera zowonjezera zimakhala zothandiza.
Kotero, ndi chiyaniubwino wa urolithin A? Chabwino, chimodzi mwazinthu zazikuluzikulu ndikuti zingathandize kusintha thanzi la minofu. Kafukufuku wofalitsidwa mu nyuzipepala ya Nature Medicine anapeza kuti pamene makoswe anapatsidwa urolithin A, anali ndi kuwonjezeka kwa 42% kupirira ndi kuwonjezeka kwa 70% mu minofu. Ngakhale kuti zotsatirazi ndi zochititsa chidwi, ndizofunika kudziwa kuti iyi inali phunziro laling'ono ndipo kafukufuku wochuluka akufunika kuti atsimikizire zomwe zapezazi mwa anthu.
Koma si zokhazo zomwe urolithin A akuti amachita. Zawonetsedwanso kuti zimathandizira ntchito ya mitochondrial. Mitochondria kwenikweni ndi zomera zamphamvu zama cell, zomwe zimapanga mphamvu zomwe thupi lingagwiritse ntchito. Tikamakalamba, ntchito yathu ya mitochondrial imayamba kuchepa, zomwe zingayambitse matenda ambiri. Komabe, kafukufuku woyambirira akuwonetsa kuti urolithin A ingathandize kuchepetsa kuchepa uku, zomwe zingapangitse thanzi labwino komanso kutalikitsa moyo.
Monga ngati izo sizinali zokwanira, urolithin A yasonyezedwanso kuti ili ndi ubwino wa chidziwitso. Kafukufuku wofalitsidwa m’nyuzipepala ya Scientific Reports anapeza kuti makoswe atapatsidwa urolithin A, kukumbukira kwawo ndi luso lawo lophunzirira bwino. Ofufuza akukhulupirira kuti izi zitha kukhala chifukwa cha anti-yotupa ya molekyulu, zomwe zimathandiza kuteteza ma cell a ubongo kuti asawonongeke.
Urolithin B, pawiri yomwe imapezeka mu zipatso zosiyanasiyana ndi makangaza, imadziwika chifukwa cha maubwino ake pakuwongolera thanzi la kagayidwe kachakudya ndikutalikitsa moyo. Kafukufuku waposachedwapa wasonyeza kuti urolithin B ali ndi anti-yotupa ndi antioxidant katundu amene angathandize kupewa matenda aakulu ndi kusintha thanzi lonse.
1. Anti-kutupa katundu
Kutupa kosatha ndizomwe zimayambitsa matenda ambiri, kuphatikizapo matenda a mtima, shuga ndi khansa. Urolithin B ali ndi anti-inflammatory properties zomwe zimathandiza kuchepetsa kutupa m'thupi, motero kuchepetsa chiopsezo cha matenda aakulu. Kafukufuku wina adapeza kuti urolithin B imachepetsa kwambiri kutupa kwa mbewa zokhala ndi matenda otupa a m'matumbo, zomwe zikuwonetsa kuthekera kwake pochiza anthu omwe ali ndi matenda ofanana.
2. Antioxidant katundu
Urolithin B ndi antioxidant wamphamvu, zomwe zikutanthauza kuti zimatha kuteteza thupi ku kupsinjika kwa okosijeni, njira yomwe imawononga maselo ndikulimbikitsa kukalamba. Urolithin B imathandizira kupewa kuwonongeka kwa okosijeni mwa kusokoneza ma free radicals, omwe angayambitse kuwonongeka kwa ma cell ndikuyambitsa matenda osatha. Kafukufuku wina adapeza kuti urolithin B idachepetsa kupsinjika kwa okosijeni mu makoswe, kuthandiziranso kuthekera kwake ngati chowonjezera choletsa kukalamba.
3. Limbikitsani thanzi la minofu
Urolithin B yawonetsedwa kuti imathandizira mitochondrial autophagy, njira yama cell yomwe imathandiza kuchotsa mitochondria yowonongeka m'maselo. Izi zimathandiza kupititsa patsogolo thanzi labwino la minofu ndi ntchito, zomwe zimapangitsa kuti zikhale zowonjezera kwa iwo omwe akufuna kuti azichita bwino. Kafukufuku wina adapeza kuti urolithin B imathandizira kugwira ntchito kwa minofu ndi mphamvu mu mbewa ndi anthu.
4. Imathandizira thanzi lachidziwitso
Urolithin B yawonetsedwa kuti imathandizira thanzi lachidziwitso polimbikitsa neuroplasticity, njira yomwe imathandiza kuti ubongo ugwirizane ndi chidziwitso chatsopano komanso ukhoza kupititsa patsogolo chidziwitso. Kafukufuku wina adapeza kuti urolithin B imathandizira kuzindikira komanso kukumbukira bwino makoswe.
5. Phindu la moyo wautali
Kafukufuku waposachedwa wawonetsa kuti urolithin B imatha kulimbikitsa moyo wautali mwa kukonza thanzi la kagayidwe kachakudya, kuchepetsa kutupa, komanso kuteteza kupsinjika kwa okosijeni. Kafukufuku wina anapeza kuti urolithin B imachulukitsa moyo wa C. elegans, mtundu wa nyongolotsi za nematode, zomwe zimathandizira phindu lake lolimbikitsa moyo wautali.
1. Khangaza
Makangaza ndi amodzi mwa magwero abwino kwambiri a urolithin. Ofufuza apeza kuti madzi a makangaza amatha kuonjezera magazi a urolithins A ndi B. Komanso, makangaza ali ndi ubwino wina wa thanzi, kuphatikizapo anti-inflammatory and antioxidant properties.
2. Zipatso
Zipatso monga sitiroberi, raspberries ndi mabulosi akuda ndi magwero abwino a urolithin. Kafukufuku wasonyeza kuti kumwa mabulosi kumatha kuwonjezera kuchuluka kwa urolithin A ndi B m'magazi.
3. Mtedza
Walnuts ndi pecans ndi mtedza wina ndi gwero labwino la urolithin. Kafukufuku wina adapeza kuti kumwa mtedza kumawonjezera kuchuluka kwa urolithin A ndi B m'magazi.
Urolithin A ndi B ndi mankhwala achilengedwe omwe amapezeka muzakudya zina, ali ndi maubwino ambiri azaumoyo. Mankhwalawa ali ndi anti-inflammatory properties, amathandizira thanzi la mitochondrial ndi minofu, ndikulimbikitsa thanzi lachidziwitso. Makangaza, zipatso, mtedza ndi ellagitannin zowonjezera ndi zina mwazakudya zabwino zomwe zingapereke urolithins. Kuphatikizira zakudya izi muzakudya zanu kumatha kukuthandizani kuti mutsegule ma urolithin A ndi B ndikulimbikitsa ukalamba wathanzi.
Nthawi yotumiza: Jun-05-2023
